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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR18A (MicroRNA 18a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR18A include Thyroid Gland Anaplastic Carcinoma and Medulloblastoma. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH13J091346 | Promoter/Enhancer | 1.8 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -1.7 | -1746 | 5.2 | GATAD2A CTCF TFE3 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 ZNF143 | MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 AB372624 MIR19B1 MIR20A MIR92A1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20940405 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 18766170 |
GO:0048471 | perinuclear region of cytoplasm | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | DNA Damage Response | ||
3 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA | 20940405 |
GO:0050861 | positive regulation of B cell receptor signaling pathway | IDA | 24169826 |
GO:1903671 | negative regulation of sprouting angiogenesis | IDA | 20299512 |
GO:1905932 | positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching | ISS | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000035CC3E_9606 | miRNA | 23 | 6 |
RefSeq: NR_029488, LncBase: hsa-miR-18a-5p, miRBase: MIMAT0000072, MirGeneDB: Hsa-Mir-17-P2a_5p, TarBase: hsa-miR-18a-5p, |
URS00004131FE_9606 | miRNA | 23 | 6 |
RefSeq: NR_029488, LncBase: hsa-miR-18a-3p, miRBase: MIMAT0002891, MirGeneDB: Hsa-Mir-17-P2a_3p, TarBase: hsa-miR-18a-3p, |
URS00003B0CDB_9606 | precursor_RNA | 71 | 5 |
HGNC: 31548, RefSeq: NR_029488, Ensembl: ENST00000362310 (view in UCSC) , miRBase: MI0000072, |
URS000025EAD4_9606 | precursor_RNA | 81 | 1 |
ENA: AB176708.1:1190..1270:ncRNA, AF480553.1:1..81:misc_RNA, |
URS0000EFE5F4_9606 | precursor_RNA | 65 | 1 |
MirGeneDB: Hsa-Mir-17-P2a, |
Disorder | Aliases | PubMed IDs |
---|---|---|
thyroid gland anaplastic carcinoma |
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medulloblastoma |
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hepatocellular carcinoma |
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lung cancer |
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lymphoma, hodgkin, classic |
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