microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR198 Gene

Data sources for MIR198 Gene:

RNA type for MIR198 Gene

miRNA

Aliases for MIR198 Gene

External Ids for MIR198 Gene

Previous HGNC Symbols for MIR198 Gene

  • MIRN198

Previous GeneCards Identifiers for MIR198 Gene

  • GC03M121599
  • GC03M120112

Summaries for MIR198 Gene

Entrez Gene Summary for MIR198 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR198 Gene

MIR198 (MicroRNA 198) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR198 include Schizophrenia and Retinoblastoma. Among its related pathways are Signaling by GPCR and Signaling by BMP.

Rfam classification for MIR198 Gene

  • mir-198 microRNA precursor family

Additional gene information for MIR198 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR198 Gene

Genomics for MIR198 Gene

Genomic Locations for MIR198 Gene

Latest Assembly
chr3:120,395,668-120,395,729
(GRCh38/hg38)
Size:
62 bases
Orientation:
Minus strand

Previous Assembly
chr3:120,114,515-120,114,576
(GRCh37/hg19 by Entrez Gene)
Size:
62 bases
Orientation:
Minus strand

Genomic View for MIR198 Gene

Genes around MIR198 on UCSC Golden Path with GeneCards custom track
MIR198 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR198 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR198 Gene

Proteins for MIR198 Gene

Post-translational modifications for MIR198 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR198 Gene

Domains & Families for MIR198 Gene

Gene Families for MIR198 Gene

HGNC:
genes like me logo Genes that share domains with MIR198: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR198 Gene

Function for MIR198 Gene

Gene Ontology (GO) - Molecular Function for MIR198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 24357456
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24357456
genes like me logo Genes that share ontologies with MIR198: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR198 Gene

Localization for MIR198 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR198 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR198: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR198 Gene

Pathways & Interactions for MIR198 Gene

PathCards logo

SuperPathways for MIR198 Gene

SuperPathway Contained pathways
1 Signaling by GPCR
2 Signaling by BMP
genes like me logo Genes that share pathways with MIR198: view

Pathways by source for MIR198 Gene

2 Reactome pathways for MIR198 Gene

Gene Ontology (GO) - Biological Process for MIR198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA, IEA --
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP 24357456
genes like me logo Genes that share ontologies with MIR198: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR198 Gene

Drugs & Compounds for MIR198 Gene

No Compound Related Data Available

Transcripts for MIR198 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR198 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000471A62_9606 pre_miRNA 62 4

RefSeq: NR_029584,

Ensembl: ENST00000637333 (view in UCSC) ,

miRBase: MI0000240,

Rfam: RF00681,

URS000075CAC3_9606 miRNA 22 4

RefSeq: NR_029584,

LncBase: hsa-miR-198,

miRBase: MIMAT0000228,

TarBase: hsa-miR-198,

URS0001BC3A29_9606 pre_miRNA 62 1

Rfam: RF00681,

URS000021862C_9606 miRNA 19 1

ENA: AJ560755.1:1..19:ncRNA,

MIR198 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR198 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR198 Gene

No ASD Table

Relevant External Links for MIR198 Gene

GeneLoc Exon Structure for
MIR198

Expression for MIR198 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR198 Gene

Orthologs for MIR198 Gene

Evolution for MIR198 Gene

ENSEMBL:
Gene Tree for MIR198 (if available)
TreeFam:
Gene Tree for MIR198 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR198

No data available for Orthologs for MIR198 Gene

Paralogs for MIR198 Gene

No data available for Paralogs for MIR198 Gene

Variants for MIR198 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR198 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR198 Gene

Variant ID Type Subtype PubMed ID
nsv829698 CNV gain 17160897

Additional Variant Information for MIR198 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR198
Leiden Open Variation Database (LOVD)
MIR198

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR198 Gene

Disorders for MIR198 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR198 Gene - From: MID, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR198

genes like me logo Genes that share disorders with MIR198: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR198 Gene

Publications for MIR198 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 40
  2. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 40
  3. Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis. (PMID: 32495982) Shi Y … Chen Y (Cancer science 2020) 3
  4. Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer. (PMID: 32192774) Xu F … Wu X (Biochemical and biophysical research communications 2020) 3
  5. MicroRNA-198 inhibits proliferation and induces apoptosis by directly suppressing FGFR1 in gastric cancer. (PMID: 31138759) Gu J … Jin J (Bioscience reports 2019) 3

Products for MIR198 Gene

Sources for MIR198 Gene