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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR199A1 (MicroRNA 199a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199A1 include Ovarian Serous Carcinoma and Endocrine Gland Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and SRF and miRs in Smooth Muscle Differentiation and Proliferation.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 23142051 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0005623 | cell | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Cell Differentiation - Index | ||
3 | MicroRNAs in cardiomyocyte hypertrophy | ||
4 | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000320 | re-entry into mitotic cell cycle | ISS | -- |
GO:0002091 | negative regulation of receptor internalization | IDA | 26163491 |
GO:0007204 | positive regulation of cytosolic calcium ion concentration | IMP | 27038547 |
GO:0010507 | negative regulation of autophagy | ISS | -- |
GO:0010595 | positive regulation of endothelial cell migration | IMP | 23142051 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000554A4F_9606 | miRNA | 23 | 6 |
LncBase: hsa-miR-199a-5p, miRBase: MIMAT0000231, MirGeneDB: Hsa-Mir-199-P2-v1_5p, Hsa-Mir-199-P3-v1_5p, TarBase: hsa-miR-199a-5p, ENA: FJ623959.1:222..244:ncRNA, HB859645.1:1..23:misc_RNA, LM378875.1:1..23:ncRNA, LM608321.1:6..28:ncRNA, LM608350.1:31..53:ncRNA, |
URS00003F2D94_9606 | miRNA | 22 | 6 |
RefSeq: NR_029586, NR_029618, NR_029619, LncBase: hsa-miR-199a-3p, hsa-miR-199b-3p, miRBase: MIMAT0000232, MIMAT0004563, MirGeneDB: Hsa-Mir-199-P1-v1_3p, Hsa-Mir-199-P2-v1_3p, Hsa-Mir-199-P3-v1_3p, TarBase: hsa-miR-199a-3p, hsa-miR-199b-3p, ENA: View 6 records in RNAcentral |
URS0000759977_9606 | precursor_RNA | 71 | 5 |
HGNC: 31571, RefSeq: NR_029586, Ensembl: ENST00000385019 (view in UCSC) , miRBase: MI0000242, |
URS00004795FC_9606 | miRNA | 22 | 2 |
MirGeneDB: Hsa-Mir-199-P2-v3_5p, Hsa-Mir-199-P3-v3_5p, ENA: AJ560756.1:1..22:ncRNA, |
URS000070707F_9606 | precursor_RNA | 102 | 1 |
Rfam: RF00144, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-199a-1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir199a-1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-199-1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-3604-1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-199b-3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-199a-1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-199-2 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian serous carcinoma |
|
|
endocrine gland cancer |
|
|
gastrointestinal system disease |
|
|
reproductive system disease |
|
|
female reproductive system disease |
|
|