microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR19B1 Gene

Subcategory (RNA class) for MIR19B1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR19B1 Gene

  • MicroRNA 19b-1 2 3 5
  • Hsa-MiR-19b-1-5p 163 173
  • Hsa-MiR-19b-3p 163 173
  • Hsa-Mir-19b-1 2 3
  • MIR19B1 2 5
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • Hsa-Mir-19-P2a 178
  • MicroRNA-19b 3
  • MIMAT0000074 50
  • MIMAT0004491 50
  • MiR-19b-1 3
  • MiRNA19B1 3
  • MI0000074 50
  • C13orf25 3
  • MIRN19B1 3
  • MIR17HG 3
  • MiR-19b 3
  • RF00245 168
  • MIR19B 3
  • MIRHG1 3
  • MIRH1 3

External Ids for MIR19B1 Gene

Previous HGNC Symbols for MIR19B1 Gene

  • MIRN19B1

Previous GeneCards Identifiers for MIR19B1 Gene

  • GC13P090873
  • GC13P090881
  • GC13P092011
  • GC13P092020
  • GC13P092027
  • GC13P092035
  • GC13P092044
  • GC13P092054
  • GC13P092063
  • GC13P092073
  • GC13P092082
  • GC13P091354
  • GC13P091359
  • GC13P091410
  • GC13P091413
  • GC13P091417
  • GC13P091428
  • GC13P091365
  • GC13P091376
  • GC13P091383
  • GC13P091390
  • GC13P091396
  • GC13P091404

Summaries for MIR19B1 Gene

Entrez Gene Summary for MIR19B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR19B1 Gene

MIR19B1 (MicroRNA 19b-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR19B1 include Luminal Breast Carcinoma A and Potocki-Shaffer Syndrome. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

Rfam classification for MIR19B1 Gene

  • mir-19 microRNA precursor family

Additional gene information for MIR19B1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR19B1 Gene

Genomics for MIR19B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR19B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J091346 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.2 -2191 5.2 GATAD2A CTCF TFE3 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 ZNF143 MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 AB372624 MIR19B1 MIR20A MIR92A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR19B1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR19B1 Gene

Genomic Locations for MIR19B1 Gene
chr13:91,351,192-91,351,278
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR19B1 Gene

Genes around MIR19B1 on UCSC Golden Path with GeneCards custom track
MIR19B1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR19B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR19B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR19B1 Gene

Proteins for MIR19B1 Gene

Post-translational modifications for MIR19B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR19B1 Gene

Domains & Families for MIR19B1 Gene

Gene Families for MIR19B1 Gene

genes like me logo Genes that share domains with MIR19B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR19B1 Gene

Function for MIR19B1 Gene

Gene Ontology (GO) - Molecular Function for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 22105995
genes like me logo Genes that share ontologies with MIR19B1: view

Animal Model Products

CRISPR Products

miRNA for MIR19B1 Gene

miRTarBase miRNAs that target MIR19B1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR19B1 Gene

Localization for MIR19B1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR19B1 gene
Compartment Confidence
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0048471 perinuclear region of cytoplasm ISS --
GO:0072562 blood microparticle IDA 24998411
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR19B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR19B1 Gene

Pathways & Interactions for MIR19B1 Gene

genes like me logo Genes that share pathways with MIR19B1: view

Pathways by source for MIR19B1 Gene

1 KEGG pathway for MIR19B1 Gene

Gene Ontology (GO) - Biological Process for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IDA 22105995
GO:0008284 positive regulation of cell proliferation ISS --
GO:0010629 negative regulation of gene expression IDA 25765596
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle IDA 22197821
genes like me logo Genes that share ontologies with MIR19B1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR19B1 Gene

Drugs & Compounds for MIR19B1 Gene

No Compound Related Data Available

Transcripts for MIR19B1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR19B1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000013D17D_9606 miRNA 23 6

RefSeq: NR_029490, NR_029491,

LncBase: hsa-miR-19b-3p,

miRBase: MIMAT0000074,

MirGeneDB: Hsa-Mir-19-P2a_3p, Hsa-Mir-19-P2b_3p,

TarBase: hsa-miR-19b-3p,

ENA: View 7 records in RNAcentral

URS00001B9622_9606 miRNA 23 6

RefSeq: NR_029490,

LncBase: hsa-miR-19b-1-5p,

miRBase: MIMAT0004491,

MirGeneDB: Hsa-Mir-19-P2a_5p,

TarBase: hsa-miR-19b-1-5p,

ENA: LM380171.1:1..23:ncRNA, LM608163.1:16..38:ncRNA,

URS00003BACA4_9606 precursor_RNA 87 5

HGNC: 31575,

RefSeq: NR_029490,

Ensembl: ENST00000384829 (view in UCSC) ,

miRBase: MI0000074,

ENA: LM608163.1:1..87:precursor_RNA,

URS000009B175_9606 precursor_RNA 80 1

ENA: AB176708.1:1640..1719:ncRNA, AF480555.1:1..80:misc_RNA,

URS0000116775_9606 precursor_RNA 75 1

Rfam: RF00245,

MIR19B1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR19B1 Gene

5 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR19B1 Gene

No ASD Table

Relevant External Links for MIR19B1 Gene

GeneLoc Exon Structure for
MIR19B1

Expression for MIR19B1 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR19B1 Gene

Orthologs for MIR19B1 Gene

Evolution for MIR19B1 Gene

ENSEMBL:
Gene Tree for MIR19B1 (if available)
TreeFam:
Gene Tree for MIR19B1 (if available)

No data available for Orthologs for MIR19B1 Gene

Paralogs for MIR19B1 Gene

No data available for Paralogs for MIR19B1 Gene

Variants for MIR19B1 Gene

Additional dbSNP identifiers (rs#s) for MIR19B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR19B1 Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR19B1 Gene

Human Gene Mutation Database (HGMD)
MIR19B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR19B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR19B1 Gene

Disorders for MIR19B1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIR19B1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
luminal breast carcinoma a
  • breast tumor luminal
potocki-shaffer syndrome
  • pss
myocarditis
  • myocardial inflammation
aortic atherosclerosis
  • atherosclerosis of aorta
oropouche fever
  • oropouche virus disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR19B1

genes like me logo Genes that share disorders with MIR19B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR19B1 Gene

Publications for MIR19B1 Gene

  1. MicroRNA-19b-3p promotes cell proliferation and osteogenic differentiation of BMSCs by interacting with lncRNA H19. (PMID: 31918667) Xiaoling G … Kailu L (BMC medical genetics 2020) 3
  2. CTGF regulates cyclic stretch-induced vascular smooth muscle cell proliferation via microRNA-19b-3p. (PMID: 30690026) Wang WB … Han Y (Experimental cell research 2019) 3
  3. MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6. (PMID: 31227976) Duan L … Wu X (Molecular and cellular biochemistry 2019) 3
  4. CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p. (PMID: 30975145) Wang L … Xu W (Molecular cancer 2019) 3
  5. MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance. (PMID: 29889802) Ecevit ÇÖ … Olgun N (Journal of pediatric hematology/oncology 2019) 3

Products for MIR19B1 Gene

Sources for MIR19B1 Gene