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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR181B1 (MicroRNA 181b-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR181B1 include Hepatocellular Carcinoma and Pancreatic Cancer. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA,IMP | 23993976 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Alzheimers Disease | ||
3 | Cell Differentiation - Index | ||
4 | miRNAs involved in DNA damage response |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009968 | negative regulation of signal transduction | IGI | 25505240 |
GO:0010839 | negative regulation of keratinocyte proliferation | IGI | 27641447 |
GO:0010917 | negative regulation of mitochondrial membrane potential | ISS | -- |
GO:0030335 | positive regulation of cell migration | IMP | 23993976 |
GO:0034144 | negative regulation of toll-like receptor 4 signaling pathway | IGI | 27641447 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000229622_9606 | miRNA | 21 | 6 |
RefSeq: NR_029612, LncBase: hsa-miR-181b-3p, miRBase: MIMAT0022692, MirGeneDB: Hsa-Mir-181-P2a_3p, TarBase: hsa-miR-181b-3p, |
URS0000530EBF_9606 | precursor_RNA | 110 | 5 |
HGNC: 31550, RefSeq: NR_029612, Ensembl: ENST00000385240 (view in UCSC) , miRBase: MI0000270, |
URS0000605E00_9606 | miRNA | 23 | 5 |
LncBase: hsa-miR-181b-5p, miRBase: MIMAT0000257, TarBase: hsa-miR-181b-5p, ENA: LM378898.1:1..23:ncRNA, LM608344.1:36..58:ncRNA, LM608612.1:16..38:ncRNA, |
URS0000EFBE70_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-181-P2a, |
URS0000574E81_9606 | miRNA | 24 | 1 |
MirGeneDB: Hsa-Mir-181-P2a_5p, Hsa-Mir-181-P2b_5p, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-181b-1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir181b-1 31 |
|
ManyToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-181b-1 31 |
|
ManyToMany | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-181b-1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-181b-1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-181b-1 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | gga-mir-181b-1 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-181b-2 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-181b-1 31 |
|
ManyToMany | |
dre-mir-181c 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
|
|
pancreatic cancer |
|
|
prostate cancer |
|
|
breast cancer |
|
|
richter's syndrome |
|
|