microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR199B Gene

Subcategory (RNA class) for MIR199B Gene

miRNA

Aliases for MIR199B Gene

External Ids for MIR199B Gene

Previous HGNC Symbols for MIR199B Gene

  • MIRN199B

Previous GeneCards Identifiers for MIR199B Gene

  • GC09M130047
  • GC09M131007

Summaries for MIR199B Gene

Entrez Gene Summary for MIR199B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199B Gene

MIR199B (MicroRNA 199b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199B include Medulloblastoma and Breast Cancer. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR199B Gene

  • mir-199 microRNA precursor

Additional gene information for MIR199B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199B Gene

Genomics for MIR199B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR199B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J128241 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas 250.7 +0.5 504 5.7 BHLHE40 ZIC2 SAP130 ETV4 GABPB1 ZBTB5 TEAD3 ZNF316 CREM TARDBP MIR199B MIR3154 GLE1 NUP188 NAIF1 URM1 SLC27A4 PHYHD1 SWI5 ST6GALNAC6
GH09J128222 Enhancer 0.2 dbSUPER 12.4 +22.2 22248 1.1 MIR199B BBLN LCN2 CIZ1 RF00017-7951 HSALNG0074593 RF00017-7950 HSALNG0074592 DNM1 SWI5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR199B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR199B Gene

Latest Assembly
chr9:128,244,721-128,244,830
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand

Previous Assembly
chr9:131,007,000-131,007,109
(GRCh37/hg19 by Entrez Gene)
Size:
110 bases
Orientation:
Minus strand

chr9:131,007,000-131,007,109
(GRCh37/hg19 by Ensembl)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR199B Gene

Genes around MIR199B on UCSC Golden Path with GeneCards custom track
MIR199B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR199B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199B Gene

Proteins for MIR199B Gene

Post-translational modifications for MIR199B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199B Gene

Domains & Families for MIR199B Gene

Gene Families for MIR199B Gene

genes like me logo Genes that share domains with MIR199B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR199B Gene

Function for MIR199B Gene

Phenotypes From GWAS Catalog for MIR199B Gene

Gene Ontology (GO) - Molecular Function for MIR199B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP,IDA 15131085
genes like me logo Genes that share ontologies with MIR199B: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199B Gene

Localization for MIR199B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR199B gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR199B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR199B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR199B Gene

Pathways & Interactions for MIR199B Gene

PathCards logo

SuperPathways for MIR199B Gene

genes like me logo Genes that share pathways with MIR199B: view

Pathways by source for MIR199B Gene

1 BioSystems pathway for MIR199B Gene
1 KEGG pathway for MIR199B Gene

Gene Ontology (GO) - Biological Process for MIR199B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle ISS --
GO:0010595 positive regulation of endothelial cell migration IMP --
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0032686 negative regulation of hepatocyte growth factor production IMP --
GO:0035195 gene silencing by miRNA IMP,IEA --
genes like me logo Genes that share ontologies with MIR199B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR199B Gene

Drugs & Compounds for MIR199B Gene

No Compound Related Data Available

Transcripts for MIR199B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR199B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000029EBD_9606 miRNA 23 6

RefSeq: NR_029619,

LncBase: hsa-miR-199b-5p,

miRBase: MIMAT0000263,

MirGeneDB: Hsa-Mir-199-P1-v1_5p,

TarBase: hsa-miR-199b-5p,

ENA: AJ535832.1:1..23:ncRNA, LM378903.1:1..23:ncRNA, LM608351.1:26..48:ncRNA,

URS00003F2D94_9606 miRNA 22 6

RefSeq: NR_029586, NR_029618, NR_029619,

LncBase: hsa-miR-199a-3p, hsa-miR-199b-3p,

miRBase: MIMAT0004563,

MirGeneDB: Hsa-Mir-199-P1-v1_3p, Hsa-Mir-199-P2-v1_3p, Hsa-Mir-199-P3-v1_3p,

TarBase: hsa-miR-199a-3p, hsa-miR-199b-3p,

ENA: View 6 records in RNAcentral

URS000075E907_9606 precursor_RNA 110 4

RefSeq: NR_029619,

Ensembl: ENST00000384849 (view in UCSC) ,

miRBase: MI0000282,

ENA: LM608351.1:1..110:precursor_RNA,

URS0001BBECF0_9606 pre_miRNA 100 1

Rfam: RF00144,

URS0000117290_9606 precursor_RNA 98 1

Rfam: RF00144,

MIR199B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR199B Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199B Gene

No ASD Table

Relevant External Links for MIR199B Gene

GeneLoc Exon Structure for
MIR199B

Expression for MIR199B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR199B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR199B

genes like me logo Genes that share expression patterns with MIR199B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199B Gene

Orthologs for MIR199B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199B Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-199-3 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199b 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir199b 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-199b 31
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-1 31
  • 92 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-199-1 31
  • 88 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-199b 31
  • 87 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-3 31
  • 74 (a)
OneToOne
Species where no ortholog for MIR199B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR199B Gene

ENSEMBL:
Gene Tree for MIR199B (if available)
TreeFam:
Gene Tree for MIR199B (if available)

Paralogs for MIR199B Gene

No data available for Paralogs for MIR199B Gene

Variants for MIR199B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR199B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR199B Gene

Variant ID Type Subtype PubMed ID
nsv831728 CNV loss 17160897
nsv951772 CNV deletion 24416366

Additional Variant Information for MIR199B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR199B Gene

Disorders for MIR199B Gene

MalaCards: The human disease database

(16) MalaCards diseases for MIR199B Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
medulloblastoma
  • mdb
breast cancer
  • breast cancer, familial
polymyositis
muscular dystrophy, limb-girdle, autosomal recessive 1
  • lgmdr1
dermatomyositis
  • amyopathic dermatomyositis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR199B

genes like me logo Genes that share disorders with MIR199B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR199B Gene

Publications for MIR199B Gene

  1. Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. (PMID: 19900756) Chao A … Lai CH (Cancer letters 2010) 3 74
  2. MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. (PMID: 19308264) Garzia L … Zollo M (PloS one 2009) 3 74
  3. Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression. (PMID: 30987652) Jin H … Xu CX (Journal of experimental & clinical cancer research : CR 2019) 3
  4. MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17. (PMID: 31081094) Su WZ … Ren LF (European review for medical and pharmacological sciences 2019) 3
  5. Micro-ribonucleic acid expression signature of metastatic castration-resistant prostate cancer: Regulation of NCAPH by antitumor miR-199a/b-3p. (PMID: 30818424) Arai T … Seki N (International journal of urology : official journal of the Japanese Urological Association 2019) 3

Products for MIR199B Gene

Sources for MIR199B Gene