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Aliases for MIR199A2 Gene

Subcategory (RNA class) for MIR199A2 Gene

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Quality Score for this RNA gene is

8.2

Aliases for MIR199A2 Gene

  • MicroRNA 199a-2 2 3 5
  • Hsa-Mir-199a-2 3
  • MiR-199a-3p 3
  • Mir-199a-2 3
  • MIR-199-S 3
  • MIRN199A2 3

External Ids for MIR199A2 Gene

Previous HGNC Symbols for MIR199A2 Gene

  • MIRN199A2

Previous GeneCards Identifiers for MIR199A2 Gene

  • GC01M170381
  • GC01M172181
  • GC01M172184
  • GC01M172190
  • GC01M172194
  • GC01M172199
  • GC01M172200
  • GC01M172202
  • GC01M172206

Summaries for MIR199A2 Gene

Entrez Gene Summary for MIR199A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199A2 Gene

MIR199A2 (MicroRNA 199a-2) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR199A2 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

Additional gene information for MIR199A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199A2 Gene

Genomics for MIR199A2 Gene

GeneHancer (GH) Regulatory Elements for MIR199A2 Gene

Promoters and enhancers for MIR199A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I172179 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -39.0 -39044 8 BMI1 BATF IRF4 ATF7 RCOR1 IKZF2 RUNX3 SMARCA5 ZNF362 JUNB MIR199A2 DNM3OS RNU6-157P GC01P172160 GC01P172209 DNM3
GH01I172108 Enhancer 0.5 ENCODE 11.5 +35.1 35056 1.7 JUND POLR2A FOXP2 RCOR1 CHD2 MIR199A2 DNM3OS GC01P172124 GC01M171926 DNM3
GH01I172210 Enhancer 0.2 ENCODE 10.6 -66.8 -66751 2.7 GC01P172209 DNM3OS MIR199A2 GC01P172216 DNM3
GH01I172137 Promoter/Enhancer 1.7 UCNEbase Ensembl ENCODE dbSUPER 0.8 +2.0 2029 9.6 USF1 TAF1 JUN ZNF398 ATF2 ZFHX2 JUND ZNF366 POLR2A GLIS1 RNU6-157P MIR199A2 MIR214 MIR3120 DNM3OS DNM3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR199A2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR199A2 Gene

Genomic Locations for MIR199A2 Gene
chr1:172,144,535-172,144,644
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr1:172,113,675-172,113,784
(GRCh37/hg19)

Genomic View for MIR199A2 Gene

Genes around MIR199A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR199A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199A2 Gene

ORGUL Member Location for MIR199A2 Gene

ORGUL Member Location for MIR199A2 gene

Proteins for MIR199A2 Gene

Post-translational modifications for MIR199A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199A2 Gene

Domains & Families for MIR199A2 Gene

Gene Families for MIR199A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR199A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR199A2 Gene

Function for MIR199A2 Gene

Gene Ontology (GO) - Molecular Function for MIR199A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24011070
genes like me logo Genes that share ontologies with MIR199A2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199A2 Gene

Localization for MIR199A2 Gene

Gene Ontology (GO) - Cellular Components for MIR199A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MIR199A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR199A2 Gene

Pathways & Interactions for MIR199A2 Gene

genes like me logo Genes that share pathways with MIR199A2: view

Pathways by source for MIR199A2 Gene

1 KEGG pathway for MIR199A2 Gene

Interacting Proteins for MIR199A2 Gene

Gene Ontology (GO) - Biological Process for MIR199A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle ISS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IMP 27038547
GO:0010507 negative regulation of autophagy ISS --
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0032008 positive regulation of TOR signaling ISS --
genes like me logo Genes that share ontologies with MIR199A2: view

No data available for SIGNOR curated interactions for MIR199A2 Gene

Drugs & Compounds for MIR199A2 Gene

No Compound Related Data Available

Transcripts for MIR199A2 Gene

mRNA/cDNA for MIR199A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199A2 Gene

No ASD Table

Relevant External Links for MIR199A2 Gene

GeneLoc Exon Structure for
MIR199A2
ECgene alternative splicing isoforms for
MIR199A2

Expression for MIR199A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR199A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR199A2 Gene

This gene is overexpressed in Ovary (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of MIR199A2 Gene:

MIR199A2
genes like me logo Genes that share expression patterns with MIR199A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199A2 Gene

Orthologs for MIR199A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199a-2 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-199a-1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-199-2 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-2 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir199a-2 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-199 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-199-2 34
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-199a-2 34
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-1 34
  • 90 (a)
OneToOne
Species where no ortholog for MIR199A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR199A2 Gene

ENSEMBL:
Gene Tree for MIR199A2 (if available)
TreeFam:
Gene Tree for MIR199A2 (if available)

Paralogs for MIR199A2 Gene

No data available for Paralogs for MIR199A2 Gene

Variants for MIR199A2 Gene

Sequence variations from dbSNP and Humsavar for MIR199A2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001559396 -- 172,144,480(-) A/T downstream_transcript_variant
rs1001614686 -- 172,144,088(-) C/T downstream_transcript_variant
rs1001675405 -- 172,144,899(-) C/A upstream_transcript_variant
rs1001948632 -- 172,145,487(-) A/G upstream_transcript_variant
rs1005226542 -- 172,146,042(-) C/T upstream_transcript_variant

Additional Variant Information for MIR199A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR199A2 Gene

Disorders for MIR199A2 Gene

Additional Disease Information for MIR199A2

No disorders were found for MIR199A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR199A2 Gene

Publications for MIR199A2 Gene

  1. MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM). (PMID: 28126676) Fan X … Huang T (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58
  2. A functional variant in the 3'-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients. (PMID: 28234972) Zhao J … Wang S (PloS one 2017) 3 58
  3. Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. (PMID: 28530657) Celià-Terrassa T … Kang Y (Nature cell biology 2017) 3 58
  4. Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer. (PMID: 28612520) Koshizuka K … Seki N (Cancer science 2017) 3 58
  5. MicroRNA-199a-5p Induced Autophagy and Inhibits the Pathogenesis of Ankylosing Spondylitis by Modulating the mTOR Signaling via Directly Targeting Ras Homolog Enriched in Brain (Rheb). (PMID: 28848090) Wang Y … Cui L (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58

Products for MIR199A2 Gene

Sources for MIR199A2 Gene

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