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Aliases for MIR181C Gene

Subcategory (RNA class) for MIR181C Gene

undefined

Quality Score for this RNA gene is

13

Aliases for MIR181C Gene

  • MicroRNA 181c 2 3 5
  • Hsa-Mir-181c 3
  • Mir-181c 3
  • MIRN181C 3

External Ids for MIR181C Gene

ORGUL Members for MIR181C Gene

Previous HGNC Symbols for MIR181C Gene

  • MIRN181C

Previous GeneCards Identifiers for MIR181C Gene

  • GC19P013855
  • GC19P013985

Summaries for MIR181C Gene

Entrez Gene Summary for MIR181C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181C Gene

MIR181C (MicroRNA 181c) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR181C include Hepatocellular Carcinoma and Alzheimer Disease. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.

Additional gene information for MIR181C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181C Gene

Genomics for MIR181C Gene

GeneHancer (GH) Regulatory Elements for MIR181C Gene

Promoters and enhancers for MIR181C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013872 Enhancer 0.7 ENCODE 600.7 -1.6 -1612 1 SP1 ZNF148 MTA1 GMEB1 ATF1 ZNF740 CTCF HDAC1 POLR2A NR2C1 GC19P013876 GC19P013877 GC19P013878 GC19P013879 MIR181C MIR181D CC2D1A NANOS3
GH19J013910 Enhancer 0.4 Ensembl 12.9 +36.4 36402 1.4 HNF4A ZBTB33 ZNF362 MIR181C MIR181D NANOS3 PALM3 EEF1DP1 MISP3 PRKACA CC2D1A C19orf57 DCAF15
GH19J014078 Enhancer 0.3 FANTOM5 12.5 +203.9 203902 0.2 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 RFX1 PKN1
GH19J013864 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -9.3 -9298 3.2 ZNF652 NKRF ZNF687 ZBTB7A YY1 MLLT1 ZNF560 GLIS2 POLR2A ZBTB8A SNRPGP15 ADGRL1 CACNA1A C19orf57 ZSWIM4 RFX1 CC2D1A NANOS3 MIR181C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR181C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR181C Gene

Genomic Locations for MIR181C Gene
chr19:13,874,699-13,874,808
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr19:13,985,513-13,985,622
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR181C Gene

Genes around MIR181C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181C Gene

Proteins for MIR181C Gene

Post-translational modifications for MIR181C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181C Gene

Domains & Families for MIR181C Gene

Gene Families for MIR181C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181C Gene

Function for MIR181C Gene

Gene Ontology (GO) - Molecular Function for MIR181C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IDA 28379604
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28379604
genes like me logo Genes that share ontologies with MIR181C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181C Gene

Localization for MIR181C Gene

Gene Ontology (GO) - Cellular Components for MIR181C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR181C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR181C Gene

Pathways & Interactions for MIR181C Gene

PathCards logo

SuperPathways for MIR181C Gene

genes like me logo Genes that share pathways with MIR181C: view

Pathways by source for MIR181C Gene

1 BioSystems pathway for MIR181C Gene
1 KEGG pathway for MIR181C Gene

Interacting Proteins for MIR181C Gene

Gene Ontology (GO) - Biological Process for MIR181C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation ISS --
GO:0031047 gene silencing by RNA IDA 28379604
GO:0035195 gene silencing by miRNA IEA --
GO:0043524 negative regulation of neuron apoptotic process ISS --
GO:0050728 negative regulation of inflammatory response ISS --
genes like me logo Genes that share ontologies with MIR181C: view

No data available for SIGNOR curated interactions for MIR181C Gene

Drugs & Compounds for MIR181C Gene

No Compound Related Data Available

Transcripts for MIR181C Gene

mRNA/cDNA for MIR181C Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181C Gene

No ASD Table

Relevant External Links for MIR181C Gene

GeneLoc Exon Structure for
MIR181C
ECgene alternative splicing isoforms for
MIR181C

Expression for MIR181C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR181C Gene

mRNA differential expression in normal tissues according to GTEx for MIR181C Gene

This gene is overexpressed in Testis (x37.3), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Cortex (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MIR181C Gene:

MIR181C
genes like me logo Genes that share expression patterns with MIR181C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181C Gene

Orthologs for MIR181C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181c 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-181c 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-181c 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181c 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181a-3 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-181a-3 35
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX649502.1 35
  • 65 (a)
OneToOne
Species where no ortholog for MIR181C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181C Gene

ENSEMBL:
Gene Tree for MIR181C (if available)
TreeFam:
Gene Tree for MIR181C (if available)

Paralogs for MIR181C Gene

No data available for Paralogs for MIR181C Gene

Variants for MIR181C Gene

Sequence variations from dbSNP and Humsavar for MIR181C Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001098416 -- 13,872,756(+) A/G upstream_transcript_variant
rs1002550292 -- 13,873,302(+) T/A upstream_transcript_variant
rs1002864031 -- 13,873,485(+) CGACGACG/CGACGACGACG upstream_transcript_variant
rs1003104628 -- 13,874,893(+) C/T downstream_transcript_variant
rs1003460913 -- 13,874,657(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR181C Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Additional Variant Information for MIR181C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181C Gene

Disorders for MIR181C Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIR181C Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
alzheimer disease
  • ad
leukemia, acute myeloid
  • aml
glioblastoma
  • glioblastoma multiforme
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR181C

genes like me logo Genes that share disorders with MIR181C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR181C Gene

Publications for MIR181C Gene

  1. The microRNA miR-181c enhances chemosensitivity and reduces chemoresistance in breast cancer cells via down-regulating osteopontin. (PMID: 30537505) Han B … Cai L (International journal of biological macromolecules 2019) 3 58
  2. Decreased MicroRNA miR-181c Expression Associated with Gastric Cancer. (PMID: 29243018) Zabaglia LM … Rasmussen LT (Journal of gastrointestinal cancer 2018) 3 58
  3. MicroRNA181c inhibits prostate cancer cell growth and invasion by targeting multiple ERK signaling pathway components. (PMID: 29341215) Su Z … Zhou Q (The Prostate 2018) 3 58
  4. MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms. (PMID: 29345059) Do T … Schulert GS (Journal of leukocyte biology 2018) 3 58
  5. miR-181c-3p and -5p promotes high-glucose-induced dysfunction in human umbilical vein endothelial cells by regulating leukemia inhibitory factor. (PMID: 29605252) Shen X … Bai X (International journal of biological macromolecules 2018) 3 58

Products for MIR181C Gene

Sources for MIR181C Gene

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