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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR192 Gene
Subcategory (RNA class) for MIR192 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR192 Gene
External Ids for MIR192 Gene
- HGNC: 31562
- Entrez Gene: 406967
- Ensembl: ENSG00000283926
- OMIM: 610939
- miRBase: hsa-mir-192
Previous HGNC Symbols for MIR192 Gene
- MIRN192
Previous GeneCards Identifiers for MIR192 Gene
- GC11M064432
- GC11M064435
- GC11M064660
- GC11M064664
- GC11M064667
- GC11M064669
- GC11M064672
- GC11M064674
- GC11M064676
- GC11M064687
Summaries for MIR192 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR192 Gene
MIR192 (MicroRNA 192) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR192 include Microvascular Complications Of Diabetes 3 and Gastric Cancer. Among its related pathways are MicroRNAs in cancer.
Rfam classification for MIR192 Gene
-
mir-192/215 microRNA precursor
Additional gene information for MIR192 Gene
- Monarch Initiative
- Search for MIR192 at DataMed
- Search for MIR192 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR192 Gene
Genomics for MIR192 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR192 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J064884 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +1.2 | 1209 | 10.2 | ARHGAP35 HNRNPL GATAD2A CTCF ATF7 PRDM10 TFE3 LEF1 SOX13 IKZF1 | EHD1 MIR192 MIR194-2 MIR194-2HG PCNX3 SF1 SYVN1 NEAT1 PLCB3 POLA2 | |
| GH11J064923 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 12 | -33.6 | -33555 | 2.8 | SP1 CREB1 ATF7 PRDM10 REST ZNF629 TFE3 SIX5 IKZF1 ZNF692 | MN309369 PPP2R5B MIR192 MAJIN ARL2 PLCB3 lnc-PPP2R5B-1 GPHA2 | |
| GH11J064846 | Promoter/Enhancer | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 12.5 | +34.3 | 34267 | 20.8 | SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 LEF1 IKZF1 NFKBIZ | EHD1 EHBP1L1 MAP4K2 MIR192 MEN1 MAJIN GPHA2 MAP3K11 CDC42EP2 CDC42BPG |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR192 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR192 Gene
Genomic Locations for MIR192 Gene
- chr11:64,891,137-64,891,246
- (GRCh38/hg38)
- Size:
- 110 bases
- Orientation:
- Minus strand
- chr11:64,658,609-64,658,718
- (GRCh37/hg19)
- Size:
- 110 bases
- Orientation:
- Minus strand
Genomic View for MIR192 Gene
Genes around MIR192 on UCSC Golden Path with GeneCards custom track
MIR192 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
MIR192 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR192 Gene
Proteins for MIR192 Gene
Post-translational modifications for MIR192 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR192
- Origene Custom Protein Services for MIR192
No data available for DME Specific Peptides for MIR192 Gene
Domains & Families for MIR192 Gene
Gene Families for MIR192 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR192 Gene
Function for MIR192 Gene
Phenotypes From GWAS Catalog for MIR192 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 26506238 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR192 - Select products 50% OFF >
- * MIR192 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR192
miRNA for MIR192 Gene
- miRTarBase miRNAs that target MIR192
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR192 - Select products 50% OFF >
- * MIR192 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR192
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR192 Gene
Localization for MIR192 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 25203061 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR192 Gene
Pathways & Interactions for MIR192 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR192 Gene
1 KEGG pathway for MIR192 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 26506238 |
| GO:0032705 | negative regulation of interleukin-21 production | IDA | 28798470 |
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0045391 | negative regulation of interleukin-21 biosynthetic process | IDA | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR192 Gene
Transcripts for MIR192 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR192 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00006ECF62_9606 | precursor_RNA | 110 | 6 |
HGNC: 31562, RefSeq: NR_029578, Ensembl: ENST00000384915 (view in UCSC) , miRBase: MI0000234, Rfam: RF00130, |
| URS00000B59A2_9606 | miRNA | 22 | 6 |
RefSeq: NR_029578, LncBase: hsa-miR-192-3p, miRBase: MIMAT0004543, MirGeneDB: Hsa-Mir-192-P1_3p, TarBase: hsa-miR-192-3p, |
| URS0000155642_9606 | miRNA | 21 | 6 |
RefSeq: NR_029578, LncBase: hsa-miR-192-5p, miRBase: MIMAT0000222, MirGeneDB: Hsa-Mir-192-P1_5p, TarBase: hsa-miR-192-5p, |
| URS0000EFD273_9606 | precursor_RNA | 66 | 1 |
MirGeneDB: Hsa-Mir-192-P1, |
| URS00004A7F38_9606 | miRNA | 22 | 1 |
ENA: AJ535826.1:1..22:ncRNA, |
MIR192 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR192 Gene
- 2 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR192 - Select products 50% OFF >
- * MIR192 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR192
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR192 - Select products 50% OFF >
- * MIR192 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR192
Relevant External Links for MIR192 Gene
- GeneLoc Exon Structure for
- MIR192
Expression for MIR192 Gene
mRNA differential expression in normal tissues according to GTEx for MIR192 Gene
This gene is overexpressed in Colon - Transverse (x22.9) and Small Intestine - Terminal Ileum (x17.6).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR192
Evidence on tissue expression from TISSUES for MIR192 Gene
- Liver(2.5)
- Kidney(2.5)
- Blood(2.4)
- Intestine(2.3)
- Urine(2.3)
- Heart(2.1)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for MIR192
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR192 Gene
Orthologs for MIR192 Gene
No data available for Orthologs for MIR192 Gene
Paralogs for MIR192 Gene
No data available for Paralogs for MIR192 Gene
Variants for MIR192 Gene
Additional Variant Information for MIR192 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR192
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR192 Gene
Disorders for MIR192 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microvascular complications of diabetes 3 |
|
|
| gastric cancer |
|
|
| colorectal cancer |
|
|
| nasopharyngeal carcinoma |
|
|
| esophageal cancer |
|
Search MIR192 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR192
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR192 Gene
Publications for MIR192 Gene
- MiR-192-5p in the Kidney Protects Against the Development of Hypertension. (PMID: 30595117) Baker MA … Liang M (Hypertension (Dallas, Tex. : 1979) 2019) 3
- MicroRNA‑192 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting caveolin 1. (PMID: 31485620) Chen P … Luo X (Oncology reports 2019) 3
- miR-192/215-5p act as tumor suppressors and link Crohn's disease and colorectal cancer by targeting common metabolic pathways: An integrated informatics analysis and experimental study. (PMID: 31020657) Zhao H … Tan J (Journal of cellular physiology 2019) 3
- miR-192 Is Overexpressed and Promotes Cell Proliferation in Prostate Cancer. (PMID: 30544100) Chen ZJ … Yang T (Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2019) 3
- miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features. (PMID: 30530815) Gu Y … Ji J (Cancer research 2019) 3
ExternalLinks
Products for MIR192 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR192
- Origene Custom Protein Services for MIR192
- Browse OriGene Inhibitory RNA Products For MIR192
- OriGene qPCR primer pairs for MIR192
- Browse CRISPR knockouts for MIR192
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR192
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIR192
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR192
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR192
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR192
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR192
Sources for MIR192 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB