microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR181D Gene

Subcategory (RNA class) for MIR181D Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR181D Gene

  • MicroRNA 181d 2 3 5
  • Hsa-MiR-181d-5p 163 173
  • Hsa-Mir-181d 2 3
  • MIR181D 2 5
  • Hsa-Mir-181-P2c 178
  • MIMAT0026608 50
  • MIMAT0002821 50
  • MI0003139 50
  • MIRN181D 3
  • Mir-181d 3

External Ids for MIR181D Gene

Additional External Ids for MIR181D Gene

Previous HGNC Symbols for MIR181D Gene

  • MIRN181D

Previous GeneCards Identifiers for MIR181D Gene

  • GC19P013856
  • GC19P013859
  • GC19P013986
  • GC19P013993
  • GC19P013997
  • GC19P014006

Summaries for MIR181D Gene

Entrez Gene Summary for MIR181D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181D Gene

MIR181D (MicroRNA 181d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR181D include Nemaline Myopathy and Autism Spectrum Disorder. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.

Additional gene information for MIR181D Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR181D Gene

Genomics for MIR181D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR181D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013872 Promoter/Enhancer 1.1 ENCODE CraniofacialAtlas 600.7 -1.8 -1788 1 CTCF MTA1 NR2C1 ZNF740 POLR2A HDAC1 SP1 HDAC2 USF1 NR2C2 MIR181C MIR181D CC2D1A NANOS3
GH19J013910 Enhancer 0.3 Ensembl 12.9 +36.2 36226 1 HNF4A ZNF362 MIR181C MIR181D NANOS3 PALM3 EEF1DP1 MISP3 PRKACA C19orf57 CC2D1A FJ601684-217
GH19J014078 Enhancer 0.2 FANTOM5 12.5 +203.7 203726 0.2 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 RFX1 PKN1
GH19J013877 Promoter 0.5 Ensembl 0.7 +2.5 2526 0.4 HNRNPL ZBTB6 CC2D1A MIR181D piR-35674-248 NANOS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR181D on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR181D Gene

Genomic Locations for MIR181D Gene
chr19:13,874,875-13,875,011
(GRCh38/hg38)
Size:
137 bases
Orientation:
Plus strand
chr19:13,985,689-13,985,825
(GRCh37/hg19)
Size:
137 bases
Orientation:
Plus strand

Genomic View for MIR181D Gene

Genes around MIR181D on UCSC Golden Path with GeneCards custom track
MIR181D in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR181D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181D Gene

Proteins for MIR181D Gene

Post-translational modifications for MIR181D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181D Gene

Domains & Families for MIR181D Gene

Gene Families for MIR181D Gene

genes like me logo Genes that share domains with MIR181D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR181D Gene

Function for MIR181D Gene

Gene Ontology (GO) - Molecular Function for MIR181D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA,IMP 23993976
genes like me logo Genes that share ontologies with MIR181D: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181D Gene

Localization for MIR181D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR181D gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR181D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005737 cytoplasm IDA 25336585
genes like me logo Genes that share ontologies with MIR181D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR181D Gene

Pathways & Interactions for MIR181D Gene

genes like me logo Genes that share pathways with MIR181D: view

Pathways by source for MIR181D Gene

2 BioSystems pathways for MIR181D Gene
1 KEGG pathway for MIR181D Gene

Gene Ontology (GO) - Biological Process for MIR181D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IMP 23993976
GO:0035195 gene silencing by miRNA IDA,IMP 23993976
GO:0035278 miRNA mediated inhibition of translation IMP 23993976
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 25336585
GO:0050724 negative regulation of interleukin-1 beta biosynthetic process IDA 28389653
genes like me logo Genes that share ontologies with MIR181D: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR181D Gene

Drugs & Compounds for MIR181D Gene

No Compound Related Data Available

Transcripts for MIR181D Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR181D Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075EF65_9606 precursor_RNA 137 5

HGNC: 32089,

RefSeq: NR_030179,

Ensembl: ENST00000384853 (view in UCSC) , ENST00000672634 (view in UCSC) ,

miRBase: MI0003139,

ENA: LM609469.1:1..137:precursor_RNA,

URS0000236310_9606 miRNA 23 5

RefSeq: NR_030179,

LncBase: hsa-miR-181d-5p,

miRBase: MIMAT0002821,

TarBase: hsa-miR-181d-5p,

ENA: LM379778.1:1..23:ncRNA, LM609469.1:36..58:ncRNA,

URS000075C355_9606 miRNA 21 3

RefSeq: NR_030179,

miRBase: MIMAT0026608,

ENA: LM383177.1:1..21:ncRNA, LM609469.1:79..99:ncRNA,

URS00005FB8F2_9606 miRNA 24 2

MirGeneDB: Hsa-Mir-181-P2c_5p,

ENA: AY785944.1:1..24:ncRNA,

URS0000EFE2D3_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-181-P2c,

MIR181D in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR181D Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181D Gene

No ASD Table

Relevant External Links for MIR181D Gene

GeneLoc Exon Structure for
MIR181D

Expression for MIR181D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR181D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR181D

genes like me logo Genes that share expression patterns with MIR181D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181D Gene

Orthologs for MIR181D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181d 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-181d 31
  • 88 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-181d 31
  • 83 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir181d 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181b-3 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181c 31
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-181b-1 31
  • 67 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-181b-2 31
  • 67 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii CABZ01039424.1 31
  • 63 (a)
OneToMany
Species where no ortholog for MIR181D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR181D Gene

ENSEMBL:
Gene Tree for MIR181D (if available)
TreeFam:
Gene Tree for MIR181D (if available)

Paralogs for MIR181D Gene

No data available for Paralogs for MIR181D Gene

Variants for MIR181D Gene

Additional dbSNP identifiers (rs#s) for MIR181D Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR181D Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Additional Variant Information for MIR181D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR181D Gene

Disorders for MIR181D Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR181D Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nemaline myopathy
  • nm
autism spectrum disorder
  • asd
muscular dystrophy, duchenne type
  • dmd
pancreatic cancer
  • pancreatic carcinoma
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR181D

genes like me logo Genes that share disorders with MIR181D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR181D Gene

Publications for MIR181D Gene

  1. Tumor-suppressive effects of microRNA-181d-5p on non-small-cell lung cancer through the CDKN3-mediated Akt signaling pathway in vivo and in vitro. (PMID: 30628487) Gao LM … Xu SF (American journal of physiology. Lung cellular and molecular physiology 2019) 3
  2. Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis. (PMID: 31352814) Zhang M … Qiu Z (Artificial cells, nanomedicine, and biotechnology 2019) 3
  3. Increased expression of miR-181d is associated with poor prognosis and tumor progression of gastric cancer. (PMID: 31524144) Li Z … Tian T (Cancer biomarkers : section A of Disease markers 2019) 3
  4. miR-181d-5p-FOXP1 feedback loop modulates the progression of osteosarcoma. (PMID: 30031607) Chen H … Zhu X (Biochemical and biophysical research communications 2018) 3
  5. MiR-181d promotes steroid-induced osteonecrosis of the femoral head by targeting SMAD3 to inhibit osteogenic differentiation of hBMSCs. (PMID: 30024590) Xie Y … Shi ZY (European review for medical and pharmacological sciences 2018) 3

Products for MIR181D Gene

Sources for MIR181D Gene