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Aliases for MIR17HG Gene

Subcategory (RNA class) for MIR17HG Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR17HG Gene

  • MiR-17-92a-1 Cluster Host Gene 2 3 5
  • Long Intergenic Non-Protein Coding RNA 48 2 3
  • MicroRNA Host Gene 1 (Non-Protein Coding) 2 3
  • MIR17 Host Gene (Non-Protein Coding) 2 3
  • C13orf25 3 4
  • MIRHG1 3 4
  • MIRH1 3 4
  • MiR-17-92 Cluster Host Gene (Non-Protein Coding) 3
  • MicroRNA Host Gene (Non-Protein Coding) 1 3
  • Putative MicroRNA Host Gene 1 Protein 4
  • Chromosome 13 Open Reading Frame 25 2
  • MiR-17-92 Cluster Host Gene 2
  • Mir-17-92 MicroRNA Cluster 3
  • Non-Protein Coding RNA 48 2
  • NCRNA00048 3
  • LINC00048 3
  • MiR-17-92 3
  • FGLDS2 3
  • MIHG1 3

External Ids for MIR17HG Gene

Previous HGNC Symbols for MIR17HG Gene

  • C13orf25
  • MIRHG1

Previous GeneCards Identifiers for MIR17HG Gene

  • GC13P090885
  • GC13P092000
  • GC13P072595

Summaries for MIR17HG Gene

Entrez Gene Summary for MIR17HG Gene

  • This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]

GeneCards Summary for MIR17HG Gene

MIR17HG (MiR-17-92a-1 Cluster Host Gene) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR17HG include Feingold Syndrome 2 and Feingold Syndrome 1. Among its related pathways are DNA Damage Response and Parkinsons Disease Pathway.

Gene Wiki entry for MIR17HG Gene

Additional gene information for MIR17HG Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR17HG Gene

Genomics for MIR17HG Gene

GeneHancer (GH) Regulatory Elements for MIR17HG Gene

Promoters and enhancers for MIR17HG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I091346 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 550.8 +1.2 1213 4.8 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 GC13P091372 GC13P091377 GC13P091384 GC13P091391 GC13P091394 GC13P091397 GC13P091399 GC13P091400 GC13P091401 MIR17
GH13I090414 Enhancer 0.8 Ensembl ENCODE 18.7 -931.9 -931909 3.3 JUND MCM3 GATA3 JUN TSC22D4 MCM5 FOS MCM2 BRF2 MIR17HG GC13M090461 LOC105370310
GH13I091137 Enhancer 0.7 ENCODE 10.4 -213.4 -213418 0.2 CTCF PKNOX1 MCM2 RAD21 FOSL1 CBX5 ARID2 PHF20 ZNF143 SMC3 MIR17HG GC13M091153 LOC105370312 LINC00379
GH13I090926 Enhancer 0.5 ENCODE 10.4 -421.2 -421172 1 SP1 MAFG MCM5 MAFK EMSY LINC00410 MIR17HG GC13P090934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR17HG on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR17HG Gene

Genomic Locations for MIR17HG Gene
chr13:91,347,820-91,354,579
(GRCh38/hg38)
Size:
6,760 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)

Genomic View for MIR17HG Gene

Genes around MIR17HG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR17HG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR17HG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR17HG Gene

Proteins for MIR17HG Gene

  • Protein details for MIR17HG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75NE6-MIRH1_HUMAN
    Recommended name:
    Putative microRNA 17 host gene protein
    Protein Accession:
    Q75NE6
    Secondary Accessions:
    • A4QMU7
    • Q75NE7

    Protein attributes for MIR17HG Gene

    Size:
    70 amino acids
    Molecular mass:
    8163 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The microRNAs that are encoded in a MIR17HG intron stimulate growth of cultured lung cancer cells.

