MIR18A Gene (RNA Gene)

MicroRNA 18a

GC13P091408
GIFtS:
17
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR18A Gene

Subcategory (RNA class) for MIR18A Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR18A Gene

  • MicroRNA 18a 2 3 5
  • Hsa-MiR-18a-5p 168 179
  • Hsa-MiR-18a-3p 168 179
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • MIMAT0000072 53
  • MIMAT0002891 53
  • Hsa-Mir-18a 3
  • MicroRNA 18 2
  • Hsa-Mir-18 3
  • MI0000072 53
  • C13orf25 3
  • MiRNA18A 3
  • MIR17HG 3
  • Mir-18a 3
  • MIRN18A 3
  • MIRHG1 3
  • MiR-18 3
  • MIRN18 3
  • MIR18A 2
  • MIR18 3
  • MIRH1 3

External Ids for MIR18A Gene

Previous HGNC Symbols for MIR18A Gene

  • MIRN18
  • MIRN18A

Previous GeneCards Identifiers for MIR18A Gene

  • GC13P090866
  • GC13P090876
  • GC13P092015
  • GC13P092023
  • GC13P092030
  • GC13P092038
  • GC13P092047
  • GC13P092057
  • GC13P092066
  • GC13P092076
  • GC13P092084
  • GC13P092098
  • GC13P092112
  • GC13P091351
  • GC13P091356
  • GC13P091402
  • GC13P091405
  • GC13P091360
  • GC13P091371
  • GC13P091379
  • GC13P091387
  • GC13P091391
  • GC13P091397

Summaries for MIR18A Gene

Entrez Gene Summary for MIR18A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR18A Gene

MIR18A (MicroRNA 18a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR18A include Thyroid Gland Anaplastic Carcinoma and Medulloblastoma. Among its related pathways are DNA Damage Response and MicroRNAs in cancer.

Additional gene information for MIR18A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR18A Gene

Genomics for MIR18A Gene

GeneHancer (GH) Regulatory Elements for MIR18A Gene

Promoters and enhancers for MIR18A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH13J091346 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 -1.7 -1746 5.2 SIN3A ZNF24 CTCF RBPJ POLR2A HDAC2 ATF1 HCFC1 ZNF362 MYC AJ421736 MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 4F3T_R AB372624 MIR19B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR18A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR18A Gene

Genomic Locations for MIR18A Gene
chr13:91,350,747-91,350,827
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr13:92,003,005-92,003,075
(GRCh37/hg19)
Size:
71 bases
Orientation:
Plus strand

Genomic View for MIR18A Gene

Genes around MIR18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR18A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR18A Gene

Proteins for MIR18A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR18A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR18A Gene

Domains & Families for MIR18A Gene

Gene Families for MIR18A Gene

HGNC:
genes like me logo Genes that share domains with MIR18A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR18A Gene

Function for MIR18A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20940405
genes like me logo Genes that share ontologies with MIR18A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR18A Gene

Localization for MIR18A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR18A gene
Compartment Confidence
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MIR18A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR18A Gene

Pathways & Interactions for MIR18A Gene

genes like me logo Genes that share pathways with MIR18A: view

Pathways by source for MIR18A Gene

1 KEGG pathway for MIR18A Gene

Gene Ontology (GO) - Biological Process for MIR18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20940405
GO:0050861 positive regulation of B cell receptor signaling pathway IDA 24169826
GO:1903671 negative regulation of sprouting angiogenesis IDA 20299512
GO:1905932 positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching ISS --
genes like me logo Genes that share ontologies with MIR18A: view

No data available for SIGNOR curated interactions for MIR18A Gene

Drugs & Compounds for MIR18A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR18A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR18A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) RNACentral transcripts :
(9) ENA transcripts :
(2) TarBase transcripts :
(3) miRBase transcripts :
(2) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR18A Gene

No ASD Table

Relevant External Links for MIR18A Gene

GeneLoc Exon Structure for
MIR18A
ECgene alternative splicing isoforms for
MIR18A

Expression for MIR18A Gene

Products:

  1. Primer
  2. Gene Expression Assay

NURSA nuclear receptor signaling pathways regulating expression of MIR18A Gene:

MIR18A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR18A Gene

Orthologs for MIR18A Gene

Evolution for MIR18A Gene

ENSEMBL:
Gene Tree for MIR18A (if available)
TreeFam:
Gene Tree for MIR18A (if available)

No data available for Orthologs for MIR18A Gene

Paralogs for MIR18A Gene

No data available for Paralogs for MIR18A Gene

Variants for MIR18A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR18A Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1002349918 -- 91,351,188(+) T/C/G downstream_transcript_variant
rs1002944928 -- 91,349,535(+) G/A upstream_transcript_variant
rs1003385207 -- 91,349,835(+) A/G upstream_transcript_variant
rs1004372915 -- 91,349,113(+) C/A/G/T upstream_transcript_variant
rs1004434983 -- 91,349,440(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR18A Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR18A Gene

Disorders for MIR18A Gene

MalaCards: The human disease database

(13) MalaCards diseases for MIR18A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
thyroid gland anaplastic carcinoma
  • anaplastic thyroid carcinoma
medulloblastoma
  • mdb
hepatocellular carcinoma
  • hcc
lung cancer
  • adenocarcinoma of lung
lymphoma, hodgkin, classic
  • chl
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR18A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR18A Gene

Publications for MIR18A Gene

  1. lncRNA CASC2/miR‑18a‑5p axis regulates the malignant potential of nasopharyngeal carcinoma by targeting RBBP8. (PMID: 30569153) Miao WJ … Jin QQ (Oncology reports 2019) 3 56
  2. Upregulated lncRNA CASC2 May Inhibit Malignant Melanoma Development Through Regulating miR-18a-5p/RUNX1. (PMID: 29422114) Zhang Y … Fan J (Oncology research 2019) 3 56
  3. A novel SOCS5/miR-18/miR-25 axis promotes tumorigenesis in liver cancer. (PMID: 30191950) Sanchez-Mejias A … Tay Y (International journal of cancer 2019) 3 56
  4. Long non-coding RNA FENDRR reduces prostate cancer malignancy by competitively binding miR-18a-5p with RUNX1. (PMID: 29465000) Zhang G … Li J (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2018) 3 56
  5. Long Noncoding RNA FER1L4 Suppresses Tumorigenesis by Regulating the Expression of PTEN Targeting miR-18a-5p in Osteosarcoma. (PMID: 30481787) Fei D … Zhang Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 56

ExternalLinks

View latest publications for MIR18A gene in Mastermind

Products for MIR18A Gene

Sources for MIR18A Gene