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Aliases for MIR19B1 Gene

Subcategory (RNA class) for MIR19B1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR19B1 Gene

  • MicroRNA 19b-1 2 3 5
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • Hsa-Mir-19b-1 3
  • MicroRNA-19b 3
  • MiR-19b-1 3
  • MiRNA19B1 3
  • C13orf25 3
  • MIRN19B1 3
  • MIR17HG 3
  • MiR-19b 3
  • MIRHG1 3
  • MIR19B 3
  • MIRH1 3

External Ids for MIR19B1 Gene

Previous HGNC Symbols for MIR19B1 Gene

  • MIRN19B1

Previous GeneCards Identifiers for MIR19B1 Gene

  • GC13P090873
  • GC13P090881
  • GC13P092011
  • GC13P092020
  • GC13P092027
  • GC13P092035
  • GC13P092044
  • GC13P092054
  • GC13P092063
  • GC13P092073
  • GC13P092082
  • GC13P091354
  • GC13P091359
  • GC13P091365
  • GC13P091376
  • GC13P091383

Summaries for MIR19B1 Gene

Entrez Gene Summary for MIR19B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR19B1 Gene

MIR19B1 (MicroRNA 19b-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA Damage Response and MicroRNAs in cancer.

Additional gene information for MIR19B1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR19B1 Gene

Genomics for MIR19B1 Gene

GeneHancer (GH) Regulatory Elements for MIR19B1 Gene

Promoters and enhancers for MIR19B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I091346 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 0.8 -2.2 -2159 4.8 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 GC13P091372 GC13P091377 GC13P091384 GC13P091391 GC13P091394 GC13P091397 GC13P091399 GC13P091400 GC13P091401 MIR17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR19B1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR19B1 Gene

Genomic Locations for MIR19B1 Gene
chr13:91,351,192-91,351,278
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)

Genomic View for MIR19B1 Gene

Genes around MIR19B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR19B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR19B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR19B1 Gene

Proteins for MIR19B1 Gene

Post-translational modifications for MIR19B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR19B1 Gene

Domains & Families for MIR19B1 Gene

Gene Families for MIR19B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR19B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR19B1 Gene

Function for MIR19B1 Gene

Gene Ontology (GO) - Molecular Function for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18728182
genes like me logo Genes that share ontologies with MIR19B1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR19B1 Gene

Localization for MIR19B1 Gene

Gene Ontology (GO) - Cellular Components for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0048471 perinuclear region of cytoplasm ISS --
GO:0072562 blood microparticle IDA 24998411
genes like me logo Genes that share ontologies with MIR19B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR19B1 Gene

Pathways & Interactions for MIR19B1 Gene

genes like me logo Genes that share pathways with MIR19B1: view

Pathways by source for MIR19B1 Gene

1 KEGG pathway for MIR19B1 Gene

Interacting Proteins for MIR19B1 Gene

Gene Ontology (GO) - Biological Process for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation ISS --
GO:0010629 negative regulation of gene expression IDA 25765596
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle IDA 22197821
GO:0035195 gene silencing by miRNA IDA 18728182
genes like me logo Genes that share ontologies with MIR19B1: view

No data available for SIGNOR curated interactions for MIR19B1 Gene

Drugs & Compounds for MIR19B1 Gene

No Compound Related Data Available

Transcripts for MIR19B1 Gene

mRNA/cDNA for MIR19B1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR19B1 Gene

No ASD Table

Relevant External Links for MIR19B1 Gene

GeneLoc Exon Structure for
MIR19B1
ECgene alternative splicing isoforms for
MIR19B1

Expression for MIR19B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR19B1 Gene:

MIR19B1
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR19B1 Gene

Orthologs for MIR19B1 Gene

Evolution for MIR19B1 Gene

ENSEMBL:
Gene Tree for MIR19B1 (if available)
TreeFam:
Gene Tree for MIR19B1 (if available)

No data available for Orthologs for MIR19B1 Gene

Paralogs for MIR19B1 Gene

No data available for Paralogs for MIR19B1 Gene

Variants for MIR19B1 Gene

Sequence variations from dbSNP and Humsavar for MIR19B1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1001980789 -- 91,351,489(+) G/A downstream_transcript_variant
rs1002349918 -- 91,351,188(+) T/C/G upstream_transcript_variant
rs1002944928 -- 91,349,535(+) G/A upstream_transcript_variant
rs1003385207 -- 91,349,835(+) A/G upstream_transcript_variant
rs1004434983 -- 91,349,440(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR19B1 Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR19B1 Gene

Human Gene Mutation Database (HGMD)
MIR19B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR19B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR19B1 Gene

Disorders for MIR19B1 Gene

Additional Disease Information for MIR19B1

No disorders were found for MIR19B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR19B1 Gene

Publications for MIR19B1 Gene

  1. Mitochondria-targeted esculetin inhibits PAI-1 levels by modulating STAT3 activation and miR-19b via SIRT3: Role in acute coronary artery syndrome. (PMID: 28213977) Katta S … Kotamraju S (Journal of cellular physiology 2018) 3 58
  2. Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer. (PMID: 28091918) Osip'yants AI … Alekseev BY (Bulletin of experimental biology and medicine 2017) 3 58
  3. Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer. (PMID: 28364280) Gu Y … Chen X (Protein & cell 2017) 3 58
  4. A serum exosomal microRNA panel as a potential biomarker test for gastric cancer. (PMID: 28986250) Wang N … Liu X (Biochemical and biophysical research communications 2017) 3 58
  5. MicroRNA-19b Expression in Human Biliary Atresia Specimens and Its Role in BA-Related Fibrosis. (PMID: 28083843) Zhao D … Xia Q (Digestive diseases and sciences 2017) 3 58

Products for MIR19B1 Gene

Sources for MIR19B1 Gene

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