microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR191 Gene

Subcategory (RNA class) for MIR191 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR191 Gene

  • MicroRNA 191 2 3 5
  • Hsa-MiR-191-3p 168 179
  • Hsa-MiR-191-5p 168 179
  • MIMAT0001618 53
  • MIMAT0000440 53
  • Hsa-Mir-191 3
  • MI0000465 53
  • MiR-191 3
  • MIRN191 3
  • RF00764 174
  • MIR191 2

External Ids for MIR191 Gene

Previous HGNC Symbols for MIR191 Gene

  • MIRN191

Previous GeneCards Identifiers for MIR191 Gene

  • GC03M049050
  • GC03M049054
  • GC03M049058
  • GC03M049025
  • GC03M049031
  • GC03M049137
  • GC03M049100
  • GC03M049078
  • GC03M049083
  • GC03M049088
  • GC03M049094
  • GC03M049129

Summaries for MIR191 Gene

Entrez Gene Summary for MIR191 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR191 Gene

MIR191 (MicroRNA 191) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR191 include Hepatocellular Carcinoma and Mitochondrial Complex I Deficiency, Nuclear Type 18.

Rfam classification for MIR191 Gene

Additional gene information for MIR191 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR191 Gene

Genomics for MIR191 Gene

GeneHancer (GH) Regulatory Elements for MIR191 Gene

Promoters and enhancers for MIR191 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049016 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.4 448 6.8 ZNF785 SIN3A ZBTB40 SP1 CTCF ZBTB6 FOXA1 RBPJ POLR2A CTBP1 DALRD3 MIR191 MIR425 NDUFAF3 ENSG00000235236 WDR6 FCF1P2 NICN1 RBM6 ATRIP
GH03J049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -325.1 -325092 16 ZNF785 ZNF24 SP1 ZBTB40 CTCF LCORL MLX RBPJ SMARCE1 POLR2A USP4 lnc-TCTA-3 AMT QRICH1 ENSG00000235236 RBM5 IP6K2 RBM6 ATRIP WDR6
GH03J048769 Enhancer 0.5 Ensembl ENCODE 9.6 +250.4 250401 1.4 PRDM1 RUNX3 PRKAR2A PRKAR2A-AS1 NCKIPSD COL7A1 PFKFB4 UCN2 QARS1 QRICH1 IMPDH2 MIR191
GH03J049080 Enhancer 0.3 Ensembl 11.6 -60.0 -59992 1.4 SP7 WDR6 QARS1 IMPDH2 DALRD3 MIR191 MIR425 NDUFAF3 USP19 LAMB2 CCDC71
GH03J049081 Enhancer 0.3 Ensembl 11.4 -61.0 -60992 0.2 SP7 RN7SL182P RF00017-3995 lnc-NDUFAF3-3 QARS1 IMPDH2 DALRD3 MIR191 MIR425 NDUFAF3 USP19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR191 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR191 Gene

Genomic Locations for MIR191 Gene
chr3:49,020,618-49,020,709
(GRCh38/hg38)
Size:
92 bases
Orientation:
Minus strand
chr3:49,058,051-49,058,142
(GRCh37/hg19)
Size:
92 bases
Orientation:
Minus strand

Genomic View for MIR191 Gene

Genes around MIR191 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR191 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR191 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR191 Gene

Proteins for MIR191 Gene

Post-translational modifications for MIR191 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR191 Gene

Domains & Families for MIR191 Gene

Gene Families for MIR191 Gene

HGNC:
genes like me logo Genes that share domains with MIR191: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR191 Gene

Function for MIR191 Gene

Phenotypes From GWAS Catalog for MIR191 Gene

Gene Ontology (GO) - Molecular Function for MIR191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 29230236
genes like me logo Genes that share ontologies with MIR191: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR191 Gene

Localization for MIR191 Gene

Gene Ontology (GO) - Cellular Components for MIR191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR191: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR191 Gene

Pathways & Interactions for MIR191 Gene

PathCards logo

SuperPathways for MIR191 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR191: view

No data available for Pathways by source and SIGNOR curated interactions for MIR191 Gene

Drugs & Compounds for MIR191 Gene

No Compound Related Data Available

Transcripts for MIR191 Gene

mRNA/cDNA for MIR191 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(5) ENA transcripts :
(2) LncBase transcripts :
(3) miRBase transcripts :
(2) TarBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR191 Gene

No ASD Table

Relevant External Links for MIR191 Gene

GeneLoc Exon Structure for
MIR191
ECgene alternative splicing isoforms for
MIR191

Expression for MIR191 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR191 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR191 Gene:

MIR191
genes like me logo Genes that share expression patterns with MIR191: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR191 Gene

Orthologs for MIR191 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR191 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-191 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-191 33
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-191 33
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-191 33
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-191 33
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm24083 33
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-191 33
  • 57 (a)
OneToOne
Species where no ortholog for MIR191 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR191 Gene

ENSEMBL:
Gene Tree for MIR191 (if available)
TreeFam:
Gene Tree for MIR191 (if available)

Paralogs for MIR191 Gene

No data available for Paralogs for MIR191 Gene

Variants for MIR191 Gene

Sequence variations from dbSNP and Humsavar for MIR191 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs121918134 pathogenic, MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 18 49,022,497(-) G/A/C upstream_transcript_variant
rs121918136 pathogenic, MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 18 49,022,146(-) T/C/G upstream_transcript_variant
rs573066357 uncertain-significance, Mitochondrial complex I deficiency 49,021,904(-) C/T upstream_transcript_variant
rs74601553 uncertain-significance, Mitochondrial complex I deficiency 49,022,018(-) G/C upstream_transcript_variant
rs752864722 uncertain-significance, likely-pathogenic, Mitochondrial complex I deficiency, not provided 49,022,449(-) /T upstream_transcript_variant

Additional Variant Information for MIR191 Gene

Human Gene Mutation Database (HGMD)
MIR191
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR191

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR191 Gene

Disorders for MIR191 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR191 Gene - From: miR2Disease, HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR191

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR191: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR191 Gene

Publications for MIR191 Gene

  1. miR-191: an emerging player in disease biology. (PMID: 24795757) Nagpal N … Kulshreshtha R (Frontiers in genetics 2014) 2 3 56
  2. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 43 56
  3. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 43 56
  4. Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma. (PMID: 30045644) Chen XY … Zhu JS (International journal of immunopathology and pharmacology 2018) 3 56
  5. Knockdown long non-coding RNA ANRIL inhibits proliferation, migration and invasion of HepG2 cells by down-regulation of miR-191. (PMID: 30249208) Huang D … Liu H (BMC cancer 2018) 3 56

Products for MIR191 Gene

Sources for MIR191 Gene