microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR181B1 Gene

Subcategory (RNA class) for MIR181B1 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR181B1 Gene

  • MicroRNA 181b-1 2 3 5
  • Hsa-MiR-181b-5p 163 173
  • Hsa-MiR-181b-3p 163 173
  • Hsa-Mir-181b-1 2 3
  • MIR181B1 2 5
  • Hsa-Mir-181-P2a 178
  • MIMAT0000257 50
  • MIMAT0022692 50
  • Mir-181b-1 3
  • MIRN181B1 3
  • MI0000270 50

External Ids for MIR181B1 Gene

Previous HGNC Symbols for MIR181B1 Gene

  • MIRN181B1

Previous GeneCards Identifiers for MIR181B1 Gene

  • GC01M197096
  • GC01M198828

Summaries for MIR181B1 Gene

Entrez Gene Summary for MIR181B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181B1 Gene

MIR181B1 (MicroRNA 181b-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR181B1 include Hepatocellular Carcinoma and Pancreatic Cancer. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.

Additional gene information for MIR181B1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR181B1 Gene

Genomics for MIR181B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR181B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J198879 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -22.0 -22029 3.2 CEBPG CREB1 ZNF629 ZNF692 ZHX2 PRDM1 ZNF501 ZNF341 SCRT2 RBAK MIR181A1 MIR181B1 ENSG00000225172 PTPRC MN296902 lnc-PTPRC-5 MIR181A1HG
GH01J198888 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.4 -32.5 -32518 6.2 FOXA1 PRDM1 RFX1 POLR2A ZNF792 ZBTB44 TCF7L2 BMI1 CEBPB FOS lnc-PTPRC-5 ENSG00000225172 MIR181A1 MIR181B1 lnc-PTPRC-6 MIR181A1HG PTPRC
GH01J198837 Enhancer 0.9 Ensembl 12.2 +20.8 20781 2.4 CREB1 PRDM10 ZNF629 ZIC2 ZSCAN4 ZNF501 ZNF600 ZNF341 ZNF561 ZNF792 MIR181A1 MIR181B1 lnc-ATP6V1G3-8 piR-35235-001 MIR181A1HG PTPRC
GH01J198775 Enhancer 0.9 Ensembl ENCODE 10.9 +82.0 81982 8.4 FOXA1 RELA SP1 ZNF792 RELB ZXDB CEBPB RUNX3 ZNF316 MAFF MIR181A1 MIR181B1 lnc-ATP6V1G3-7 MN309032 PTPRC MIR181A1HG
GH01J198919 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 10.6 -61.3 -61253 1.1 CREB1 RELB RUNX3 JUNB POLR2A BHLHE40 ZNF217 RF00994-078 MIR181A1 MIR181B1 PTPRC MN296905 MIR181A1HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR181B1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR181B1 Gene

Genomic Locations for MIR181B1 Gene
chr1:198,858,873-198,858,982
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr1:198,828,002-198,828,111
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR181B1 Gene

Genes around MIR181B1 on UCSC Golden Path with GeneCards custom track
MIR181B1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR181B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181B1 Gene

Proteins for MIR181B1 Gene

Post-translational modifications for MIR181B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181B1 Gene

Domains & Families for MIR181B1 Gene

Gene Families for MIR181B1 Gene

genes like me logo Genes that share domains with MIR181B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR181B1 Gene

Function for MIR181B1 Gene

Phenotypes From GWAS Catalog for MIR181B1 Gene

Gene Ontology (GO) - Molecular Function for MIR181B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA,IMP 23993976
genes like me logo Genes that share ontologies with MIR181B1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181B1 Gene

Localization for MIR181B1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR181B1 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR181B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR181B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR181B1 Gene

Pathways & Interactions for MIR181B1 Gene

genes like me logo Genes that share pathways with MIR181B1: view

Pathways by source for MIR181B1 Gene

1 KEGG pathway for MIR181B1 Gene

Gene Ontology (GO) - Biological Process for MIR181B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009968 negative regulation of signal transduction IGI 25505240
GO:0010839 negative regulation of keratinocyte proliferation IGI 27641447
GO:0010917 negative regulation of mitochondrial membrane potential ISS --
GO:0030335 positive regulation of cell migration IMP 23993976
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway IGI 27641447
genes like me logo Genes that share ontologies with MIR181B1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR181B1 Gene

