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Aliases for MIR1827 Gene

Subcategory (RNA class) for MIR1827 Gene


Quality Score for this RNA gene is


Aliases for MIR1827 Gene

  • MicroRNA 1827 2 3 5
  • Hsa-Mir-1827 3
  • MIRN1827 3

External Ids for MIR1827 Gene

Previous HGNC Symbols for MIR1827 Gene

  • MIRN1827

Previous GeneCards Identifiers for MIR1827 Gene

  • GC00U922942
  • GC12P099107
  • GC12P100583

Summaries for MIR1827 Gene

Entrez Gene Summary for MIR1827 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1827 Gene

MIR1827 (MicroRNA 1827) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1827 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1827 Gene

Genomics for MIR1827 Gene

GeneHancer (GH) Regulatory Elements for MIR1827 Gene

Promoters and enhancers for MIR1827 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I100185 Enhancer 0.5 Ensembl 0.8 -4.3 -4283 0.8 POLR2A RCOR1 EBF1 CHD2 SPI1 UHRF1BP1L SCYL2 DEPDC4 MIR1827 PIR35895 ENSG00000257489
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1827 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1827 Gene

Genomic Locations for MIR1827 Gene
66 bases
Plus strand

Genomic View for MIR1827 Gene

Genes around MIR1827 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1827 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1827 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1827 Gene

Proteins for MIR1827 Gene

Post-translational modifications for MIR1827 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1827 Gene

Domains & Families for MIR1827 Gene

Gene Families for MIR1827 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1827: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1827 Gene

Function for MIR1827 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1827 Gene

Localization for MIR1827 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1827 Gene

Pathways & Interactions for MIR1827 Gene

SuperPathways for MIR1827 Gene

No Data Available

Interacting Proteins for MIR1827 Gene

Gene Ontology (GO) - Biological Process for MIR1827 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR1827 Gene

Drugs & Compounds for MIR1827 Gene

No Compound Related Data Available

Transcripts for MIR1827 Gene

mRNA/cDNA for MIR1827 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1827 Gene

No ASD Table

Relevant External Links for MIR1827 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1827 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1827 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1827 Gene

Orthologs for MIR1827 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1827 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-1827 34
  • 98 (a)
Species where no ortholog for MIR1827 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1827 Gene

Gene Tree for MIR1827 (if available)
Gene Tree for MIR1827 (if available)

Paralogs for MIR1827 Gene

No data available for Paralogs for MIR1827 Gene

Variants for MIR1827 Gene

Sequence variations from dbSNP and Humsavar for MIR1827 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000872322 -- 100,188,094(+) G/C upstream_transcript_variant
rs1000986186 -- 100,188,693(+) A/G upstream_transcript_variant
rs1002102290 -- 100,188,261(+) G/T upstream_transcript_variant
rs1003297486 -- 100,189,716(+) A/C upstream_transcript_variant
rs1004015350 -- 100,190,288(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1827 Gene

Variant ID Type Subtype PubMed ID
esv3892256 CNV loss 25118596
nsv1048784 CNV gain 25217958
nsv559964 CNV gain 21841781

Additional Variant Information for MIR1827 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1827 Gene

Disorders for MIR1827 Gene

Additional Disease Information for MIR1827

No disorders were found for MIR1827 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1827 Gene

Publications for MIR1827 Gene

  1. microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. (PMID: 26840028) Zhang C … Feng Z (Oncotarget 2016) 3 58
  2. Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer. (PMID: 21676885) Xiong F … Lin D (Cancer research 2011) 3 58
  3. Discovering microRNAs from deep sequencing data using miRDeep. (PMID: 18392026) Friedländer MR … Rajewsky N (Nature biotechnology 2008) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR1827 Gene

Sources for MIR1827 Gene

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