microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR192 Gene

Subcategory (RNA class) for MIR192 Gene

miRNA

Aliases for MIR192 Gene

External Ids for MIR192 Gene

Previous HGNC Symbols for MIR192 Gene

  • MIRN192

Previous GeneCards Identifiers for MIR192 Gene

  • GC11M064432
  • GC11M064435
  • GC11M064660
  • GC11M064664
  • GC11M064667
  • GC11M064669
  • GC11M064672
  • GC11M064674
  • GC11M064676
  • GC11M064687

Summaries for MIR192 Gene

Entrez Gene Summary for MIR192 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR192 Gene

MIR192 (MicroRNA 192) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR192 include Microvascular Complications Of Diabetes 3 and Gastric Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR192 Gene

  • mir-192/215 microRNA precursor

Additional gene information for MIR192 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR192 Gene

Genomics for MIR192 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR192 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064884 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.2 1209 10.2 TBP ZBTB10 MXD4 CEBPA NR2C1 MNT DEK IKZF1 SMAD5 IRF2 EHD1 HSALNG0084832 MIR192 MIR194-2 MIR194-2HG SF1 SYVN1 NEAT1 PLCB3 POLA2
GH11J064923 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12 -33.6 -33558 2.8 CHD2 ZBTB10 SP1 MXD4 CEBPA SIX5 NR2C1 MNT DEK IKZF1 MN309369 PPP2R5B MIR192 MAJIN ARL2 lnc-PPP2R5B-1 GPHA2
GH11J064846 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +34.3 34267 20.8 ZBTB10 SP1 BCL11A MXD4 CEBPA NR2C1 MNT DEK IKZF1 ZFP64 EHD1 EHBP1L1 MAP4K2 MIR192 MEN1 MAJIN GPHA2 MAP3K11 CDC42EP2 CDC42BPG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR192 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR192 Gene

Latest Assembly
chr11:64,891,137-64,891,246
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand

Previous Assembly
chr11:64,658,609-64,658,718
(GRCh37/hg19 by Entrez Gene)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR192 Gene

Genes around MIR192 on UCSC Golden Path with GeneCards custom track
MIR192 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR192 Gene

Proteins for MIR192 Gene

Post-translational modifications for MIR192 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR192 Gene

Domains & Families for MIR192 Gene

Gene Families for MIR192 Gene

genes like me logo Genes that share domains with MIR192: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR192 Gene

Function for MIR192 Gene

Phenotypes From GWAS Catalog for MIR192 Gene

Gene Ontology (GO) - Molecular Function for MIR192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26506238
genes like me logo Genes that share ontologies with MIR192: view

CRISPR products for research

miRNA for MIR192 Gene

miRTarBase miRNAs that target MIR192

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR192 Gene

Localization for MIR192 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR192 gene
Compartment Confidence
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR192: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR192 Gene

Pathways & Interactions for MIR192 Gene

PathCards logo

SuperPathways for MIR192 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR192: view

Pathways by source for MIR192 Gene

1 KEGG pathway for MIR192 Gene

Gene Ontology (GO) - Biological Process for MIR192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion IDA 26506238
GO:0032705 negative regulation of interleukin-21 production IDA 28798470
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR192: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR192 Gene

Drugs & Compounds for MIR192 Gene

No Compound Related Data Available

Transcripts for MIR192 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR192 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000B59A2_9606 miRNA 22 6

RefSeq: NR_029578,

LncBase: hsa-miR-192-3p,

miRBase: MIMAT0004543,

MirGeneDB: Hsa-Mir-192-P1_3p,

TarBase: hsa-miR-192-3p,

ENA: LM380222.1:1..22:ncRNA, LM608314.1:67..88:ncRNA,

URS0000155642_9606 miRNA 21 6

RefSeq: NR_029578,

LncBase: hsa-miR-192-5p,

miRBase: MIMAT0000222,

MirGeneDB: Hsa-Mir-192-P1_5p,

TarBase: hsa-miR-192-5p,

ENA: LM378867.1:1..21:ncRNA, LM608314.1:24..44:ncRNA,

URS00006ECF62_9606 precursor_RNA 110 5

RefSeq: NR_029578,

Ensembl: ENST00000384915 (view in UCSC) ,

miRBase: MI0000234,

Rfam: RF00130,

ENA: LM608314.1:1..110:precursor_RNA,

URS0001BC0CD3_9606 pre_miRNA 110 1

Rfam: RF00130,

URS0000EFD273_9606 precursor_RNA 66 1

MirGeneDB: Hsa-Mir-192-P1,

MIR192 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR192 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR192 Gene

No ASD Table

Relevant External Links for MIR192 Gene

GeneLoc Exon Structure for
MIR192

Expression for MIR192 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR192 Gene

mRNA differential expression in normal tissues according to GTEx for MIR192 Gene

This gene is overexpressed in Colon - Transverse (x22.9) and Small Intestine - Terminal Ileum (x17.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR192

Evidence on tissue expression from TISSUES for MIR192 Gene

  • Liver(2.2)
  • Kidney(2.2)
  • Blood(2.1)
  • Urine(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MIR192: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR192 Gene

Orthologs for MIR192 Gene

Evolution for MIR192 Gene

ENSEMBL:
Gene Tree for MIR192 (if available)
TreeFam:
Gene Tree for MIR192 (if available)

No data available for Orthologs for MIR192 Gene

Paralogs for MIR192 Gene

No data available for Paralogs for MIR192 Gene

Variants for MIR192 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR192 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR192 Gene

Variant ID Type Subtype PubMed ID
nsv360 CNV deletion 18451855
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781
nsv951014 CNV deletion 24416366

Additional Variant Information for MIR192 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR192

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR192 Gene

Disorders for MIR192 Gene

MalaCards: The human disease database

(37) MalaCards diseases for MIR192 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
microvascular complications of diabetes 3
  • microvascular complications of diabetes, susceptibility to, 3
gastric cancer
  • gastric cancer, somatic
colorectal cancer
  • crc
nasopharyngeal carcinoma
  • npca
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR192

genes like me logo Genes that share disorders with MIR192: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR192 Gene

Publications for MIR192 Gene

  1. MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. (PMID: 21119604) Jin Z … Meltzer SJ (Oncogene 2011) 3 74
  2. Loss of MicroRNA-192 promotes fibrogenesis in diabetic nephropathy. (PMID: 20056746) Krupa A … Fraser D (Journal of the American Society of Nephrology : JASN 2010) 3 74
  3. New signatures of poor CD4 cell recovery after suppressive antiretroviral therapy in HIV-1-infected individuals: involvement of miR-192, IL-6, sCD14 and miR-144. (PMID: 32076107) Hernández-Walias F … Vallejo A (Scientific reports 2020) 3
  4. LncRNA KCNQ1OT1 attenuates sepsis-induced myocardial injury via regulating miR-192-5p/XIAP axis. (PMID: 32102564) Sun F … Lei M (Experimental biology and medicine (Maywood, N.J.) 2020) 3
  5. Specific circulating microRNAs during hepatitis E infection can serve as indicator for chronic hepatitis E. (PMID: 32210284) Harms D … Bock CT (Scientific reports 2020) 3

Products for MIR192 Gene

Sources for MIR192 Gene