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Aliases for MIR195 Gene

Subcategory (RNA class) for MIR195 Gene

miRNA

Quality Score for this RNA gene is

20.2

Aliases for MIR195 Gene

  • MicroRNA 195 2 3 5
  • Hsa-Mir-195 3
  • MiRNA195 3
  • Mir-195 3
  • MIRN195 3

External Ids for MIR195 Gene

Previous HGNC Symbols for MIR195 Gene

  • MIRN195

Previous GeneCards Identifiers for MIR195 Gene

  • GC17M006866
  • GC17M006920

Summaries for MIR195 Gene

Entrez Gene Summary for MIR195 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR195 Gene

MIR195 (MicroRNA 195) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR195 include Adrenocortical Carcinoma, Hereditary and Hepatocellular Carcinoma. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR195 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR195

Additional gene information for MIR195 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR195 Gene

Genomics for MIR195 Gene

GeneHancer (GH) Regulatory Elements for MIR195 Gene

Promoters and enhancers for MIR195 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007010 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 0.0 -13 13.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MIR497HG RNASEK BCL6B C17orf49 ENSG00000267047 MIR497 MIR195 DVL2 SNORD10 CNTROB
GH17J006853 Promoter/Enhancer 1.6 Ensembl ENCODE 10.3 +163.0 163040 2.7 ARID4B SIN3A DMAP1 ZBTB7B YY1 ETS1 ELK1 ZNF143 FOS NFKBIZ ALOX12P2 TEKT1 FBXO39 BCL6B SLC13A5 MIR195 GC17M006868
GH17J006913 Enhancer 0.9 Ensembl ENCODE 11.4 +103.6 103560 0.9 CTCF RB1 RAD21 CC2D1A POLR2A BRD9 ARID2 SMC3 ZNF143 CREM ALOX12 ALOX12-AS1 RNASEK RNASEK-C17orf49 MIR195 BCL6B SLC16A11 C17orf100 MED31 SLC13A5
GH17J006666 Enhancer 0.7 ENCODE 9.9 +351.4 351424 0.4 ELF3 CTCF IRF2 SAP130 ARID4B RAD21 RFX5 TEAD3 POLR2A SMC3 ENSG00000261996 KIAA0753 TXNDC17 SLC13A5 MIR195 PITPNM3 BCL6B PIR54331 GC17P006673 ALOX15P1
GH17J006919 Enhancer 0.6 FANTOM5 10 +97.9 97948 0.4 HDAC1 PKNOX1 AFF1 CEBPG GABPA ATF4 CTBP1 SMARCA4 TARDBP ZKSCAN8 ALOX12 RNASEK RNASEK-C17orf49 ALOX12-AS1 BCL6B SLC13A5 MIR195 SLC16A11 GC17M006933 GC17P006901
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR195 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR195 Gene

Genomic Locations for MIR195 Gene
chr17:7,017,615-7,017,701
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand
chr17:6,919,137-6,922,978
(GRCh37/hg19)
Size:
3,842 bases
Orientation:
Minus strand

Genomic View for MIR195 Gene

Genes around MIR195 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR195 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR195 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR195 Gene

ORGUL Member Location for MIR195 Gene

ORGUL Member Location for MIR195 gene

Proteins for MIR195 Gene

Post-translational modifications for MIR195 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR195 Gene

Domains & Families for MIR195 Gene

Gene Families for MIR195 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR195: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR195 Gene

Function for MIR195 Gene

Phenotypes From GWAS Catalog for MIR195 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR195 Gene

Localization for MIR195 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR195 Gene

Pathways & Interactions for MIR195 Gene

genes like me logo Genes that share pathways with MIR195: view

Pathways by source for MIR195 Gene

1 BioSystems pathway for MIR195 Gene
1 KEGG pathway for MIR195 Gene

Interacting Proteins for MIR195 Gene

Gene Ontology (GO) - Biological Process for MIR195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis ISS --
GO:0003300 cardiac muscle hypertrophy ISS --
GO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS --
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle ISS --
GO:0045930 negative regulation of mitotic cell cycle ISS --
genes like me logo Genes that share ontologies with MIR195: view

No data available for SIGNOR curated interactions for MIR195 Gene

Drugs & Compounds for MIR195 Gene

No Compound Related Data Available

Transcripts for MIR195 Gene

fRNAdb Secondary structures for MIR195 Gene

  • hsa-miR-195-5p_MIMAT0000461_Homo_sapiens_miR-195-5p_mature
  • FR228819

mRNA/cDNA for MIR195 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR195 Gene

No ASD Table

Relevant External Links for MIR195 Gene

GeneLoc Exon Structure for
MIR195
ECgene alternative splicing isoforms for
MIR195

Expression for MIR195 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR195 Gene:

MIR195
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR195 Gene

Orthologs for MIR195 Gene

Evolution for MIR195 Gene

ENSEMBL:
Gene Tree for MIR195 (if available)
TreeFam:
Gene Tree for MIR195 (if available)

No data available for Orthologs for MIR195 Gene

Paralogs for MIR195 Gene

No data available for Paralogs for MIR195 Gene

Variants for MIR195 Gene

Sequence variations from dbSNP and Humsavar for MIR195 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001337651 -- 7,017,410(-) G/A downstream_transcript_variant
rs1001397642 -- 7,017,139(-) C/T downstream_transcript_variant
rs1001872040 -- 7,017,629(-) G/C non_coding_transcript_variant
rs1003037341 -- 7,019,600(-) C/A upstream_transcript_variant
rs1003412908 -- 7,018,673(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR195 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv1121929 CNV deletion 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Additional Variant Information for MIR195 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR195

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR195 Gene

Disorders for MIR195 Gene

MalaCards: The human disease database

(17) MalaCards diseases for MIR195 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
adrenocortical carcinoma, hereditary
  • adcc
hepatocellular carcinoma
  • hcc
ulcerative colitis
  • left-sided ulcerative colitis
pancreatitis, hereditary
  • pctt
heart disease
  • congestive heart failure
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR195

genes like me logo Genes that share disorders with MIR195: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR195 Gene

Publications for MIR195 Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M … Tuschl T (RNA (New York, N.Y.) 2003) 1 3 58
  2. Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation. (PMID: 29426937) Guo J … Li J (Nature communications 2018) 3 58
  3. LncRNA SNHG12 promotes tumorigenesis and metastasis in osteosarcoma by upregulating Notch2 by sponging miR-195-5p. (PMID: 29229388) Zhou S … Dai G (Biochemical and biophysical research communications 2018) 3 58
  4. LINC00473 antagonizes the tumour suppressor miR-195 to mediate the pathogenesis of Wilms tumour via IKKα. (PMID: 29159834) Zhu S … Liu G (Cell proliferation 2018) 3 58
  5. Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195. (PMID: 29042220) Xiao L … Wang JY (Gastroenterology 2018) 3 58

Products for MIR195 Gene

Sources for MIR195 Gene

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