microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of target mRNAs. This microRNA represents the most abundant miRNA in the corneal and lens epithelia of the eye and has been shown to interfere with target binding by another miR... See more...

Aliases for MIR184 Gene

Subcategory (RNA class) for MIR184 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR184 Gene

  • MicroRNA 184 2 3 5
  • Hsa-MiR-184 166 177
  • MIMAT0000454 51
  • Hsa-Mir-184 3
  • MI0000481 51
  • MiR-184 3
  • MIRN184 3
  • RF00657 172
  • MIR184 2
  • EDICT 3

External Ids for MIR184 Gene

Previous HGNC Symbols for MIR184 Gene

  • MIRN184

Previous GeneCards Identifiers for MIR184 Gene

  • GC15P077293
  • GC15P079502

Summaries for MIR184 Gene

Entrez Gene Summary for MIR184 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of target mRNAs. This microRNA represents the most abundant miRNA in the corneal and lens epithelia of the eye and has been shown to interfere with target binding by another miRNA, miR-205. Through regulation of the VEGF and Akt signaling pathways, this microRNA may inhibit corneal angiogenesis. Mutations in the seed region of this microRNA cause familial keratoconus with cataract, also known as EDICT syndrome. [provided by RefSeq, Mar 2017]

GeneCards Summary for MIR184 Gene

MIR184 (MicroRNA 184) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR184 include Edict Syndrome and Glioma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Rfam classification for MIR184 Gene

Additional gene information for MIR184 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR184 Gene

Genomics for MIR184 Gene

GeneHancer (GH) Regulatory Elements for MIR184 Gene

Promoters and enhancers for MIR184 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J079209 Promoter 0.8 Ensembl 500.7 +0.0 13 0.4 CTCF NRF1 TEAD4 GABPA HDAC2 PBX2 RAD21 MEIS2 EP300 GATA1 MIR184 lnc-ANKRD34C-1 ANKRD34C-AS1
GH15J079210 Enhancer 0.3 Ensembl 500.7 +0.7 713 0.2 EZH2 MIR184 lnc-ANKRD34C-1 ANKRD34C-AS1
GH15J079024 Enhancer 1.1 FANTOM5 Ensembl 10.3 -186.4 -186387 5.2 CTCF USF1 FOXA1 TEAD1 CTBP1 ZSCAN9 ZNF282 FOXA2 ZBTB17 NKRF WDR61 RASGRF1 ENSG00000259562 ENSG00000177699 CTSH HYKK MIR184 ENSG00000259322 HSALNG0107521 LOC105370917
GH15J079035 Enhancer 0.8 Ensembl ENCODE 10.7 -174.0 -173988 1.2 CTCF TCF12 ARNT MEF2B BATF IRF4 EBF1 RAD21 JUNB CUX1 RASGRF1 MIR184 ENSG00000177699 CHRNA5 HSALNG0107521 LOC105370917
GH15J079184 Enhancer 0.7 ENCODE 11.2 -25.2 -25224 0.2 CTCF REST RAD21 TRIM22 SMC3 DEK TCF12 CEBPB MBD1 ZNF654 MIR184 ENSG00000177699 CTSH lnc-RASGRF1-5 ANKRD34C-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR184 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR184 Gene

Genomic Locations for MIR184 Gene
chr15:79,209,788-79,209,871
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr15:79,502,130-79,502,213
(GRCh37/hg19)
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR184 Gene

Genes around MIR184 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR184 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR184 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR184 Gene

Proteins for MIR184 Gene

Post-translational modifications for MIR184 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR184 Gene

Domains & Families for MIR184 Gene

Gene Families for MIR184 Gene

HGNC:
genes like me logo Genes that share domains with MIR184: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR184 Gene

Function for MIR184 Gene

Phenotypes From GWAS Catalog for MIR184 Gene

Human Phenotype Ontology for MIR184 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR184 Gene

Localization for MIR184 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR184 gene
Compartment Confidence
plasma membrane 2
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR184 Gene

Pathways & Interactions for MIR184 Gene

genes like me logo Genes that share pathways with MIR184: view

Pathways by source for MIR184 Gene

1 BioSystems pathway for MIR184 Gene
;

Gene Ontology (GO) - Biological Process for MIR184 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR184 Gene

Drugs & Compounds for MIR184 Gene

No Compound Related Data Available

Transcripts for MIR184 Gene

mRNA/cDNA for MIR184 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 LncBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR184 Gene

No ASD Table

Relevant External Links for MIR184 Gene

GeneLoc Exon Structure for
MIR184

Expression for MIR184 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR184 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR184

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR184 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • eyelid
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with MIR184: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for MIR184 Gene

Orthologs for MIR184 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR184 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-184 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-184 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-184 31
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir184 31
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-184 31
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-184 31 31
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-184 31
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-184-2 31
  • 75 (a)
OneToMany
dre-mir-184-1 31
  • 74 (a)
OneToMany
Species where no ortholog for MIR184 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR184 Gene

ENSEMBL:
Gene Tree for MIR184 (if available)
TreeFam:
Gene Tree for MIR184 (if available)

Paralogs for MIR184 Gene

No data available for Paralogs for MIR184 Gene

Variants for MIR184 Gene

Additional dbSNP identifiers (rs#s) for MIR184 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR184 Gene

Variant ID Type Subtype PubMed ID
esv2760042 CNV gain 17122850

Additional Variant Information for MIR184 Gene

Human Gene Mutation Database (HGMD)
MIR184
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR184

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR184 Gene

Disorders for MIR184 Gene

MalaCards: The human disease database

(18) MalaCards diseases for MIR184 Gene - From: miR2Disease, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR184

genes like me logo Genes that share disorders with MIR184: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR184 Gene

Publications for MIR184 Gene

  1. microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells. (PMID: 19286996) Weitzel RP … Laughlin MJ (Blood 2009) 3 23 54
  2. Assessment of miR-182, miR-183, miR-184, and miR-221 Expressions in Primary Pterygium and Comparison With the Normal Conjunctiva. (PMID: 30688676) İçme G … Tamer L (Eye & contact lens 2019) 3 54
  3. Quantitative RT-PCR-based miRNA profiling of blastemal Wilms' tumors from formalin-fixed paraffin-embedded samples. (PMID: 30959135) Buglyó G … Nagy B (Journal of biotechnology 2019) 3 54
  4. MicroRNA-184 inhibits proliferation and promotes apoptosis of human colon cancer SW480 and HCT116 cells by downregulating C-MYC and BCL-2. (PMID: 28782841) Wang YB … Qiu W (Journal of cellular biochemistry 2018) 3 54
  5. Long Noncoding RNA MEG3 Inhibits Cell Proliferation and Metastasis in Chronic Myeloid Leukemia via Targeting miR-184. (PMID: 28653609) Li J … Li Y (Oncology research 2018) 3 54

Products for MIR184 Gene

Sources for MIR184 Gene