microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR194-2 Gene

Data sources for MIR194-2 Gene:

Subcategory (RNA class) for MIR194-2 Gene

miRNA

Aliases for MIR194-2 Gene

External Ids for MIR194-2 Gene

Previous HGNC Symbols for MIR194-2 Gene

  • MIRN194-2

Previous GeneCards Identifiers for MIR194-2 Gene

  • GC11M064433
  • GC11M064436
  • GC11M064661
  • GC11M064665
  • GC11M064668
  • GC11M064671
  • GC11M064673
  • GC11M064675
  • GC11M064677
  • GC11M064682
  • GC11M064688
  • GC11M064693
  • GC11M064892
  • GC11M064893
  • GC11M064962
  • GC11M064971
  • GC11M064983
  • GC11M065003
  • GC11M064911
  • GC11M064921
  • GC11M064930
  • GC11M064934
  • GC11M064946
  • GC11M064954

Summaries for MIR194-2 Gene

Entrez Gene Summary for MIR194-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR194-2 Gene

MIR194-2 (MicroRNA 194-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR194-2 include Coffin-Siris Syndrome 1. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR194-2 Gene

  • mir-194 microRNA precursor family

Additional gene information for MIR194-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR194-2 Gene

Genomics for MIR194-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR194-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064884 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.4 1403 10.2 TBP ZBTB10 MXD4 CEBPA NR2C1 MNT DEK IKZF1 SMAD5 IRF2 EHD1 HSALNG0084832 MIR192 MIR194-2 MIR194-2HG SF1 SYVN1 NEAT1 PLCB3 POLA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR194-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR194-2 Gene

Latest Assembly
chr11:64,891,355-64,891,440
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand

Previous Assembly
chr11:64,658,827-64,658,911
(GRCh37/hg19 by Entrez Gene)
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR194-2 Gene

Genes around MIR194-2 on UCSC Golden Path with GeneCards custom track
MIR194-2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR194-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR194-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR194-2 Gene

Proteins for MIR194-2 Gene

Post-translational modifications for MIR194-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR194-2 Gene

Domains & Families for MIR194-2 Gene

Gene Families for MIR194-2 Gene

genes like me logo Genes that share domains with MIR194-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR194-2 Gene

Function for MIR194-2 Gene

Phenotypes From GWAS Catalog for MIR194-2 Gene

Gene Ontology (GO) - Molecular Function for MIR194-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR194-2: view

CRISPR products for research

miRNA for MIR194-2 Gene

miRTarBase miRNAs that target MIR194-2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR194-2 Gene

Localization for MIR194-2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR194-2 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR194-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA --
GO:1903561 extracellular vesicle HDA --
genes like me logo Genes that share ontologies with MIR194-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR194-2 Gene

Pathways & Interactions for MIR194-2 Gene

PathCards logo

SuperPathways for MIR194-2 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR194-2: view

Pathways by source for MIR194-2 Gene

1 KEGG pathway for MIR194-2 Gene

Gene Ontology (GO) - Biological Process for MIR194-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032693 negative regulation of interleukin-10 production IDA --
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR194-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR194-2 Gene

Drugs & Compounds for MIR194-2 Gene

No Compound Related Data Available

Transcripts for MIR194-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR194-2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000065566_9606 miRNA 22 6

RefSeq: NR_029829,

LncBase: hsa-miR-194-3p,

miRBase: MIMAT0004671,

MirGeneDB: Hsa-Mir-194-P1_3p,

TarBase: hsa-miR-194-3p,

ENA: LM380335.1:1..22:ncRNA, LM608659.1:51..72:ncRNA,

URS000029C2DC_9606 miRNA 22 6

RefSeq: NR_029711, NR_029829,

LncBase: hsa-miR-194-5p,

miRBase: MIMAT0000460,

MirGeneDB: Hsa-Mir-194-P2_5p,

TarBase: hsa-miR-194-5p,

ENA: AJ535827.1:1..22:ncRNA, LM379078.1:1..22:ncRNA, LM608527.1:15..36:ncRNA, LM608659.1:15..36:ncRNA,

URS0000759DC6_9606 precursor_RNA 85 4

RefSeq: NR_029829,

Ensembl: ENST00000384864 (view in UCSC) ,

miRBase: MI0000732,

ENA: LM608659.1:1..85:precursor_RNA,

URS000069818E_9606 precursor_RNA 86 1

Rfam: RF00257,

URS0001BC6079_9606 pre_miRNA 85 1

Rfam: RF00257,

MIR194-2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR194-2 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR194-2 Gene

No ASD Table

Relevant External Links for MIR194-2 Gene

GeneLoc Exon Structure for
MIR194-2

Expression for MIR194-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR194-2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR194-2 Gene

This gene is overexpressed in Colon - Transverse (x20.0) and Small Intestine - Terminal Ileum (x18.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR194-2

genes like me logo Genes that share expression patterns with MIR194-2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR194-2 Gene

Orthologs for MIR194-2 Gene

Evolution for MIR194-2 Gene

ENSEMBL:
Gene Tree for MIR194-2 (if available)
TreeFam:
Gene Tree for MIR194-2 (if available)

No data available for Orthologs for MIR194-2 Gene

Paralogs for MIR194-2 Gene

No data available for Paralogs for MIR194-2 Gene

Variants for MIR194-2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR194-2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR194-2 Gene

Variant ID Type Subtype PubMed ID
nsv360 CNV deletion 18451855
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781
nsv951014 CNV deletion 24416366

Additional Variant Information for MIR194-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR194-2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR194-2 Gene

Disorders for MIR194-2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR194-2 Gene - From: COP

Disorder Aliases PubMed IDs
coffin-siris syndrome 1
  • css1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR194-2

genes like me logo Genes that share disorders with MIR194-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR194-2 Gene

Publications for MIR194-2 Gene

  1. MiR-194-5p inhibited metastasis and EMT of nephroblastoma cells through targeting Crk. (PMID: 31889432) Liu H … Ma H (The Kaohsiung journal of medical sciences 2020) 3
  2. Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer. (PMID: 32228703) Jiang MJ … Tian L (Molecular cancer 2020) 3
  3. miR-194-5p inhibits LPS-induced astrocytes activation by directly targeting neurexophilin 1. (PMID: 32533463) Wang M … Zuo Q (Molecular and cellular biochemistry 2020) 3
  4. Long non‑coding RNA Unigene56159 promotes glioblastoma multiforme cell proliferation and invasion through negatively regulating microRNA‑194‑5p. (PMID: 31789416) Jiang G … Yang X (Molecular medicine reports 2020) 3
  5. LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR-194-5p/ACVR2B signaling. (PMID: 30334578) Ye Y … Li M (Molecular carcinogenesis 2019) 3

Products for MIR194-2 Gene

Sources for MIR194-2 Gene