Aliases for MIR199B Gene
Subcategory (RNA class) for MIR199B Gene
miRNA
Quality Score for this RNA gene is
10.2
External Ids for MIR199B Gene
- HGNC: 31573
- Entrez Gene: 406978
- Ensembl: ENSG00000207581
- OMIM: 614791
- miRBase: hsa-mir-199b
ORGUL Members for MIR199B Gene
Previous HGNC Symbols for MIR199B Gene
- MIRN199B
Previous GeneCards Identifiers for MIR199B Gene
- GC09M130047
- GC09M131007
Summaries for MIR199B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR199B Gene
MIR199B (MicroRNA 199b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.
fRNAdb sequence ontologies for MIR199B Gene - the ORGUL cluster for this gene includes several descriptions:
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for MIR199B Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199B Gene
Genomics for MIR199B Gene
GeneHancer (GH) Regulatory Elements for MIR199B Gene
Promoters and enhancers for MIR199B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09I128241 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 550.8 | +0.5 | 504 | 5.7 | HDAC1 ELF3 HDGF PKNOX1 ATF1 NFXL1 DNMT3B GLIS2 EGR1 ARID2 | MIR199B MIR3154 GLE1 NUP188 NAIF1 URM1 SLC27A4 PHYHD1 SWI5 ST6GALNAC6 | |
| GH09I128222 | Enhancer | 0.2 | dbSUPER | 12.4 | +22.2 | 22248 | 1.1 | MIR199B C9orf16 LCN2 CIZ1 GC09M128212 DNM1 | ||
| GH09I128232 | Enhancer | 0.6 | ENCODE | 0.4 | +12.7 | 12723 | 0.2 | SMARCA5 ZNF263 L3MBTL2 BHLHE40 USF2 MNT MITF FOSL1 CBX1 ADNP | GC09M128212 MIR199B DNM1 | |
| GH09I128230 | Enhancer | 0.3 | FANTOM5 | 0.4 | +14.5 | 14503 | 0.1 | DNM1 CIZ1 C9orf16 LCN2 SLC25A25 SH2D3C ST6GALNAC6 SPTAN1 GC09M128212 MIR199B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR199B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR199B Gene
Genomic Locations for MIR199B Gene
- chr9:128,244,721-128,244,830
- (GRCh38/hg38)
- Size:
- 110 bases
- Orientation:
- Minus strand
- chr9:131,007,000-131,007,109
- (GRCh37/hg19)
Genomic View for MIR199B Gene
Genes around MIR199B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.11 by Ensembl
- 9q34.11 by Entrez Gene
- 9q34.11 by HGNC
MIR199B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR199B Gene
ORGUL Member Location for MIR199B Gene
Proteins for MIR199B Gene
Post-translational modifications for MIR199B Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR199B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR199B
- Origene Custom Protein Services for MIR199B
- Search GeneTex for Proteins for MIR199B
No data available for DME Specific Peptides for MIR199B Gene
Domains & Families for MIR199B Gene
Gene Families for MIR199B Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR199B Gene
Function for MIR199B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 15131085 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR199B
-
- Search ViGene Biosciences for MIR199B
CRISPR Products
- Browse CRISPR knockouts for MIR199B
- Applied Biological Materials CRISPR for MIR199B
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR199B
Clone Products
- GenScript: Custom all cDNA clones Services for MIR199B
- VectorBuilder custom plasmid, inducible vectors for MIR199B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR199B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR199B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199B Gene
Localization for MIR199B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR199B Gene
Pathways & Interactions for MIR199B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
Pathways by source for MIR199B Gene
1 BioSystems pathway for MIR199B Gene
1 KEGG pathway for MIR199B Gene
Interacting Proteins for MIR199B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000320 | re-entry into mitotic cell cycle | ISS | -- |
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
| GO:0035195 | gene silencing by miRNA | IDA | 15131085 |
| GO:0045603 | positive regulation of endothelial cell differentiation | ISS | -- |
| GO:0045765 | NOT regulation of angiogenesis | ISS | -- |
No data available for SIGNOR curated interactions for MIR199B Gene
Transcripts for MIR199B Gene
fRNAdb Secondary structures for MIR199B Gene
mRNA/cDNA for MIR199B Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR199B
- Applied Biological Materials CRISPR for MIR199B
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR199B
Clone Products
- GenScript: Custom all cDNA clones Services for MIR199B
- VectorBuilder custom plasmid, inducible vectors for MIR199B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR199B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR199B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR199B Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR199B Gene:
MIR199BPrimer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199B Gene
Orthologs for MIR199B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | cfa-mir-199-3 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-199b 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-mir-199b 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mir199b 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-199b-1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-mir-199-1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | aca-mir-199b 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dre-mir-199-3 34 |
|
OneToOne |
- Species where no ortholog for MIR199B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR199B Gene
No data available for Paralogs for MIR199B Gene
Variants for MIR199B Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs111534551 | benign, not specified, Epileptic encephalopathy, early infantile, 31 | 128,246,486(-) | C/T | upstream_transcript_variant | |
| rs145318071 | likely-benign, not specified, Epileptic encephalopathy, early infantile, 31 | 128,246,429(-) | C/G/T | upstream_transcript_variant | |
| rs772239774 | uncertain-significance, Epileptic encephalopathy, early infantile, 31 | 128,246,494(-) | C/T | upstream_transcript_variant | |
| rs776254391 | likely-benign, not specified | 128,246,465(-) | G/A | upstream_transcript_variant | |
| rs1001157151 | -- | 128,246,086(-) | T/A | upstream_transcript_variant |
Additional Variant Information for MIR199B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR199B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR199B Gene
Disorders for MIR199B Gene
Additional Disease Information for MIR199B
No disorders were found for MIR199B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR199B Gene
Publications for MIR199B Gene
- Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 58
- Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael MZ … James RJ (Molecular cancer research : MCR 2003) 1 3 58
- A functional variant in the 3'-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients. (PMID: 28234972) Zhao J … Wang S (PloS one 2017) 3 58
- MicroRNA-199b-5p attenuates TGF-β1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. (PMID: 28588321) Zhou SJ … Sun NF (British journal of cancer 2017) 3 58
- Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer. (PMID: 28612520) Koshizuka K … Seki N (Cancer science 2017) 3 58
Products for MIR199B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Assay Services
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- Browse CRISPR knockouts for MIR199B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR199B
- GenScript: Custom all cDNA clones Services for MIR199B
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- Cloud-Clone Corp. disease models service
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- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR199B
- VectorBuilder custom plasmid, inducible vectors for MIR199B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR199B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR199B
- Search GeneTex for Proteins for MIR199B
Sources for MIR199B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew