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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR194-2 Gene
Subcategory (RNA class) for MIR194-2 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR194-2 Gene
External Ids for MIR194-2 Gene
- HGNC: 31565
- Entrez Gene: 406970
- Ensembl: ENSG00000284155
- OMIM: 610941
- miRBase: hsa-mir-194-2
Previous HGNC Symbols for MIR194-2 Gene
- MIRN194-2
Previous GeneCards Identifiers for MIR194-2 Gene
- GC11M064433
- GC11M064436
- GC11M064661
- GC11M064665
- GC11M064668
- GC11M064671
- GC11M064673
- GC11M064675
- GC11M064677
- GC11M064682
- GC11M064688
- GC11M064693
- GC11M064892
- GC11M064893
- GC11M064962
- GC11M064971
- GC11M064983
- GC11M065003
- GC11M064911
- GC11M064921
- GC11M064930
- GC11M064934
- GC11M064946
Summaries for MIR194-2 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR194-2 Gene
MIR194-2 (MicroRNA 194-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR194-2 include Coffin-Siris Syndrome 1. Among its related pathways are MicroRNAs in cancer.
Rfam classification for MIR194-2 Gene
-
mir-194 microRNA precursor family
Additional gene information for MIR194-2 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR194-2 Gene
Genomics for MIR194-2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR194-2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J064884 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +1.4 | 1403 | 10.2 | ARHGAP35 HNRNPL GATAD2A CTCF ATF7 PRDM10 TFE3 LEF1 SOX13 IKZF1 | EHD1 MIR192 MIR194-2 MIR194-2HG PCNX3 SF1 SYVN1 NEAT1 PLCB3 POLA2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR194-2 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR194-2 Gene
Genomic Locations for MIR194-2 Gene
- chr11:64,891,355-64,891,440
- (GRCh38/hg38)
- Size:
- 86 bases
- Orientation:
- Minus strand
- chr11:64,658,827-64,660,921
- (GRCh37/hg19)
- Size:
- 2,095 bases
- Orientation:
- Minus strand
Genomic View for MIR194-2 Gene
Genes around MIR194-2 on UCSC Golden Path with GeneCards custom track
MIR194-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
MIR194-2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR194-2 Gene
Proteins for MIR194-2 Gene
Post-translational modifications for MIR194-2 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR194-2
- Origene Custom Protein Services for MIR194-2
No data available for DME Specific Peptides for MIR194-2 Gene
Domains & Families for MIR194-2 Gene
Gene Families for MIR194-2 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR194-2 Gene
Function for MIR194-2 Gene
Phenotypes From GWAS Catalog for MIR194-2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 26147452 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR194-2 - Select products 50% OFF >
- * MIR194-2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR194-2
miRNA for MIR194-2 Gene
- miRTarBase miRNAs that target MIR194-2
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR194-2 - Select products 50% OFF >
- * MIR194-2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR194-2 Gene
Localization for MIR194-2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 25203061 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR194-2 Gene
Pathways & Interactions for MIR194-2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR194-2 Gene
1 KEGG pathway for MIR194-2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0045081 | negative regulation of interleukin-10 biosynthetic process | IDA | 26147452 |
| GO:2001180 | negative regulation of interleukin-10 secretion | IDA | 26147452 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR194-2 Gene
Transcripts for MIR194-2 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR194-2 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000065566_9606 | miRNA | 22 | 6 |
RefSeq: NR_029829, LncBase: hsa-miR-194-3p, miRBase: MIMAT0004671, MirGeneDB: Hsa-Mir-194-P1_3p, TarBase: hsa-miR-194-3p, |
| URS000029C2DC_9606 | miRNA | 22 | 6 |
LncBase: hsa-miR-194-5p, miRBase: MIMAT0000460, MirGeneDB: Hsa-Mir-194-P2_5p, TarBase: hsa-miR-194-5p, ENA: AJ535827.1:1..22:ncRNA, LM379078.1:1..22:ncRNA, LM608527.1:15..36:ncRNA, LM608659.1:15..36:ncRNA, |
| URS0000759DC6_9606 | precursor_RNA | 85 | 5 |
HGNC: 31565, RefSeq: NR_029829, Ensembl: ENST00000384864 (view in UCSC) , miRBase: MI0000732, |
| URS000069818E_9606 | precursor_RNA | 86 | 1 |
Rfam: RF00257, |
| URS0000EFCED7_9606 | precursor_RNA | 59 | 1 |
MirGeneDB: Hsa-Mir-194-P1, |
MIR194-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR194-2 Gene
- 1 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR194-2 - Select products 50% OFF >
- * MIR194-2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR194-2
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR194-2 - Select products 50% OFF >
- * MIR194-2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIR194-2 Gene
- GeneLoc Exon Structure for
- MIR194-2
Expression for MIR194-2 Gene
mRNA differential expression in normal tissues according to GTEx for MIR194-2 Gene
This gene is overexpressed in Colon - Transverse (x20.0) and Small Intestine - Terminal Ileum (x18.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR194-2
Primer Products
-
OriGene qPCR primer pairs for MIR194-2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR194-2 Gene
Orthologs for MIR194-2 Gene
No data available for Orthologs for MIR194-2 Gene
Paralogs for MIR194-2 Gene
No data available for Paralogs for MIR194-2 Gene
Variants for MIR194-2 Gene
Additional Variant Information for MIR194-2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR194-2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR194-2 Gene
Disorders for MIR194-2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| coffin-siris syndrome 1 |
|
|
Search MIR194-2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR194-2
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR194-2 Gene
Publications for MIR194-2 Gene
- LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR-194-5p/ACVR2B signaling. (PMID: 30334578) Ye Y … Li M (Molecular carcinogenesis 2019) 3
- Inflammation-dependent downregulation of miR-194-5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B. (PMID: 30945295) Chen Z … Qian L (Journal of cellular physiology 2019) 3
- MicroRNA-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2. (PMID: 31496625) Wu JC … Xu MY (World journal of gastroenterology 2019) 3
- LINC00909 promotes tumor progression in human glioma through regulation of miR-194/MUC1-C axis. (PMID: 31132669) Liu Z … Hu G (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
- A miR-194/PTBP1/CCND3 axis regulates tumor growth in human hepatocellular carcinoma. (PMID: 31301177) Kang H … Kim W (The Journal of pathology 2019) 3
ExternalLinks
Products for MIR194-2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR194-2
- Origene Custom Protein Services for MIR194-2
- Browse OriGene Inhibitory RNA Products For MIR194-2
- OriGene qPCR primer pairs for MIR194-2
- Browse CRISPR knockouts for MIR194-2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR194-2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR194-2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR194-2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR194-2
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR194-2
Sources for MIR194-2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB