microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR181A2 Gene

Subcategory (RNA class) for MIR181A2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR181A2 Gene

  • MicroRNA 181a-2 2 3 5
  • Hsa-MiR-181a-2-3p 163 173
  • Hsa-MiR-181a-5p 163 173
  • Hsa-Mir-181a 2 3
  • MIR181A2 2 5
  • Hsa-Mir-181-P1b 178
  • Hsa-Mir-181a-2 3
  • MicroRNA 181a 2
  • MIMAT0000256 50
  • MIMAT0004558 50
  • Mir-181a-2 3
  • MIRN181A2 3
  • MI0000269 50
  • MIRN181A 3
  • RF00076 168

External Ids for MIR181A2 Gene

Previous HGNC Symbols for MIR181A2 Gene

  • MIRN181A
  • MIRN181A2

Previous GeneCards Identifiers for MIR181A2 Gene

  • GC09P126496
  • GC09P127455
  • GC09P127460
  • GC09P127466
  • GC09P127471

Summaries for MIR181A2 Gene

Entrez Gene Summary for MIR181A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181A2 Gene

MIR181A2 (MicroRNA 181a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR181A2 include Leukemia, Chronic Lymphocytic and Glioma. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.

Rfam classification for MIR181A2 Gene

  • mir-181 microRNA precursor

Additional gene information for MIR181A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR181A2 Gene

Genomics for MIR181A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR181A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR181A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR181A2 Gene

Genomic Locations for MIR181A2 Gene
chr9:124,692,442-124,692,551
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr9:127,454,721-127,454,830
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR181A2 Gene

Genes around MIR181A2 on UCSC Golden Path with GeneCards custom track
MIR181A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR181A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181A2 Gene

Proteins for MIR181A2 Gene

Post-translational modifications for MIR181A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181A2 Gene

Domains & Families for MIR181A2 Gene

Gene Families for MIR181A2 Gene

genes like me logo Genes that share domains with MIR181A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR181A2 Gene

Function for MIR181A2 Gene

Gene Ontology (GO) - Molecular Function for MIR181A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23993976
genes like me logo Genes that share ontologies with MIR181A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181A2 Gene

Localization for MIR181A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR181A2 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR181A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26322847
GO:0045177 apical part of cell IDA 26322847
genes like me logo Genes that share ontologies with MIR181A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR181A2 Gene

Pathways & Interactions for MIR181A2 Gene

genes like me logo Genes that share pathways with MIR181A2: view

Pathways by source for MIR181A2 Gene

2 BioSystems pathways for MIR181A2 Gene
1 KEGG pathway for MIR181A2 Gene

Gene Ontology (GO) - Biological Process for MIR181A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IGI 18728182
GO:0030335 positive regulation of cell migration IMP 23993976
GO:0032691 negative regulation of interleukin-1 beta production IDA 23516523
GO:0032715 negative regulation of interleukin-6 production IDA 23516523
GO:0032720 negative regulation of tumor necrosis factor production IDA 23516523
genes like me logo Genes that share ontologies with MIR181A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR181A2 Gene

Drugs & Compounds for MIR181A2 Gene

No Compound Related Data Available

Transcripts for MIR181A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR181A2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00003DA300_9606 miRNA 23 6

RefSeq: NR_029611, NR_029626,

LncBase: hsa-miR-181a-5p,

miRBase: MIMAT0000256,

MirGeneDB: Hsa-Mir-181-P1a_5p, Hsa-Mir-181-P1b_5p,

TarBase: hsa-miR-181a-5p,

ENA: LM378897.1:1..23:ncRNA, LM608343.1:39..61:ncRNA, LM608358.1:24..46:ncRNA,

URS0000241987_9606 miRNA 22 6

RefSeq: NR_029611,

LncBase: hsa-miR-181a-2-3p,

miRBase: MIMAT0004558,

MirGeneDB: Hsa-Mir-181-P1b_3p,

TarBase: hsa-miR-181a-2-3p,

ENA: AY940854.1:1..22:ncRNA, LM380237.1:1..22:ncRNA, LM608343.1:77..98:ncRNA,

URS00000DD591_9606 precursor_RNA 110 5

HGNC: 31549,

RefSeq: NR_029611,

Ensembl: ENST00000384863 (view in UCSC) ,

miRBase: MI0000269,

ENA: LM608343.1:1..110:precursor_RNA,

URS000070931D_9606 precursor_RNA 74 1

Rfam: RF00076,

URS0000EFD8CD_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-181-P1b,

MIR181A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR181A2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181A2 Gene

No ASD Table

Relevant External Links for MIR181A2 Gene

GeneLoc Exon Structure for
MIR181A2

Expression for MIR181A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR181A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR181A2

genes like me logo Genes that share expression patterns with MIR181A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181A2 Gene

Orthologs for MIR181A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-181a-2 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-181a-2 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-181a-2 31
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir181a-2 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-181a-2 31
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-181a-2 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-181a-2 31
  • 78 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-181a-2 31
  • 78 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-181a-2 31
  • 72 (a)
ManyToMany
CABZ01086560.1 31
  • 66 (a)
ManyToMany
Species where no ortholog for MIR181A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR181A2 Gene

ENSEMBL:
Gene Tree for MIR181A2 (if available)
TreeFam:
Gene Tree for MIR181A2 (if available)

Paralogs for MIR181A2 Gene

No data available for Paralogs for MIR181A2 Gene

Variants for MIR181A2 Gene

Additional dbSNP identifiers (rs#s) for MIR181A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR181A2 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV gain 17160897

Additional Variant Information for MIR181A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR181A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR181A2 Gene

Disorders for MIR181A2 Gene

MalaCards: The human disease database

(11) MalaCards diseases for MIR181A2 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
glioma
myeloma, multiple
  • multiple myeloma, susceptibility to
hepatocellular carcinoma
  • hcc
diabetes mellitus
  • diabetes
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR181A2

genes like me logo Genes that share disorders with MIR181A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR181A2 Gene

Publications for MIR181A2 Gene

  1. BCL2 and hsa-miR-181a-5p are potential biomarkers associated with papillary thyroid cancer based on bioinformatics analysis. (PMID: 31842912) Zhang C … Gu X (World journal of surgical oncology 2019) 3
  2. MicroRNA-34a and MicroRNA-181a Mediate Visfatin-Induced Apoptosis and Oxidative Stress via NF-κB Pathway in Human Osteoarthritic Chondrocytes. (PMID: 31405216) Cheleschi S … Fioravanti A (Cells 2019) 3
  3. Effects of miR‑181a on the biological function of multiple myeloma. (PMID: 31115560) Liu N … Guo X (Oncology reports 2019) 3
  4. Downregulation of lncRNA CASC2 facilitates osteosarcoma growth and invasion through miR-181a. (PMID: 29194827) Ba Z … Nie G (Cell proliferation 2018) 3
  5. Up-regulation of miR-181a in clear cell renal cell carcinoma is associated with lower KLF6 expression, enhanced cell proliferation, accelerated cell cycle transition, and diminished apoptosis. (PMID: 29066014) Lei Z … Zhang X (Urologic oncology 2018) 3

Products for MIR181A2 Gene

Sources for MIR181A2 Gene