microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR191 Gene

Subcategory (RNA class) for MIR191 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR191 Gene

  • MIMAT0000440 50
  • MIMAT0001618 50
  • MI0000465 50
  • MIRN191 3
  • MiR-191 3
  • RF00764 168

External Ids for MIR191 Gene

Previous HGNC Symbols for MIR191 Gene

  • MIRN191

Previous GeneCards Identifiers for MIR191 Gene

  • GC03M049050
  • GC03M049054
  • GC03M049058
  • GC03M049025
  • GC03M049031
  • GC03M049137
  • GC03M049100
  • GC03M049162
  • GC03M049202
  • GC03M049078
  • GC03M049083
  • GC03M049088
  • GC03M049094
  • GC03M049129

Summaries for MIR191 Gene

Entrez Gene Summary for MIR191 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR191 Gene

MIR191 (MicroRNA 191) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR191 include Hepatocellular Carcinoma and Kidney Cancer.

Rfam classification for MIR191 Gene

Additional gene information for MIR191 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR191 Gene

Genomics for MIR191 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR191 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049016 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.4 448 6.8 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 REST RFX1 SOX13 DALRD3 MIR191 MIR425 NDUFAF3 WDR6 ENSG00000235236 RBM6 FCF1P2 ATRIP QRICH1
GH03J049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -325.1 -325092 16 RNF2 SP1 HNRNPL GATAD2A CTCF PRDM10 TFE3 LEF1 IKZF1 POLR2A USP4 lnc-TCTA-3 AMT WDR6 QRICH1 RBM6 ENSG00000235236 DALRD3 RHOA NICN1
GH03J048769 Enhancer 0.5 Ensembl ENCODE 9.6 +250.4 250401 1.4 PRDM1 RUNX3 PRKAR2A PRKAR2A-AS1 NCKIPSD COL7A1 PFKFB4 UCN2 QARS1 QRICH1 MIR425 IMPDH2
GH03J049080 Enhancer 0.3 Ensembl 11.6 -60.0 -59992 1.4 SPI1 SP7 WDR6 QARS1 IMPDH2 DALRD3 MIR191 MIR425 NDUFAF3 USP19 LAMB2 CCDC71
GH03J049081 Enhancer 0.3 Ensembl 11.4 -61.0 -60992 0.2 SP7 RF00017-3997 RN7SL182P lnc-NDUFAF3-3 QARS1 IMPDH2 DALRD3 MIR191 MIR425 NDUFAF3 USP19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR191 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR191 Gene

Genomic Locations for MIR191 Gene
chr3:49,020,618-49,020,709
(GRCh38/hg38)
Size:
92 bases
Orientation:
Minus strand
chr3:49,058,051-49,058,142
(GRCh37/hg19)
Size:
92 bases
Orientation:
Minus strand

Genomic View for MIR191 Gene

Genes around MIR191 on UCSC Golden Path with GeneCards custom track
MIR191 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR191 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR191 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR191 Gene

Proteins for MIR191 Gene

Post-translational modifications for MIR191 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR191 Gene

Domains & Families for MIR191 Gene

Gene Families for MIR191 Gene

HGNC:
genes like me logo Genes that share domains with MIR191: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR191 Gene

Function for MIR191 Gene

Phenotypes From GWAS Catalog for MIR191 Gene

Gene Ontology (GO) - Molecular Function for MIR191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 29230236
genes like me logo Genes that share ontologies with MIR191: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR191 Gene

Localization for MIR191 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR191 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR191: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR191 Gene

Pathways & Interactions for MIR191 Gene

PathCards logo

SuperPathways for MIR191 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR191: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR191 Gene

Drugs & Compounds for MIR191 Gene

No Compound Related Data Available

Transcripts for MIR191 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR191 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00005C2E31_9606 miRNA 23 6

RefSeq: NR_029690,

LncBase: hsa-miR-191-5p,

miRBase: MIMAT0000440,

MirGeneDB: Hsa-Mir-191_5p,

TarBase: hsa-miR-191-5p,

ENA: LM379058.1:1..23:ncRNA, LM608505.1:16..38:ncRNA,

URS00002B2B5C_9606 miRNA 22 6

RefSeq: NR_029690,

LncBase: hsa-miR-191-3p,

miRBase: MIMAT0001618,

MirGeneDB: Hsa-Mir-191_3p,

TarBase: hsa-miR-191-3p,

ENA: LM379527.1:1..22:ncRNA, LM608505.1:58..79:ncRNA,

URS000075BBD9_9606 precursor_RNA 92 5

HGNC: 31561,

RefSeq: NR_029690,

Ensembl: ENST00000384873 (view in UCSC) ,

miRBase: MI0000465,

ENA: LM608505.1:1..92:precursor_RNA,

URS0000663EAF_9606 precursor_RNA 91 1

Rfam: RF00764,

URS0000EFC951_9606 precursor_RNA 65 1

MirGeneDB: Hsa-Mir-191,

MIR191 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR191 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR191 Gene

No ASD Table

Relevant External Links for MIR191 Gene

GeneLoc Exon Structure for
MIR191

Expression for MIR191 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR191 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR191

Evidence on tissue expression from TISSUES for MIR191 Gene

  • Blood(2.4)
  • Saliva(2)
genes like me logo Genes that share expression patterns with MIR191: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR191 Gene

Orthologs for MIR191 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR191 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-191 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-191 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-191 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-191 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-191 31
  • 70 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm24083 31
  • 48 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-191 31
  • 57 (a)
OneToOne
Species where no ortholog for MIR191 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR191 Gene

ENSEMBL:
Gene Tree for MIR191 (if available)
TreeFam:
Gene Tree for MIR191 (if available)

Paralogs for MIR191 Gene

No data available for Paralogs for MIR191 Gene

Variants for MIR191 Gene

Additional dbSNP identifiers (rs#s) for MIR191 Gene

Additional Variant Information for MIR191 Gene

Human Gene Mutation Database (HGMD)
MIR191
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR191

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR191 Gene

Disorders for MIR191 Gene

MalaCards: The human disease database

(31) MalaCards diseases for MIR191 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
kidney cancer
  • renal cell carcinoma
squamous cell carcinoma, head and neck
  • hnscc
pancreatic cancer
  • pancreatic carcinoma
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR191

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR191: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR191 Gene

Publications for MIR191 Gene

  1. miR-191: an emerging player in disease biology. (PMID: 24795757) Nagpal N … Kulshreshtha R (Frontiers in genetics 2014) 2 3
  2. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  3. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
  4. miR-191 secreted by platelet-derived microvesicles induced apoptosis of renal tubular epithelial cells and participated in renal ischemia-reperfusion injury via inhibiting CBS. (PMID: 30394829) Wu XQ … Yan TZ (Cell cycle (Georgetown, Tex.) 2019) 3
  5. Hypoxia-induced miR-191-C/EBPβ signaling regulates cell proliferation and apoptosis of fibroblast-like synoviocytes from patients with rheumatoid arthritis. (PMID: 30894209) Yu S … Fan L (Arthritis research & therapy 2019) 3

Products for MIR191 Gene

Sources for MIR191 Gene