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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR199B (MicroRNA 199b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199B include Medulloblastoma and Breast Cancer. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09J128241 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.5 | 504 | 5.7 | ARHGAP35 MTA2 ZIC2 PKNOX1 GABPA MNT TCF7 CBX3 UBTF ZNF184 | MIR199B MIR3154 GLE1 NUP188 NAIF1 URM1 SLC27A4 PHYHD1 SWI5 ST6GALNAC6 | |
GH09J128222 | Enhancer | 0.2 | dbSUPER | 12.4 | +22.2 | 22248 | 1.1 | MIR199B C9orf16 LCN2 CIZ1 RF00017-7953 NONHSAG053526.2 RF00017-7952 DNM1 SWI5 RF00017-7950 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 23142051 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Alzheimers Disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000320 | re-entry into mitotic cell cycle | ISS | -- |
GO:0010595 | positive regulation of endothelial cell migration | IMP | 23142051 |
GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
GO:0032686 | negative regulation of hepatocyte growth factor production | IMP | 28358369 |
GO:0035195 | gene silencing by miRNA | IMP | 23142051 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000029EBD_9606 | miRNA | 23 | 6 |
RefSeq: NR_029619, LncBase: hsa-miR-199b-5p, miRBase: MIMAT0000263, MirGeneDB: Hsa-Mir-199-P1-v1_5p, TarBase: hsa-miR-199b-5p, ENA: AJ535832.1:1..23:ncRNA, LM378903.1:1..23:ncRNA, LM608351.1:26..48:ncRNA, |
URS00003F2D94_9606 | miRNA | 22 | 6 |
RefSeq: NR_029586, NR_029618, NR_029619, LncBase: hsa-miR-199a-3p, hsa-miR-199b-3p, miRBase: MIMAT0000232, MIMAT0004563, MirGeneDB: Hsa-Mir-199-P1-v1_3p, Hsa-Mir-199-P2-v1_3p, Hsa-Mir-199-P3-v1_3p, TarBase: hsa-miR-199a-3p, hsa-miR-199b-3p, ENA: View 6 records in RNAcentral |
URS000075E907_9606 | precursor_RNA | 110 | 5 |
HGNC: 31573, RefSeq: NR_029619, Ensembl: ENST00000384849 (view in UCSC) , miRBase: MI0000282, |
URS0000117290_9606 | precursor_RNA | 98 | 1 |
Rfam: RF00144, |
URS0000EFD44C_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-199-P1-v1, Hsa-Mir-199-P1-v2, Hsa-Mir-199-P1-v3, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | cfa-mir-199-3 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-199b 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir199b 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-199b 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-199b-1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-199-1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-199b 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-199-3 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
medulloblastoma |
|
|
breast cancer |
|
|
polymyositis |
|
|
dermatomyositis |
|
|
muscular dystrophy, duchenne type |
|