microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR197 Gene

Subcategory (RNA class) for MIR197 Gene

miRNA

Aliases for MIR197 Gene

External Ids for MIR197 Gene

Previous HGNC Symbols for MIR197 Gene

  • MIRN197

Previous GeneCards Identifiers for MIR197 Gene

  • GC01P109943
  • GC01P110141
  • GC01P109598

Summaries for MIR197 Gene

Entrez Gene Summary for MIR197 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR197 Gene

MIR197 (MicroRNA 197) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR197 include Thyroid Gland Follicular Carcinoma and Diabetes Mellitus. Among its related pathways are Signaling by GPCR and Response to elevated platelet cytosolic Ca2+.

Rfam classification for MIR197 Gene

Additional gene information for MIR197 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR197 Gene

Genomics for MIR197 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR197 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J109600 Enhancer 0.2 FANTOM5 250.7 +1.4 1387 0.3 MIR197 GNAT2 PSRC1 HSALNG0005902 AMPD2 GNAI3
GH01J109761 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.2 +166.0 166038 6.1 IKZF1 ZFP64 MCM7 KDM6A THAP11 CEBPB ZNF395 VEZF1 SMAD4 SAP130 EPS8L3 lnc-GSTM3-4 piR-30350-006 GSTM3 AHCYL1 ENSG00000228703 AMPD2 ENSG00000254942 GPR61 GNAT2
GH01J109640 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +42.9 42908 5.6 ZBTB10 DEK ZNF217 CTCF BHLHE40 ZEB1 NONO ZIC2 ARNT REST GSTM4 GSTM3 GNAT2 AMPD2 GNAI3 MIR197 ENSG00000225113 RNU6V GSTM2 GSTM1
GH01J109776 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 +178.5 178527 2 MXD4 IRF2 ZNF217 CTCF ELF1 HOMEZ THAP11 REST SIN3B FOXA2 lnc-GSTM5-1 GSTM3 AHCYL1 ENSG00000228703 AMPD2 CSF1 GNAI3 ENSG00000254942 GPR61 MIR197
GH01J109773 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 +175.0 175008 1 MXD4 MNT DEK ZNF217 CTCF BHLHE40 HOMEZ CEBPB ARNT REST AHCYL1 ENSG00000228703 AMPD2 GSTM3 CSF1 GNAI3 ENSG00000254942 GPR61 MIR197 UBL4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR197 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR197 Gene

Latest Assembly
chr1:109,598,893-109,598,967
(GRCh38/hg38)
Size:
75 bases
Orientation:
Plus strand

Previous Assembly
chr1:110,141,515-110,141,589
(GRCh37/hg19 by Entrez Gene)
Size:
75 bases
Orientation:
Plus strand

Genomic View for MIR197 Gene

Genes around MIR197 on UCSC Golden Path with GeneCards custom track
MIR197 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR197 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR197 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR197 Gene

Proteins for MIR197 Gene

Post-translational modifications for MIR197 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR197 Gene

Domains & Families for MIR197 Gene

Gene Families for MIR197 Gene

HGNC:
genes like me logo Genes that share domains with MIR197: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR197 Gene

Function for MIR197 Gene

Phenotypes From GWAS Catalog for MIR197 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR197 Gene

Localization for MIR197 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR197 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 31926946
genes like me logo Genes that share ontologies with MIR197: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR197 Gene

Pathways & Interactions for MIR197 Gene

genes like me logo Genes that share pathways with MIR197: view

Gene Ontology (GO) - Biological Process for MIR197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032701 negative regulation of interleukin-18 production IDA 23710316
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:1900015 regulation of cytokine production involved in inflammatory response IDA 23710316
genes like me logo Genes that share ontologies with MIR197: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR197 Gene

Drugs & Compounds for MIR197 Gene

No Compound Related Data Available

Transcripts for MIR197 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR197 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000020E2DD_9606 miRNA 23 6

RefSeq: NR_029583,

LncBase: hsa-miR-197-5p,

miRBase: MIMAT0022691,

MirGeneDB: Hsa-Mir-197_5p,

TarBase: hsa-miR-197-5p,

ENA: LM382999.1:1..23:ncRNA, LM608319.1:9..31:ncRNA,

URS000061E740_9606 miRNA 22 6

RefSeq: NR_029583,

LncBase: hsa-miR-197-3p,

miRBase: MIMAT0000227,

MirGeneDB: Hsa-Mir-197_3p,

TarBase: hsa-miR-197-3p,

ENA: AJ560754.1:1..22:ncRNA, LM378872.1:1..22:ncRNA, LM608319.1:48..69:ncRNA,

URS00000F4AC3_9606 precursor_RNA 75 5

RefSeq: NR_029583,

Ensembl: ENST00000384976 (view in UCSC) ,

miRBase: MI0000239,

Rfam: RF00707,

ENA: LM608319.1:1..75:precursor_RNA,

URS0000EFD809_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-197,

MIR197 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR197 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR197 Gene

No ASD Table

Relevant External Links for MIR197 Gene

GeneLoc Exon Structure for
MIR197

Expression for MIR197 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR197

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR197 Gene

Orthologs for MIR197 Gene

Evolution for MIR197 Gene

ENSEMBL:
Gene Tree for MIR197 (if available)
TreeFam:
Gene Tree for MIR197 (if available)

No data available for Orthologs for MIR197 Gene

Paralogs for MIR197 Gene

No data available for Paralogs for MIR197 Gene

Variants for MIR197 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR197 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR197 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR197

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR197 Gene

Disorders for MIR197 Gene

MalaCards: The human disease database

(20) MalaCards diseases for MIR197 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
thyroid gland follicular carcinoma
  • follicular adenocarcinoma
diabetes mellitus
  • diabetes
lung cancer
  • lung cancer, susceptibility to
leiomyoma, uterine
  • ul
primary biliary cholangitis
  • biliary liver cirrhosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR197

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR197: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR197 Gene

Publications for MIR197 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
  3. LncRNA MALAT1 Depressed Chemo-Sensitivity of NSCLC Cells through Directly Functioning on miR-197-3p/p120 Catenin Axis. (PMID: 30841025) Yang T … Chen M (Molecules and cells 2019) 3
  4. Hsa_circ_0002577 promotes endometrial carcinoma progression via regulating miR-197/CTNND1 axis and activating Wnt/β-catenin pathway. (PMID: 31081718) Shen Q … Yuan H (Cell cycle (Georgetown, Tex.) 2019) 3
  5. Long noncoding RNA DLX6-AS1 accelerates the glioma carcinogenesis by competing endogenous sponging miR-197-5p to relieve E2F1. (PMID: 30366080) Li X … Wu X (Gene 2019) 3

Products for MIR197 Gene

Sources for MIR197 Gene