Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR181B2 Gene

Subcategory (RNA class) for MIR181B2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR181B2 Gene

  • MicroRNA 181b-2 2 3 5
  • Hsa-Mir-181b-2 3
  • Mir-181b-2 3
  • MIRN181B2 3

External Ids for MIR181B2 Gene

ORGUL Members for MIR181B2 Gene

Previous HGNC Symbols for MIR181B2 Gene

  • MIRN181B2

Previous GeneCards Identifiers for MIR181B2 Gene

  • GC09P126497
  • GC09P127456
  • GC09P127461
  • GC09P127467
  • GC09P127473

Summaries for MIR181B2 Gene

Entrez Gene Summary for MIR181B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181B2 Gene

MIR181B2 (MicroRNA 181b-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cell Differentiation - Index and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR181B2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181B2 Gene

Genomics for MIR181B2 Gene

GeneHancer (GH) Regulatory Elements for MIR181B2 Gene

Promoters and enhancers for MIR181B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I124656 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.5 -34.3 -34319 5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 IRF4 YY1 MIR181A2HG PRPS1P2 MIR181A2 MIR181B2 GAPVD1 GOLGA1 PIR50063 NR6A1
GH09I124592 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.9 -99.0 -98974 5.4 HDGF PKNOX1 ATF1 FOXA2 MLX ARID4B DMAP1 YY1 ETS1 RXRA MIR181A2HG PRPS1P2 MIR181A2 MIR181B2 ENSG00000231149 NR5A1 GAPVD1 LOC100419284 PIR56415 NR6A1
GH09I124720 Enhancer 1.1 Ensembl ENCODE 12.2 +27.5 27528 2 FOXA2 MLX ARID4B FEZF1 ZNF766 RXRA SP5 PPARG GLIS1 NR2C1 MIR181A2 MIR181B2 ENSG00000236643 NR6A1 WDR38 ARPC5L RPL35 ENSG00000231149 NR5A1 GC09P124694
GH09I124651 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 -41.1 -41090 2.2 ZNF133 KLF17 RAD21 RFX5 ZNF366 ZSCAN5C RCOR1 FOS DEK USF2 MIR181A2 MIR181B2 MIR181A2HG RN7SL302P NR6A1
GH09I124664 Enhancer 1 ENCODE dbSUPER 12 -28.3 -28313 1.9 ELF3 ATF1 FOXA2 ZNF366 FOS ATF7 CREM MIXL1 KLF11 ZNF362 MIR181A2 MIR181B2 MIR181A2HG PIR50063 NR6A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR181B2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR181B2 Gene

Genomic Locations for MIR181B2 Gene
chr9:124,693,710-124,693,798
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr9:127,455,989-127,456,077
(GRCh37/hg19)

Genomic View for MIR181B2 Gene

Genes around MIR181B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181B2 Gene

Proteins for MIR181B2 Gene

Post-translational modifications for MIR181B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181B2 Gene

Domains & Families for MIR181B2 Gene

Gene Families for MIR181B2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181B2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181B2 Gene

Function for MIR181B2 Gene

Gene Ontology (GO) - Molecular Function for MIR181B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23993976
genes like me logo Genes that share ontologies with MIR181B2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181B2 Gene

Localization for MIR181B2 Gene

Gene Ontology (GO) - Cellular Components for MIR181B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR181B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR181B2 Gene

Pathways & Interactions for MIR181B2 Gene

genes like me logo Genes that share pathways with MIR181B2: view

Pathways by source for MIR181B2 Gene

2 BioSystems pathways for MIR181B2 Gene
1 KEGG pathway for MIR181B2 Gene

Interacting Proteins for MIR181B2 Gene

Gene Ontology (GO) - Biological Process for MIR181B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IMP 23993976
GO:0035195 gene silencing by miRNA IMP 23993976
GO:0035278 miRNA mediated inhibition of translation IMP 23993976
GO:0110015 positive regulation of elastin catabolic process ISS --
GO:0120041 positive regulation of macrophage proliferation ISS --
genes like me logo Genes that share ontologies with MIR181B2: view

No data available for SIGNOR curated interactions for MIR181B2 Gene

Drugs & Compounds for MIR181B2 Gene

No Compound Related Data Available

Transcripts for MIR181B2 Gene

mRNA/cDNA for MIR181B2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181B2 Gene

No ASD Table

Relevant External Links for MIR181B2 Gene

GeneLoc Exon Structure for
MIR181B2
ECgene alternative splicing isoforms for
MIR181B2

Expression for MIR181B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR181B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR181B2 Gene:

MIR181B2
genes like me logo Genes that share expression patterns with MIR181B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181B2 Gene

Orthologs for MIR181B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181B2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-181b-2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181b-2 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-181b-2 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181b-2 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir181b-2 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181b-2 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-181b-2 34
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-181b-1 34
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-181b-2 34
  • 84 (a)
OneToOne
Species where no ortholog for MIR181B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181B2 Gene

ENSEMBL:
Gene Tree for MIR181B2 (if available)
TreeFam:
Gene Tree for MIR181B2 (if available)

Paralogs for MIR181B2 Gene

No data available for Paralogs for MIR181B2 Gene

Variants for MIR181B2 Gene

Sequence variations from dbSNP and Humsavar for MIR181B2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000058003 -- 124,692,233(+) CATTCA/CA upstream_transcript_variant
rs1003502829 -- 124,693,600(+) G/A upstream_transcript_variant
rs1007324400 -- 124,692,395(+) G/A/C upstream_transcript_variant
rs1007570168 -- 124,692,756(+) A/G/T upstream_transcript_variant
rs1008999914 -- 124,694,072(+) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR181B2 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV gain 17160897

Additional Variant Information for MIR181B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181B2 Gene

Disorders for MIR181B2 Gene

Additional Disease Information for MIR181B2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR181B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181B2 Gene

Publications for MIR181B2 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 44 58
  2. MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin. (PMID: 27756793) Di Gregoli K … Johnson JL (Circulation research 2017) 3 58
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  4. Epigenetic silencing of miR-181b contributes to tumorigenicity in colorectal cancer by targeting RASSF1A. (PMID: 26935905) Zhao LD … Hao S (International journal of oncology 2016) 3 58
  5. Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs. (PMID: 25410655) Presnell SR … Lutz CT (Genes and immunity 2015) 3 58

Products for MIR181B2 Gene

Sources for MIR181B2 Gene

Content
Loading form....