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Aliases for MIR19A Gene

Subcategory (RNA class) for MIR19A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR19A Gene

  • MicroRNA 19a 2 3 5
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • Hsa-Mir-19a 3
  • C13orf25 3
  • MiRNA19A 3
  • MIR17HG 3
  • MiR-19a 3
  • MIRN19A 3
  • MIRHG1 3
  • MIRH1 3

External Ids for MIR19A Gene

Previous HGNC Symbols for MIR19A Gene

  • MIRN19A

Previous GeneCards Identifiers for MIR19A Gene

  • GC13P090871
  • GC13P090879
  • GC13P092008
  • GC13P092017
  • GC13P092025
  • GC13P092033
  • GC13P092042
  • GC13P092052
  • GC13P092060
  • GC13P092070
  • GC13P092081
  • GC13P091352
  • GC13P091357
  • GC13P091363
  • GC13P091373
  • GC13P091381

Summaries for MIR19A Gene

Entrez Gene Summary for MIR19A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR19A Gene

MIR19A (MicroRNA 19a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA Damage Response and MicroRNAs in cancer.

Additional gene information for MIR19A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR19A Gene

Genomics for MIR19A Gene

GeneHancer (GH) Regulatory Elements for MIR19A Gene

Promoters and enhancers for MIR19A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I091346 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 550.8 -1.9 -1858 4.8 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 GC13P091372 GC13P091377 GC13P091384 GC13P091391 GC13P091394 GC13P091397 GC13P091399 GC13P091400 GC13P091401 MIR17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR19A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR19A Gene

Genomic Locations for MIR19A Gene
chr13:91,350,891-91,350,972
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)

Genomic View for MIR19A Gene

Genes around MIR19A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR19A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR19A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR19A Gene

Proteins for MIR19A Gene

Post-translational modifications for MIR19A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR19A Gene

Domains & Families for MIR19A Gene

Gene Families for MIR19A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR19A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR19A Gene

Function for MIR19A Gene

Gene Ontology (GO) - Molecular Function for MIR19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18728182
genes like me logo Genes that share ontologies with MIR19A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR19A Gene

Localization for MIR19A Gene

Gene Ontology (GO) - Cellular Components for MIR19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome ISS --
genes like me logo Genes that share ontologies with MIR19A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR19A Gene

Pathways & Interactions for MIR19A Gene

genes like me logo Genes that share pathways with MIR19A: view

Pathways by source for MIR19A Gene

1 KEGG pathway for MIR19A Gene

Interacting Proteins for MIR19A Gene

Gene Ontology (GO) - Biological Process for MIR19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0035195 gene silencing by miRNA IDA 18728182
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP 18728182
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development IGI 24117217
GO:1903202 negative regulation of oxidative stress-induced cell death ISS --
genes like me logo Genes that share ontologies with MIR19A: view

No data available for SIGNOR curated interactions for MIR19A Gene

Drugs & Compounds for MIR19A Gene

No Compound Related Data Available

Transcripts for MIR19A Gene

mRNA/cDNA for MIR19A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR19A Gene

No ASD Table

Relevant External Links for MIR19A Gene

GeneLoc Exon Structure for
MIR19A
ECgene alternative splicing isoforms for
MIR19A

Expression for MIR19A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR19A Gene:

MIR19A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR19A Gene

Orthologs for MIR19A Gene

Evolution for MIR19A Gene

ENSEMBL:
Gene Tree for MIR19A (if available)
TreeFam:
Gene Tree for MIR19A (if available)

No data available for Orthologs for MIR19A Gene

Paralogs for MIR19A Gene

No data available for Paralogs for MIR19A Gene

Variants for MIR19A Gene

Sequence variations from dbSNP and Humsavar for MIR19A Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1002349918 -- 91,351,188(+) T/C/G downstream_transcript_variant
rs1002944928 -- 91,349,535(+) G/A upstream_transcript_variant
rs1003385207 -- 91,349,835(+) A/G upstream_transcript_variant
rs1004372915 -- 91,349,113(+) C/G/T upstream_transcript_variant
rs1004434983 -- 91,349,440(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR19A Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR19A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR19A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR19A Gene

Disorders for MIR19A Gene

Additional Disease Information for MIR19A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR19A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR19A Gene

Publications for MIR19A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. High bone marrow miR-19b level predicts poor prognosis and disease recurrence in de novo acute myeloid leukemia. (PMID: 29032147) Zhang TJ … Qian J (Gene 2018) 3 58
  3. miR-19 promotes osteosarcoma progression by targeting SOCS6. (PMID: 28986253) Sun Z … Zhang T (Biochemical and biophysical research communications 2018) 3 58
  4. A panel of microRNA signature in serum for colorectal cancer diagnosis. (PMID: 28177881) Zhu M … Liu P (Oncotarget 2017) 3 58
  5. miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1. (PMID: 28257633) Liu Y … Chen X (Molecular cancer 2017) 3 58

Products for MIR19A Gene

Sources for MIR19A Gene

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