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Aliases for MIR196A2 Gene

Subcategory (RNA class) for MIR196A2 Gene

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Quality Score for this RNA gene is

3

Aliases for MIR196A2 Gene

  • MicroRNA 196a-2 2 3 5
  • MicroRNA 196-2 2 3
  • Hsa-Mir-196a-2 3
  • Hsa-Mir-196-2 3
  • Mir-196a-2 3
  • MIRN196-2 3
  • MIRN196A2 3

External Ids for MIR196A2 Gene

ORGUL Members for MIR196A2 Gene

Previous HGNC Symbols for MIR196A2 Gene

  • MIRN196-2
  • MIRN196A2

Previous GeneCards Identifiers for MIR196A2 Gene

  • GC12P052675
  • GC12P054385
  • GC12P053992
  • GC12P053997
  • GC12P054012
  • GC12P054041
  • GC12P054052
  • GC12P054061
  • GC12P054073

Summaries for MIR196A2 Gene

Entrez Gene Summary for MIR196A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A2 Gene

MIR196A2 (MicroRNA 196a-2) is an RNA Gene, and is affiliated with the undefined RNA class.

Additional gene information for MIR196A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR196A2 Gene

Genomics for MIR196A2 Gene

GeneHancer (GH) Regulatory Elements for MIR196A2 Gene

Promoters and enhancers for MIR196A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I053971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.5 -1495 36.8 FEZF1 DMAP1 IRF4 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC ZNF610 HOXC11 HOXC9 HOXC6 HOXC10 GC12P054010 GC12P054044 MIR196A2 HNRNPA1 ZNF740 ENSG00000258344
GH12I054188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 +197.1 197075 1.6 PKNOX1 ARNT ARID4B SIN3A ETS1 ZNF766 GLIS2 ZNF213 E2F8 ELK1 LOC105369777 SMUG1 FLJ12825 HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 ENSG00000257605 MIR615
GH12I054051 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.2 +61.8 61779 4.8 HDGF PKNOX1 SMAD1 ARNT FEZF1 ZNF2 ZNF213 ZNF143 SP3 JUNB HOXC4 AAAS ATF7 RARG HNRNPA1 ENSG00000260470 PCBP2 HOTAIR SP1 IGFBP6
GH12I054195 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.8 +204.9 204938 3.1 HDGF PKNOX1 KLF17 ZNF335 ZNF121 GLIS2 ZNF366 SMARCC2 KLF7 FOS HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR196A2 MIR615 HOXC4 HOXC5 LOC102724030
GH12I054079 Promoter/Enhancer 1.4 Ensembl ENCODE 10.1 +89.6 89551 4.6 HDGF PKNOX1 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF213 KLF7 REST LOC100240735 LOC100240734 SMUG1 FLJ12825 CBX5 MIR615 HOXC4 HOXC5 HOXC6 HOXC8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR196A2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR196A2 Gene

Genomic Locations for MIR196A2 Gene
chr12:53,991,738-53,991,847
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr12:54,385,522-54,385,631
(GRCh37/hg19)

Genomic View for MIR196A2 Gene

Genes around MIR196A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A2 Gene

Proteins for MIR196A2 Gene

Post-translational modifications for MIR196A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A2 Gene

Domains & Families for MIR196A2 Gene

Gene Families for MIR196A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196A2 Gene

Function for MIR196A2 Gene

Phenotypes From GWAS Catalog for MIR196A2 Gene

Gene Ontology (GO) - Molecular Function for MIR196A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22773844
genes like me logo Genes that share ontologies with MIR196A2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A2 Gene

Localization for MIR196A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR196A2 Gene

Pathways & Interactions for MIR196A2 Gene

SuperPathways for MIR196A2 Gene

No Data Available

Interacting Proteins for MIR196A2 Gene

Gene Ontology (GO) - Biological Process for MIR196A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010593 negative regulation of lamellipodium assembly IDA 22773844
GO:0035195 gene silencing by miRNA IDA 22773844
GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA 22773844
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 22773844
genes like me logo Genes that share ontologies with MIR196A2: view

No data available for Pathways by source and SIGNOR curated interactions for MIR196A2 Gene

Drugs & Compounds for MIR196A2 Gene

No Compound Related Data Available

Transcripts for MIR196A2 Gene

mRNA/cDNA for MIR196A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A2 Gene

No ASD Table

Relevant External Links for MIR196A2 Gene

GeneLoc Exon Structure for
MIR196A2
ECgene alternative splicing isoforms for
MIR196A2

Expression for MIR196A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR196A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR196A2 Gene:

MIR196A2
genes like me logo Genes that share expression patterns with MIR196A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196A2 Gene

Orthologs for MIR196A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-196a-2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-2 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-196a-2 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196a-2 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-196a 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-3 34
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-196a-2 34
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196a-1 34
  • 78 (a)
OneToMany
mir196c 34
  • 75 (a)
OneToMany
mir196d 34
  • 74 (a)
OneToMany
Species where no ortholog for MIR196A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A2 Gene

ENSEMBL:
Gene Tree for MIR196A2 (if available)
TreeFam:
Gene Tree for MIR196A2 (if available)

Paralogs for MIR196A2 Gene

No data available for Paralogs for MIR196A2 Gene

Variants for MIR196A2 Gene

Sequence variations from dbSNP and Humsavar for MIR196A2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000637790 -- 53,990,067(+) A/G upstream_transcript_variant
rs1001220548 -- 53,991,023(+) G/A upstream_transcript_variant
rs1003794287 -- 53,991,718(+) C/T upstream_transcript_variant
rs1005665014 -- 53,990,247(+) A/T upstream_transcript_variant
rs1006362729 -- 53,990,485(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR196A2 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV gain 20364138
nsv428282 CNV gain 18775914
esv2759900 CNV gain+loss 17122850

Additional Variant Information for MIR196A2 Gene

Human Gene Mutation Database (HGMD)
MIR196A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196A2 Gene

Disorders for MIR196A2 Gene

Additional Disease Information for MIR196A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR196A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196A2 Gene

Publications for MIR196A2 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 44 58
  2. A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population. (PMID: 20229273) Dou T … Lu D (Journal of cancer research and clinical oncology 2010) 3 44 58
  3. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 44 58
  4. A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis. (PMID: 21080878) Li XD … Liu CF (Pathology 2010) 3 44 58
  5. Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population. (PMID: 21073609) Okubo M … Hirata I (Helicobacter 2010) 3 44 58

Products for MIR196A2 Gene

Sources for MIR196A2 Gene

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