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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR197 Gene
Subcategory (RNA class) for MIR197 Gene
miRNA
Aliases for MIR197 Gene
- MI0000239 (miRBase)
- MiRNA197 (NCBI Entrez Gene)
- MIRN197 (NCBI Entrez Gene)
- MiR-197 (NCBI Entrez Gene)
- RF00707 (Rfam)
- MIR197 (Ensembl)
External Ids for MIR197 Gene
- HGNC: 31569
- NCBI Entrez Gene: 406974
- Ensembl: ENSG00000284443
- OMIM®: 611189
- miRBase: hsa-mir-197
Previous HGNC Symbols for MIR197 Gene
- MIRN197
Previous GeneCards Identifiers for MIR197 Gene
- GC01P109943
- GC01P110141
- GC01P109598
Summaries for MIR197 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR197 Gene
MIR197 (MicroRNA 197) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR197 include Thyroid Gland Follicular Carcinoma and Diabetes Mellitus. Among its related pathways are Signaling by GPCR and Response to elevated platelet cytosolic Ca2+.
Rfam classification for MIR197 Gene
-
microRNA mir-197
Additional gene information for MIR197 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR197 Gene
Genomics for MIR197 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR197 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR197 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR197 Gene
Latest Assembly
- chr1:109,598,893-109,598,967
- (GRCh38/hg38)
- Size:
- 75 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:110,141,515-110,141,589
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 75 bases
- Orientation:
- Plus strand
Genomic View for MIR197 Gene
Genes around MIR197 on UCSC Golden Path with GeneCards custom track
MIR197 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
MIR197 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR197 Gene
Proteins for MIR197 Gene
Post-translational modifications for MIR197 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR197 Gene
Domains & Families for MIR197 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR197 Gene
Function for MIR197 Gene
Phenotypes From GWAS Catalog for MIR197 Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR197 - Starting at $85 >
- * MIR197 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR197 - Starting at $45 >
- * MIR197 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR197 Gene
Localization for MIR197 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
| GO:0070062 | extracellular exosome | IDA | 31926946 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR197 Gene
Pathways & Interactions for MIR197 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | ADP signalling through P2Y purinoceptor 12 | ||
| 2 | DAG and IP3 signaling | ||
| 3 | GABA receptor activation | ||
| 4 | Signaling by GPCR | ||
| 5 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for MIR197 Gene
4 BioSystems pathways for MIR197 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032701 | negative regulation of interleukin-18 production | IDA | 23710316 |
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:1900015 | regulation of cytokine production involved in inflammatory response | IDA | 23710316 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR197 Gene
Transcripts for MIR197 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR197 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000020E2DD_9606 | miRNA | 23 | 6 |
RefSeq: NR_029583, LncBase: hsa-miR-197-5p, miRBase: MIMAT0022691, MirGeneDB: Hsa-Mir-197_5p, TarBase: hsa-miR-197-5p, |
| URS000061E740_9606 | miRNA | 22 | 6 |
RefSeq: NR_029583, LncBase: hsa-miR-197-3p, miRBase: MIMAT0000227, MirGeneDB: Hsa-Mir-197_3p, TarBase: hsa-miR-197-3p, ENA: AJ560754.1:1..22:ncRNA, LM378872.1:1..22:ncRNA, LM608319.1:48..69:ncRNA, |
| URS00000F4AC3_9606 | precursor_RNA | 75 | 5 |
RefSeq: NR_029583, Ensembl: ENST00000384976 (view in UCSC) , miRBase: MI0000239, Rfam: RF00707, |
| URS0000EFD809_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-197, |
MIR197 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR197 Gene
- 2 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR197 - Starting at $85 >
- * MIR197 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR197 - Starting at $45 >
- * MIR197 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR197 Gene
- GeneLoc Exon Structure for
- MIR197
Expression for MIR197 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR197
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for MIR197
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR197 Gene
Orthologs for MIR197 Gene
No data available for Orthologs for MIR197 Gene
Paralogs for MIR197 Gene
No data available for Paralogs for MIR197 Gene
Variants for MIR197 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR197 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR197
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR197 Gene
Disorders for MIR197 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thyroid gland follicular carcinoma |
|
|
| diabetes mellitus |
|
|
| lung cancer |
|
|
| leiomyoma, uterine |
|
|
| primary biliary cholangitis |
|
Search MIR197 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR197
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR197 Gene
Publications for MIR197 Gene
- Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
- Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
- LncRNA MALAT1 Depressed Chemo-Sensitivity of NSCLC Cells through Directly Functioning on miR-197-3p/p120 Catenin Axis. (PMID: 30841025) Yang T … Chen M (Molecules and cells 2019) 3
- Hsa_circ_0002577 promotes endometrial carcinoma progression via regulating miR-197/CTNND1 axis and activating Wnt/β-catenin pathway. (PMID: 31081718) Shen Q … Yuan H (Cell cycle (Georgetown, Tex.) 2019) 3
- Long noncoding RNA DLX6-AS1 accelerates the glioma carcinogenesis by competing endogenous sponging miR-197-5p to relieve E2F1. (PMID: 30366080) Li X … Wu X (Gene 2019) 3
ExternalLinks
Products for MIR197 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR197
- Origene Custom Protein Services for MIR197
- Browse OriGene Inhibitory RNA Products For MIR197
- OriGene qPCR primer pairs for MIR197
- Browse CRISPR knockouts for MIR197
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR197
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR197
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR197
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR197
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR197
Sources for MIR197 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB