microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR193B Gene

Subcategory (RNA class) for MIR193B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR193B Gene

  • MicroRNA 193b 2 3 5
  • Hsa-MiR-193b-5p 163 173
  • Hsa-MiR-193b-3p 163 173
  • Hsa-Mir-193b 2 3
  • MIR193B 2 5
  • Hsa-Mir-193-P1b 178
  • MIMAT0002819 50
  • MIMAT0004767 50
  • MI0003137 50
  • MIRN193B 3
  • Mir-193b 3
  • RF01895 168

External Ids for MIR193B Gene

Previous HGNC Symbols for MIR193B Gene

  • MIRN193B

Previous GeneCards Identifiers for MIR193B Gene

  • GC16P014306
  • GC16P014397

Summaries for MIR193B Gene

Entrez Gene Summary for MIR193B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR193B Gene

MIR193B (MicroRNA 193b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR193B include Melanoma and Breast Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR193B Gene

Additional gene information for MIR193B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR193B Gene

Genomics for MIR193B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR193B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR193B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR193B Gene

Genomic Locations for MIR193B Gene
chr16:14,303,957-14,304,058
(GRCh38/hg38)
Size:
102 bases
Orientation:
Plus strand
chr16:14,397,824-14,397,906
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR193B Gene

Genes around MIR193B on UCSC Golden Path with GeneCards custom track
MIR193B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR193B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR193B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR193B Gene

Proteins for MIR193B Gene

Post-translational modifications for MIR193B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR193B Gene

Domains & Families for MIR193B Gene

Gene Families for MIR193B Gene

genes like me logo Genes that share domains with MIR193B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR193B Gene

Function for MIR193B Gene

Phenotypes From GWAS Catalog for MIR193B Gene

Gene Ontology (GO) - Molecular Function for MIR193B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25119742
genes like me logo Genes that share ontologies with MIR193B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR193B Gene

Localization for MIR193B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR193B gene
Compartment Confidence
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR193B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 25119742
genes like me logo Genes that share ontologies with MIR193B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR193B Gene

Pathways & Interactions for MIR193B Gene

PathCards logo

SuperPathways for MIR193B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR193B: view

Pathways by source for MIR193B Gene

1 KEGG pathway for MIR193B Gene

Gene Ontology (GO) - Biological Process for MIR193B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR193B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR193B Gene

Drugs & Compounds for MIR193B Gene

No Compound Related Data Available

Transcripts for MIR193B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR193B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000AA464_9606 miRNA 22 6

RefSeq: NR_030177,

LncBase: hsa-miR-193b-3p,

miRBase: MIMAT0002819,

MirGeneDB: Hsa-Mir-193-P1b_3p,

TarBase: hsa-miR-193b-3p,

ENA: AY882278.1:1..22:ncRNA, LM379776.1:1..22:ncRNA, LM609467.1:51..72:ncRNA,

URS00000E1DC5_9606 miRNA 22 6

RefSeq: NR_030177,

LncBase: hsa-miR-193b-5p,

miRBase: MIMAT0004767,

MirGeneDB: Hsa-Mir-193-P1b_5p,

TarBase: hsa-miR-193b-5p,

ENA: LM380384.1:1..22:ncRNA, LM609467.1:14..35:ncRNA,

URS000075BAEB_9606 precursor_RNA 83 5

HGNC: 32087,

RefSeq: NR_030177,

Ensembl: ENST00000384907 (view in UCSC) ,

miRBase: MI0003137,

ENA: LM609467.1:1..83:precursor_RNA,

URS00006AAB37_9606 precursor_RNA 102 1

Rfam: RF01895,

URS0000EFB9CA_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-193-P1b,

MIR193B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR193B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR193B Gene

No ASD Table

Relevant External Links for MIR193B Gene

GeneLoc Exon Structure for
MIR193B

Expression for MIR193B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR193B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR193B

genes like me logo Genes that share expression patterns with MIR193B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR193B Gene

Orthologs for MIR193B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR193B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-193b 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-193b 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-193b 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir193b 31
  • 90 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-193b 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-193 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-193b 31
  • 87 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-193b 31
  • 74 (a)
OneToOne
Species where no ortholog for MIR193B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR193B Gene

ENSEMBL:
Gene Tree for MIR193B (if available)
TreeFam:
Gene Tree for MIR193B (if available)

Paralogs for MIR193B Gene

No data available for Paralogs for MIR193B Gene

Variants for MIR193B Gene

Additional dbSNP identifiers (rs#s) for MIR193B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR193B Gene

Variant ID Type Subtype PubMed ID
nsv1070750 CNV deletion 25765185

Additional Variant Information for MIR193B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR193B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR193B Gene

Disorders for MIR193B Gene

MalaCards: The human disease database

(37) MalaCards diseases for MIR193B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
breast cancer
  • breast lobular carcinoma
melanoma, uveal
  • uveal melanoma
autism spectrum disorder
  • asd
muscular dystrophy, duchenne type
  • dmd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR193B

genes like me logo Genes that share disorders with MIR193B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR193B Gene

Publications for MIR193B Gene

  1. Macrophages-induced long noncoding RNA H19 up-regulation triggers and activates the miR-193b/MAPK1 axis and promotes cell aggressiveness in hepatocellular carcinoma. (PMID: 31705929) Ye Y … Yu J (Cancer letters 2020) 3
  2. Additive effect of metastamiR-193b and breast cancer metastasis suppressor 1 as an anti-metastatic strategy. (PMID: 30284194) Hashemi ZS … Sadroddiny E (Breast cancer (Tokyo, Japan) 2019) 3
  3. MiR-193b inhibits the growth and metastasis of renal cell carcinoma by targeting IGF1R. (PMID: 31126198) Chen J … Cai W (Artificial cells, nanomedicine, and biotechnology 2019) 3
  4. Genome-wide identification of microRNAs regulating the human prion protein. (PMID: 30451334) Pease D … Aguzzi A (Brain pathology (Zurich, Switzerland) 2019) 3
  5. MORC4 is a novel breast cancer oncogene regulated by miR-193b-3p. (PMID: 30320920) Yang Z … Geng S (Journal of cellular biochemistry 2019) 3

Products for MIR193B Gene

Sources for MIR193B Gene