microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR183 Gene

Subcategory (RNA class) for MIR183 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR183 Gene

  • MicroRNA 183 2 3 5
  • Hsa-MiR-183-5p 163 173
  • Hsa-MiR-183-3p 163 173
  • Hsa-Mir-183 2 3
  • MIR183 2 5
  • Hsa-Mir-96-P3-V2 178
  • Hsa-Mir-96-P3-V1 178
  • MIMAT0000261 50
  • MIMAT0004560 50
  • MI0000273 50
  • MiRNA183 3
  • MIRN183 3
  • MiR-183 3
  • RF00663 168

External Ids for MIR183 Gene

Previous HGNC Symbols for MIR183 Gene

  • MIRN183

Previous GeneCards Identifiers for MIR183 Gene

  • GC07M129204
  • GC07M129415
  • GC07M129416
  • GC07M129420
  • GC07M129429
  • GC07M129775
  • GC07M129776
  • GC07M129786
  • GC07M129785
  • GC07M129787
  • GC07M129788
  • GC07M129777
  • GC07M129778
  • GC07M129779
  • GC07M129780
  • GC07M129782
  • GC07M129784

Summaries for MIR183 Gene

Entrez Gene Summary for MIR183 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR183 Gene

MIR183 (MicroRNA 183) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR183 include Lung Cancer and Non-Alcoholic Fatty Liver Disease. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR183 Gene

Additional gene information for MIR183 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR183 Gene

Genomics for MIR183 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR183 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J129776 Enhancer 0.5 ENCODE 600.7 -1.8 -1760 1 IKZF1 EZH2 POLR2A BCOR ETS1 KLF1 NANOG POU5F1 MIR183 ENSG00000273329 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H
GH07J129775 Enhancer 0.5 ENCODE 600.7 -0.8 -812 0.2 ZBTB17 POLR2A KLF17 TAF1 ZBTB6 MIR183 MIR96 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H
GH07J129777 Enhancer 0.3 ENCODE 600.7 -1.2 -1162 0.2 POLR2A BCOR MIR183 MIR96 ENSG00000273329 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H
GH07J129779 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 0.4 -5.2 -5201 4.4 ZNF221 HNRNPL PRDM10 LEF1 IKZF1 KDM1A ZNF692 TARDBP JUND MTA2 KLHDC10 UBE2H FLNC STRIP2 ENSG00000242078 MIR183 RF00017-6611 RF00017-6613 NRF1
GH07J129778 Enhancer 0.4 ENCODE 0.7 -2.4 -2422 0.2 IKZF1 EZH2 ZBTB33 KLF1 ENSG00000273329 MIR183 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR183 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR183 Gene

Genomic Locations for MIR183 Gene
chr7:129,774,905-129,775,014
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr7:129,414,745-129,414,854
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR183 Gene

Genes around MIR183 on UCSC Golden Path with GeneCards custom track
MIR183 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR183 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR183 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR183 Gene

Proteins for MIR183 Gene

Post-translational modifications for MIR183 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR183 Gene

Domains & Families for MIR183 Gene

Gene Families for MIR183 Gene

HGNC:
genes like me logo Genes that share domains with MIR183: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR183 Gene

Function for MIR183 Gene

Phenotypes From GWAS Catalog for MIR183 Gene

Gene Ontology (GO) - Molecular Function for MIR183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24586048
genes like me logo Genes that share ontologies with MIR183: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR183 Gene

Localization for MIR183 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR183 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR183: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR183 Gene

Pathways & Interactions for MIR183 Gene

PathCards logo

SuperPathways for MIR183 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR183: view

Pathways by source for MIR183 Gene

1 KEGG pathway for MIR183 Gene

Gene Ontology (GO) - Biological Process for MIR183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 24586048
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045542 positive regulation of cholesterol biosynthetic process IGI 23823476
GO:0045723 positive regulation of fatty acid biosynthetic process IGI 23823476
genes like me logo Genes that share ontologies with MIR183: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR183 Gene

