microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR196A1 Gene

Subcategory (RNA class) for MIR196A1 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR196A1 Gene

  • MicroRNA 196a-1 2 3 5
  • Hsa-MiR-196a-5p 166 177
  • MicroRNA 196-1 2 3
  • MicroRNA 196a 2 3
  • MicroRNA MiR-196 3
  • Hsa-Mir-196a-1 3
  • Hsa-Mir-196-1 3
  • MIMAT0037307 51
  • MIMAT0000226 51
  • Mir-196a-1 3
  • MIRN196-1 3
  • MIRN196A1 3
  • MI0000238 51
  • MIR196A1 2
  • RF00256 172

External Ids for MIR196A1 Gene

Previous HGNC Symbols for MIR196A1 Gene

  • MIRN196-1
  • MIRN196A1

Previous GeneCards Identifiers for MIR196A1 Gene

  • GC17M044069
  • GC17M046709

Summaries for MIR196A1 Gene

Entrez Gene Summary for MIR196A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A1 Gene

MIR196A1 (MicroRNA 196a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR196A1 include Ampulla Of Vater Cancer and Cervix Disease.

Rfam classification for MIR196A1 Gene

  • mir-196 microRNA precursor family

Additional gene information for MIR196A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196A1 Gene

Genomics for MIR196A1 Gene

GeneHancer (GH) Regulatory Elements for MIR196A1 Gene

Promoters and enhancers for MIR196A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J048631 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 500.7 +1.4 1357 0.2 AFF1 HES1 MYC CTBP1 TAF9B EZH2 GTF2F1 NCOR1 NFRKB KDM5B HOXB9 MIR196A1 CDK5RAP3 HOXB-AS4 HOXB7
GH17J048633 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 500.7 -1.2 -1215 0.4 USF1 CTCF PRPF4 EZH2 POLR2G CBX8 SUZ12 RNF2 ZBTB33 ATF3 HOXB7 MIR196A1 HOXB9 HOXB2 ENSG00000263412 HOXB-AS4 LINC02086
GH17J048869 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 9.9 -238.9 -238862 5.7 EP300 FOXK2 ZSCAN5C TCF12 POLR2G NCOR1 ZIC2 KDM6A TCF7 FOXA1 ATP5MC1 UBE2Z TTLL6 CALCOCO2 ENSG00000262837 SP2 ENSG00000230532 HOXB13 PRAC1 PRAC2
GH17J048470 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.4 +160.6 160570 3.6 ZSCAN5C JUND FOS EP300 ZNF423 NFYB CTCF ZNF341 OSR2 WT1 HOXB2 SKAP1 SNX11 HOXB-AS2 HOXB3 HOXB4 MIR10A HOXB-AS1 HOXB1 MIR196A1
GH17J048264 Enhancer 1 Ensembl ENCODE 10.6 +367.2 367228 3.5 EP300 TCF12 CTCF ZNF10 TRIM28 KLF9 WT1 NFIC CEBPG NCOR1 lnc-SNX11-12 SKAP1 COPZ2 CDK5RAP3 MIR1203 RNU6-1152P MIR196A1 SNX11 CBX1 HOXB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR196A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR196A1 Gene

Genomic Locations for MIR196A1 Gene
chr17:48,632,480-48,632,571
(GRCh38/hg38)
Size:
92 bases
Orientation:
Minus strand
chr17:46,709,852-46,709,921
(GRCh37/hg19)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR196A1 Gene

Genes around MIR196A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A1 Gene

Proteins for MIR196A1 Gene

Post-translational modifications for MIR196A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A1 Gene

Domains & Families for MIR196A1 Gene

Gene Families for MIR196A1 Gene

genes like me logo Genes that share domains with MIR196A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR196A1 Gene

Function for MIR196A1 Gene

Phenotypes From GWAS Catalog for MIR196A1 Gene

Gene Ontology (GO) - Molecular Function for MIR196A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22773844
genes like me logo Genes that share ontologies with MIR196A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A1 Gene

Localization for MIR196A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR196A1 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR196A1 Gene

Pathways & Interactions for MIR196A1 Gene

PathCards logo

SuperPathways for MIR196A1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR196A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010593 negative regulation of lamellipodium assembly IDA 22773844
GO:0035195 gene silencing by miRNA IDA 22773844
GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA 22773844
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 22773844
genes like me logo Genes that share ontologies with MIR196A1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR196A1 Gene

Drugs & Compounds for MIR196A1 Gene

No Compound Related Data Available

Transcripts for MIR196A1 Gene

mRNA/cDNA for MIR196A1 Gene

5 RNACentral transcripts :
2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
1 LncBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A1 Gene

No ASD Table

Relevant External Links for MIR196A1 Gene

GeneLoc Exon Structure for
MIR196A1

Expression for MIR196A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR196A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR196A1

genes like me logo Genes that share expression patterns with MIR196A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196A1 Gene

Orthologs for MIR196A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-1 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-196a-1 31
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-196a-1 31
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-196a 31
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196a-1 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-1 31
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-196c 31
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196b 31
  • 63 (a)
OneToOne
Species where no ortholog for MIR196A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A1 Gene

ENSEMBL:
Gene Tree for MIR196A1 (if available)
TreeFam:
Gene Tree for MIR196A1 (if available)

Paralogs for MIR196A1 Gene

No data available for Paralogs for MIR196A1 Gene

Variants for MIR196A1 Gene

Additional dbSNP identifiers (rs#s) for MIR196A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR196A1 Gene

Variant ID Type Subtype PubMed ID
esv2758694 CNV gain 17122850
nsv833471 CNV gain 17160897

Additional Variant Information for MIR196A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR196A1 Gene

Disorders for MIR196A1 Gene

MalaCards: The human disease database

(118) MalaCards diseases for MIR196A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ampulla of vater cancer
  • malignant tumour of ampulla of vater
cervix disease
  • cervix disorders
esophageal disease
  • esophageal ulcer
pancreas disease
  • pancreatic diseases
duodenum adenocarcinoma
  • duodenal adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR196A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR196A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR196A1 Gene

Publications for MIR196A1 Gene

  1. A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han. (PMID: 20722507) Wang K … Bai Y (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2010) 3 41 54
  2. HOXA5 inhibits tumor growth of gastric cancer under the regulation of microRNA-196a. (PMID: 30267809) Wu Y … Xiao J (Gene 2019) 3 54
  3. Identification of miR-146a and miR-196a-2 single nucleotide polymorphisms at patients with high-grade serous ovarian cancer. (PMID: 30904593) Lukács J … Póka R (Journal of biotechnology 2019) 3 54
  4. Association of serum annexin A1 with treatment response and prognosis in patients with esophageal squamous cell carcinoma. (PMID: 30249885) Han GH … Dai CL (Journal of cancer research and therapeutics 2018) 3 54
  5. CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC. (PMID: 29286141) Wang L … Ge L (Oncology reports 2018) 3 54

Products for MIR196A1 Gene

Sources for MIR196A1 Gene