    Alternative splice isoforms for MIR17HG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR17HG Gene

Post-translational modifications for MIR17HG Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR17HG Gene

Domains & Families for MIR17HG Gene

Gene Families for MIR17HG Gene

Protein Domains for MIR17HG Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MIR17HG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR17HG: view

No data available for UniProtKB/Swiss-Prot for MIR17HG Gene

Function for MIR17HG Gene

Phenotypes From GWAS Catalog for MIR17HG Gene

Phenotypes for MIR17HG Gene

genes like me logo Genes that share phenotypes with MIR17HG: view

Human Phenotype Ontology for MIR17HG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for MIR17HG Gene

miRTarBase miRNAs that target MIR17HG

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR17HG Gene

Localization for MIR17HG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR17HG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR17HG gene
Compartment Confidence
extracellular 2
nucleus 1

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR17HG Gene

Pathways & Interactions for MIR17HG Gene

genes like me logo Genes that share pathways with MIR17HG: view

Pathways by source for MIR17HG Gene

Interacting Proteins for MIR17HG Gene

Gene Ontology (GO) - Biological Process for MIR17HG Gene

None

No data available for SIGNOR curated interactions for MIR17HG Gene

Drugs & Compounds for MIR17HG Gene

No Compound Related Data Available

Transcripts for MIR17HG Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR17HG Gene

No ASD Table

Relevant External Links for MIR17HG Gene

GeneLoc Exon Structure for
MIR17HG
ECgene alternative splicing isoforms for
MIR17HG

Expression for MIR17HG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR17HG Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR17HG Gene:

MIR17HG

SOURCE GeneReport for Unigene cluster for MIR17HG Gene:

Hs.24115

mRNA Expression by UniProt/SwissProt for MIR17HG Gene:

Q75NE6-MIRH1_HUMAN
Tissue specificity: Highly expressed in B-cell lymphoma and lung cancer.

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR17HG Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • skull
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • toe
  • upper limb
genes like me logo Genes that share expression patterns with MIR17HG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for MIR17HG Gene

Orthologs for MIR17HG Gene

Evolution for MIR17HG Gene

ENSEMBL:
Gene Tree for MIR17HG (if available)
TreeFam:
Gene Tree for MIR17HG (if available)

No data available for Orthologs for MIR17HG Gene

Paralogs for MIR17HG Gene

No data available for Paralogs for MIR17HG Gene

Variants for MIR17HG Gene

Sequence variations from dbSNP and Humsavar for MIR17HG Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000172085 -- 91,347,710(+) G/A upstream_transcript_variant
rs1000282527 -- 91,354,875(+) T/C downstream_transcript_variant
rs1000599438 -- 91,347,229(+) A/G upstream_transcript_variant
rs1000971182 -- 91,352,246(+) G/C intron_variant, non_coding_transcript_variant
rs1001980789 -- 91,351,489(+) G/A intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR17HG Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897
nsv562697 CNV loss 21841781
nsv562696 CNV loss 21841781
esv28603 CNV loss 19812545
dgv3317n54 CNV loss 21841781
dgv3316n54 CNV gain 21841781
dgv3315n54 CNV gain+loss 21841781
dgv3314n54 CNV gain+loss 21841781
dgv3313n54 CNV loss 21841781

Additional Variant Information for MIR17HG Gene

Human Gene Mutation Database (HGMD)
MIR17HG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR17HG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR17HG Gene

Disorders for MIR17HG Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR17HG Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
feingold syndrome 2
  • fglds2
feingold syndrome 1
  • fglds1
mantle cell lymphoma
  • mcl
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MIRH1_HUMAN
  • Feingold syndrome 2 (FGLDS2) [MIM:614326]: A syndrome characterized by microcephaly, short stature, and digital abnormalities including brachydactyly, brachymesophalangy of the second and fifth fingers, hypoplastic thumbs of variable severity, and cutaneous syndactyly of the toes. {ECO:0000269 PubMed:21892160}. Note=The disease is caused by mutations affecting the gene represented in this entry. Microdeletions encompassing the MIR17HG locus can be responsible of FGLDS2.

Additional Disease Information for MIR17HG

genes like me logo Genes that share disorders with MIR17HG: view

No data available for Genatlas for MIR17HG Gene

Publications for MIR17HG Gene

  1. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. (PMID: 16266980) Hayashita Y … Takahashi T (Cancer research 2005) 2 3 4 22 58
  2. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. (PMID: 15126345) Ota A … Seto M (Cancer research 2004) 2 3 4 58
  3. Role of microRNA in the pathogenesis of malignant lymphoma. (PMID: 23551855) Tagawa H … Sawada K (Cancer science 2013) 2 3 58
  4. Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans. (PMID: 21892160) de Pontual L … Amiel J (Nature genetics 2011) 3 4 58
  5. Role for amplification and expression of glypican-5 in rhabdomyosarcoma. (PMID: 17210683) Williamson D … Shipley J (Cancer research 2007) 2 3 58

Products for MIR17HG Gene

Sources for MIR17HG Gene

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