Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR188 Gene

Subcategory (RNA class) for MIR188 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR188 Gene

  • MicroRNA 188 2 3 5
  • Hsa-Mir-188 3
  • MiR-188 3
  • MIRN188 3

External Ids for MIR188 Gene

ORGUL Members for MIR188 Gene

Previous HGNC Symbols for MIR188 Gene

  • MIRN188

Previous GeneCards Identifiers for MIR188 Gene

  • GC0XP049657
  • GC0XP049768

Summaries for MIR188 Gene

Entrez Gene Summary for MIR188 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR188 Gene

MIR188 (MicroRNA 188) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR188 include Leukemia, Chronic Lymphocytic.

Additional gene information for MIR188 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR188 Gene

Genomics for MIR188 Gene

GeneHancer (GH) Regulatory Elements for MIR188 Gene

Promoters and enhancers for MIR188 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ050002 Promoter 0.8 Ensembl 600.7 -1.2 -1202 0.2 IKZF1 IKZF2 EED NBN TARDBP GC0XP050005 GC0XP050007 GC0XP050054 MIR188 MIR532 GC0XP049999 CLCN5
GH0XJ049976 Enhancer 0.6 ENCODE 11.9 -25.1 -25146 3 PRDM10 TCF7L2 POLR2A PRDM4 GATA3 FEZF1 IKZF1 PRDM6 BCL6B MIR532 MIR188 MIR362 MIR501 MIR500B MIR500A CLCN5 GC0XP049999 GC0XM049946
GH0XJ049957 Enhancer 0.4 Ensembl ENCODE 12.5 -44.3 -44328 4.7 MIR188 MIR532 MIR500A MIR362 MIR500B MIR501 CLCN5 GC0XM049946 GC0XP049999
GH0XJ050045 Enhancer 0.3 Ensembl 13.1 +42.4 42398 0.2 PRDM6 MIR501 MIR500B MIR500A MIR362 MIR188 MIR532 GC0XP050051 PYY3 CLCN5
GH0XJ050034 Enhancer 0.2 ENCODE 13.7 +32.4 32447 2.3 MIR500B MIR501 MIR500A MIR362 MIR188 MIR532 CLCN5 GC0XP050051 PYY3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR188 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR188 Gene

Genomic Locations for MIR188 Gene
chrX:50,003,503-50,003,588
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chrX:49,768,109-49,768,194
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR188 Gene

Genes around MIR188 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR188 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR188 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR188 Gene

Proteins for MIR188 Gene

Post-translational modifications for MIR188 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR188 Gene

Domains & Families for MIR188 Gene

Gene Families for MIR188 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR188: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR188 Gene

Function for MIR188 Gene

Gene Ontology (GO) - Molecular Function for MIR188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28640956
genes like me logo Genes that share ontologies with MIR188: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR188 Gene

Localization for MIR188 Gene

Gene Ontology (GO) - Cellular Components for MIR188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR188: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR188 Gene

Pathways & Interactions for MIR188 Gene

PathCards logo

SuperPathways for MIR188 Gene

No Data Available

Interacting Proteins for MIR188 Gene

Gene Ontology (GO) - Biological Process for MIR188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IGI 28640956
GO:1903769 negative regulation of cell proliferation in bone marrow IDA 28640956
GO:2000774 positive regulation of cellular senescence IDA 28640956
genes like me logo Genes that share ontologies with MIR188: view

No data available for Pathways by source and SIGNOR curated interactions for MIR188 Gene

Drugs & Compounds for MIR188 Gene

No Compound Related Data Available

Transcripts for MIR188 Gene

mRNA/cDNA for MIR188 Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR188 Gene

No ASD Table

Relevant External Links for MIR188 Gene

GeneLoc Exon Structure for
MIR188
ECgene alternative splicing isoforms for
MIR188

Expression for MIR188 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR188 Gene:

MIR188
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR188 Gene

Orthologs for MIR188 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR188 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-188 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-188 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir188 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-188 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR188 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR188 Gene

ENSEMBL:
Gene Tree for MIR188 (if available)
TreeFam:
Gene Tree for MIR188 (if available)

Paralogs for MIR188 Gene

No data available for Paralogs for MIR188 Gene

Variants for MIR188 Gene

Sequence variations from dbSNP and Humsavar for MIR188 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001517399 -- 50,003,361(+) G/T upstream_transcript_variant
rs1001630408 -- 50,002,981(+) A/G upstream_transcript_variant
rs1004724940 -- 50,001,926(+) C/T upstream_transcript_variant
rs1004775636 -- 50,002,556(+) A/G upstream_transcript_variant
rs1008617626 -- 50,001,512(+) A/C upstream_transcript_variant

Additional Variant Information for MIR188 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR188

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR188 Gene

Disorders for MIR188 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR188 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR188

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR188: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR188 Gene

Publications for MIR188 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 58
  2. miR-188 Inhibits Glioma Cell Proliferation and Cell Cycle Progression Through Targeting β-Catenin. (PMID: 29268818) Li N … Guo S (Oncology research 2018) 3 58
  3. miR-188-5p Suppresses Gastric Cancer Cell Proliferation and Invasion via Targeting ZFP91. (PMID: 29471891) Peng Y … Li J (Oncology research 2018) 3 58
  4. miR‑188 suppresses tumor progression by targeting SOX4 in pediatric osteosarcoma. (PMID: 29749512) Pan L … Cao L (Molecular medicine reports 2018) 3 58
  5. Genome-wide identification of microRNAs regulating the human prion protein. (PMID: 30451334) Pease D … Aguzzi A (Brain pathology (Zurich, Switzerland) 2018) 3 58

Products for MIR188 Gene

Sources for MIR188 Gene

Content
Loading form....