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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR194-1 (MicroRNA 194-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J220158 | Enhancer | 0.3 | ENCODE | 12.4 | -41.3 | -41313 | 1.7 | CEBPB CEBPG | IARS2 MIR194-1 MIR215 EPRS1 RAB3GAP2 lnc-BPNT1-1 MIR664A lnc-BPNT1-2 | |
GH01J220114 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 0.7 | -2.1 | -2055 | 11.1 | CTCF PRDM10 ZNF629 ZNF512 LEF1 IKZF1 ZNF692 JUND PRDM1 MTA2 | RPS15AP12 EPRS1 ZC3H11B RIMKLBP2 RAB3GAP2 ENSG00000272823 MIR194-1 MIR215 RF00257-001 lnc-RAB3GAP2-1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 26147452 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 25203061 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0045081 | negative regulation of interleukin-10 biosynthetic process | IDA | 26147452 |
GO:2001180 | negative regulation of interleukin-10 secretion | IDA | 26147452 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00002D5B50_9606 | precursor_RNA | 85 | 6 |
HGNC: 31564, RefSeq: NR_029711, Ensembl: ENST00000384892 (view in UCSC) , miRBase: MI0000488, Rfam: RF00257, |
URS000029C2DC_9606 | miRNA | 22 | 6 |
LncBase: hsa-miR-194-5p, miRBase: MIMAT0000460, MirGeneDB: Hsa-Mir-194-P2_5p, TarBase: hsa-miR-194-5p, ENA: AJ535827.1:1..22:ncRNA, LM379078.1:1..22:ncRNA, LM608527.1:15..36:ncRNA, LM608659.1:15..36:ncRNA, |
URS0000EFD8E7_9606 | precursor_RNA | 59 | 1 |
MirGeneDB: Hsa-Mir-194-P2, |
URS00007599F9_9606 | miRNA | 22 | 1 |
MirGeneDB: Hsa-Mir-194-P2_3p, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-194 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-194 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir194-1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-194-1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-194-1 31 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | gga-mir-194 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-194-1 31 |
|
OneToOne |
No disorders were found for MIR194-1 Gene.