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Aliases for MIR188 Gene

Subcategory (RNA class) for MIR188 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR188 Gene

  • MicroRNA 188 2 3 5
  • Hsa-Mir-188 3
  • MiR-188 3
  • MIRN188 3

External Ids for MIR188 Gene

ORGUL Members for MIR188 Gene

Previous HGNC Symbols for MIR188 Gene

  • MIRN188

Previous GeneCards Identifiers for MIR188 Gene

  • GC0XP049657
  • GC0XP049768

Summaries for MIR188 Gene

Entrez Gene Summary for MIR188 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR188 Gene

MIR188 (MicroRNA 188) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR188 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR188 Gene

Genomics for MIR188 Gene

GeneHancer (GH) Regulatory Elements for MIR188 Gene

Promoters and enhancers for MIR188 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI050002 Enhancer 0.5 Ensembl 550.8 -1.2 -1199 0.4 TARDBP IKZF1 NBN IKZF2 IRF4 RUNX3 SPI1 GC0XP050005 GC0XP050007 GC0XP050042 MIR188 MIR532 CLCN5 GC0XP049999
GH0XI049976 Enhancer 0.8 Ensembl ENCODE 11.8 -25.1 -25146 3 FEZF1 PRDM6 GATA3 POLR2A IKZF1 BCL6B PRDM10 PRDM4 TRIM28 TCF7L2 MIR532 MIR188 MIR362 MIR500A MIR500B MIR501 CLCN5 GC0XP049999 GC0XM049946
GH0XI049957 Enhancer 0.5 Ensembl ENCODE 12.5 -43.8 -43798 3.7 SPI1 MIR188 MIR532 MIR500A MIR362 MIR501 MIR500B CLCN5 GC0XM049946 GC0XP049999
GH0XI050034 Enhancer 0.2 ENCODE 13.7 +32.4 32447 2.3 MIR501 MIR500B MIR500A MIR362 MIR188 MIR532 CLCN5 GC0XP050039 PYY3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR188 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR188 Gene

Genomic Locations for MIR188 Gene
chrX:50,003,503-50,003,588
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chrX:49,768,109-49,768,194
(GRCh37/hg19)

Genomic View for MIR188 Gene

Genes around MIR188 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR188 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR188 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR188 Gene

Proteins for MIR188 Gene

Post-translational modifications for MIR188 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR188 Gene

Domains & Families for MIR188 Gene

Gene Families for MIR188 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR188: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR188 Gene

Function for MIR188 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR188 Gene

Localization for MIR188 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR188 Gene

Pathways & Interactions for MIR188 Gene

SuperPathways for MIR188 Gene

No Data Available

Interacting Proteins for MIR188 Gene

Gene Ontology (GO) - Biological Process for MIR188 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR188 Gene

Drugs & Compounds for MIR188 Gene

No Compound Related Data Available

Transcripts for MIR188 Gene

mRNA/cDNA for MIR188 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR188 Gene

No ASD Table

Relevant External Links for MIR188 Gene

GeneLoc Exon Structure for
MIR188
ECgene alternative splicing isoforms for
MIR188

Expression for MIR188 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR188 Gene:

MIR188
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR188 Gene

Orthologs for MIR188 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR188 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-188 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir188 34
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-188 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-188 34
  • 98 (a)
OneToOne
Species where no ortholog for MIR188 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR188 Gene

ENSEMBL:
Gene Tree for MIR188 (if available)
TreeFam:
Gene Tree for MIR188 (if available)

Paralogs for MIR188 Gene

No data available for Paralogs for MIR188 Gene

Variants for MIR188 Gene

Sequence variations from dbSNP and Humsavar for MIR188 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001517399 -- 50,003,361(+) G/T upstream_transcript_variant
rs1001630408 -- 50,002,981(+) A/G upstream_transcript_variant
rs1004724940 -- 50,001,926(+) C/T upstream_transcript_variant
rs1004775636 -- 50,002,556(+) A/G upstream_transcript_variant
rs1008617626 -- 50,001,512(+) A/C upstream_transcript_variant

Additional Variant Information for MIR188 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR188

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR188 Gene

Disorders for MIR188 Gene

Additional Disease Information for MIR188

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR188 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR188 Gene

Publications for MIR188 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. Reduced microRNA-188-3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia. (PMID: 27868267) Song WY … Sun YP (Cell proliferation 2017) 3 58
  3. microRNA-188 is downregulated in oral squamous cell carcinoma and inhibits proliferation and invasion by targeting SIX1. (PMID: 26490981) Wang L … Liu H (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
  4. Identification of let-7a-2-3p or/and miR-188-5p as prognostic biomarkers in cytogenetically normal acute myeloid leukemia. (PMID: 25646775) Jinlong S … Weidong W (PloS one 2015) 3 58
  5. miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression. (PMID: 25714029) Zhang H … Xu Y (Oncotarget 2015) 3 58

Products for MIR188 Gene

Sources for MIR188 Gene

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