microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR199A1 Gene

Subcategory (RNA class) for MIR199A1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR199A1 Gene

  • MicroRNA 199a-1 2 3 5
  • Hsa-MiR-199a-5p 163 173
  • Hsa-MiR-199b-3p 163 173
  • Hsa-MiR-199a-3p 163 173
  • Hsa-Mir-199a-1 2 3
  • MIR199A1 2 5
  • Hsa-Mir-199-P2-V3 178
  • Hsa-Mir-199-P2-V2 178
  • Hsa-Mir-199-P2-V1 178
  • MIMAT0000231 50
  • MIMAT0004563 50
  • MIMAT0000232 50
  • MiR-199a-3p 3
  • Mir-199a-1 3
  • MIR-199-S 3
  • MIRN199A1 3
  • MI0000242 50
  • RF00144 168

External Ids for MIR199A1 Gene

Previous HGNC Symbols for MIR199A1 Gene

  • MIRN199A1

Previous GeneCards Identifiers for MIR199A1 Gene

  • GC19M010928

Summaries for MIR199A1 Gene

Entrez Gene Summary for MIR199A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199A1 Gene

MIR199A1 (MicroRNA 199a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199A1 include Ovarian Serous Carcinoma and Endocrine Gland Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and SRF and miRs in Smooth Muscle Differentiation and Proliferation.

Rfam classification for MIR199A1 Gene

  • mir-199 microRNA precursor

Additional gene information for MIR199A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199A1 Gene

Genomics for MIR199A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR199A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010758 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 12.4 +54.4 54350 8.9 SP1 HNRNPL GATAD2A PRDM10 ZNF629 TFE3 RFX1 NFKBIZ ZNF692 RCOR2 KRI1 FBXL12 ILF3 RAVER1 ZNF823 PPAN MIR199A1 SLC44A2 MIR638 DNM2
GH19J010776 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.6 +36.6 36580 8.9 ZNF629 PRDM1 NR2C1 ZNF140 ARID3A ZNF639 ZNF580 ZNF266 RBM22 JUND MIR4748 piR-43105-321 KRI1 ILF3 ZNF627 FBXL12 PPAN YIPF2 DNMT1 RAVER1
GH19J010759 Promoter/Enhancer 0.9 Ensembl dbSUPER 12.4 +59.1 59110 0.4 ZNF512 IKZF1 ZNF444 TRIM24 PCBP1 WT1 ZNF366 ZNF398 MLLT1 MIR199A1 MIR638 DNM2 lnc-QTRT1-3 piR-53141 TMED1 lnc-TIMM29-1
GH19J010852 Enhancer 0.8 Ensembl ENCODE 12.1 -36.2 -36190 3.4 GATAD2A PRDM10 FOXA1 CEBPA ATF7 UBTF ZEB1 JUN JUND ZNF623 MIR199A1 SMARCA4 HIKESHIP2 C19orf38 CARM1 lnc-TIMM29-1
GH19J010757 Enhancer 0.6 ENCODE dbSUPER 12.4 +59.4 59350 0 ZNF512 IKZF1 PCBP1 ZNF366 ZNF398 MIR199A1 MIR638 DNM2 lnc-QTRT1-3 piR-53141 TMED1 lnc-TIMM29-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR199A1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR199A1 Gene

Genomic Locations for MIR199A1 Gene
chr19:10,817,410-10,817,511
(GRCh38/hg38)
Size:
102 bases
Orientation:
Minus strand
chr19:10,928,102-10,928,172
(GRCh37/hg19)
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR199A1 Gene

Genes around MIR199A1 on UCSC Golden Path with GeneCards custom track
MIR199A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR199A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199A1 Gene

Proteins for MIR199A1 Gene

Post-translational modifications for MIR199A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199A1 Gene

Domains & Families for MIR199A1 Gene

Gene Families for MIR199A1 Gene

genes like me logo Genes that share domains with MIR199A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR199A1 Gene

Function for MIR199A1 Gene

Phenotypes From GWAS Catalog for MIR199A1 Gene

Gene Ontology (GO) - Molecular Function for MIR199A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23142051
genes like me logo Genes that share ontologies with MIR199A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199A1 Gene

Localization for MIR199A1 Gene

Gene Ontology (GO) - Cellular Components for MIR199A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MIR199A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR199A1 Gene

Pathways & Interactions for MIR199A1 Gene

genes like me logo Genes that share pathways with MIR199A1: view

Pathways by source for MIR199A1 Gene

Gene Ontology (GO) - Biological Process for MIR199A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle ISS --
GO:0002091 negative regulation of receptor internalization IDA 26163491
GO:0007204 positive regulation of cytosolic calcium ion concentration IMP 27038547
GO:0010507 negative regulation of autophagy ISS --
GO:0010595 positive regulation of endothelial cell migration IMP 23142051
genes like me logo Genes that share ontologies with MIR199A1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR199A1 Gene

