This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistr... See more...

Aliases for MIR17HG Gene

Subcategory (RNA class) for MIR17HG Gene

lncRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR17HG Gene

  • MiR-17-92a-1 Cluster Host Gene 2 3 5
  • MIR17HG 2 5 165
  • MIRH1 2 3 4
  • Long Intergenic Non-Protein Coding RNA 48 2 3
  • MicroRNA Host Gene 1 (Non-Protein Coding) 2 3
  • MIR17 Host Gene (Non-Protein Coding) 2 3
  • NCRNA00048 2 3
  • LINC00048 2 3
  • MiR-17-92 2 3
  • C13orf25 3 4
  • MIRHG1 3 4
  • MIHG1 2 3
  • MiR-17-92 Cluster Host Gene (Non-Protein Coding) 3
  • MicroRNA Host Gene (Non-Protein Coding) 1 3
  • Putative MicroRNA 17 Host Gene Protein 4
  • Putative MicroRNA Host Gene 1 Protein 4
  • Chromosome 13 Open Reading Frame 25 2
  • MiR-17-92 Cluster Host Gene 2
  • Mir-17-92 MicroRNA Cluster 3
  • Non-Protein Coding RNA 48 2
  • NONHSAG013949.2 91
  • HSALNG0098601 164
  • FLJ14178 2
  • FGLDS2 3
  • 4F3T_R 167

External Ids for MIR17HG Gene

Previous HGNC Symbols for MIR17HG Gene

  • C13orf25
  • MIRHG1

Previous GeneCards Identifiers for MIR17HG Gene

  • GC13P090885
  • GC13P092000
  • GC13P072595

Summaries for MIR17HG Gene

Entrez Gene Summary for MIR17HG Gene

  • This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]

GeneCards Summary for MIR17HG Gene

MIR17HG (MiR-17-92a-1 Cluster Host Gene) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MIR17HG include Feingold Syndrome 2 and Diffuse Large B-Cell Lymphoma. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

Gene Wiki entry for MIR17HG Gene

Rfam classification for MIR17HG Gene

  • mir-17 microRNA precursor family
  • mir-19 microRNA precursor family
  • mir-92 microRNA precursor family

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MIR17HG Gene

Genomics for MIR17HG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR17HG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J091346 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.3 1314 5.2 GATAD2A CTCF TFE3 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 ZNF143 MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 AB372624 MIR19B1 MIR20A MIR92A1
GH13J091137 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 18.7 -210.7 -210695 5.6 CTCF JUND REST NR2C1 RAD21 TRIM22 MCM7 EP300 ARNT TCF7L2 MIR17HG piR-50443-107 LOC105370312 lnc-GPC5-2 LINC00379 GPC5
GH13J090414 Enhancer 0.7 Ensembl ENCODE 18.7 -931.8 -931801 3.4 JUND TSC22D4 MCM3 JUN MCM5 FOS XRCC3 GATA3 IRF2 BRF2 MIR17HG piR-38352-160 piR-50443-105 GPC5
GH13J091785 Enhancer 0.5 Ensembl 18.7 +438.0 437965 0.3 MCM3 MCM5 MAFG RFX5 JUNB BATF EMSY FJ601684-106 MIR17HG piR-38051-087 GPC5
GH13J090396 Enhancer 0.4 Ensembl 18.7 -950.6 -950586 1.8 MCM3 GATA3 MCM5 MIR17HG piR-50443-105 piR-38352-160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR17HG on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR17HG Gene

Genomic Locations for MIR17HG Gene
chr13:91,347,687-91,397,097
(GRCh38/hg38)
Size:
49,411 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR17HG Gene

Genes around MIR17HG on UCSC Golden Path with GeneCards custom track
MIR17HG in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR17HG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR17HG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR17HG Gene

Proteins for MIR17HG Gene

  • Protein details for MIR17HG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75NE6-MIRH1_HUMAN
    Recommended name:
    Putative microRNA 17 host gene protein
    Protein Accession:
    Q75NE6
    Secondary Accessions:
    • A4QMU7
    • Q75NE7

    Protein attributes for MIR17HG Gene

    Size:
    70 amino acids
    Molecular mass:
    8163 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The microRNAs that are encoded in a MIR17HG intron stimulate growth of cultured lung cancer cells.

    Alternative splice isoforms for MIR17HG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR17HG Gene

Post-translational modifications for MIR17HG Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR17HG Gene

Domains & Families for MIR17HG Gene

Gene Families for MIR17HG Gene

Protein Domains for MIR17HG Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MIR17HG Gene

GenScript: Design optimal peptide antigens:
  • Putative microRNA host gene 1 protein (MIRH1_HUMAN)
genes like me logo Genes that share domains with MIR17HG: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR17HG Gene

Function for MIR17HG Gene

Phenotypes From GWAS Catalog for MIR17HG Gene

Gene Ontology (GO) - Molecular Function for MIR17HG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21145484
genes like me logo Genes that share ontologies with MIR17HG: view

Phenotypes for MIR17HG Gene

genes like me logo Genes that share phenotypes with MIR17HG: view

Human Phenotype Ontology for MIR17HG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for MIR17HG Gene

miRTarBase miRNAs that target MIR17HG

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR17HG Gene

Localization for MIR17HG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR17HG Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR17HG gene
Compartment Confidence
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR17HG Gene

