microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR195 Gene

Subcategory (RNA class) for MIR195 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR195 Gene

  • MicroRNA 195 2 3 5
  • Hsa-MiR-195-5p 163 173
  • Hsa-MiR-195-3p 163 173
  • Hsa-Mir-195 2 3
  • MIR195 2 5
  • Hsa-Mir-15-P2c 178
  • MIMAT0000461 50
  • MIMAT0004615 50
  • MI0000489 50
  • MiRNA195 3
  • MIRN195 3
  • Mir-195 3
  • RF00254 168

External Ids for MIR195 Gene

Previous HGNC Symbols for MIR195 Gene

  • MIRN195

Previous GeneCards Identifiers for MIR195 Gene

  • GC17M006866
  • GC17M006920

Summaries for MIR195 Gene

Entrez Gene Summary for MIR195 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR195 Gene

MIR195 (MicroRNA 195) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR195 include Adrenocortical Carcinoma, Hereditary and Hepatocellular Carcinoma. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR195 Gene

  • mir-16 microRNA precursor family

Additional gene information for MIR195 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR195 Gene

Genomics for MIR195 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR195 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR195 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR195 Gene

Genomic Locations for MIR195 Gene
chr17:7,017,615-7,017,701
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand
chr17:6,919,137-6,922,978
(GRCh37/hg19)
Size:
3,842 bases
Orientation:
Minus strand

Genomic View for MIR195 Gene

Genes around MIR195 on UCSC Golden Path with GeneCards custom track
MIR195 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR195 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR195 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR195 Gene

Proteins for MIR195 Gene

Post-translational modifications for MIR195 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR195 Gene

Domains & Families for MIR195 Gene

Gene Families for MIR195 Gene

genes like me logo Genes that share domains with MIR195: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR195 Gene

Function for MIR195 Gene

Phenotypes From GWAS Catalog for MIR195 Gene

Gene Ontology (GO) - Molecular Function for MIR195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24294368
genes like me logo Genes that share ontologies with MIR195: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR195 Gene

Localization for MIR195 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR195 gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR195 Gene

Pathways & Interactions for MIR195 Gene

PathCards logo

SuperPathways for MIR195 Gene

genes like me logo Genes that share pathways with MIR195: view

Pathways by source for MIR195 Gene

1 BioSystems pathway for MIR195 Gene
1 KEGG pathway for MIR195 Gene

Gene Ontology (GO) - Biological Process for MIR195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEP 30497184
GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis ISS --
GO:0003300 cardiac muscle hypertrophy ISS --
GO:0008285 negative regulation of cell proliferation IDA 24294368
GO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS --
genes like me logo Genes that share ontologies with MIR195: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR195 Gene

Drugs & Compounds for MIR195 Gene

No Compound Related Data Available

Transcripts for MIR195 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR195 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000040EE1D_9606 precursor_RNA 87 5

HGNC: 31566,

RefSeq: NR_029712,

Ensembl: ENST00000385194 (view in UCSC) ,

miRBase: MI0000489,

ENA: LM608528.1:1..87:precursor_RNA,

URS0000476C64_9606 miRNA 22 5

RefSeq: NR_029712,

LncBase: hsa-miR-195-3p,

miRBase: MIMAT0004615,

TarBase: hsa-miR-195-3p,

ENA: LM608528.1:53..74:ncRNA,

URS00005B3525_9606 miRNA 21 5

RefSeq: NR_029712,

LncBase: hsa-miR-195-5p,

miRBase: MIMAT0000461,

TarBase: hsa-miR-195-5p,

ENA: LM379079.1:1..21:ncRNA, LM608528.1:15..35:ncRNA,

URS00006D9757_9606 precursor_RNA 77 1

Rfam: RF00254,

URS0000EFC120_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-15-P2c,

MIR195 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR195 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR195 Gene

No ASD Table

Relevant External Links for MIR195 Gene

GeneLoc Exon Structure for
MIR195

Expression for MIR195 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR195

Evidence on tissue expression from TISSUES for MIR195 Gene

  • Blood(2.4)
  • Heart(2.4)
  • Muscle(2.3)
  • Liver(2.2)
  • Nervous system(2.1)
  • Intestine(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR195 Gene

Orthologs for MIR195 Gene

Evolution for MIR195 Gene

ENSEMBL:
Gene Tree for MIR195 (if available)
TreeFam:
Gene Tree for MIR195 (if available)

No data available for Orthologs for MIR195 Gene

Paralogs for MIR195 Gene

No data available for Paralogs for MIR195 Gene

Variants for MIR195 Gene

Additional dbSNP identifiers (rs#s) for MIR195 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR195 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv1121929 CNV deletion 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Additional Variant Information for MIR195 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR195

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR195 Gene

Disorders for MIR195 Gene

MalaCards: The human disease database

(63) MalaCards diseases for MIR195 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR195

genes like me logo Genes that share disorders with MIR195: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR195 Gene

Publications for MIR195 Gene

  1. LINC00511 as a ceRNA promotes cell malignant behaviors and correlates with prognosis of hepatocellular carcinoma patients by modulating miR-195/EYA1 axis. (PMID: 31731191) Hu WY … Feng R (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  2. MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma. (PMID: 31927122) Song LR … Zhang JT (World neurosurgery 2020) 3
  3. Linc-ROR targets FGF2 to regulate HASMC proliferation and migration via sponging miR-195-5p. (PMID: 31629816) Ji Z … Chen Y (Gene 2020) 3
  4. Downregulation of lncRNA SNHG12 reversed IGF1R-induced osteosarcoma metastasis and proliferation by targeting miR-195-5p. (PMID: 31743769) Xu N … Han C (Gene 2020) 3
  5. [Expression and Clinical Significance of MicroRNA-195 in Patients with Diffuse Large B Cell Lymphoma]. (PMID: 32027270) Liu RD … Li CC (Zhongguo shi yan xue ye xue za zhi 2020) 3

Products for MIR195 Gene

Sources for MIR195 Gene