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Aliases for MIR18A Gene

Subcategory (RNA class) for MIR18A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR18A Gene

  • MicroRNA 18a 2 3 5
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • MicroRNA 18 2
  • Hsa-Mir-18a 3
  • Hsa-Mir-18 3
  • C13orf25 3
  • MiRNA18A 3
  • MIR17HG 3
  • Mir-18a 3
  • MIRN18A 3
  • MIRHG1 3
  • MiR-18 3
  • MIRN18 3
  • MIRH1 3
  • MIR18 3

External Ids for MIR18A Gene

Previous HGNC Symbols for MIR18A Gene

  • MIRN18
  • MIRN18A

Previous GeneCards Identifiers for MIR18A Gene

  • GC13P090866
  • GC13P090876
  • GC13P092015
  • GC13P092023
  • GC13P092030
  • GC13P092038
  • GC13P092047
  • GC13P092057
  • GC13P092066
  • GC13P092076
  • GC13P092084
  • GC13P092098
  • GC13P092112
  • GC13P091351
  • GC13P091356
  • GC13P091360
  • GC13P091371
  • GC13P091379

Summaries for MIR18A Gene

Entrez Gene Summary for MIR18A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR18A Gene

MIR18A (MicroRNA 18a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA Damage Response and MicroRNAs in cancer.

Additional gene information for MIR18A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR18A Gene

Genomics for MIR18A Gene

GeneHancer (GH) Regulatory Elements for MIR18A Gene

Promoters and enhancers for MIR18A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I091346 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 550.8 -1.7 -1718 4.8 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 GC13P091391 MIR17 MIR17HG MIR18A MIR19A PIR60569 GC13P091401 GC13P091400 GC13P091399 GC13P091397
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR18A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR18A Gene

Genomic Locations for MIR18A Gene
chr13:91,350,751-91,350,821
(GRCh38/hg38)
Size:
71 bases
Orientation:
Plus strand
chr13:92,003,005-92,003,075
(GRCh37/hg19)

Genomic View for MIR18A Gene

Genes around MIR18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR18A Gene

Proteins for MIR18A Gene

Post-translational modifications for MIR18A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR18A Gene

Domains & Families for MIR18A Gene

Gene Families for MIR18A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR18A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR18A Gene

Function for MIR18A Gene

Gene Ontology (GO) - Molecular Function for MIR18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20940405
genes like me logo Genes that share ontologies with MIR18A: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR18A Gene

Localization for MIR18A Gene

Gene Ontology (GO) - Cellular Components for MIR18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MIR18A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR18A Gene

Pathways & Interactions for MIR18A Gene

genes like me logo Genes that share pathways with MIR18A: view

Pathways by source for MIR18A Gene

1 KEGG pathway for MIR18A Gene

Interacting Proteins for MIR18A Gene

Gene Ontology (GO) - Biological Process for MIR18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20940405
GO:1903671 negative regulation of sprouting angiogenesis IDA 20299512
GO:1905932 positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching ISS --
genes like me logo Genes that share ontologies with MIR18A: view

No data available for SIGNOR curated interactions for MIR18A Gene

Drugs & Compounds for MIR18A Gene

No Compound Related Data Available

Transcripts for MIR18A Gene

mRNA/cDNA for MIR18A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR18A Gene

No ASD Table

Relevant External Links for MIR18A Gene

GeneLoc Exon Structure for
MIR18A
ECgene alternative splicing isoforms for
MIR18A

Expression for MIR18A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR18A Gene:

MIR18A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR18A Gene

Orthologs for MIR18A Gene

Evolution for MIR18A Gene

ENSEMBL:
Gene Tree for MIR18A (if available)
TreeFam:
Gene Tree for MIR18A (if available)

No data available for Orthologs for MIR18A Gene

Paralogs for MIR18A Gene

No data available for Paralogs for MIR18A Gene

Variants for MIR18A Gene

Sequence variations from dbSNP and Humsavar for MIR18A Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1002349918 -- 91,351,188(+) T/C/G downstream_transcript_variant
rs1002944928 -- 91,349,535(+) G/A upstream_transcript_variant
rs1003385207 -- 91,349,835(+) A/G upstream_transcript_variant
rs1004372915 -- 91,349,113(+) C/G/T upstream_transcript_variant
rs1004434983 -- 91,349,440(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR18A Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR18A Gene

Disorders for MIR18A Gene

Additional Disease Information for MIR18A

No disorders were found for MIR18A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR18A Gene

Publications for MIR18A Gene

  1. The long noncoding RNA CASC2 inhibits tumorigenesis through modulating the expression of PTEN by targeting miR-18a-5p in esophageal carcinoma. (PMID: 28964779) Zhang W … Zhao G (Experimental cell research 2017) 3 58
  2. MiR-18a-5p inhibits endothelial-mesenchymal transition and cardiac fibrosis through the Notch2 pathway. (PMID: 28733035) Geng H … Guan J (Biochemical and biophysical research communications 2017) 3 58
  3. A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation. (PMID: 28607111) Montoya MM … Baumjohann D (Journal of immunology (Baltimore, Md. : 1950) 2017) 3 58
  4. Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation. (PMID: 28481041) Busch M … Dünker N (International journal of cancer 2017) 3 58
  5. microRNA-18a Promotes Cell Migration and Invasion Through Inhibiting Dicer l Expression in Hepatocellular Carcinoma In Vitro. (PMID: 28399983) Zhang X … Li L (Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 2017) 3 58

Products for MIR18A Gene

Sources for MIR18A Gene

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