Drugs & Compounds for MIR199A1 Gene

No Compound Related Data Available

Transcripts for MIR199A1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR199A1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000554A4F_9606 miRNA 23 6

RefSeq: NR_029586, NR_029618,

LncBase: hsa-miR-199a-5p,

miRBase: MIMAT0000231,

MirGeneDB: Hsa-Mir-199-P2-v1_5p, Hsa-Mir-199-P3-v1_5p,

TarBase: hsa-miR-199a-5p,

ENA: FJ623959.1:222..244:ncRNA, HB859645.1:1..23:misc_RNA, LM378875.1:1..23:ncRNA, LM608321.1:6..28:ncRNA, LM608350.1:31..53:ncRNA,

URS00003F2D94_9606 miRNA 22 6

RefSeq: NR_029586, NR_029618, NR_029619,

LncBase: hsa-miR-199a-3p, hsa-miR-199b-3p,

miRBase: MIMAT0000232, MIMAT0004563,

MirGeneDB: Hsa-Mir-199-P1-v1_3p, Hsa-Mir-199-P2-v1_3p, Hsa-Mir-199-P3-v1_3p,

TarBase: hsa-miR-199a-3p, hsa-miR-199b-3p,

ENA: View 6 records in RNAcentral

URS0000759977_9606 precursor_RNA 71 5

HGNC: 31571,

RefSeq: NR_029586,

Ensembl: ENST00000385019 (view in UCSC) ,

miRBase: MI0000242,

ENA: LM608321.1:1..71:precursor_RNA,

URS00004795FC_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-199-P2-v3_5p, Hsa-Mir-199-P3-v3_5p,

ENA: AJ560756.1:1..22:ncRNA,

URS000070707F_9606 precursor_RNA 102 1

Rfam: RF00144,

MIR199A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR199A1 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199A1 Gene

No ASD Table

Relevant External Links for MIR199A1 Gene

GeneLoc Exon Structure for
MIR199A1

Expression for MIR199A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR199A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR199A1

genes like me logo Genes that share expression patterns with MIR199A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199A1 Gene

Orthologs for MIR199A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199a-1 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir199a-1 31
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-199-1 31
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-3604-1 31
  • 86 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-3 31
  • 56 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-199a-1 31
  • 57 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-2 31
  • 63 (a)
ManyToMany
Species where no ortholog for MIR199A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR199A1 Gene

ENSEMBL:
Gene Tree for MIR199A1 (if available)
TreeFam:
Gene Tree for MIR199A1 (if available)

Paralogs for MIR199A1 Gene

No data available for Paralogs for MIR199A1 Gene

Variants for MIR199A1 Gene

Additional dbSNP identifiers (rs#s) for MIR199A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR199A1 Gene

Variant ID Type Subtype PubMed ID
nsv1160584 CNV deletion 26073780
nsv2416 CNV insertion 18451855
nsv833746 CNV loss 17160897
nsv833748 CNV loss 17160897

Additional Variant Information for MIR199A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR199A1 Gene

Disorders for MIR199A1 Gene

MalaCards: The human disease database

(172) MalaCards diseases for MIR199A1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
endocrine gland cancer
  • endocrine neoplasm
gastrointestinal system disease
  • alimentary system disease
reproductive system disease
  • genital system disease
female reproductive system disease
  • genital diseases, female
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR199A1

genes like me logo Genes that share disorders with MIR199A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR199A1 Gene

Publications for MIR199A1 Gene

  1. Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. (PMID: 31451657) Hsu AY … Deng Q (Proceedings of the National Academy of Sciences of the United States of America 2019) 3
  2. Altered Expression of DDR1 in Clear Cell Renal Cell Carcinoma Correlates With miR-199a/b-5p and Patients' Outcome. (PMID: 31018949) Krazinski BE … Kmiec Z (Cancer genomics & proteomics 2019) 3
  3. miR-199a-3p targets ETNK1 to promote invasion and migration in gastric cancer cells and is associated with poor prognosis. (PMID: 31255331) Li L … Mou XZ (Pathology, research and practice 2019) 3
  4. Histone deacetylase 6 negatively regulated microRNA-199a-5p induces the occurrence of preeclampsia by targeting VEGFA in vitro. (PMID: 30947018) Mei Z … Deng N (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  5. MiR-199a-3p inhibition facilitates cardiomyocyte differentiation of embryonic stem cell through promotion of MEF2C. (PMID: 31140610) Chen HP … Zhu GC (Journal of cellular physiology 2019) 3

Products for MIR199A1 Gene

Sources for MIR199A1 Gene