Drugs & Compounds for MIR183 Gene

No Compound Related Data Available

Transcripts for MIR183 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR183 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000345DEB_9606 miRNA 22 6

RefSeq: NR_029615,

LncBase: hsa-miR-183-3p,

miRBase: MIMAT0004560,

MirGeneDB: Hsa-Mir-96-P3-v2_3p,

TarBase: hsa-miR-183-3p,

ENA: LM380239.1:1..22:ncRNA, LM608347.1:66..87:ncRNA,

URS0000528CBC_9606 miRNA 22 6

RefSeq: NR_029615,

LncBase: hsa-miR-183-5p,

miRBase: MIMAT0000261,

MirGeneDB: Hsa-Mir-96-P3-v1_5p,

TarBase: hsa-miR-183-5p,

ENA: AY194153.1:1..22:ncRNA, LM378901.1:1..22:ncRNA, LM608347.1:27..48:ncRNA,

URS00005BBC98_9606 precursor_RNA 110 5

HGNC: 31554,

RefSeq: NR_029615,

Ensembl: ENST00000384958 (view in UCSC) ,

miRBase: MI0000273,

ENA: LM608347.1:1..110:precursor_RNA,

URS0000639105_9606 precursor_RNA 102 1

Rfam: RF00663,

URS0000EFD807_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-96-P3-v1,

MIR183 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR183 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR183 Gene

No ASD Table

Relevant External Links for MIR183 Gene

GeneLoc Exon Structure for
MIR183

Expression for MIR183 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR183 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR183

Evidence on tissue expression from TISSUES for MIR183 Gene

  • Nervous system(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR183: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR183 Gene

Orthologs for MIR183 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR183 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Mir183 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-183 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-183 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-183 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-183 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-183 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-183 31
  • 87 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-183 31
  • 89 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-183 31
  • 50 (a)
OneToOne
Species where no ortholog for MIR183 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR183 Gene

ENSEMBL:
Gene Tree for MIR183 (if available)
TreeFam:
Gene Tree for MIR183 (if available)

Paralogs for MIR183 Gene

No data available for Paralogs for MIR183 Gene

Variants for MIR183 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR183 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs563046665 Not Provided: not specified 129,774,910(-) G/T NON_CODING_TRANSCRIPT_VARIANT
rs72631833 Likely Benign: not specified 129,774,964(-) C/A NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for MIR183 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR183 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV gain 19812545
nsv464721 CNV loss 19166990
nsv516024 CNV gain+loss 19592680
nsv608420 CNV loss 21841781
nsv949946 CNV deletion 24416366

Additional Variant Information for MIR183 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR183

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR183 Gene

Disorders for MIR183 Gene

MalaCards: The human disease database

(53) MalaCards diseases for MIR183 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
non-alcoholic fatty liver disease
  • nafld
leukemia, chronic lymphocytic
  • cll
prostate cancer
  • prostate cancer, somatic
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR183

genes like me logo Genes that share disorders with MIR183: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR183 Gene

Publications for MIR183 Gene

  1. Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. (PMID: 19940135) Li G … Gonzalez P (The Journal of biological chemistry 2010) 3 23
  2. CircLMTK2 acts as a tumor suppressor in prostate cancer via regulating the expression of microRNA-183. (PMID: 31760099) Jin C … Liu W (Life sciences 2020) 3
  3. Long non-coding RNA CASC2 regulates Sprouty2 via functioning as a competing endogenous RNA for miR-183 to modulate the sensitivity of prostate cancer cells to docetaxel. (PMID: 29373811) Gao W … Hong Z (Archives of biochemistry and biophysics 2019) 3
  4. miR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2. (PMID: 31558304) Li W … Li B (Pathology, research and practice 2019) 3
  5. Association of FCRL3 Gene Polymorphisms with IgA Nephropathy in a Chinese Han Population. (PMID: 31433201) Zhong Z … Li M (DNA and cell biology 2019) 3

Products for MIR183 Gene

Sources for MIR183 Gene