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Aliases for MIR196B Gene

Subcategory (RNA class) for MIR196B Gene

miRNA

Quality Score for this RNA gene is

20.2

Aliases for MIR196B Gene

  • MicroRNA 196b 2 3 5
  • Hsa-Mir-196b 3
  • MiRNA196B 3
  • MiR-196b 3
  • MIRN196B 3

External Ids for MIR196B Gene

Previous HGNC Symbols for MIR196B Gene

  • MIRN196B

Previous GeneCards Identifiers for MIR196B Gene

  • GC07M027177
  • GC07M027209
  • GC07M027178
  • GC07M027179
  • GC07M027184
  • GC07M027165

Summaries for MIR196B Gene

Entrez Gene Summary for MIR196B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196B Gene

MIR196B (MicroRNA 196b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR196B include Gastric Cancer and Endometriosis.

fRNAdb sequence ontologies for MIR196B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR196B

Additional gene information for MIR196B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196B Gene

Genomics for MIR196B Gene

GeneHancer (GH) Regulatory Elements for MIR196B Gene

Promoters and enhancers for MIR196B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J027095 Promoter/Enhancer 3.4 VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 +31.4 31368 86.3 MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 HOXA2 HOXA9 HOXA10 HOXA1 HOXA3 HOXA6 HOXA4 HOXA5 HOXA7 HNRNPA2B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR196B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR196B Gene

Genomic Locations for MIR196B Gene
chr7:27,169,480-27,169,563
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr7:27,209,099-27,209,183
(GRCh37/hg19)
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR196B Gene

Genes around MIR196B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196B Gene

ORGUL Member Location for MIR196B Gene

ORGUL Member Location for MIR196B gene

Proteins for MIR196B Gene

Post-translational modifications for MIR196B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196B Gene

Domains & Families for MIR196B Gene

Gene Families for MIR196B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196B Gene

Function for MIR196B Gene

Phenotypes From GWAS Catalog for MIR196B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196B Gene

Localization for MIR196B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR196B Gene

Pathways & Interactions for MIR196B Gene

SuperPathways for MIR196B Gene

No Data Available

Interacting Proteins for MIR196B Gene

Gene Ontology (GO) - Biological Process for MIR196B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR196B Gene

Drugs & Compounds for MIR196B Gene

No Compound Related Data Available

Transcripts for MIR196B Gene

fRNAdb Secondary structures for MIR196B Gene

  • FR196588
  • FR186367
  • FR166337

mRNA/cDNA for MIR196B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196B Gene

No ASD Table

Relevant External Links for MIR196B Gene

GeneLoc Exon Structure for
MIR196B
ECgene alternative splicing isoforms for
MIR196B

Expression for MIR196B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR196B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR196B Gene:

MIR196B
genes like me logo Genes that share expression patterns with MIR196B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196B Gene

Orthologs for MIR196B Gene

Evolution for MIR196B Gene

ENSEMBL:
Gene Tree for MIR196B (if available)
TreeFam:
Gene Tree for MIR196B (if available)

No data available for Orthologs for MIR196B Gene

Paralogs for MIR196B Gene

No data available for Paralogs for MIR196B Gene

Variants for MIR196B Gene

Sequence variations from dbSNP and Humsavar for MIR196B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1002835168 -- 27,170,176(-) C/G upstream_transcript_variant
rs1003298437 -- 27,170,006(-) C/G upstream_transcript_variant
rs1003587495 -- 27,169,126(-) G/A downstream_transcript_variant
rs1003980797 -- 27,170,972(-) A/C upstream_transcript_variant
rs1005170518 -- 27,169,701(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR196B Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
nsv606465 CNV loss 21841781
nsv606468 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Additional Variant Information for MIR196B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196B Gene

Disorders for MIR196B Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIR196B Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
endometriosis
leiomyoma, uterine
  • ul
leukemia, acute lymphoblastic
  • all
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR196B

genes like me logo Genes that share disorders with MIR196B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR196B Gene

Publications for MIR196B Gene

  1. MicroRNA-directed cleavage of HOXB8 mRNA. (PMID: 15105502) Yekta S … Bartel DP (Science (New York, N.Y.) 2004) 1 3 58
  2. Over-expression of miR-196b-5p is significantly associated with the progression of myelodysplastic syndrome. (PMID: 28224273) Wen J … Liu Z (International journal of hematology 2017) 3 58
  3. Overexpression of microRNA-196b Accelerates Invasiveness of Cancer Cells in Recurrent Epithelial Ovarian Cancer Through Regulation of Homeobox A9. (PMID: 28387653) Chong GO … Cho YL (Cancer genomics & proteomics 2017) 3 58
  4. MicroRNA-196b Inhibits Cell Growth and Metastasis of Lung Cancer Cells by Targeting Runx2. (PMID: 28950255) Bai X … Hua S (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  5. Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway. (PMID: 28591704) Ren D … Zeng J (Oncotarget 2017) 3 58

Products for MIR196B Gene

Sources for MIR196B Gene

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