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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR192 (MicroRNA 192) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR192 include Microvascular Complications Of Diabetes 3 and Gastric Cancer. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J064884 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +1.2 | 1209 | 10.2 | TBP ZBTB10 MXD4 CEBPA NR2C1 MNT DEK IKZF1 SMAD5 IRF2 | EHD1 HSALNG0084832 MIR192 MIR194-2 MIR194-2HG SF1 SYVN1 NEAT1 PLCB3 POLA2 | |
GH11J064923 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 12 | -33.6 | -33558 | 2.8 | CHD2 ZBTB10 SP1 MXD4 CEBPA SIX5 NR2C1 MNT DEK IKZF1 | MN309369 PPP2R5B MIR192 MAJIN ARL2 lnc-PPP2R5B-1 GPHA2 | |
GH11J064846 | Promoter/Enhancer | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 12.5 | +34.3 | 34267 | 20.8 | ZBTB10 SP1 BCL11A MXD4 CEBPA NR2C1 MNT DEK IKZF1 ZFP64 | EHD1 EHBP1L1 MAP4K2 MIR192 MEN1 MAJIN GPHA2 MAP3K11 CDC42EP2 CDC42BPG |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 26506238 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 25203061 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 26506238 |
GO:0032705 | negative regulation of interleukin-21 production | IDA | 28798470 |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00000B59A2_9606 | miRNA | 22 | 6 |
RefSeq: NR_029578, LncBase: hsa-miR-192-3p, miRBase: MIMAT0004543, MirGeneDB: Hsa-Mir-192-P1_3p, TarBase: hsa-miR-192-3p, |
URS0000155642_9606 | miRNA | 21 | 6 |
RefSeq: NR_029578, LncBase: hsa-miR-192-5p, miRBase: MIMAT0000222, MirGeneDB: Hsa-Mir-192-P1_5p, TarBase: hsa-miR-192-5p, |
URS00006ECF62_9606 | precursor_RNA | 110 | 5 |
RefSeq: NR_029578, Ensembl: ENST00000384915 (view in UCSC) , miRBase: MI0000234, Rfam: RF00130, |
URS0001BC0CD3_9606 | pre_miRNA | 110 | 1 |
Rfam: RF00130, |
URS0000EFD273_9606 | precursor_RNA | 66 | 1 |
MirGeneDB: Hsa-Mir-192-P1, |
Disorder | Aliases | PubMed IDs |
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microvascular complications of diabetes 3 |
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gastric cancer |
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colorectal cancer |
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nasopharyngeal carcinoma |
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esophageal cancer |
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