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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR199A1 Gene
Subcategory (RNA class) for MIR199A1 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR199A1 Gene
External Ids for MIR199A1 Gene
- HGNC: 31571
- Entrez Gene: 406976
- Ensembl: ENSG00000207752
- OMIM: 610719
- miRBase: hsa-mir-199a-1
Previous HGNC Symbols for MIR199A1 Gene
- MIRN199A1
Previous GeneCards Identifiers for MIR199A1 Gene
- GC19M010928
Summaries for MIR199A1 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR199A1 Gene
MIR199A1 (MicroRNA 199a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199A1 include Ovarian Serous Carcinoma and Endocrine Gland Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and SRF and miRs in Smooth Muscle Differentiation and Proliferation.
Rfam classification for MIR199A1 Gene
-
mir-199 microRNA precursor
Additional gene information for MIR199A1 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199A1 Gene
Genomics for MIR199A1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR199A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR199A1 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR199A1 Gene
Genomic Locations for MIR199A1 Gene
- chr19:10,817,410-10,817,511
- (GRCh38/hg38)
- Size:
- 102 bases
- Orientation:
- Minus strand
- chr19:10,928,102-10,928,172
- (GRCh37/hg19)
- Size:
- 71 bases
- Orientation:
- Minus strand
Genomic View for MIR199A1 Gene
Genes around MIR199A1 on UCSC Golden Path with GeneCards custom track
MIR199A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
MIR199A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR199A1 Gene
Proteins for MIR199A1 Gene
Post-translational modifications for MIR199A1 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR199A1
- Origene Custom Protein Services for MIR199A1
No data available for DME Specific Peptides for MIR199A1 Gene
Domains & Families for MIR199A1 Gene
Gene Families for MIR199A1 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR199A1 Gene
Function for MIR199A1 Gene
Phenotypes From GWAS Catalog for MIR199A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 23142051 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR199A1 - Select products 50% OFF >
- * MIR199A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR199A1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR199A1 - Select products 50% OFF >
- * MIR199A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199A1 Gene
Localization for MIR199A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:0005623 | cell | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR199A1 Gene
Pathways & Interactions for MIR199A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Cell Differentiation - Index | ||
| 3 | MicroRNAs in cardiomyocyte hypertrophy | ||
| 4 | SRF and miRs in Smooth Muscle Differentiation and Proliferation | ||
Pathways by source for MIR199A1 Gene
3 BioSystems pathways for MIR199A1 Gene
1 KEGG pathway for MIR199A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000320 | re-entry into mitotic cell cycle | ISS | -- |
| GO:0002091 | negative regulation of receptor internalization | IDA | 26163491 |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IMP | 27038547 |
| GO:0010507 | negative regulation of autophagy | ISS | -- |
| GO:0010595 | positive regulation of endothelial cell migration | IMP | 23142051 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR199A1 Gene
Transcripts for MIR199A1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR199A1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000554A4F_9606 | miRNA | 23 | 6 |
LncBase: hsa-miR-199a-5p, miRBase: MIMAT0000231, MirGeneDB: Hsa-Mir-199-P2-v1_5p, Hsa-Mir-199-P3-v1_5p, TarBase: hsa-miR-199a-5p, ENA: FJ623959.1:222..244:ncRNA, HB859645.1:1..23:misc_RNA, LM378875.1:1..23:ncRNA, LM608321.1:6..28:ncRNA, LM608350.1:31..53:ncRNA, |
| URS00003F2D94_9606 | miRNA | 22 | 6 |
RefSeq: NR_029586, NR_029618, NR_029619, LncBase: hsa-miR-199a-3p, hsa-miR-199b-3p, miRBase: MIMAT0000232, MIMAT0004563, MirGeneDB: Hsa-Mir-199-P1-v1_3p, Hsa-Mir-199-P2-v1_3p, Hsa-Mir-199-P3-v1_3p, TarBase: hsa-miR-199a-3p, hsa-miR-199b-3p, ENA: View 6 records in RNAcentral |
| URS0000759977_9606 | precursor_RNA | 71 | 5 |
HGNC: 31571, RefSeq: NR_029586, Ensembl: ENST00000385019 (view in UCSC) , miRBase: MI0000242, |
| URS00004795FC_9606 | miRNA | 22 | 2 |
MirGeneDB: Hsa-Mir-199-P2-v3_5p, Hsa-Mir-199-P3-v3_5p, ENA: AJ560756.1:1..22:ncRNA, |
| URS000070707F_9606 | precursor_RNA | 102 | 1 |
Rfam: RF00144, |
MIR199A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR199A1 Gene
- 2 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR199A1 - Select products 50% OFF >
- * MIR199A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR199A1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR199A1 - Select products 50% OFF >
- * MIR199A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIR199A1 Gene
- GeneLoc Exon Structure for
- MIR199A1
Expression for MIR199A1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR199A1
Primer Products
-
OriGene qPCR primer pairs for MIR199A1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199A1 Gene
Orthologs for MIR199A1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-199a-1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir199a-1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-199-1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-3604-1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-199b-3 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-199a-1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-199-2 31 |
|
ManyToMany |
- Species where no ortholog for MIR199A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIR199A1 Gene
No data available for Paralogs for MIR199A1 Gene
Variants for MIR199A1 Gene
Additional Variant Information for MIR199A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR199A1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR199A1 Gene
Disorders for MIR199A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian serous carcinoma |
|
|
| endocrine gland cancer |
|
|
| gastrointestinal system disease |
|
|
| reproductive system disease |
|
|
| female reproductive system disease |
|
|
Search MIR199A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR199A1
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR199A1 Gene
Publications for MIR199A1 Gene
- Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. (PMID: 31451657) Hsu AY … Deng Q (Proceedings of the National Academy of Sciences of the United States of America 2019) 3
- Altered Expression of DDR1 in Clear Cell Renal Cell Carcinoma Correlates With miR-199a/b-5p and Patients' Outcome. (PMID: 31018949) Krazinski BE … Kmiec Z (Cancer genomics & proteomics 2019) 3
- miR-199a-3p targets ETNK1 to promote invasion and migration in gastric cancer cells and is associated with poor prognosis. (PMID: 31255331) Li L … Mou XZ (Pathology, research and practice 2019) 3
- Histone deacetylase 6 negatively regulated microRNA-199a-5p induces the occurrence of preeclampsia by targeting VEGFA in vitro. (PMID: 30947018) Mei Z … Deng N (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
- MiR-199a-3p inhibition facilitates cardiomyocyte differentiation of embryonic stem cell through promotion of MEF2C. (PMID: 31140610) Chen HP … Zhu GC (Journal of cellular physiology 2019) 3
ExternalLinks
Products for MIR199A1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR199A1
- Origene Custom Protein Services for MIR199A1
- Browse OriGene Inhibitory RNA Products For MIR199A1
- OriGene qPCR primer pairs for MIR199A1
- Browse CRISPR knockouts for MIR199A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR199A1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR199A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR199A1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR199A1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR199A1
Sources for MIR199A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB