microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR194-1 Gene

Subcategory (RNA class) for MIR194-1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR194-1 Gene

  • MicroRNA 194-1 2 3 5
  • Hsa-MiR-194-5p 163 173
  • Hsa-Mir-194-1 2 3
  • MIR194-1 2 5
  • Hsa-Mir-194-P2 178
  • MIMAT0000460 50
  • MIRN194-1 3
  • Mir-194-1 3
  • MI0000488 50
  • RF00257 168

External Ids for MIR194-1 Gene

Previous HGNC Symbols for MIR194-1 Gene

  • MIRN194-1

Previous GeneCards Identifiers for MIR194-1 Gene

  • GC01M218360
  • GC01M220292
  • GC01M220293
  • GC01M220295

Summaries for MIR194-1 Gene

Entrez Gene Summary for MIR194-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR194-1 Gene

MIR194-1 (MicroRNA 194-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR194-1 Gene

  • mir-194 microRNA precursor family

Additional gene information for MIR194-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR194-1 Gene

Genomics for MIR194-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR194-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J220158 Enhancer 0.3 ENCODE 12.4 -41.3 -41313 1.7 CEBPB CEBPG IARS2 MIR194-1 MIR215 EPRS1 RAB3GAP2 lnc-BPNT1-1 MIR664A lnc-BPNT1-2
GH01J220114 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.7 -2.1 -2055 11.1 CTCF PRDM10 ZNF629 ZNF512 LEF1 IKZF1 ZNF692 JUND PRDM1 MTA2 RPS15AP12 EPRS1 ZC3H11B RIMKLBP2 RAB3GAP2 ENSG00000272823 MIR194-1 MIR215 RF00257-001 lnc-RAB3GAP2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR194-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR194-1 Gene

Genomic Locations for MIR194-1 Gene
chr1:220,118,157-220,118,241
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand
chr1:220,291,499-220,291,583
(GRCh37/hg19)
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR194-1 Gene

Genes around MIR194-1 on UCSC Golden Path with GeneCards custom track
MIR194-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR194-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR194-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR194-1 Gene

Proteins for MIR194-1 Gene

Post-translational modifications for MIR194-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR194-1 Gene

Domains & Families for MIR194-1 Gene

Gene Families for MIR194-1 Gene

genes like me logo Genes that share domains with MIR194-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR194-1 Gene

Function for MIR194-1 Gene

Gene Ontology (GO) - Molecular Function for MIR194-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26147452
genes like me logo Genes that share ontologies with MIR194-1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR194-1 Gene

Localization for MIR194-1 Gene

Gene Ontology (GO) - Cellular Components for MIR194-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR194-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR194-1 Gene

Pathways & Interactions for MIR194-1 Gene

PathCards logo

SuperPathways for MIR194-1 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR194-1: view

Pathways by source for MIR194-1 Gene

1 KEGG pathway for MIR194-1 Gene

Gene Ontology (GO) - Biological Process for MIR194-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045081 negative regulation of interleukin-10 biosynthetic process IDA 26147452
GO:2001180 negative regulation of interleukin-10 secretion IDA 26147452
genes like me logo Genes that share ontologies with MIR194-1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR194-1 Gene

Drugs & Compounds for MIR194-1 Gene

No Compound Related Data Available

Transcripts for MIR194-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR194-1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00002D5B50_9606 precursor_RNA 85 6

HGNC: 31564,

RefSeq: NR_029711,

Ensembl: ENST00000384892 (view in UCSC) ,

miRBase: MI0000488,

Rfam: RF00257,

ENA: LM608527.1:1..85:precursor_RNA,

URS000029C2DC_9606 miRNA 22 6

RefSeq: NR_029711, NR_029829,

LncBase: hsa-miR-194-5p,

miRBase: MIMAT0000460,

MirGeneDB: Hsa-Mir-194-P2_5p,

TarBase: hsa-miR-194-5p,

ENA: AJ535827.1:1..22:ncRNA, LM379078.1:1..22:ncRNA, LM608527.1:15..36:ncRNA, LM608659.1:15..36:ncRNA,

URS0000EFD8E7_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-194-P2,

URS00007599F9_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-194-P2_3p,

MIR194-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR194-1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR194-1 Gene

No ASD Table

Relevant External Links for MIR194-1 Gene

GeneLoc Exon Structure for
MIR194-1

Expression for MIR194-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR194-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR194-1

genes like me logo Genes that share expression patterns with MIR194-1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR194-1 Gene

Orthologs for MIR194-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR194-1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-194 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-194 31
  • 95 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir194-1 31
  • 79 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-194-1 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-194-1 31 31
  • 69 (a)
OneToMany
Chicken
(Gallus gallus)
Aves gga-mir-194 31
  • 80 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-194-1 31
  • 65 (a)
OneToOne
Species where no ortholog for MIR194-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR194-1 Gene

ENSEMBL:
Gene Tree for MIR194-1 (if available)
TreeFam:
Gene Tree for MIR194-1 (if available)

Paralogs for MIR194-1 Gene

No data available for Paralogs for MIR194-1 Gene

Variants for MIR194-1 Gene

Additional dbSNP identifiers (rs#s) for MIR194-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR194-1 Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV loss 17160897
nsv947468 CNV deletion 23825009

Additional Variant Information for MIR194-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR194-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR194-1 Gene

Disorders for MIR194-1 Gene

No disorders were found for MIR194-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR194-1 Gene

Publications for MIR194-1 Gene

  1. LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR-194-5p/ACVR2B signaling. (PMID: 30334578) Ye Y … Li M (Molecular carcinogenesis 2019) 3
  2. LncRNA H19/miR-194/PFTK1 axis modulates the cell proliferation and migration of pancreatic cancer. (PMID: 30474270) Sun Y … Wu H (Journal of cellular biochemistry 2019) 3
  3. Inflammation-dependent downregulation of miR-194-5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B. (PMID: 30945295) Chen Z … Qian L (Journal of cellular physiology 2019) 3
  4. MicroRNA-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2. (PMID: 31496625) Wu JC … Xu MY (World journal of gastroenterology 2019) 3
  5. A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis. (PMID: 30782188) Wang Y … Tu K (Molecular cancer 2019) 3

Products for MIR194-1 Gene

Sources for MIR194-1 Gene