microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR187 Gene

Subcategory (RNA class) for MIR187 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR187 Gene

  • MIMAT0004561 50
  • MI0000274 50
  • MiRNA187 3
  • MIRN187 3
  • MiR-187 3
  • RF00674 168

External Ids for MIR187 Gene

Previous HGNC Symbols for MIR187 Gene

  • MIRN187

Previous GeneCards Identifiers for MIR187 Gene

  • GC18M031741
  • GC18M033484

Summaries for MIR187 Gene

Entrez Gene Summary for MIR187 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR187 Gene

MIR187 (MicroRNA 187) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR187 include Ampulla Of Vater Cancer and Non-Alcoholic Fatty Liver Disease.

Rfam classification for MIR187 Gene

Additional gene information for MIR187 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR187 Gene

Genomics for MIR187 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR187 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR187 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR187 Gene

Genomic Locations for MIR187 Gene
chr18:35,904,818-35,904,926
(GRCh38/hg38)
Size:
109 bases
Orientation:
Minus strand
chr18:33,484,781-33,484,889
(GRCh37/hg19)
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR187 Gene

Genes around MIR187 on UCSC Golden Path with GeneCards custom track
MIR187 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR187 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR187 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR187 Gene

Proteins for MIR187 Gene

Post-translational modifications for MIR187 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR187 Gene

Domains & Families for MIR187 Gene

Gene Families for MIR187 Gene

HGNC:
genes like me logo Genes that share domains with MIR187: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR187 Gene

Function for MIR187 Gene

Phenotypes From GWAS Catalog for MIR187 Gene

Gene Ontology (GO) - Molecular Function for MIR187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23071313
genes like me logo Genes that share ontologies with MIR187: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR187 Gene

Localization for MIR187 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR187 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR187 Gene

Pathways & Interactions for MIR187 Gene

PathCards logo

SuperPathways for MIR187 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0050728 negative regulation of inflammatory response IDA 23071313
GO:0071222 cellular response to lipopolysaccharide IDA 23071313
genes like me logo Genes that share ontologies with MIR187: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR187 Gene

Drugs & Compounds for MIR187 Gene

No Compound Related Data Available

Transcripts for MIR187 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR187 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001EB9FC_9606 miRNA 22 6

RefSeq: NR_029616,

LncBase: hsa-miR-187-3p,

miRBase: MIMAT0000262,

MirGeneDB: Hsa-Mir-187_3p,

TarBase: hsa-miR-187-3p,

ENA: LM378902.1:1..22:ncRNA, LM608348.1:71..92:ncRNA,

URS00005677F7_9606 precursor_RNA 109 5

HGNC: 31558,

RefSeq: NR_029616,

Ensembl: ENST00000385062 (view in UCSC) ,

miRBase: MI0000274,

ENA: LM608348.1:1..109:precursor_RNA,

URS000047FD4C_9606 miRNA 22 5

RefSeq: NR_029616,

LncBase: hsa-miR-187-5p,

miRBase: MIMAT0004561,

TarBase: hsa-miR-187-5p,

ENA: LM380240.1:1..22:ncRNA, LM608348.1:35..56:ncRNA,

URS000067827B_9606 precursor_RNA 104 1

Rfam: RF00674,

URS0000EFDA34_9606 precursor_RNA 58 1

MirGeneDB: Hsa-Mir-187,

MIR187 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR187 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR187 Gene

No ASD Table

Relevant External Links for MIR187 Gene

GeneLoc Exon Structure for
MIR187

Expression for MIR187 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR187 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR187

genes like me logo Genes that share expression patterns with MIR187: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR187 Gene

Orthologs for MIR187 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR187 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-187 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir187 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-187 31
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-187 31
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-187 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-187 31
  • 83 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-187 31
  • 78 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-187-2 31 31
  • 73 (a)
OneToMany
Species where no ortholog for MIR187 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR187 Gene

ENSEMBL:
Gene Tree for MIR187 (if available)
TreeFam:
Gene Tree for MIR187 (if available)

Paralogs for MIR187 Gene

No data available for Paralogs for MIR187 Gene

Variants for MIR187 Gene

Additional dbSNP identifiers (rs#s) for MIR187 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR187 Gene

Variant ID Type Subtype PubMed ID
nsv1065113 CNV loss 25217958

Additional Variant Information for MIR187 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR187

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR187 Gene

Disorders for MIR187 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MIR187 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ampulla of vater cancer
  • malignant tumour of ampulla of vater
non-alcoholic fatty liver disease
  • nafld
thyroid gland medullary carcinoma
  • medullary thyroid carcinoma
duodenum cancer
  • cancer of duodenum
ampulla of vater adenocarcinoma
  • adenocarcinoma of ampulla of vater
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR187

genes like me logo Genes that share disorders with MIR187: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR187 Gene

Publications for MIR187 Gene

  1. miR-187* Enhances SiHa Cervical Cancer Cell Oncogenicity Via Suppression of WWOX. (PMID: 32132039) Hung PS … Lo SS (Anticancer research 2020) 3
  2. Downregulated miR-187 contributes to the keratinocytes hyperproliferation in psoriasis. (PMID: 30607907) Tang L … Zheng G (Journal of cellular physiology 2019) 3
  3. MicroRNA-187 Inhibits Growth and Metastasis of Osteosarcoma by Downregulating S100A4. (PMID: 29303365) Xiao Y … Zhou DZ (Cancer investigation 2018) 3
  4. Oncogene miR-187-5p is associated with cellular proliferation, migration, invasion, apoptosis and an increased risk of recurrence in bladder cancer. (PMID: 29883941) Li Z … Lai Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3
  5. MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. (PMID: 28393200) Cai Y … Wang B (Oncology reports 2017) 3

Products for MIR187 Gene

Sources for MIR187 Gene