microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR190B Gene

Subcategory (RNA class) for MIR190B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR190B Gene

  • MicroRNA 190b 2 3 5
  • Hsa-Mir-190b 2 3
  • Hsa-MiR-190b 163 173
  • MIR190B 2 5
  • Hsa-Mir-190-P2 178
  • MIMAT0004929 50
  • MIMAT0037332 50
  • MI0005545 50
  • MIRN190B 3
  • Mir-190b 3
  • RF00672 168

External Ids for MIR190B Gene

Previous HGNC Symbols for MIR190B Gene

  • MIRN190B

Previous GeneCards Identifiers for MIR190B Gene

  • GC01M152436
  • GC01M154166

Summaries for MIR190B Gene

Entrez Gene Summary for MIR190B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR190B Gene

MIR190B (MicroRNA 190b) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR190B Gene

Additional gene information for MIR190B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR190B Gene

Genomics for MIR190B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR190B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR190B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR190B Gene

Genomic Locations for MIR190B Gene
chr1:154,193,662-154,193,747
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand
chr1:154,166,141-154,166,219
(GRCh37/hg19)
Size:
79 bases
Orientation:
Minus strand

Genomic View for MIR190B Gene

Genes around MIR190B on UCSC Golden Path with GeneCards custom track
MIR190B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR190B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR190B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR190B Gene

Proteins for MIR190B Gene

Post-translational modifications for MIR190B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR190B Gene

Domains & Families for MIR190B Gene

Gene Families for MIR190B Gene

genes like me logo Genes that share domains with MIR190B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR190B Gene

Function for MIR190B Gene

Phenotypes From GWAS Catalog for MIR190B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR190B Gene

Localization for MIR190B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR190B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR190B Gene

Pathways & Interactions for MIR190B Gene

PathCards logo

SuperPathways for MIR190B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR190B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR190B: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR190B Gene

Drugs & Compounds for MIR190B Gene

No Compound Related Data Available

Transcripts for MIR190B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR190B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075AE48_9606 precursor_RNA 79 5

HGNC: 33656,

RefSeq: NR_030600,

Ensembl: ENST00000401119 (view in UCSC) ,

miRBase: MI0005545,

ENA: LM609952.1:1..79:precursor_RNA,

URS000075CB24_9606 miRNA 22 3

RefSeq: NR_030600,

miRBase: MIMAT0004929,

MirGeneDB: Hsa-Mir-190-P2_5p,

URS0000D5564C_9606 miRNA 21 2

RefSeq: NR_030600,

miRBase: MIMAT0037332,

URS00000FFE5F_9606 miRNA 21 3

LncBase: hsa-miR-190b,

TarBase: hsa-miR-190b,

ENA: LM380492.1:1..21:ncRNA, LM609952.1:11..31:ncRNA,

URS00006BD364_9606 precursor_RNA 86 1

Rfam: RF00672,

MIR190B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR190B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR190B Gene

No ASD Table

Relevant External Links for MIR190B Gene

GeneLoc Exon Structure for
MIR190B

Expression for MIR190B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR190B

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR190B Gene

Orthologs for MIR190B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR190B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-190b 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-190b 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-190b 31
  • 93 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-190b 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir190b 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-190b 31
  • 42 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 79 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-190b 31
  • 61 (a)
ManyToMany
Species where no ortholog for MIR190B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR190B Gene

ENSEMBL:
Gene Tree for MIR190B (if available)
TreeFam:
Gene Tree for MIR190B (if available)

Paralogs for MIR190B Gene

No data available for Paralogs for MIR190B Gene

Variants for MIR190B Gene

Additional dbSNP identifiers (rs#s) for MIR190B Gene

Additional Variant Information for MIR190B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR190B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR190B Gene

Disorders for MIR190B Gene

Additional Disease Information for MIR190B

No disorders were found for MIR190B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR190B Gene

Publications for MIR190B Gene

  1. MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease. (PMID: 29575055) Xu M … Qiu WQ (Journal of cellular biochemistry 2018) 3
  2. MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells. (PMID: 28044223) Wang C … Qiao C (Biotechnology letters 2017) 3
  3. MicroRNA-190b inhibits tumor cell proliferation and induces apoptosis by regulating Bcl-2 in U2OS osteosarcoma cells. (PMID: 29441873) Kang M … Yang X (Die Pharmazie 2017) 3
  4. MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers? (PMID: 26141719) Cizeron-Clairac G … Callens C (BMC cancer 2015) 3
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3

Products for MIR190B Gene

Sources for MIR190B Gene