microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR199A2 Gene

Subcategory (RNA class) for MIR199A2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR199A2 Gene

  • MicroRNA 199a-2 2 3 5
  • Hsa-MiR-199b-3p 163 173
  • Hsa-MiR-199a-3p 163 173
  • Hsa-MiR-199a-5p 163 173
  • Hsa-Mir-199a-2 2 3
  • MIR199A2 2 5
  • Hsa-Mir-199-P3-V1 178
  • Hsa-Mir-199-P3-V2 178
  • Hsa-Mir-199-P3-V3 178
  • MIMAT0000231 50
  • MIMAT0004563 50
  • MIMAT0000232 50
  • MiR-199a-3p 3
  • Mir-199a-2 3
  • MIR-199-S 3
  • MIRN199A2 3
  • MI0000281 50
  • RF00144 168

External Ids for MIR199A2 Gene

Previous HGNC Symbols for MIR199A2 Gene

  • MIRN199A2

Previous GeneCards Identifiers for MIR199A2 Gene

  • GC01M170381
  • GC01M172181
  • GC01M172184
  • GC01M172190
  • GC01M172194
  • GC01M172199
  • GC01M172220
  • GC01M172223
  • GC01M172225
  • GC01M172230
  • GC01M172200
  • GC01M172202
  • GC01M172206
  • GC01M172209
  • GC01M172212
  • GC01M172216

Summaries for MIR199A2 Gene

Entrez Gene Summary for MIR199A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199A2 Gene

MIR199A2 (MicroRNA 199a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199A2 include Pancreatitis, Hereditary and Oral Squamous Cell Carcinoma. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Cell Differentiation - Index.

Rfam classification for MIR199A2 Gene

  • mir-199 microRNA precursor

Additional gene information for MIR199A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199A2 Gene

Genomics for MIR199A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR199A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR199A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR199A2 Gene

Genomic Locations for MIR199A2 Gene
chr1:172,144,535-172,144,644
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr1:172,113,675-172,113,784
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR199A2 Gene

Genes around MIR199A2 on UCSC Golden Path with GeneCards custom track
MIR199A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR199A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199A2 Gene

Proteins for MIR199A2 Gene

Post-translational modifications for MIR199A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199A2 Gene

Domains & Families for MIR199A2 Gene

Gene Families for MIR199A2 Gene

genes like me logo Genes that share domains with MIR199A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR199A2 Gene

Function for MIR199A2 Gene

Phenotypes From GWAS Catalog for MIR199A2 Gene

Gene Ontology (GO) - Molecular Function for MIR199A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23142051
genes like me logo Genes that share ontologies with MIR199A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199A2 Gene

Localization for MIR199A2 Gene

Gene Ontology (GO) - Cellular Components for MIR199A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MIR199A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR199A2 Gene

Pathways & Interactions for MIR199A2 Gene

genes like me logo Genes that share pathways with MIR199A2: view

Pathways by source for MIR199A2 Gene

1 KEGG pathway for MIR199A2 Gene

Gene Ontology (GO) - Biological Process for MIR199A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle ISS --
GO:0002091 negative regulation of receptor internalization IDA 26163491
GO:0007204 positive regulation of cytosolic calcium ion concentration IMP 27038547
GO:0010507 negative regulation of autophagy ISS --
GO:0010595 positive regulation of endothelial cell migration IMP 23142051
genes like me logo Genes that share ontologies with MIR199A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR199A2 Gene

Drugs & Compounds for MIR199A2 Gene

No Compound Related Data Available

Transcripts for MIR199A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR199A2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000554A4F_9606 miRNA 23 6

RefSeq: NR_029586, NR_029618,

LncBase: hsa-miR-199a-5p,

miRBase: MIMAT0000231,

MirGeneDB: Hsa-Mir-199-P2-v1_5p, Hsa-Mir-199-P3-v1_5p,

TarBase: hsa-miR-199a-5p,

ENA: FJ623959.1:222..244:ncRNA, HB859645.1:1..23:misc_RNA, LM378875.1:1..23:ncRNA, LM608321.1:6..28:ncRNA, LM608350.1:31..53:ncRNA,

URS00003F2D94_9606 miRNA 22 6

RefSeq: NR_029586, NR_029618, NR_029619,

LncBase: hsa-miR-199a-3p, hsa-miR-199b-3p,

miRBase: MIMAT0000232, MIMAT0004563,

MirGeneDB: Hsa-Mir-199-P1-v1_3p, Hsa-Mir-199-P2-v1_3p, Hsa-Mir-199-P3-v1_3p,

TarBase: hsa-miR-199a-3p, hsa-miR-199b-3p,

ENA: View 6 records in RNAcentral

URS000043F622_9606 precursor_RNA 110 5

HGNC: 31572,

RefSeq: NR_029618,

Ensembl: ENST00000385289 (view in UCSC) ,

miRBase: MI0000281,

ENA: LM608350.1:1..110:precursor_RNA,

URS00004795FC_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-199-P2-v3_5p, Hsa-Mir-199-P3-v3_5p,

ENA: AJ560756.1:1..22:ncRNA,

URS000063540B_9606 precursor_RNA 100 1

Rfam: RF00144,

MIR199A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR199A2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199A2 Gene

No ASD Table

Relevant External Links for MIR199A2 Gene

GeneLoc Exon Structure for
MIR199A2

Expression for MIR199A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR199A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR199A2 Gene

This gene is overexpressed in Ovary (x5.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR199A2

genes like me logo Genes that share expression patterns with MIR199A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199A2 Gene

Orthologs for MIR199A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199a-2 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-199a-1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-199-2 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-2 31
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir199a-2 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-199 31
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-199-2 31
  • 96 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-199a-2 31
  • 83 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-1 31
  • 90 (a)
OneToOne
Species where no ortholog for MIR199A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR199A2 Gene

ENSEMBL:
Gene Tree for MIR199A2 (if available)
TreeFam:
Gene Tree for MIR199A2 (if available)

Paralogs for MIR199A2 Gene

No data available for Paralogs for MIR199A2 Gene

Variants for MIR199A2 Gene

Additional dbSNP identifiers (rs#s) for MIR199A2 Gene

Additional Variant Information for MIR199A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR199A2 Gene

Disorders for MIR199A2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR199A2 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • cp
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR199A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR199A2 Gene

Publications for MIR199A2 Gene

  1. Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. (PMID: 31451657) Hsu AY … Deng Q (Proceedings of the National Academy of Sciences of the United States of America 2019) 3
  2. miR-199a-3p targets ETNK1 to promote invasion and migration in gastric cancer cells and is associated with poor prognosis. (PMID: 31255331) Li L … Mou XZ (Pathology, research and practice 2019) 3
  3. MiR-199a-3p inhibition facilitates cardiomyocyte differentiation of embryonic stem cell through promotion of MEF2C. (PMID: 31140610) Chen HP … Zhu GC (Journal of cellular physiology 2019) 3
  4. MicroRNA‑199a‑5p suppresses migration and invasion in oral squamous cell carcinoma through inhibiting the EMT‑related transcription factor SOX4. (PMID: 31059001) Wei D … Shao Y (International journal of molecular medicine 2019) 3
  5. Demethylation by low-dose 5-aza-2'-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma. (PMID: 30651148) Desjobert C … Arimondo PB (Clinical epigenetics 2019) 3

Products for MIR199A2 Gene

Sources for MIR199A2 Gene