microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR181C Gene

Subcategory (RNA class) for MIR181C Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR181C Gene

  • MicroRNA 181c 2 3 5
  • Hsa-MiR-181c-5p 163 173
  • Hsa-MiR-181c-3p 163 173
  • Hsa-Mir-181c 2 3
  • MIR181C 2 5
  • Hsa-Mir-181-P1c 178
  • MIMAT0004559 50
  • MIMAT0000258 50
  • MI0000271 50
  • MIRN181C 3
  • Mir-181c 3
  • RF00076 168

External Ids for MIR181C Gene

Additional External Ids for MIR181C Gene

Previous HGNC Symbols for MIR181C Gene

  • MIRN181C

Previous GeneCards Identifiers for MIR181C Gene

  • GC19P013855
  • GC19P013858
  • GC19P013985

Summaries for MIR181C Gene

Entrez Gene Summary for MIR181C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181C Gene

MIR181C (MicroRNA 181c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR181C include Hepatocellular Carcinoma and Alzheimer Disease. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.

Rfam classification for MIR181C Gene

  • mir-181 microRNA precursor

Additional gene information for MIR181C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR181C Gene

Genomics for MIR181C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR181C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013872 Promoter/Enhancer 1.1 ENCODE CraniofacialAtlas 600.7 -1.6 -1612 1 CTCF MTA1 NR2C1 ZNF740 POLR2A HDAC1 SP1 HDAC2 USF1 NR2C2 MIR181C MIR181D CC2D1A NANOS3
GH19J013910 Enhancer 0.3 Ensembl 12.9 +36.4 36402 1 HNF4A ZNF362 MIR181C MIR181D NANOS3 PALM3 EEF1DP1 MISP3 PRKACA C19orf57 CC2D1A FJ601684-217
GH19J014078 Enhancer 0.2 FANTOM5 12.5 +203.9 203902 0.2 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 RFX1 PKN1
GH19J013860 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -11.0 -10987 6.3 SP1 GATAD2A CTCF PRDM10 LEF1 IKZF1 ZNF692 POLR2A BACH1 ZHX2 NANOS3 SNRPGP15 CCDC130 ADGRL1 CACNA1A ZSWIM4 RFX1 DCAF15 C19orf57 IL27RA
GH19J013868 Enhancer 0.5 CraniofacialAtlas 0.4 -5.6 -5612 0.6 TCF12 PKNOX1 EGR1 NBN ZFHX2 MTA2 TARDBP BHLHE40 EGR2 NANOS3 MIR181C CC2D1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR181C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR181C Gene

Genomic Locations for MIR181C Gene
chr19:13,874,699-13,874,808
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr19:13,985,513-13,985,622
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR181C Gene

Genes around MIR181C on UCSC Golden Path with GeneCards custom track
MIR181C in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR181C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181C Gene

Proteins for MIR181C Gene

Post-translational modifications for MIR181C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181C Gene

Domains & Families for MIR181C Gene

Gene Families for MIR181C Gene

genes like me logo Genes that share domains with MIR181C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR181C Gene

Function for MIR181C Gene

Gene Ontology (GO) - Molecular Function for MIR181C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IDA 28379604
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21112091
genes like me logo Genes that share ontologies with MIR181C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181C Gene

Localization for MIR181C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR181C gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR181C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR181C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR181C Gene

Pathways & Interactions for MIR181C Gene

PathCards logo

SuperPathways for MIR181C Gene

genes like me logo Genes that share pathways with MIR181C: view

Pathways by source for MIR181C Gene

1 BioSystems pathway for MIR181C Gene
1 KEGG pathway for MIR181C Gene

Gene Ontology (GO) - Biological Process for MIR181C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation ISS --
GO:0031047 gene silencing by RNA IDA 28379604
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 21112091
GO:0043524 negative regulation of neuron apoptotic process ISS --
genes like me logo Genes that share ontologies with MIR181C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR181C Gene

Drugs & Compounds for MIR181C Gene

No Compound Related Data Available

Transcripts for MIR181C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR181C Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000394A9E_9606 precursor_RNA 110 5

HGNC: 31552,

RefSeq: NR_029613,

Ensembl: ENST00000384881 (view in UCSC) , ENST00000671759 (view in UCSC) ,

miRBase: MI0000271,

ENA: LM608345.1:1..110:precursor_RNA,

URS000018C928_9606 miRNA 22 5

RefSeq: NR_029613,

LncBase: hsa-miR-181c-5p,

miRBase: MIMAT0000258,

TarBase: hsa-miR-181c-5p,

ENA: LM378899.1:1..22:ncRNA, LM608345.1:27..48:ncRNA,

URS0000244A71_9606 miRNA 22 5

RefSeq: NR_029613,

LncBase: hsa-miR-181c-3p,

miRBase: MIMAT0004559,

TarBase: hsa-miR-181c-3p,

ENA: LM380238.1:1..22:ncRNA, LM608345.1:65..86:ncRNA,

URS0000676B07_9606 precursor_RNA 75 1

Rfam: RF00076,

URS0000EFCEF6_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-181-P1c,

MIR181C in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR181C Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181C Gene

No ASD Table

Relevant External Links for MIR181C Gene

GeneLoc Exon Structure for
MIR181C

Expression for MIR181C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR181C Gene

mRNA differential expression in normal tissues according to GTEx for MIR181C Gene

This gene is overexpressed in Testis (x37.3), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Cortex (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR181C

Evidence on tissue expression from TISSUES for MIR181C Gene

  • Nervous system(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR181C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181C Gene

Orthologs for MIR181C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181c 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-181c 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-181c 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir181c 31
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181a-3 31
  • 90 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-181a-3 31
  • 80 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii BX649502.1 31
  • 65 (a)
OneToOne
Species where no ortholog for MIR181C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR181C Gene

ENSEMBL:
Gene Tree for MIR181C (if available)
TreeFam:
Gene Tree for MIR181C (if available)

Paralogs for MIR181C Gene

No data available for Paralogs for MIR181C Gene

Variants for MIR181C Gene

Additional dbSNP identifiers (rs#s) for MIR181C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR181C Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Additional Variant Information for MIR181C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR181C Gene

Disorders for MIR181C Gene

MalaCards: The human disease database

(15) MalaCards diseases for MIR181C Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR181C

genes like me logo Genes that share disorders with MIR181C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR181C Gene

Publications for MIR181C Gene

  1. MicroRNA‑181 exerts an inhibitory role during renal fibrosis by targeting early growth response factor‑1 and attenuating the expression of profibrotic markers. (PMID: 30816527) Zhang X … Miao C (Molecular medicine reports 2019) 3
  2. Silencing interleukin 1α underlies a novel inhibitory role of miR-181c-5p in alleviating low-grade inflammation of rats with irritable bowel syndrome. (PMID: 31172560) Ji LJ … Liu LN (Journal of cellular biochemistry 2019) 3
  3. MicroRNA-181c Suppresses the Biological Progression of Osteosarcoma via Targeting SMAD7 and Regulating Transforming Growth Factor-β (TGF-β) Signaling Pathway. (PMID: 31251735) Fu Y … Guo Z (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  4. Genome-wide analysis reveals miR-3184-5p and miR-181c-3p as a critical regulator for adipocytes-associated breast cancer. (PMID: 30847933) Rajarajan D … Kasiappan R (Journal of cellular physiology 2019) 3
  5. The microRNA miR-181c enhances chemosensitivity and reduces chemoresistance in breast cancer cells via down-regulating osteopontin. (PMID: 30537505) Han B … Cai L (International journal of biological macromolecules 2019) 3

Products for MIR181C Gene

Sources for MIR181C Gene