Pathways & Interactions for MIR17HG Gene

PathCards logo

SuperPathways for MIR17HG Gene

genes like me logo Genes that share pathways with MIR17HG: view

Pathways by source for MIR17HG Gene

Gene Ontology (GO) - Biological Process for MIR17HG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0002903 negative regulation of B cell apoptotic process ISS --
GO:0003151 outflow tract morphogenesis ISS --
GO:0003215 cardiac right ventricle morphogenesis ISS --
GO:0014739 positive regulation of muscle hyperplasia IDA 23271053
genes like me logo Genes that share ontologies with MIR17HG: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR17HG Gene

Drugs & Compounds for MIR17HG Gene

No Compound Related Data Available

Transcripts for MIR17HG Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR17HG Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00008BF7B1_9606 lncRNA 2032 4

Ensembl: ENST00000581816 (view in UCSC) ,

LncBook: HSALNT0205333, HSALNT0205334,

LNCipedia: MIR17HG:5,

NONCODE: NONHSAT034667.2,

URS00008B3CB9_9606 lncRNA 931 4

Ensembl: ENST00000400282 (view in UCSC) ,

LncBook: HSALNT0205330,

LNCipedia: MIR17HG:1,

NONCODE: NONHSAT034666.2,

URS000075DA42_9606 lncRNA 927 4

HGNC: 23564,

RefSeq: NR_027349,

LncBook: HSALNT0205332,

LNCipedia: MIR17HG:4,

URS000075DE64_9606 lncRNA 5018 3

RefSeq: NR_027350,

LNCipedia: MIR17HG:3,

NONCODE: NONHSAT034665.2,

URS0000EEB37D_9606 lncRNA 1096 1

Ensembl: ENST00000659898 (view in UCSC) ,

MIR17HG in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR17HG Gene

6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR17HG Gene

No ASD Table

Relevant External Links for MIR17HG Gene

GeneLoc Exon Structure for
MIR17HG

Expression for MIR17HG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR17HG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR17HG

SOURCE GeneReport for Unigene cluster for MIR17HG Gene:

Hs.24115

mRNA Expression by UniProt/SwissProt for MIR17HG Gene:

Q75NE6-MIRH1_HUMAN
Tissue specificity: Highly expressed in B-cell lymphoma and lung cancer.

Evidence on tissue expression from TISSUES for MIR17HG Gene

  • Blood(2.6)
  • Heart(2.4)
  • Intestine(2.3)
  • Muscle(2.2)
  • Nervous system(2.2)
  • Liver(2.2)
  • Lymph node(2.2)
  • Skin(2.1)
  • Bone marrow(2.1)
  • Kidney(2)
  • Lung(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR17HG Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • skull
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • toe
  • upper limb
genes like me logo Genes that share expression patterns with MIR17HG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR17HG Gene

Orthologs for MIR17HG Gene

Evolution for MIR17HG Gene

ENSEMBL:
Gene Tree for MIR17HG (if available)
TreeFam:
Gene Tree for MIR17HG (if available)

No data available for Orthologs for MIR17HG Gene

Paralogs for MIR17HG Gene

No data available for Paralogs for MIR17HG Gene

Variants for MIR17HG Gene

Additional dbSNP identifiers (rs#s) for MIR17HG Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR17HG Gene

Variant ID Type Subtype PubMed ID
dgv3313n54 CNV loss 21841781
dgv3314n54 CNV gain+loss 21841781
dgv3315n54 CNV gain+loss 21841781
dgv3316n54 CNV gain 21841781
dgv3317n54 CNV loss 21841781
esv28603 CNV loss 19812545
nsv562696 CNV loss 21841781
nsv562697 CNV loss 21841781
nsv832679 CNV gain 17160897

Additional Variant Information for MIR17HG Gene

Human Gene Mutation Database (HGMD)
MIR17HG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR17HG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR17HG Gene

Disorders for MIR17HG Gene

MalaCards: The human disease database

(15) MalaCards diseases for MIR17HG Gene - From: LncRNADisease, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
feingold syndrome 2
  • fglds2
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
astrocytoma
  • astrocytic tumor
glioma susceptibility 1
  • glm1
b-cell lymphoma
  • b-cell lymphocytic neoplasm
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MIRH1_HUMAN
  • Feingold syndrome 2 (FGLDS2) [MIM:614326]: A syndrome characterized by microcephaly, short stature, and digital abnormalities including brachydactyly, brachymesophalangy of the second and fifth fingers, hypoplastic thumbs of variable severity, and cutaneous syndactyly of the toes. {ECO:0000269 PubMed:21892160}. Note=The disease is caused by mutations affecting the gene represented in this entry. Microdeletions encompassing the MIR17HG locus can be responsible of FGLDS2.

Additional Disease Information for MIR17HG

genes like me logo Genes that share disorders with MIR17HG: view

No data available for Genatlas for MIR17HG Gene

Publications for MIR17HG Gene

  1. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. (PMID: 16266980) Hayashita Y … Takahashi T (Cancer research 2005) 2 3 4 23
  2. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. (PMID: 15126345) Ota A … Seto M (Cancer research 2004) 2 3 4
  3. Role of microRNA in the pathogenesis of malignant lymphoma. (PMID: 23551855) Tagawa H … Sawada K (Cancer science 2013) 2 3
  4. Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans. (PMID: 21892160) de Pontual L … Amiel J (Nature genetics 2011) 3 4
  5. Role for amplification and expression of glypican-5 in rhabdomyosarcoma. (PMID: 17210683) Williamson D … Shipley J (Cancer research 2007) 2 3

Products for MIR17HG Gene

Sources for MIR17HG Gene