microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR196A1 Gene

Data sources for MIR196A1 Gene:

RNA type for MIR196A1 Gene

miRNA

Aliases for MIR196A1 Gene

External Ids for MIR196A1 Gene

Previous HGNC Symbols for MIR196A1 Gene

  • MIRN196-1
  • MIRN196A1

Previous GeneCards Identifiers for MIR196A1 Gene

  • GC17M044069
  • GC17M046709

Summaries for MIR196A1 Gene

Entrez Gene Summary for MIR196A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A1 Gene

MIR196A1 (MicroRNA 196a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR196A1 include Ampulla Of Vater Cancer and Cervix Disease.

Rfam classification for MIR196A1 Gene

  • mir-196 microRNA precursor family

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196A1 Gene

Genomics for MIR196A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR196A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J048631 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 250.7 +1.4 1357 0.2 MYC NCOR1 IKZF1 ZNF592 SMAD5 HES1 MBD2 TBP TAF9B NBN HOXB9 MIR196A1 CDK5RAP3 HOXB-AS4 HOXB7 ENSG00000272763
GH17J048633 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 250.7 -1.3 -1314 0.6 CBX8 ZBTB33 CEBPB CTCF MLLT1 ATF3 TRIM24 BCOR USF1 EZH2 HOXB7 MIR196A1 HOXB9 LRRC46 HOXB2 NFE2L1-DT HOXB-AS4 ENSG00000272763 LINC02086 PRAC2
GH17J048634 Enhancer 0.7 Ensembl dbSUPER 250.7 -1.9 -1930 0.2 ZNF592 CBX8 ZBTB33 L3MBTL2 CEBPB TRIM24 BCOR EZH2 CBFA2T3 MGA HOXB7 MIR196A1 LRRC46 HOXB-AS4 ENSG00000272763 LINC02086 PRAC2
GH17J048149 Enhancer 1.4 VISTA FANTOM5 Ensembl 9.6 +482.8 482770 3.6 MYC ZNF600 ATF2 ZIC2 REST FEZF1 ZNF341 ZNF623 TAL1 ELF1 HSALNG0117084 lnc-SNX11-9 COPZ2 SKAP1 CBX1 SNX11 NFE2L1 MIR152 HOXB-AS4 HOXB9
GH17J048869 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 9.9 -239.1 -239061 5.3 NCOR1 ZNF600 SSRP1 ZMYM3 KLF9 CEBPA NFIC ZIC2 YY1 FOXA1 UBE2Z ATP5MC1 ENSG00000262837 LOC105371814 SP2 TTLL6 CALCOCO2 ENSG00000230532 ENSG00000264701 CDK5RAP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR196A1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR196A1 Gene

Latest Assembly
chr17:48,632,480-48,632,571
(GRCh38/hg38)
Size:
92 bases
Orientation:
Minus strand

Previous Assembly
chr17:46,709,852-46,709,921
(GRCh37/hg19 by Entrez Gene)
Size:
70 bases
Orientation:
Minus strand

chr17:46,709,852-46,709,921
(GRCh37/hg19 by Ensembl)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR196A1 Gene

Genes around MIR196A1 on UCSC Golden Path with GeneCards custom track
MIR196A1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR196A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A1 Gene

Proteins for MIR196A1 Gene

Post-translational modifications for MIR196A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A1 Gene

Domains & Families for MIR196A1 Gene

Gene Families for MIR196A1 Gene

genes like me logo Genes that share domains with MIR196A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR196A1 Gene

Function for MIR196A1 Gene

Phenotypes From GWAS Catalog for MIR196A1 Gene

Gene Ontology (GO) - Molecular Function for MIR196A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22773844
genes like me logo Genes that share ontologies with MIR196A1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A1 Gene

Localization for MIR196A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR196A1 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR196A1 Gene

Pathways & Interactions for MIR196A1 Gene

PathCards logo

SuperPathways for MIR196A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR196A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010593 negative regulation of lamellipodium assembly IDA 22773844
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA 22773844
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 22773844
genes like me logo Genes that share ontologies with MIR196A1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR196A1 Gene

