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MIR194-1 Gene(RNA Gene)

MicroRNA 194-1

GCID:
GC01M220118
GIFtS:
16
Genes Participants
UDN Logo

Aliases for MIR194-1 Gene

Subcategory (RNA class) for MIR194-1 Gene

miRNA

Quality Score for this RNA gene is

18

Aliases for MIR194-1 Gene

  • MicroRNA 194-1 2 3 5
  • Hsa-Mir-194-1 3
  • Mir-194-1 3
  • MIRN194-1 3

External Ids for MIR194-1 Gene

ORGUL Members for MIR194-1 Gene

Previous HGNC Symbols for MIR194-1 Gene

  • MIRN194-1

Previous GeneCards Identifiers for MIR194-1 Gene

  • GC01M218360
  • GC01M220292
  • GC01M220293
  • GC01M220295

Summaries for MIR194-1 Gene

Entrez Gene Summary for MIR194-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR194-1 Gene

MIR194-1 (MicroRNA 194-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR194-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR194-1 Gene

Genomics for MIR194-1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR194-1 Gene

Promoters and enhancers for MIR194-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J220158 Enhancer 0.3 ENCODE 12.4 -41.3 -41313 1.7 CEBPG IARS2 MIR215 MIR194-1 EPRS RAB3GAP2 GC01P220165 RPS15AP12
GH01J220114 Enhancer 1.2 ENCODE dbSUPER 0.7 -2.1 -2055 11.1 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 YY1 ZNF213 E2F8 SP3 REST EPRS RPS15AP12 ZC3H11B RIMKLBP2 RAB3GAP2 ENSG00000272823 MIR194-1 MIR215 GC01P220118 IARS2
GH01J220136 Enhancer 0.4 ENCODE dbSUPER 0.4 -19.2 -19183 1.8 RPS15AP12 MIR194-1 IARS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR194-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR194-1 Gene

Genomic Locations for MIR194-1 Gene
chr1:220,118,157-220,118,241
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand
chr1:220,291,499-220,291,583
(GRCh37/hg19)
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR194-1 Gene

Genes around MIR194-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR194-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR194-1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR194-1 Gene

ORGUL Member Location for MIR194-1 Gene

ORGUL Member Location for MIR194-1 gene

Proteins for MIR194-1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR194-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR194-1 Gene

Domains & Families for MIR194-1 Gene

Gene Families for MIR194-1 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR194-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR194-1 Gene

Function for MIR194-1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR194-1 Gene

Localization for MIR194-1 Gene

Gene Ontology (GO) - Cellular Components for MIR194-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR194-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR194-1 Gene

Pathways & Interactions for MIR194-1 Gene

SuperPathways for MIR194-1 Gene

PathCards logo More details on SuperPathways for MIR194-1
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR194-1: view

Pathways by source for MIR194-1 Gene

1 KEGG pathway for MIR194-1 Gene

Interacting Proteins for MIR194-1 Gene

Gene Ontology (GO) - Biological Process for MIR194-1 Gene

None

No data available for SIGNOR curated interactions for MIR194-1 Gene

Drugs & Compounds for MIR194-1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR194-1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR194-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(2) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR194-1 Gene

No ASD Table

Relevant External Links for MIR194-1 Gene

GeneLoc Exon Structure for
MIR194-1
ECgene alternative splicing isoforms for
MIR194-1

Expression for MIR194-1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR194-1 Gene

mRNA expression in normal human tissues for MIR194-1 Gene
mRNA expression by GTEx for MIR194-1 Gene
genes like me logo Genes that share expression patterns with MIR194-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR194-1 Gene

Orthologs for MIR194-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR194-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-194 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-194 34
  • 95 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir194-1 34
  • 79 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-194-1 34
  • 77 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-194-1 34 34
  • 69 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves gga-mir-194 34
  • 80 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-194-1 34
  • 65 (a)
 OneToOne
Species where no ortholog for MIR194-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR194-1 Gene

ENSEMBL:
Gene Tree for MIR194-1 (if available)
TreeFam:
Gene Tree for MIR194-1 (if available)

Paralogs for MIR194-1 Gene

No data available for Paralogs for MIR194-1 Gene

Variants for MIR194-1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR194-1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000510918 -- 220,119,793(-) G/A upstream_transcript_variant
rs1003012789 -- 220,119,271(-) G/T upstream_transcript_variant
rs1004985583 -- 220,118,075(-) TTTTTTT/TTTTTTTT downstream_transcript_variant
rs1010346154 -- 220,118,858(-) A/G upstream_transcript_variant
rs1010439904 -- 220,119,156(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR194-1 Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV loss 17160897
nsv947468 CNV deletion 23825009

Additional Variant Information for MIR194-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR194-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR194-1 Gene

Disorders for MIR194-1 Gene

Additional Disease Information for MIR194-1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR194-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR194-1 Gene

Publications for MIR194-1 Gene

  1. miR-194 Suppresses Proliferation and Migration and Promotes Apoptosis of Osteosarcoma Cells by Targeting CDH2. (PMID: 29518783) Miao J … Chen S (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 58
  2. miR-194 as predictive biomarker of responsiveness to neoadjuvant chemoradiotherapy in patients with locally advanced rectal adenocarcinoma. (PMID: 28870889) D'Angelo E … Agostini M (Journal of clinical pathology 2018) 3 58
  3. Original Research: miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells. (PMID: 27480251) Cui G … Zhao S (Experimental biology and medicine (Maywood, N.J.) 2017) 3 58
  4. MicroRNA-194 represses glioma cell epithelial‑to‑mesenchymal transition by targeting Bmi1. (PMID: 28098896) Zhang X … Qu J (Oncology reports 2017) 3 58
  5. Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway. (PMID: 28358423) Bai M … Zhao R (Oncology reports 2017) 3 58

Products for MIR194-1 Gene

Sources for MIR194-1 Gene

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