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Aliases for MIR185 Gene

Subcategory (RNA class) for MIR185 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR185 Gene

  • MicroRNA 185 2 3 5
  • Hsa-Mir-185 3
  • MiR-185 3
  • MIRN185 3

External Ids for MIR185 Gene

ORGUL Members for MIR185 Gene

Previous HGNC Symbols for MIR185 Gene

  • MIRN185

Previous GeneCards Identifiers for MIR185 Gene

  • GC22P018400
  • GC22P020022
  • GC22P020026

Summaries for MIR185 Gene

Entrez Gene Summary for MIR185 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR185 Gene

MIR185 (MicroRNA 185) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

Additional gene information for MIR185 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR185 Gene

Genomics for MIR185 Gene

GeneHancer (GH) Regulatory Elements for MIR185 Gene

Promoters and enhancers for MIR185 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I020031 Enhancer 0.8 Ensembl ENCODE 550.8 -0.3 -332 2.2 KLF1 USF1 ATF1 RXRA ZNF449 KLF17 TSC22D4 ELF1 RAD21 ARHGAP35 GC22P020033 GC22P020036 GC22P020037 MIR185 ABHD17AP4 ARVCF ENSG00000236540 GC22P020027 TANGO2
GH22I020078 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 +48.4 48382 5.2 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 DGCR8 LZTR1 TRMT2A MED15 RPL7AP70 RPL8P5 UFD1 ENSG00000273300 LOC100420177 ENSG00000243762
GH22I019947 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 -82.4 -82415 7.3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 ZNF2 POLR2B COMT DGCR8 TRMT2A ENSG00000273300 RPL8P5 LOC100420177 LINC01311 MED15 DGCR11 RPL7AP70
GH22I020076 Enhancer 0.9 ENCODE 12 +43.8 43770 1.1 HDGF PKNOX1 ATF1 ARNT YBX1 TCF12 GATA2 E2F8 ATF7 CAVIN1 TRMT2A ENSG00000273300 LZTR1 ENSG00000243762 RANBP1 MIR185 RPL7AP70 MED15 DGCR8 RPL8P5
GH22I020110 Enhancer 0.9 ENCODE 11.5 +78.9 78878 2.2 HDGF ARNT SIN3A ZNF2 POLR2B GLIS2 E2F8 ZNF143 ATF7 NCOA1 ENSG00000243762 TRMT2A MIR185 ZDHHC8 CCDC188 GC22M020115 DGCR8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR185 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR185 Gene

Genomic Locations for MIR185 Gene
chr22:20,033,139-20,033,220
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr22:20,020,662-20,020,743
(GRCh37/hg19)

Genomic View for MIR185 Gene

Genes around MIR185 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR185 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR185 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR185 Gene

Proteins for MIR185 Gene

Post-translational modifications for MIR185 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR185 Gene

Domains & Families for MIR185 Gene

Gene Families for MIR185 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR185: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR185 Gene

Function for MIR185 Gene

Gene Ontology (GO) - Molecular Function for MIR185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26694763
genes like me logo Genes that share ontologies with MIR185: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR185 Gene

Localization for MIR185 Gene

Gene Ontology (GO) - Cellular Components for MIR185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR185: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR185 Gene

Pathways & Interactions for MIR185 Gene

genes like me logo Genes that share pathways with MIR185: view

Pathways by source for MIR185 Gene

1 BioSystems pathway for MIR185 Gene

Interacting Proteins for MIR185 Gene

Gene Ontology (GO) - Biological Process for MIR185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016525 negative regulation of angiogenesis IDA 26694763
GO:0035195 gene silencing by miRNA IDA 26694763
genes like me logo Genes that share ontologies with MIR185: view

No data available for SIGNOR curated interactions for MIR185 Gene

Drugs & Compounds for MIR185 Gene

No Compound Related Data Available

Transcripts for MIR185 Gene

mRNA/cDNA for MIR185 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR185 Gene

No ASD Table

Relevant External Links for MIR185 Gene

GeneLoc Exon Structure for
MIR185
ECgene alternative splicing isoforms for
MIR185

Expression for MIR185 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR185 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR185 Gene:

MIR185
genes like me logo Genes that share expression patterns with MIR185: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR185 Gene

Orthologs for MIR185 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR185 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-185 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir185 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-185 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-185 34
  • 92 (a)
OneToOne
Species where no ortholog for MIR185 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR185 Gene

ENSEMBL:
Gene Tree for MIR185 (if available)
TreeFam:
Gene Tree for MIR185 (if available)

Paralogs for MIR185 Gene

No data available for Paralogs for MIR185 Gene

Variants for MIR185 Gene

Sequence variations from dbSNP and Humsavar for MIR185 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000298392 -- 20,032,726(+) G/A upstream_transcript_variant
rs1002890699 -- 20,032,798(+) G/A upstream_transcript_variant
rs1003091578 -- 20,032,476(+) C/T upstream_transcript_variant
rs1003453846 -- 20,031,330(+) G/A upstream_transcript_variant
rs1009418512 -- 20,033,065(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR185 Gene

Variant ID Type Subtype PubMed ID
nsv953026 CNV deletion 24416366
nsv834133 CNV loss 17160897
nsv828939 CNV loss 20364138
nsv828938 CNV gain 20364138
nsv471183 CNV loss 18288195
nsv469641 CNV loss 16826518
nsv3560 CNV insertion 18451855
esv3893434 CNV gain 25118596
esv3647284 CNV gain 21293372
dgv7983n54 CNV gain 21841781
dgv72n68 CNV loss 17160897

Additional Variant Information for MIR185 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR185

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR185 Gene

Disorders for MIR185 Gene

Additional Disease Information for MIR185

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR185 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR185 Gene

Publications for MIR185 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. miR-185/P2Y6 Axis Inhibits Angiotensin II-Induced Human Aortic Vascular Smooth Muscle Cell Proliferation. (PMID: 28277742) Wang S … Tan Y (DNA and cell biology 2017) 3 58
  3. MicroRNA‑185 regulates transforming growth factor‑β1 and collagen‑1 in hypertrophic scar fibroblasts. (PMID: 28259900) Xiao K … Gao Z (Molecular medicine reports 2017) 3 58
  4. MicroRNA-185 induces potent autophagy via AKT signaling in hepatocellular carcinoma. (PMID: 28240051) Zhou L … Cheng J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58

Products for MIR185 Gene

Sources for MIR185 Gene

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