Drugs & Compounds for MIR196A1 Gene

No Compound Related Data Available

Transcripts for MIR196A1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR196A1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000DA6A7_9606 miRNA 22 6

RefSeq: NR_029582, NR_029617,

LncBase: hsa-miR-196a-5p,

miRBase: MIMAT0000226,

MirGeneDB: Hsa-Mir-196-P1_5p,

TarBase: hsa-miR-196a-5p,

ENA: LM378871.1:1..22:ncRNA, LM608318.1:7..28:ncRNA, LM608349.1:25..46:ncRNA,

URS000014C145_9606 pre_miRNA 70 4

RefSeq: NR_029582,

Ensembl: ENST00000388006 (view in UCSC) ,

miRBase: MI0000238,

ENA: LM608318.1:1..70:precursor_RNA,

URS0000D5297E_9606 miRNA 21 2

RefSeq: NR_029582,

miRBase: MIMAT0037307,

URS0000707F35_9606 pre_miRNA 92 1

Rfam: RF00256,

URS0000EFE71C_9606 pre_miRNA 61 1

MirGeneDB: Hsa-Mir-196-P1,

MIR196A1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR196A1 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A1 Gene

No ASD Table

Relevant External Links for MIR196A1 Gene

GeneLoc Exon Structure for
MIR196A1

Expression for MIR196A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR196A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR196A1

genes like me logo Genes that share expression patterns with MIR196A1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196A1 Gene

Orthologs for MIR196A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-1 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-196a-1 30
  • 75 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-196a-1 30
  • 66 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-196a 30
  • 64 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir196a-1 30
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-196-1 30
  • 61 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-196c 30
  • 59 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii mir196b 30
  • 63 (a)
OneToOne
Species where no ortholog for MIR196A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR196A1 Gene

ENSEMBL:
Gene Tree for MIR196A1 (if available)
TreeFam:
Gene Tree for MIR196A1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR196A1

Paralogs for MIR196A1 Gene

No data available for Paralogs for MIR196A1 Gene

Variants for MIR196A1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR196A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR196A1 Gene

Variant ID Type Subtype PubMed ID
esv2758694 CNV gain 17122850
nsv833471 CNV gain 17160897

Additional Variant Information for MIR196A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196A1
Leiden Open Variation Database (LOVD)
MIR196A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR196A1 Gene

Disorders for MIR196A1 Gene

MalaCards: The human disease database

(127) MalaCards diseases for MIR196A1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ampulla of vater cancer
  • malignant tumour of ampulla of vater
cervix disease
  • cervix disorders
pancreas disease
  • abnormality of the pancreas
esophageal disease
  • esophageal ulcer
duodenum adenocarcinoma
  • duodenal adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR196A1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MIR196A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR196A1 Gene

Publications for MIR196A1 Gene

  1. A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han. (PMID: 20722507) Wang K … Bai Y (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2010) 3 40
  2. LncRNA LOXL1-AS1 controls osteogenic and adipocytic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis through regulating the miR-196a-5p/Hmga2 axis. (PMID: 32651705) Zhang L … Li S (Journal of bone and mineral metabolism 2020) 3
  3. Increased urinary miR-196a level predicts the progression of renal injury in patients with diabetic nephropathy. (PMID: 30521014) An Y … Liu Z (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2020) 3
  4. Mechanism of lncRNA FEZF1-AS1 in promoting the occurrence and development of oral squamous cell carcinoma through targeting miR-196a. (PMID: 31378890) Xu L … Yang P (European review for medical and pharmacological sciences 2019) 3
  5. Downregulation of microRNA-196a inhibits stem cell self-renewal ability and stemness in non-small-cell lung cancer through upregulating GPX3 expression. (PMID: 31352088) Liu Q … Lin X (The international journal of biochemistry & cell biology 2019) 3

Products for MIR196A1 Gene

Sources for MIR196A1 Gene