Aliases for MIR194-2 Gene
Subcategory (RNA class) for MIR194-2 Gene
miRNA
Quality Score for this RNA gene is
20.2
External Ids for MIR194-2 Gene
- HGNC: 31565
- Entrez Gene: 406970
- Ensembl: ENSG00000284155
- OMIM: 610941
- miRBase: hsa-mir-194-2
ORGUL Members for MIR194-2 Gene
Previous HGNC Symbols for MIR194-2 Gene
- MIRN194-2
Previous GeneCards Identifiers for MIR194-2 Gene
- GC11M064433
- GC11M064436
- GC11M064661
- GC11M064665
- GC11M064668
- GC11M064671
- GC11M064673
- GC11M064675
- GC11M064677
- GC11M064682
- GC11M064688
- GC11M064693
- GC11M064892
- GC11M064893
- GC11M064911
- GC11M064921
- GC11M064930
Summaries for MIR194-2 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR194-2 Gene
MIR194-2 (MicroRNA 194-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.
fRNAdb sequence ontologies for MIR194-2 Gene - the ORGUL cluster for this gene includes several descriptions:
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
Additional gene information for MIR194-2 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR194-2 Gene
Genomics for MIR194-2 Gene
GeneHancer (GH) Regulatory Elements for MIR194-2 Gene
Promoters and enhancers for MIR194-2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11I064886 | Enhancer | 1.5 | Ensembl ENCODE dbSUPER | 550.8 | +0.4 | 405 | 8.2 | HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 | MIR192 MIR194-2 GC11M064957 GC11M064954 MAJIN EEF1A1P18 ARL2 CDC42BPG SPDYC PLCB3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR194-2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR194-2 Gene
Genomic Locations for MIR194-2 Gene
- chr11:64,891,355-64,891,439
- (GRCh38/hg38)
- Size:
- 85 bases
- Orientation:
- Minus strand
- chr11:64,658,827-64,660,921
- (GRCh37/hg19)
Genomic View for MIR194-2 Gene
Genes around MIR194-2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
MIR194-2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR194-2 Gene
ORGUL Member Location for MIR194-2 Gene
Proteins for MIR194-2 Gene
Post-translational modifications for MIR194-2 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR194-2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR194-2
- Origene Custom Protein Services for MIR194-2
- Search GeneTex for Proteins for MIR194-2
No data available for DME Specific Peptides for MIR194-2 Gene
Domains & Families for MIR194-2 Gene
Gene Families for MIR194-2 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR194-2 Gene
Function for MIR194-2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR194-2
-
- Search ViGene Biosciences for MIR194-2
CRISPR Products
- Browse CRISPR knockouts for MIR194-2
- Applied Biological Materials CRISPR for MIR194-2
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA for MIR194-2 Gene
- miRTarBase miRNAs that target MIR194-2
Inhibitory RNA Products
- Search ViGene Biosciences for MIR194-2
Clone Products
- GenScript: Custom all cDNA clones Services for MIR194-2
- VectorBuilder custom plasmid, inducible vectors for MIR194-2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR194-2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR194-2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR194-2 Gene
Localization for MIR194-2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 25203061 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR194-2 Gene
Pathways & Interactions for MIR194-2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR194-2 Gene
1 KEGG pathway for MIR194-2 Gene
Interacting Proteins for MIR194-2 Gene
No data available for SIGNOR curated interactions for MIR194-2 Gene
Transcripts for MIR194-2 Gene
fRNAdb Secondary structures for MIR194-2 Gene
mRNA/cDNA for MIR194-2 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR194-2
- Applied Biological Materials CRISPR for MIR194-2
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR194-2
Clone Products
- GenScript: Custom all cDNA clones Services for MIR194-2
- VectorBuilder custom plasmid, inducible vectors for MIR194-2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR194-2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR194-2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR194-2 Gene
mRNA differential expression in normal tissues according to GTEx for MIR194-2 Gene
This gene is overexpressed in Colon - Transverse (x20.0) and Small Intestine - Terminal Ileum (x18.2).
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR194-2 Gene
Orthologs for MIR194-2 Gene
No data available for Orthologs for MIR194-2 Gene
Paralogs for MIR194-2 Gene
No data available for Paralogs for MIR194-2 Gene
Variants for MIR194-2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000588419 | -- | 64,891,594(-) | G/A | upstream_transcript_variant | |
| rs1001108883 | -- | 64,891,132(-) | T/C | downstream_transcript_variant | |
| rs1002200033 | -- | 64,891,658(-) | C/T | upstream_transcript_variant | |
| rs1002302129 | -- | 64,891,698(-) | C/T | upstream_transcript_variant | |
| rs1002551245 | -- | 64,891,881(-) | G/T | upstream_transcript_variant |
Additional Variant Information for MIR194-2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR194-2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR194-2 Gene
Disorders for MIR194-2 Gene
Additional Disease Information for MIR194-2
No disorders were found for MIR194-2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR194-2 Gene
Publications for MIR194-2 Gene
- New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M … Tuschl T (RNA (New York, N.Y.) 2003) 1 3 58
- Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael MZ … James RJ (Molecular cancer research : MCR 2003) 1 3 58
- Original Research: miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells. (PMID: 27480251) Cui G … Zhao S (Experimental biology and medicine (Maywood, N.J.) 2017) 3 58
- Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway. (PMID: 28358423) Bai M … Zhao R (Oncology reports 2017) 3 58
- MicroRNA-194 regulates keratinocyte proliferation and differentiation by targeting Grainyhead-like 2 in psoriasis. (PMID: 28040329) Yu X … Su C (Pathology, research and practice 2017) 3 58
Products for MIR194-2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR194-2
- Origene Custom Protein Services for MIR194-2
- Browse OriGene Inhibitory RNA Products For MIR194-2
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR194-2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR194-2
- GenScript: Custom all cDNA clones Services for MIR194-2
- GenScript Custom Purified and Recombinant Proteins Services for MIR194-2
- GenScript Custom Assay Services for MIR194-2
- GenScript Custom overexpressing Cell Line Services for MIR194-2
- Browse GenScript CRISPR for MIR194-2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MIR194-2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR194-2
- VectorBuilder custom plasmid, inducible vectors for MIR194-2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR194-2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR194-2
- Search GeneTex for Proteins for MIR194-2
- Search ViGene Biosciences for MIR194-2
Sources for MIR194-2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems