microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR196A2 Gene

Subcategory (RNA class) for MIR196A2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR196A2 Gene

  • MicroRNA 196a-2 2 3 5
  • Hsa-MiR-196a-3p 163 173
  • Hsa-MiR-196a-5p 163 173
  • MicroRNA 196-2 2 3
  • Hsa-Mir-196a-2 2 3
  • Hsa-Mir-196-2 2 3
  • MIR196A2 2 5
  • Hsa-Mir-196-P2 178
  • MIMAT0004562 50
  • MIMAT0000226 50
  • Mir-196a-2 3
  • MIRN196-2 3
  • MIRN196A2 3
  • MI0000279 50
  • RF00256 168

External Ids for MIR196A2 Gene

Previous HGNC Symbols for MIR196A2 Gene

  • MIRN196-2
  • MIRN196A2

Previous GeneCards Identifiers for MIR196A2 Gene

  • GC12P052675
  • GC12P054385
  • GC12P053992
  • GC12P053997
  • GC12P054103
  • GC12P054118
  • GC12P054113
  • GC12P054167
  • GC12P054012
  • GC12P054041
  • GC12P054052
  • GC12P054061
  • GC12P054073
  • GC12P054085
  • GC12P054094
  • GC12P054099

Summaries for MIR196A2 Gene

Entrez Gene Summary for MIR196A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A2 Gene

MIR196A2 (MicroRNA 196a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR196A2 include Dilated Cardiomyopathy and Breast Cancer.

Rfam classification for MIR196A2 Gene

  • mir-196 microRNA precursor family

Additional gene information for MIR196A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196A2 Gene

Genomics for MIR196A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR196A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR196A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR196A2 Gene

Genomic Locations for MIR196A2 Gene
chr12:53,991,738-53,991,847
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr12:54,385,522-54,385,631
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR196A2 Gene

Genes around MIR196A2 on UCSC Golden Path with GeneCards custom track
MIR196A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR196A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A2 Gene

Proteins for MIR196A2 Gene

Post-translational modifications for MIR196A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A2 Gene

Domains & Families for MIR196A2 Gene

Gene Families for MIR196A2 Gene

genes like me logo Genes that share domains with MIR196A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR196A2 Gene

Function for MIR196A2 Gene

Phenotypes From GWAS Catalog for MIR196A2 Gene

Gene Ontology (GO) - Molecular Function for MIR196A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22773844
genes like me logo Genes that share ontologies with MIR196A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A2 Gene

Localization for MIR196A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR196A2 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR196A2 Gene

Pathways & Interactions for MIR196A2 Gene

PathCards logo

SuperPathways for MIR196A2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR196A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010593 negative regulation of lamellipodium assembly IDA 22773844
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA 22773844
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 22773844
genes like me logo Genes that share ontologies with MIR196A2: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR196A2 Gene

Drugs & Compounds for MIR196A2 Gene

No Compound Related Data Available

Transcripts for MIR196A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR196A2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000DA6A7_9606 miRNA 22 6

RefSeq: NR_029582, NR_029617,

LncBase: hsa-miR-196a-5p,

miRBase: MIMAT0000226,

MirGeneDB: Hsa-Mir-196-P1_5p,

TarBase: hsa-miR-196a-5p,

ENA: LM378871.1:1..22:ncRNA, LM608318.1:7..28:ncRNA, LM608349.1:25..46:ncRNA,

URS00000D6378_9606 precursor_RNA 110 5

HGNC: 31568,

RefSeq: NR_029617,

Ensembl: ENST00000385189 (view in UCSC) ,

miRBase: MI0000279,

ENA: LM608349.1:1..110:precursor_RNA,

URS00000E4877_9606 miRNA 22 5

RefSeq: NR_029617,

LncBase: hsa-miR-196a-3p,

miRBase: MIMAT0004562,

TarBase: hsa-miR-196a-3p,

ENA: LM380241.1:1..22:ncRNA, LM608349.1:62..83:ncRNA,

URS0000625942_9606 precursor_RNA 91 1

Rfam: RF00256,

URS0000EFEB8F_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-196-P2,

MIR196A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR196A2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A2 Gene

No ASD Table

Relevant External Links for MIR196A2 Gene

GeneLoc Exon Structure for
MIR196A2

Expression for MIR196A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR196A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR196A2

genes like me logo Genes that share expression patterns with MIR196A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196A2 Gene

Orthologs for MIR196A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-196a-2 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-2 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir196a-2 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-196a-2 31
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-196a 31
  • 91 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-196-3 31
  • 84 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-196a-2 31
  • 82 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii mir196a-1 31
  • 78 (a)
OneToMany
mir196c 31
  • 75 (a)
OneToMany
mir196d 31
  • 74 (a)
OneToMany
Species where no ortholog for MIR196A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR196A2 Gene

ENSEMBL:
Gene Tree for MIR196A2 (if available)
TreeFam:
Gene Tree for MIR196A2 (if available)

Paralogs for MIR196A2 Gene

No data available for Paralogs for MIR196A2 Gene

Variants for MIR196A2 Gene

Additional dbSNP identifiers (rs#s) for MIR196A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR196A2 Gene

Variant ID Type Subtype PubMed ID
esv2759900 CNV gain+loss 17122850
nsv428282 CNV gain 18775914
nsv826379 CNV gain 20364138

Additional Variant Information for MIR196A2 Gene

Human Gene Mutation Database (HGMD)
MIR196A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR196A2 Gene

Disorders for MIR196A2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR196A2 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
breast cancer
  • breast lobular carcinoma
hepatocellular carcinoma
  • hcc
heart disease
  • congenital heart disease
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR196A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR196A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR196A2 Gene

Publications for MIR196A2 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 41
  3. Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy. (PMID: 20488170) Zhou B … Zhang L (Clinica chimica acta; international journal of clinical chemistry 2010) 3 41
  4. Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. (PMID: 20549817) Liu Z … Wei Q (Cancer 2010) 3 41
  5. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M … Ni C (Journal of human genetics 2010) 3 41

Products for MIR196A2 Gene

Sources for MIR196A2 Gene