Drugs & Compounds for MIR181B1 Gene

No Compound Related Data Available

Transcripts for MIR181B1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR181B1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000229622_9606 miRNA 21 6

RefSeq: NR_029612,

LncBase: hsa-miR-181b-3p,

miRBase: MIMAT0022692,

MirGeneDB: Hsa-Mir-181-P2a_3p,

TarBase: hsa-miR-181b-3p,

ENA: LM383000.1:1..21:ncRNA, LM608344.1:76..96:ncRNA,

URS0000530EBF_9606 precursor_RNA 110 5

HGNC: 31550,

RefSeq: NR_029612,

Ensembl: ENST00000385240 (view in UCSC) ,

miRBase: MI0000270,

ENA: LM608344.1:1..110:precursor_RNA,

URS0000605E00_9606 miRNA 23 5

RefSeq: NR_029612, NR_029782,

LncBase: hsa-miR-181b-5p,

miRBase: MIMAT0000257,

TarBase: hsa-miR-181b-5p,

ENA: LM378898.1:1..23:ncRNA, LM608344.1:36..58:ncRNA, LM608612.1:16..38:ncRNA,

URS0000EFBE70_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-181-P2a,

URS0000574E81_9606 miRNA 24 1

MirGeneDB: Hsa-Mir-181-P2a_5p, Hsa-Mir-181-P2b_5p,

MIR181B1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR181B1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181B1 Gene

No ASD Table

Relevant External Links for MIR181B1 Gene

GeneLoc Exon Structure for
MIR181B1

Expression for MIR181B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR181B1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR181B1

genes like me logo Genes that share expression patterns with MIR181B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181B1 Gene

Orthologs for MIR181B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181B1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181b-1 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir181b-1 31
  • 98 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181b-1 31
  • 97 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia cfa-mir-181b-1 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-181b-1 31
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181b-1 31
  • 76 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves gga-mir-181b-1 31
  • 96 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-181b-2 31
  • 97 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-181b-1 31
  • 72 (a)
ManyToMany
dre-mir-181c 31
  • 67 (a)
ManyToMany
Species where no ortholog for MIR181B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR181B1 Gene

ENSEMBL:
Gene Tree for MIR181B1 (if available)
TreeFam:
Gene Tree for MIR181B1 (if available)

Paralogs for MIR181B1 Gene

No data available for Paralogs for MIR181B1 Gene

Variants for MIR181B1 Gene

Additional dbSNP identifiers (rs#s) for MIR181B1 Gene

Additional Variant Information for MIR181B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR181B1 Gene

Disorders for MIR181B1 Gene

MalaCards: The human disease database

(24) MalaCards diseases for MIR181B1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
pancreatic cancer
  • pancreatic carcinoma
prostate cancer
  • prostate cancer, somatic
breast cancer
  • breast lobular carcinoma
richter's syndrome
  • richter syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR181B1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR181B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR181B1 Gene

Publications for MIR181B1 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41
  2. MiR-125b-5p and miR-181b-5p inhibit keratinocyte proliferation in skin by targeting Akt3. (PMID: 31518563) Zheng Y … Yin G (European journal of pharmacology 2019) 3
  3. Hepatic miR-181b-5p Contributes to Glycogen Synthesis Through Targeting EGR1. (PMID: 30627917) Wang S … Zhao H (Digestive diseases and sciences 2019) 3
  4. Interleukin-1β/nuclear factor-κB signaling promotes osteosarcoma cell growth through the microRNA-181b/phosphatase and tensin homolog axis. (PMID: 30977354) Wang W … Miao J (Journal of cellular biochemistry 2019) 3
  5. microRNA-181b suppresses the metastasis of lung cancer cells by targeting sex determining region Y-related high mobility group-box 6 (Sox6). (PMID: 30580904) Zhou Y … Jiang JT (Pathology, research and practice 2019) 3

Products for MIR181B1 Gene

Sources for MIR181B1 Gene