Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR194-2 (MicroRNA 194-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR194-2 include Coffin-Siris Syndrome 1. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J064884 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +1.4 | 1403 | 10.2 | ARHGAP35 HNRNPL GATAD2A CTCF ATF7 PRDM10 TFE3 LEF1 SOX13 IKZF1 | EHD1 MIR192 MIR194-2 MIR194-2HG PCNX3 SF1 SYVN1 NEAT1 PLCB3 POLA2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 26147452 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 25203061 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0045081 | negative regulation of interleukin-10 biosynthetic process | IDA | 26147452 |
GO:2001180 | negative regulation of interleukin-10 secretion | IDA | 26147452 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000065566_9606 | miRNA | 22 | 6 |
RefSeq: NR_029829, LncBase: hsa-miR-194-3p, miRBase: MIMAT0004671, MirGeneDB: Hsa-Mir-194-P1_3p, TarBase: hsa-miR-194-3p, |
URS000029C2DC_9606 | miRNA | 22 | 6 |
LncBase: hsa-miR-194-5p, miRBase: MIMAT0000460, MirGeneDB: Hsa-Mir-194-P2_5p, TarBase: hsa-miR-194-5p, ENA: AJ535827.1:1..22:ncRNA, LM379078.1:1..22:ncRNA, LM608527.1:15..36:ncRNA, LM608659.1:15..36:ncRNA, |
URS0000759DC6_9606 | precursor_RNA | 85 | 5 |
HGNC: 31565, RefSeq: NR_029829, Ensembl: ENST00000384864 (view in UCSC) , miRBase: MI0000732, |
URS000069818E_9606 | precursor_RNA | 86 | 1 |
Rfam: RF00257, |
URS0000EFCED7_9606 | precursor_RNA | 59 | 1 |
MirGeneDB: Hsa-Mir-194-P1, |
Disorder | Aliases | PubMed IDs |
---|---|---|
coffin-siris syndrome 1 |
|
|