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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR199B Gene
Subcategory (RNA class) for MIR199B Gene
miRNA
Aliases for MIR199B Gene
- Hsa-Mir-199-P1-V3 (MirGeneDB)
- MIMAT0004563 (miRBase)
- MIMAT0000263 (miRBase)
- MI0000282 (miRBase)
- MIRN199B (NCBI Entrez Gene)
- Mir-199b (NCBI Entrez Gene)
- MIR199B (Ensembl)
- RF00144 (Rfam)
External Ids for MIR199B Gene
- HGNC: 31573
- NCBI Entrez Gene: 406978
- Ensembl: ENSG00000207581
- OMIM®: 614791
- miRBase: hsa-mir-199b
Previous HGNC Symbols for MIR199B Gene
- MIRN199B
Previous GeneCards Identifiers for MIR199B Gene
- GC09M130047
- GC09M131007
Summaries for MIR199B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR199B Gene
MIR199B (MicroRNA 199b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199B include Medulloblastoma and Breast Cancer. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.
Rfam classification for MIR199B Gene
-
mir-199 microRNA precursor
Additional gene information for MIR199B Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199B Gene
Genomics for MIR199B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR199B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J128241 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE CraniofacialAtlas | 250.7 | +0.5 | 504 | 5.7 | BHLHE40 ZIC2 SAP130 ETV4 GABPB1 ZBTB5 TEAD3 ZNF316 CREM TARDBP | MIR199B MIR3154 GLE1 NUP188 NAIF1 URM1 SLC27A4 PHYHD1 SWI5 ST6GALNAC6 | |
| GH09J128222 | Enhancer | 0.2 | dbSUPER | 12.4 | +22.2 | 22248 | 1.1 | MIR199B BBLN LCN2 CIZ1 RF00017-7951 HSALNG0074593 RF00017-7950 HSALNG0074592 DNM1 SWI5 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR199B on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR199B Gene
Latest Assembly
- chr9:128,244,721-128,244,830
- (GRCh38/hg38)
- Size:
- 110 bases
- Orientation:
- Minus strand
Previous Assembly
- chr9:131,007,000-131,007,109
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 110 bases
- Orientation:
- Minus strand
- chr9:131,007,000-131,007,109
- (GRCh37/hg19 by Ensembl)
- Size:
- 110 bases
- Orientation:
- Minus strand
Genomic View for MIR199B Gene
Genes around MIR199B on UCSC Golden Path with GeneCards custom track
MIR199B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 9q34.11 by HGNC
- 9q34.11 by Entrez Gene
- 9q34.11 by Ensembl
MIR199B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR199B Gene
Proteins for MIR199B Gene
Post-translational modifications for MIR199B Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR199B Gene
Domains & Families for MIR199B Gene
Gene Families for MIR199B Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR199B Gene
Function for MIR199B Gene
Phenotypes From GWAS Catalog for MIR199B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP,IDA | 15131085 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR199B - Starting at $85 >
- * MIR199B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR199B - Starting at $45 >
- * MIR199B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199B Gene
Localization for MIR199B Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR199B Gene
Pathways & Interactions for MIR199B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Alzheimers Disease | ||
Pathways by source for MIR199B Gene
1 BioSystems pathway for MIR199B Gene
1 KEGG pathway for MIR199B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000320 | re-entry into mitotic cell cycle | ISS | -- |
| GO:0010595 | positive regulation of endothelial cell migration | IMP | -- |
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
| GO:0032686 | negative regulation of hepatocyte growth factor production | IMP | -- |
| GO:0035195 | gene silencing by miRNA | IMP,IEA | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR199B Gene
Transcripts for MIR199B Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR199B Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000029EBD_9606 | miRNA | 23 | 6 |
RefSeq: NR_029619, LncBase: hsa-miR-199b-5p, miRBase: MIMAT0000263, MirGeneDB: Hsa-Mir-199-P1-v1_5p, TarBase: hsa-miR-199b-5p, ENA: AJ535832.1:1..23:ncRNA, LM378903.1:1..23:ncRNA, LM608351.1:26..48:ncRNA, |
| URS00003F2D94_9606 | miRNA | 22 | 6 |
RefSeq: NR_029586, NR_029618, NR_029619, LncBase: hsa-miR-199a-3p, hsa-miR-199b-3p, miRBase: MIMAT0004563, MirGeneDB: Hsa-Mir-199-P1-v1_3p, Hsa-Mir-199-P2-v1_3p, Hsa-Mir-199-P3-v1_3p, TarBase: hsa-miR-199a-3p, hsa-miR-199b-3p, ENA: View 6 records in RNAcentral |
| URS000075E907_9606 | precursor_RNA | 110 | 4 |
RefSeq: NR_029619, Ensembl: ENST00000384849 (view in UCSC) , miRBase: MI0000282, |
| URS0001BBECF0_9606 | pre_miRNA | 100 | 1 |
Rfam: RF00144, |
| URS0000117290_9606 | precursor_RNA | 98 | 1 |
Rfam: RF00144, |
MIR199B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR199B Gene
- 2 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR199B - Starting at $85 >
- * MIR199B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR199B - Starting at $45 >
- * MIR199B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR199B Gene
- GeneLoc Exon Structure for
- MIR199B
Expression for MIR199B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR199B
Primer products for research
-
OriGene qPCR primer pairs for MIR199B
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199B Gene
Orthologs for MIR199B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | cfa-mir-199-3 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-199b 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir199b 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-199b 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-199b-1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-mir-199-1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-199b 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-199-3 31 |
|
OneToOne |
- Species where no ortholog for MIR199B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIR199B Gene
No data available for Paralogs for MIR199B Gene
Variants for MIR199B Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR199B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR199B
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR199B Gene
Disorders for MIR199B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| medulloblastoma |
|
|
| breast cancer |
|
|
| polymyositis |
|
|
| muscular dystrophy, limb-girdle, autosomal recessive 1 |
|
|
| dermatomyositis |
|
Search MIR199B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR199B
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR199B Gene
Publications for MIR199B Gene
- Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. (PMID: 19900756) Chao A … Lai CH (Cancer letters 2010) 3 74
- MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. (PMID: 19308264) Garzia L … Zollo M (PloS one 2009) 3 74
- Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression. (PMID: 30987652) Jin H … Xu CX (Journal of experimental & clinical cancer research : CR 2019) 3
- MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17. (PMID: 31081094) Su WZ … Ren LF (European review for medical and pharmacological sciences 2019) 3
- Micro-ribonucleic acid expression signature of metastatic castration-resistant prostate cancer: Regulation of NCAPH by antitumor miR-199a/b-3p. (PMID: 30818424) Arai T … Seki N (International journal of urology : official journal of the Japanese Urological Association 2019) 3
ExternalLinks
Products for MIR199B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR199B
- Origene Custom Protein Services for MIR199B
- Browse OriGene Inhibitory RNA Products For MIR199B
- OriGene qPCR primer pairs for MIR199B
- Browse CRISPR knockouts for MIR199B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR199B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR199B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR199B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR199B
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR199B
Sources for MIR199B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB