microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR19A Gene

Subcategory (RNA class) for MIR19A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR19A Gene

  • MicroRNA 19a 2 3 5
  • Hsa-MiR-19a-3p 163 173
  • Hsa-MiR-19a-5p 163 173
  • Hsa-Mir-19a 2 3
  • MIR19A 2 5
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • Hsa-Mir-19-P1 178
  • MIMAT0004490 50
  • MIMAT0000073 50
  • MI0000073 50
  • C13orf25 3
  • MiRNA19A 3
  • MIR17HG 3
  • MIRN19A 3
  • MiR-19a 3
  • RF00245 168
  • MIRHG1 3
  • MIRH1 3

External Ids for MIR19A Gene

Previous HGNC Symbols for MIR19A Gene

  • MIRN19A

Previous GeneCards Identifiers for MIR19A Gene

  • GC13P090871
  • GC13P090879
  • GC13P092008
  • GC13P092017
  • GC13P092025
  • GC13P092033
  • GC13P092042
  • GC13P092052
  • GC13P092060
  • GC13P092070
  • GC13P092081
  • GC13P091352
  • GC13P091357
  • GC13P091407
  • GC13P091411
  • GC13P091415
  • GC13P091426
  • GC13P091363
  • GC13P091373
  • GC13P091381
  • GC13P091388
  • GC13P091394
  • GC13P091401

Summaries for MIR19A Gene

Entrez Gene Summary for MIR19A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR19A Gene

MIR19A (MicroRNA 19a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR19A include Thyroid Gland Anaplastic Carcinoma and Cowden Syndrome. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

Rfam classification for MIR19A Gene

  • mir-19 microRNA precursor family

Additional gene information for MIR19A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR19A Gene

Genomics for MIR19A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR19A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J091346 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.9 -1890 5.2 GATAD2A CTCF TFE3 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 ZNF143 MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 AB372624 MIR19B1 MIR20A MIR92A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR19A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR19A Gene

Genomic Locations for MIR19A Gene
chr13:91,350,891-91,350,972
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR19A Gene

Genes around MIR19A on UCSC Golden Path with GeneCards custom track
MIR19A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR19A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR19A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR19A Gene

Proteins for MIR19A Gene

Post-translational modifications for MIR19A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR19A Gene

Domains & Families for MIR19A Gene

Gene Families for MIR19A Gene

genes like me logo Genes that share domains with MIR19A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR19A Gene

Function for MIR19A Gene

Gene Ontology (GO) - Molecular Function for MIR19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 22105995
genes like me logo Genes that share ontologies with MIR19A: view

Animal Model Products

CRISPR Products

miRNA for MIR19A Gene

miRTarBase miRNAs that target MIR19A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR19A Gene

Localization for MIR19A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR19A gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome ISS --
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR19A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR19A Gene

Pathways & Interactions for MIR19A Gene

genes like me logo Genes that share pathways with MIR19A: view

Pathways by source for MIR19A Gene

1 KEGG pathway for MIR19A Gene

Gene Ontology (GO) - Biological Process for MIR19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IDA 22105995
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0034122 negative regulation of toll-like receptor signaling pathway IMP 26041742
GO:0035195 gene silencing by miRNA IMP 22105995
GO:0042113 B cell activation IDA 26017478
genes like me logo Genes that share ontologies with MIR19A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR19A Gene

Drugs & Compounds for MIR19A Gene

No Compound Related Data Available

Transcripts for MIR19A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR19A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000006FDD4_9606 miRNA 23 6

RefSeq: NR_029489,

LncBase: hsa-miR-19a-3p,

miRBase: MIMAT0000073,

MirGeneDB: Hsa-Mir-19-P1_3p,

TarBase: hsa-miR-19a-3p,

ENA: AB176708.1:1382..1404:ncRNA, AF480522.1:1..23:ncRNA, AJ421737.1:1..23:misc_RNA, LM378760.1:1..23:ncRNA, LM608162.1:49..71:ncRNA,

URS0000539083_9606 precursor_RNA 82 5

HGNC: 31574,

RefSeq: NR_029489,

Ensembl: ENST00000384878 (view in UCSC) ,

miRBase: MI0000073,

ENA: LM608162.1:1..82:precursor_RNA,

URS00001754CF_9606 miRNA 22 5

RefSeq: NR_029489,

LncBase: hsa-miR-19a-5p,

miRBase: MIMAT0004490,

TarBase: hsa-miR-19a-5p,

ENA: LM380170.1:1..22:ncRNA, LM608162.1:14..35:ncRNA,

URS000001006F_9606 precursor_RNA 80 1

ENA: AB176708.1:1335..1414:ncRNA, AF480554.1:1..80:misc_RNA,

URS0000016B10_9606 precursor_RNA 72 1

Rfam: RF00245,

MIR19A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR19A Gene

5 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR19A Gene

No ASD Table

Relevant External Links for MIR19A Gene

GeneLoc Exon Structure for
MIR19A

Expression for MIR19A Gene

Evidence on tissue expression from TISSUES for MIR19A Gene

  • Blood(2.5)
  • Heart(2.2)
  • Nervous system(2.1)
  • Intestine(2.1)
  • Muscle(2.1)
  • Liver(2)
  • Lymph node(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR19A Gene

Orthologs for MIR19A Gene

Evolution for MIR19A Gene

ENSEMBL:
Gene Tree for MIR19A (if available)
TreeFam:
Gene Tree for MIR19A (if available)

No data available for Orthologs for MIR19A Gene

Paralogs for MIR19A Gene

No data available for Paralogs for MIR19A Gene

Variants for MIR19A Gene

Additional dbSNP identifiers (rs#s) for MIR19A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR19A Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR19A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR19A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR19A Gene

Disorders for MIR19A Gene

MalaCards: The human disease database

(35) MalaCards diseases for MIR19A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
thyroid gland anaplastic carcinoma
  • anaplastic thyroid carcinoma
cowden syndrome
  • cs
myeloma, multiple
  • multiple myeloma, susceptibility to
medulloblastoma
  • mdb
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR19A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR19A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR19A Gene

Publications for MIR19A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. MicroRNA-19a regulates the proliferation, migration and invasion of human gastric cancer cells by targeting CUL5. (PMID: 30521783) Zhu Y … Gong K (Archives of biochemistry and biophysics 2019) 3
  3. Differential network analysis depicts regulatory mechanisms for hepatocellular carcinoma from diverse backgrounds. (PMID: 31729887) Yu MC … Xu Y (Future oncology (London, England) 2019) 3
  4. miR-19 targets PTEN and mediates high mobility group protein B1(HMGB1)-induced proliferation and migration of human airway smooth muscle cells. (PMID: 31247032) Hou C … Tan X (PloS one 2019) 3
  5. The NF-κB-modulated miR-19a-3p enhances malignancy of human ovarian cancer cells through inhibition of IGFBP-3 expression. (PMID: 31513316) Bai R … Sun J (Molecular carcinogenesis 2019) 3

Products for MIR19A Gene

Sources for MIR19A Gene