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Aliases for MIR181D Gene

Subcategory (RNA class) for MIR181D Gene


Quality Score for this RNA gene is


Aliases for MIR181D Gene

  • MicroRNA 181d 2 3 5
  • Hsa-Mir-181d 3
  • Mir-181d 3
  • MIRN181D 3

External Ids for MIR181D Gene

ORGUL Members for MIR181D Gene

Previous HGNC Symbols for MIR181D Gene

  • MIRN181D

Previous GeneCards Identifiers for MIR181D Gene

  • GC19P013856
  • GC19P013859
  • GC19P013986
  • GC19P013993
  • GC19P013997
  • GC19P014006

Summaries for MIR181D Gene

Entrez Gene Summary for MIR181D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181D Gene

MIR181D (MicroRNA 181d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR181D include Autism Spectrum Disorder and Muscular Dystrophy, Duchenne Type. Among its related pathways are Cell Differentiation - Index and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR181D Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181D Gene

Genomics for MIR181D Gene

GeneHancer (GH) Regulatory Elements for MIR181D Gene

Promoters and enhancers for MIR181D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013872 Enhancer 0.7 ENCODE 600.7 -1.8 -1788 1 SP1 ZNF148 MTA1 GMEB1 ATF1 ZNF740 CTCF HDAC1 POLR2A NR2C1 GC19P013876 GC19P013877 GC19P013878 GC19P013879 MIR181C MIR181D CC2D1A NANOS3
GH19J013910 Enhancer 0.4 Ensembl 12.9 +36.2 36226 1.4 HNF4A ZBTB33 ZNF362 MIR181C MIR181D NANOS3 PALM3 EEF1DP1 MISP3 PRKACA CC2D1A C19orf57 DCAF15
GH19J014078 Enhancer 0.3 FANTOM5 12.5 +203.7 203726 0.2 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 RFX1 PKN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR181D on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR181D Gene

Genomic Locations for MIR181D Gene
137 bases
Plus strand
137 bases
Plus strand

Genomic View for MIR181D Gene

Genes around MIR181D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181D Gene

Proteins for MIR181D Gene

Post-translational modifications for MIR181D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181D Gene

Domains & Families for MIR181D Gene

Gene Families for MIR181D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181D Gene

Function for MIR181D Gene

Gene Ontology (GO) - Molecular Function for MIR181D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23993976
genes like me logo Genes that share ontologies with MIR181D: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181D Gene

Localization for MIR181D Gene

Gene Ontology (GO) - Cellular Components for MIR181D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005737 cytoplasm IDA 25336585
genes like me logo Genes that share ontologies with MIR181D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR181D Gene

Pathways & Interactions for MIR181D Gene

genes like me logo Genes that share pathways with MIR181D: view

Pathways by source for MIR181D Gene

2 BioSystems pathways for MIR181D Gene
1 KEGG pathway for MIR181D Gene

Interacting Proteins for MIR181D Gene

Gene Ontology (GO) - Biological Process for MIR181D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IMP 23993976
GO:0035195 gene silencing by miRNA IMP 23993976
GO:0035278 miRNA mediated inhibition of translation IMP 23993976
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 25336585
GO:1900745 positive regulation of p38MAPK cascade IMP 23993976
genes like me logo Genes that share ontologies with MIR181D: view

No data available for SIGNOR curated interactions for MIR181D Gene

Drugs & Compounds for MIR181D Gene

No Compound Related Data Available

Transcripts for MIR181D Gene

mRNA/cDNA for MIR181D Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181D Gene

No ASD Table

Relevant External Links for MIR181D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR181D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR181D Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR181D Gene:

genes like me logo Genes that share expression patterns with MIR181D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181D Gene

Orthologs for MIR181D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-181d 35
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-181d 35
  • 88 (a)
(Bos Taurus)
Mammalia bta-mir-181d 35
  • 83 (a)
(Mus musculus)
Mammalia Mir181d 35
  • 78 (a)
(Monodelphis domestica)
Mammalia mdo-mir-181b-3 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-181c 35
  • 66 (a)
(Gallus gallus)
Aves gga-mir-181b-1 35
  • 67 (a)
(Anolis carolinensis)
Reptilia aca-mir-181b-2 35
  • 67 (a)
(Danio rerio)
Actinopterygii CABZ01039424.1 35
  • 63 (a)
Species where no ortholog for MIR181D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181D Gene

Gene Tree for MIR181D (if available)
Gene Tree for MIR181D (if available)

Paralogs for MIR181D Gene

No data available for Paralogs for MIR181D Gene

Variants for MIR181D Gene

Sequence variations from dbSNP and Humsavar for MIR181D Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1002550292 -- 13,873,302(+) T/A upstream_transcript_variant
rs1002864031 -- 13,873,485(+) CGACGACG/CGACGACGACG upstream_transcript_variant
rs1003104628 -- 13,874,893(+) C/T non_coding_transcript_variant
rs1003460913 -- 13,874,657(+) C/G upstream_transcript_variant
rs1003608890 -- 13,874,546(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR181D Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Additional Variant Information for MIR181D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181D Gene

Disorders for MIR181D Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR181D Gene - From: miR2Disease and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR181D

genes like me logo Genes that share disorders with MIR181D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR181D Gene

Publications for MIR181D Gene

  1. miR-181d-5p-FOXP1 feedback loop modulates the progression of osteosarcoma. (PMID: 30031607) Chen H … Zhu X (Biochemical and biophysical research communications 2018) 3 58
  2. Long non-coding RNA NEAT1 regulates permeability of the blood-tumor barrier via miR-181d-5p-mediated expression changes in ZO-1, occludin, and claudin-5. (PMID: 28185956) Guo J … Xue Y (Biochimica et biophysica acta. Molecular basis of disease 2017) 3 58
  3. miR-181d/MALT1 regulatory axis attenuates mesenchymal phenotype through NF-κB pathways in glioblastoma. (PMID: 28286260) Yang F … Wang Y (Cancer letters 2017) 3 58
  4. Downregulation of microRNA-181d had suppressive effect on pancreatic cancer development through inverse regulation of KNAIN2. (PMID: 28381166) Zhang G … Liu S (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. miR-181d regulates human dendritic cell maturation through NF-κB pathway. (PMID: 28731516) Su XW … Poon WS (Cell proliferation 2017) 3 58

Products for MIR181D Gene

Sources for MIR181D Gene

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