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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR197 (MicroRNA 197) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR197 include Thyroid Cancer, Nonmedullary, 2 and Diabetes Mellitus. Among its related pathways are DAG and IP3 signaling and Signaling by GPCR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 26646931 |
SuperPathway | Contained pathways | ||
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1 | ADP signalling through P2Y purinoceptor 12 | ||
2 | DAG and IP3 signaling | ||
3 | GABA receptor activation | ||
4 | Signaling by GPCR | ||
5 | Transmission across Chemical Synapses |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0045382 | negative regulation of interleukin-18 biosynthetic process | IDA | 23710316 |
GO:1900015 | regulation of cytokine production involved in inflammatory response | IDA | 23710316 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00000F4AC3_9606 | precursor_RNA | 75 | 6 |
HGNC: 31569, RefSeq: NR_029583, Ensembl: ENST00000384976 (view in UCSC) , miRBase: MI0000239, Rfam: RF00707, |
URS000020E2DD_9606 | miRNA | 23 | 6 |
RefSeq: NR_029583, LncBase: hsa-miR-197-5p, miRBase: MIMAT0022691, MirGeneDB: Hsa-Mir-197_5p, TarBase: hsa-miR-197-5p, |
URS000061E740_9606 | miRNA | 22 | 6 |
RefSeq: NR_029583, LncBase: hsa-miR-197-3p, miRBase: MIMAT0000227, MirGeneDB: Hsa-Mir-197_3p, TarBase: hsa-miR-197-3p, ENA: AJ560754.1:1..22:ncRNA, LM378872.1:1..22:ncRNA, LM608319.1:48..69:ncRNA, |
URS0000EFD809_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-197, |
Disorder | Aliases | PubMed IDs |
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thyroid cancer, nonmedullary, 2 |
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diabetes mellitus |
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lung cancer |
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leiomyoma, uterine |
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inclusion body myositis |
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