microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR186 Gene

Subcategory (RNA class) for MIR186 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR186 Gene

  • MIMAT0000456 50
  • MIMAT0004612 50
  • MI0000483 50
  • MIRN186 3
  • MiR-186 3
  • RF00697 168

External Ids for MIR186 Gene

Previous HGNC Symbols for MIR186 Gene

  • MIRN186

Previous GeneCards Identifiers for MIR186 Gene

  • GC01M071305
  • GC01M071533

Summaries for MIR186 Gene

Entrez Gene Summary for MIR186 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR186 Gene

MIR186 (MicroRNA 186) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR186 include Lymphoma, Hodgkin, Classic and Multiple Sclerosis.

Rfam classification for MIR186 Gene

Additional gene information for MIR186 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR186 Gene

Genomics for MIR186 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR186 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J070352 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.7 +713.7 713716 4.8 BRCA1 ARHGAP35 CREB1 GATAD2A HNRNPL ATF7 TEAD4 PRDM10 REST ZNF629 HHLA3 ANKRD13C ZRANB2 MIR186 LRRC40 HHLA3-AS1 lnc-LRRC40-5 SRSF11
GH01J070674 Enhancer 1.1 Ensembl ENCODE 10.2 +392.0 391996 1.8 SIX5 LEF1 IKZF1 JUND DDX20 MTA2 PHF21A PKNOX1 ZNF24 MTA1 PTGER3 ZRANB2-AS1 MIR186 ZRANB2 SRSF11 CASP3P1 LINC01788 CTH
GH01J070504 Enhancer 1.1 Ensembl ENCODE 9.6 +563.3 563316 2.8 PRDM10 ZNF629 BACH1 JUND STAT3 PKNOX1 TCF12 IKZF2 RCOR1 SP1 ZRANB2 MIR186 lnc-ANKRD13C-3 CHORDC1P5 lnc-CTH-11 CTH PTGER3
GH01J070509 Enhancer 0.9 Ensembl 9.6 +557.9 557858 1.3 CEBPG CTCF HNRNPL PRDM10 ZNF629 ZNF692 JUND FOXA1 PRDM1 ZSCAN4 ZRANB2 MIR186 lnc-ANKRD13C-3 CHORDC1P5 lnc-CTH-11 CTH PTGER3
GH01J071026 Enhancer 0.4 dbSUPER 10.8 +39.5 39496 3 ATF7 USF1 ATF2 USF2 PTGER3 ENSG00000235782 MIR186 ZRANB2 lnc-CTH-13 ZRANB2-AS1 lnc-CTH-14 CTH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR186 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR186 Gene

Genomic Locations for MIR186 Gene
chr1:71,067,631-71,067,717
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand
chr1:71,533,314-71,533,399
(GRCh37/hg19)
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR186 Gene

Genes around MIR186 on UCSC Golden Path with GeneCards custom track
MIR186 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR186 Gene

Proteins for MIR186 Gene

Post-translational modifications for MIR186 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR186 Gene

Domains & Families for MIR186 Gene

Gene Families for MIR186 Gene

HGNC:
genes like me logo Genes that share domains with MIR186: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR186 Gene

Function for MIR186 Gene

Phenotypes From GWAS Catalog for MIR186 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR186 Gene

Localization for MIR186 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR186 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR186: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR186 Gene

Pathways & Interactions for MIR186 Gene

PathCards logo

SuperPathways for MIR186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR186: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR186 Gene

Drugs & Compounds for MIR186 Gene

No Compound Related Data Available

Transcripts for MIR186 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR186 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000021D7C8_9606 miRNA 22 6

RefSeq: NR_029707,

LncBase: hsa-miR-186-3p,

miRBase: MIMAT0004612,

MirGeneDB: Hsa-Mir-186_3p,

TarBase: hsa-miR-186-3p,

ENA: LM380287.1:1..22:ncRNA, LM608523.1:54..75:ncRNA,

URS000059EAAC_9606 precursor_RNA 86 5

HGNC: 31557,

RefSeq: NR_029707,

Ensembl: ENST00000384988 (view in UCSC) ,

miRBase: MI0000483,

ENA: LM608523.1:1..86:precursor_RNA,

URS000040DCFF_9606 miRNA 22 5

RefSeq: NR_029707,

LncBase: hsa-miR-186-5p,

miRBase: MIMAT0000456,

TarBase: hsa-miR-186-5p,

ENA: LM379074.1:1..22:ncRNA, LM608523.1:15..36:ncRNA,

URS000015CB3A_9606 miRNA 23 2

MirGeneDB: Hsa-Mir-186_5p,

ENA: AJ560752.1:1..23:ncRNA,

URS0000687CA4_9606 precursor_RNA 87 1

Rfam: RF00697,

MIR186 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR186 Gene

3 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR186 Gene

No ASD Table

Relevant External Links for MIR186 Gene

GeneLoc Exon Structure for
MIR186

Expression for MIR186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR186 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR186

genes like me logo Genes that share expression patterns with MIR186: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR186 Gene

Orthologs for MIR186 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR186 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-186 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-186 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-186 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir186 31
  • 93 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-186 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-186 31
  • 76 (a)
OneToOne
Species where no ortholog for MIR186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR186 Gene

ENSEMBL:
Gene Tree for MIR186 (if available)
TreeFam:
Gene Tree for MIR186 (if available)

Paralogs for MIR186 Gene

No data available for Paralogs for MIR186 Gene

Variants for MIR186 Gene

Additional dbSNP identifiers (rs#s) for MIR186 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR186 Gene

Variant ID Type Subtype PubMed ID
nsv546472 CNV gain 21841781

Additional Variant Information for MIR186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR186 Gene

Disorders for MIR186 Gene

MalaCards: The human disease database

(31) MalaCards diseases for MIR186 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lymphoma, hodgkin, classic
  • chl
multiple sclerosis
  • multiple sclerosis, susceptibility to
squamous cell carcinoma, head and neck
  • hnscc
hepatocellular carcinoma
  • hcc
pancreas disease
  • pancreatic diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR186

genes like me logo Genes that share disorders with MIR186: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR186 Gene

Publications for MIR186 Gene

  1. SNHG14 stimulates cell autophagy to facilitate cisplatin resistance of colorectal cancer by regulating miR-186/ATG14 axis. (PMID: 31704614) Han Y … Huang L (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  2. Cross talk between RNA N6-methyladenosine methyltransferase-like 3 and miR-186 regulates hepatoblastoma progression through Wnt/β-catenin signalling pathway. (PMID: 31967701) Cui X … Sun R (Cell proliferation 2020) 3
  3. miR-186-5p targeting SIX1 inhibits cisplatin resistance in non-small-cell lung cancer cells (NSCLCs). (PMID: 31686523) Liu X … Luo H (Neoplasma 2020) 3
  4. Lycorine inhibited the cell growth of non-small cell lung cancer by modulating the miR-186/CDK1 axis. (PMID: 31176784) Li L … Ning M (Life sciences 2019) 3
  5. Overexpression of microRNA-186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2. (PMID: 30993715) Wu S … Zhang C (Journal of cellular physiology 2019) 3

Products for MIR186 Gene

Sources for MIR186 Gene