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Aliases for MIR181A2 Gene

Subcategory (RNA class) for MIR181A2 Gene


Quality Score for this RNA gene is


Aliases for MIR181A2 Gene

  • MicroRNA 181a-2 2 3 5
  • Hsa-Mir-181a-2 3
  • MicroRNA 181a 2
  • Hsa-Mir-181a 3
  • Mir-181a-2 3
  • MIRN181A2 3
  • MIRN181A 3

External Ids for MIR181A2 Gene

ORGUL Members for MIR181A2 Gene

Previous HGNC Symbols for MIR181A2 Gene

  • MIRN181A
  • MIRN181A2

Previous GeneCards Identifiers for MIR181A2 Gene

  • GC09P126496
  • GC09P127455
  • GC09P127460
  • GC09P127466
  • GC09P127471

Summaries for MIR181A2 Gene

Entrez Gene Summary for MIR181A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR181A2 Gene

MIR181A2 (MicroRNA 181a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cell Differentiation - Index and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR181A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR181A2 Gene

Genomics for MIR181A2 Gene

GeneHancer (GH) Regulatory Elements for MIR181A2 Gene

Promoters and enhancers for MIR181A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I124656 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.5 -33.1 -33051 5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 IRF4 YY1 MIR181A2HG PRPS1P2 MIR181A2 MIR181B2 GAPVD1 GOLGA1 PIR50063 NR6A1
GH09I124592 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.9 -97.7 -97706 5.4 HDGF PKNOX1 ATF1 FOXA2 MLX ARID4B DMAP1 YY1 ETS1 RXRA MIR181A2HG PRPS1P2 MIR181A2 MIR181B2 ENSG00000231149 NR5A1 GAPVD1 LOC100419284 PIR56415 NR6A1
GH09I124720 Enhancer 1.1 Ensembl ENCODE 12.2 +28.8 28796 2 FOXA2 MLX ARID4B FEZF1 ZNF766 RXRA SP5 PPARG GLIS1 NR2C1 MIR181A2 MIR181B2 ENSG00000236643 NR6A1 WDR38 ARPC5L RPL35 ENSG00000231149 NR5A1 GC09P124694
GH09I124651 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 -39.8 -39822 2.2 ZNF133 KLF17 RAD21 RFX5 ZNF366 ZSCAN5C RCOR1 FOS DEK USF2 MIR181A2 MIR181B2 MIR181A2HG RN7SL302P NR6A1
GH09I124664 Enhancer 1 ENCODE dbSUPER 12 -27.0 -27045 1.9 ELF3 ATF1 FOXA2 ZNF366 FOS ATF7 CREM MIXL1 KLF11 ZNF362 MIR181A2 MIR181B2 MIR181A2HG PIR50063 NR6A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR181A2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR181A2 Gene

Genomic Locations for MIR181A2 Gene
110 bases
Plus strand

Genomic View for MIR181A2 Gene

Genes around MIR181A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR181A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR181A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR181A2 Gene

Proteins for MIR181A2 Gene

Post-translational modifications for MIR181A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR181A2 Gene

Domains & Families for MIR181A2 Gene

Gene Families for MIR181A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR181A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR181A2 Gene

Function for MIR181A2 Gene

Gene Ontology (GO) - Molecular Function for MIR181A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23993976
genes like me logo Genes that share ontologies with MIR181A2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR181A2 Gene

Localization for MIR181A2 Gene

Gene Ontology (GO) - Cellular Components for MIR181A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26322847
GO:0045177 apical part of cell IDA 26322847
genes like me logo Genes that share ontologies with MIR181A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR181A2 Gene

Pathways & Interactions for MIR181A2 Gene

genes like me logo Genes that share pathways with MIR181A2: view

Pathways by source for MIR181A2 Gene

2 BioSystems pathways for MIR181A2 Gene
1 KEGG pathway for MIR181A2 Gene

Interacting Proteins for MIR181A2 Gene

Gene Ontology (GO) - Biological Process for MIR181A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IGI 18728182
GO:0030335 positive regulation of cell migration IMP 23993976
GO:0035195 gene silencing by miRNA IMP 23993976
GO:0035278 miRNA mediated inhibition of translation IMP 23993976
GO:1900745 positive regulation of p38MAPK cascade IMP 23993976
genes like me logo Genes that share ontologies with MIR181A2: view

No data available for SIGNOR curated interactions for MIR181A2 Gene

Drugs & Compounds for MIR181A2 Gene

No Compound Related Data Available

Transcripts for MIR181A2 Gene

mRNA/cDNA for MIR181A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR181A2 Gene

No ASD Table

Relevant External Links for MIR181A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR181A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR181A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR181A2 Gene:

genes like me logo Genes that share expression patterns with MIR181A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR181A2 Gene

Orthologs for MIR181A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR181A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-181a-2 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-181a-2 34
  • 95 (a)
(Bos Taurus)
Mammalia bta-mir-181a-2 34
  • 86 (a)
(Mus musculus)
Mammalia Mir181a-2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-181a-2 34
  • 81 (a)
(Monodelphis domestica)
Mammalia mdo-mir-181a-2 34
  • 76 (a)
(Gallus gallus)
Aves gga-mir-181a-2 34
  • 78 (a)
(Anolis carolinensis)
Reptilia aca-mir-181a-2 34
  • 78 (a)
(Danio rerio)
Actinopterygii dre-mir-181a-2 34
  • 72 (a)
CABZ01086560.1 34
  • 66 (a)
Species where no ortholog for MIR181A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR181A2 Gene

Gene Tree for MIR181A2 (if available)
Gene Tree for MIR181A2 (if available)

Paralogs for MIR181A2 Gene

No data available for Paralogs for MIR181A2 Gene

Variants for MIR181A2 Gene

Sequence variations from dbSNP and Humsavar for MIR181A2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000058003 -- 124,692,233(+) CATTCA/CA upstream_transcript_variant
rs1000152779 -- 124,690,516(+) T/C/G upstream_transcript_variant
rs1001774490 -- 124,691,669(+) G/A upstream_transcript_variant
rs1002120456 -- 124,690,644(+) CCC/CCCC upstream_transcript_variant
rs1005651127 -- 124,690,844(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR181A2 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV gain 17160897

Additional Variant Information for MIR181A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR181A2 Gene

Disorders for MIR181A2 Gene

Additional Disease Information for MIR181A2

No disorders were found for MIR181A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR181A2 Gene

Publications for MIR181A2 Gene

  1. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. (PMID: 26028030) Niu J … Wu ZH (Oncogene 2016) 3 58
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  3. TGF-β regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a, and Smad signaling. (PMID: 26915797) Choi SI … Kim EK (Biochemical and biophysical research communications 2016) 3 58
  4. Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. (PMID: 27354409) Zhou Y … Yao ZQ (Journal of leukocyte biology 2016) 3 58
  5. IL-1β/NF-kb signaling promotes colorectal cancer cell growth through miR-181a/PTEN axis. (PMID: 27264420) Hai Ping P … Hong Z (Archives of biochemistry and biophysics 2016) 3 58

Products for MIR181A2 Gene

Sources for MIR181A2 Gene

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