microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR185 Gene

Subcategory (RNA class) for MIR185 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR185 Gene

  • MIMAT0004611 50
  • MIMAT0000455 50
  • MI0000482 50
  • MIRN185 3
  • MiR-185 3
  • RF00771 168

External Ids for MIR185 Gene

Previous HGNC Symbols for MIR185 Gene

  • MIRN185

Previous GeneCards Identifiers for MIR185 Gene

  • GC22P018400
  • GC22P020022
  • GC22P020026

Summaries for MIR185 Gene

Entrez Gene Summary for MIR185 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR185 Gene

MIR185 (MicroRNA 185) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR185 include Lung Cancer and Kidney Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

Rfam classification for MIR185 Gene

Additional gene information for MIR185 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR185 Gene

Genomics for MIR185 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around MIR185 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR185 Gene

Genomic Locations for MIR185 Gene
chr22:20,033,139-20,033,220
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr22:20,020,662-20,020,743
(GRCh37/hg19)
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR185 Gene

Genes around MIR185 on UCSC Golden Path with GeneCards custom track
MIR185 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR185 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR185 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR185 Gene

Proteins for MIR185 Gene

Post-translational modifications for MIR185 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR185 Gene

Domains & Families for MIR185 Gene

Gene Families for MIR185 Gene

HGNC:
genes like me logo Genes that share domains with MIR185: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR185 Gene

Function for MIR185 Gene

Phenotypes From GWAS Catalog for MIR185 Gene

Gene Ontology (GO) - Molecular Function for MIR185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24296663
genes like me logo Genes that share ontologies with MIR185: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR185 Gene

Localization for MIR185 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR185 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR185: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR185 Gene

Pathways & Interactions for MIR185 Gene

PathCards logo

SuperPathways for MIR185 Gene

genes like me logo Genes that share pathways with MIR185: view

Pathways by source for MIR185 Gene

1 BioSystems pathway for MIR185 Gene

Gene Ontology (GO) - Biological Process for MIR185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 24296663
GO:0010744 positive regulation of macrophage derived foam cell differentiation IMP 26523989
GO:0010989 negative regulation of low-density lipoprotein particle clearance IDA 24296663
GO:0016525 negative regulation of angiogenesis IDA 26694763
GO:0035195 gene silencing by miRNA IDA 24296663
genes like me logo Genes that share ontologies with MIR185: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR185 Gene

Drugs & Compounds for MIR185 Gene

No Compound Related Data Available

Transcripts for MIR185 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR185 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004176D4_9606 miRNA 22 6

RefSeq: NR_029706,

LncBase: hsa-miR-185-5p,

miRBase: MIMAT0000455,

MirGeneDB: Hsa-Mir-185_5p,

TarBase: hsa-miR-185-5p,

ENA: LM379073.1:1..22:ncRNA, LM608522.1:15..36:ncRNA,

URS000075D261_9606 precursor_RNA 82 5

HGNC: 31556,

RefSeq: NR_029706,

Ensembl: ENST00000385288 (view in UCSC) ,

miRBase: MI0000482,

ENA: LM608522.1:1..82:precursor_RNA,

URS00002367FA_9606 miRNA 22 5

RefSeq: NR_029706,

LncBase: hsa-miR-185-3p,

miRBase: MIMAT0004611,

TarBase: hsa-miR-185-3p,

ENA: LM380286.1:1..22:ncRNA, LM608522.1:50..71:ncRNA,

URS0000729723_9606 precursor_RNA 81 1

Rfam: RF00771,

URS0000EFF2A0_9606 precursor_RNA 57 1

MirGeneDB: Hsa-Mir-185,

MIR185 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR185 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR185 Gene

No ASD Table

Relevant External Links for MIR185 Gene

GeneLoc Exon Structure for
MIR185

Expression for MIR185 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR185 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR185

Evidence on tissue expression from TISSUES for MIR185 Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR185: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR185 Gene

Orthologs for MIR185 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR185 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-185 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir185 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-185 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-185 31
  • 92 (a)
OneToOne
Species where no ortholog for MIR185 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR185 Gene

ENSEMBL:
Gene Tree for MIR185 (if available)
TreeFam:
Gene Tree for MIR185 (if available)

Paralogs for MIR185 Gene

No data available for Paralogs for MIR185 Gene

Variants for MIR185 Gene

Additional dbSNP identifiers (rs#s) for MIR185 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR185 Gene

Variant ID Type Subtype PubMed ID
dgv72n68 CNV loss 17160897
dgv7983n54 CNV gain 21841781
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv3560 CNV insertion 18451855
nsv469641 CNV loss 16826518
nsv471183 CNV loss 18288195
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953026 CNV deletion 24416366

Additional Variant Information for MIR185 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR185

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR185 Gene

Disorders for MIR185 Gene

MalaCards: The human disease database

(52) MalaCards diseases for MIR185 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
kidney cancer
  • renal cell carcinoma
glioblastoma multiforme
  • adult glioblastoma multiforme
bladder cancer
  • bladder cancer, somatic
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR185

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR185: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR185 Gene

Publications for MIR185 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. Long Noncoding RNA (lncRNA) FOXD2-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Regulating MiR-185/AKT Axis. (PMID: 31841454) Chen Z … Shi X (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  3. miR-183-5p enhances the radioresistance of colorectal cancer by directly targeting ATG5. (PMID: 31502570) Zheng S … Wang D (Journal of biosciences 2019) 3
  4. CCAT1 lncRNA Promotes Inflammatory Bowel Disease Malignancy by Destroying Intestinal Barrier via Downregulating miR-185-3p. (PMID: 30615124) Ma D … Hong J (Inflammatory bowel diseases 2019) 3
  5. Long noncoding FOXD2-AS1 is activated by CREB1 and promotes cell proliferation and metastasis in glioma by sponging miR-185 through targeting AKT1. (PMID: 30553445) Dong H … Xue J (Biochemical and biophysical research communications 2019) 3

Products for MIR185 Gene

Sources for MIR185 Gene