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Aliases for MIR193B Gene

Subcategory (RNA class) for MIR193B Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR193B Gene

  • MicroRNA 193b 2 3 5
  • Hsa-Mir-193b 3
  • Mir-193b 3
  • MIRN193B 3

External Ids for MIR193B Gene

ORGUL Members for MIR193B Gene

Previous HGNC Symbols for MIR193B Gene

  • MIRN193B

Previous GeneCards Identifiers for MIR193B Gene

  • GC16P014306
  • GC16P014397

Summaries for MIR193B Gene

Entrez Gene Summary for MIR193B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR193B Gene

MIR193B (MicroRNA 193b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR193B include Melanoma and Breast Cancer. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR193B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR193B Gene

Genomics for MIR193B Gene

GeneHancer (GH) Regulatory Elements for MIR193B Gene

Promoters and enhancers for MIR193B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J014508 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +206.8 206767 4 ZNF652 ELF3 CEBPG RERE ZNF24 MAFK TFE3 SP1 HNF1A PPARG MIR193B LOC100505915 LOC105371094 RN7SL274P PARN
GH16J014497 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.8 +196.1 196134 8.6 ZNF652 SP1 ELF3 MNT CEBPG ZNF384 ZNF687 BACH1 MAFK MYC PARN BFAR MIR193B ERCC4 RPS26P52 LOC100505915 LOC105371094 RN7SL274P
GH16J014337 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.1 +33.8 33803 1.1 ZNF473 MTA3 ZNF652 ELF3 CEBPG AHR IKZF1 ZBTB7A SP1 PPARG ENSG00000183458 PARN NPIPA2 LOC100505915 NPIPA3 NPIPA1 NPIPP1 ERCC4 ENSG00000261819 PKD1P6
GH16J014561 Promoter/Enhancer 1.5 Ensembl ENCODE 10.4 +260.0 259971 4 ZNF652 ELF3 CEBPG RERE ZSCAN21 TFE3 SP7 SP1 HNF1A PPARG MIR193B LOC100505915 NPIPA2 RN7SL274P PARN LOC105371094
GH16J014504 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +201.9 201885 2.1 MAFK SP1 CREB1 GATAD2A FOXA2 SAP130 JUND FOSL2 ZGPAT HNF4A MIR193B LOC105371094 RN7SL274P PARN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR193B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR193B Gene

Genomic Locations for MIR193B Gene
chr16:14,303,967-14,304,049
(GRCh38/hg38)
Size:
83 bases
Orientation:
Plus strand
chr16:14,397,824-14,397,906
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR193B Gene

Genes around MIR193B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR193B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR193B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR193B Gene

Proteins for MIR193B Gene

Post-translational modifications for MIR193B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR193B Gene

Domains & Families for MIR193B Gene

Gene Families for MIR193B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR193B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR193B Gene

Function for MIR193B Gene

Phenotypes From GWAS Catalog for MIR193B Gene

Gene Ontology (GO) - Molecular Function for MIR193B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25119742
genes like me logo Genes that share ontologies with MIR193B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR193B Gene

Localization for MIR193B Gene

Gene Ontology (GO) - Cellular Components for MIR193B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035068 micro-ribonucleoprotein complex IEA --
GO:0070062 extracellular exosome IDA 25119742
genes like me logo Genes that share ontologies with MIR193B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR193B Gene

Pathways & Interactions for MIR193B Gene

PathCards logo

SuperPathways for MIR193B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR193B: view

Pathways by source for MIR193B Gene

1 KEGG pathway for MIR193B Gene

Interacting Proteins for MIR193B Gene

Gene Ontology (GO) - Biological Process for MIR193B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR193B: view

No data available for SIGNOR curated interactions for MIR193B Gene

Drugs & Compounds for MIR193B Gene

No Compound Related Data Available

Transcripts for MIR193B Gene

mRNA/cDNA for MIR193B Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR193B Gene

No ASD Table

Relevant External Links for MIR193B Gene

GeneLoc Exon Structure for
MIR193B
ECgene alternative splicing isoforms for
MIR193B

Expression for MIR193B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR193B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR193B Gene:

MIR193B
genes like me logo Genes that share expression patterns with MIR193B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR193B Gene

Orthologs for MIR193B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR193B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-193b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-193b 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-193b 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir193b 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-193b 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-193 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-193b 35
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-193b 35
  • 74 (a)
OneToOne
Species where no ortholog for MIR193B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR193B Gene

ENSEMBL:
Gene Tree for MIR193B (if available)
TreeFam:
Gene Tree for MIR193B (if available)

Paralogs for MIR193B Gene

No data available for Paralogs for MIR193B Gene

Variants for MIR193B Gene

Sequence variations from dbSNP and Humsavar for MIR193B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1001545400 -- 14,304,546(+) T/C downstream_transcript_variant
rs1001731864 -- 14,303,560(+) C/G upstream_transcript_variant
rs1001789284 -- 14,303,757(+) T/G upstream_transcript_variant
rs1002548814 -- 14,302,934(+) T/C upstream_transcript_variant
rs1002950707 -- 14,303,180(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR193B Gene

Variant ID Type Subtype PubMed ID
nsv1070750 CNV deletion 25765185

Additional Variant Information for MIR193B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR193B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR193B Gene

Disorders for MIR193B Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR193B Gene - From: miR2Disease

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
breast cancer
  • breast tumor
melanoma, uveal
  • uveal melanoma
autism spectrum disorder
  • asd
muscular dystrophy, duchenne type
  • dmd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR193B

genes like me logo Genes that share disorders with MIR193B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR193B Gene

Publications for MIR193B Gene

  1. miR-193b availability is antagonized by LncRNA-SNHG7 for FAIM2-induced tumour progression in non-small cell lung cancer. (PMID: 29131440) She K … He J (Cell proliferation 2018) 3 58
  2. MicroRNA-193b-3p regulates matrix metalloproteinase 19 expression in interleukin-1β-induced human chondrocytes. (PMID: 29323744) Chang ZK … He AS (Journal of cellular biochemistry 2018) 3 58
  3. MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3. (PMID: 29774080) Meng F … Liao W (Theranostics 2018) 3 58
  4. Regulation of RAB22A by mir-193b inhibits breast cancer growth and metastasis mediated by exosomes. (PMID: 30272274) Sun L … Li YJ (International journal of oncology 2018) 3 58
  5. Genome-wide identification of microRNAs regulating the human prion protein. (PMID: 30451334) Pease D … Aguzzi A (Brain pathology (Zurich, Switzerland) 2018) 3 58

Products for MIR193B Gene

Sources for MIR193B Gene

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