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Aliases for MIR17HG Gene

Subcategory (RNA class) for MIR17HG Gene


Quality Score for this RNA gene is


Aliases for MIR17HG Gene

  • MiR-17-92a-1 Cluster Host Gene 2 3 5
  • Long Intergenic Non-Protein Coding RNA 48 2 3
  • MicroRNA Host Gene 1 (Non-Protein Coding) 2 3
  • MIR17 Host Gene (Non-Protein Coding) 2 3
  • C13orf25 3 4
  • MIRHG1 3 4
  • MIRH1 3 4
  • MiR-17-92 Cluster Host Gene (Non-Protein Coding) 3
  • MicroRNA Host Gene (Non-Protein Coding) 1 3
  • Putative MicroRNA Host Gene 1 Protein 4
  • Chromosome 13 Open Reading Frame 25 2
  • MiR-17-92 Cluster Host Gene 2
  • Mir-17-92 MicroRNA Cluster 3
  • Non-Protein Coding RNA 48 2
  • NCRNA00048 3
  • LINC00048 3
  • MiR-17-92 3
  • FGLDS2 3
  • MIHG1 3

External Ids for MIR17HG Gene

Previous HGNC Symbols for MIR17HG Gene

  • C13orf25
  • MIRHG1

Previous GeneCards Identifiers for MIR17HG Gene

  • GC13P090885
  • GC13P092000
  • GC13P072595

Summaries for MIR17HG Gene

Entrez Gene Summary for MIR17HG Gene

  • This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]

GeneCards Summary for MIR17HG Gene

MIR17HG (MiR-17-92a-1 Cluster Host Gene) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR17HG include Feingold Syndrome 2 and Diffuse Large B-Cell Lymphoma. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

Gene Wiki entry for MIR17HG Gene

Additional gene information for MIR17HG Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR17HG Gene

Genomics for MIR17HG Gene

GeneHancer (GH) Regulatory Elements for MIR17HG Gene

Promoters and enhancers for MIR17HG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J091346 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 650.7 +1.2 1213 4.8 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 GC13P091377 GC13P091378 GC13P091393 GC13P091397 GC13P091402 GC13P091404 GC13P091405 GC13P091406 GC13P091407 MIR17
GH13J090414 Enhancer 0.8 Ensembl ENCODE 18.7 -931.9 -931909 3.3 IRF2 MCM3 JUN TSC22D4 MCM5 MCM2 BRF2 GATA3 JUND FOS MIR17HG GC13M090461 LOC105370310
GH13J091137 Enhancer 0.7 ENCODE 10.4 -213.4 -213418 0.2 CTCF PKNOX1 MCM2 RAD21 FOSL1 CBX5 ARID2 PHF20 ZNF143 SMC3 MIR17HG GC13M091153 LOC105370312 LINC00379
GH13J090926 Enhancer 0.5 ENCODE 10.4 -421.2 -421172 1 SP1 MAFG MCM5 EMSY MAFK LINC00410 MIR17HG GC13P090934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR17HG on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR17HG Gene

Genomic Locations for MIR17HG Gene
6,760 bases
Plus strand
6,760 bases
Plus strand

Genomic View for MIR17HG Gene

Genes around MIR17HG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR17HG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR17HG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR17HG Gene

Proteins for MIR17HG Gene

  • Protein details for MIR17HG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative microRNA 17 host gene protein
    Protein Accession:
    Secondary Accessions:
    • A4QMU7
    • Q75NE7

    Protein attributes for MIR17HG Gene

    70 amino acids
    Molecular mass:
    8163 Da
    Quaternary structure:
    No Data Available
    • The microRNAs that are encoded in a MIR17HG intron stimulate growth of cultured lung cancer cells.

    Alternative splice isoforms for MIR17HG Gene


neXtProt entry for MIR17HG Gene

Post-translational modifications for MIR17HG Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR17HG Gene

Domains & Families for MIR17HG Gene

Gene Families for MIR17HG Gene

Protein Domains for MIR17HG Gene


Suggested Antigen Peptide Sequences for MIR17HG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR17HG: view

No data available for UniProtKB/Swiss-Prot for MIR17HG Gene

Function for MIR17HG Gene

Phenotypes From GWAS Catalog for MIR17HG Gene

Gene Ontology (GO) - Molecular Function for MIR17HG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21145484
genes like me logo Genes that share ontologies with MIR17HG: view

Phenotypes for MIR17HG Gene

genes like me logo Genes that share phenotypes with MIR17HG: view

Human Phenotype Ontology for MIR17HG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for MIR17HG Gene

miRTarBase miRNAs that target MIR17HG

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR17HG Gene

Localization for MIR17HG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR17HG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR17HG gene
Compartment Confidence
extracellular 2
nucleus 1

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR17HG Gene

Pathways & Interactions for MIR17HG Gene

genes like me logo Genes that share pathways with MIR17HG: view

Pathways by source for MIR17HG Gene

Interacting Proteins for MIR17HG Gene

Gene Ontology (GO) - Biological Process for MIR17HG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0002903 negative regulation of B cell apoptotic process ISS --
GO:0003151 outflow tract morphogenesis ISS --
GO:0003215 cardiac right ventricle morphogenesis ISS --
GO:0014739 positive regulation of muscle hyperplasia IDA 23271053
genes like me logo Genes that share ontologies with MIR17HG: view

No data available for SIGNOR curated interactions for MIR17HG Gene

Drugs & Compounds for MIR17HG Gene

No Compound Related Data Available

Transcripts for MIR17HG Gene

mRNA/cDNA for MIR17HG Gene

Unigene Clusters for MIR17HG Gene

MiR-17-92 cluster host gene (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIR17HG Gene

No ASD Table

Relevant External Links for MIR17HG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR17HG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR17HG Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR17HG Gene:


SOURCE GeneReport for Unigene cluster for MIR17HG Gene:


mRNA Expression by UniProt/SwissProt for MIR17HG Gene:

Tissue specificity: Highly expressed in B-cell lymphoma and lung cancer.

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR17HG Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • nervous
  • skeleton
Head and neck:
  • brain
  • head
  • skull
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • toe
  • upper limb
genes like me logo Genes that share expression patterns with MIR17HG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for MIR17HG Gene

Orthologs for MIR17HG Gene

Evolution for MIR17HG Gene

Gene Tree for MIR17HG (if available)
Gene Tree for MIR17HG (if available)

No data available for Orthologs for MIR17HG Gene

Paralogs for MIR17HG Gene

No data available for Paralogs for MIR17HG Gene

Variants for MIR17HG Gene

Sequence variations from dbSNP and Humsavar for MIR17HG Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000172085 -- 91,347,710(+) G/A upstream_transcript_variant
rs1000282527 -- 91,354,875(+) T/C downstream_transcript_variant
rs1000599438 -- 91,347,229(+) A/G upstream_transcript_variant
rs1000971182 -- 91,352,246(+) G/C intron_variant, non_coding_transcript_variant
rs1001980789 -- 91,351,489(+) G/A intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR17HG Gene

Variant ID Type Subtype PubMed ID
dgv3313n54 CNV loss 21841781
dgv3314n54 CNV gain+loss 21841781
dgv3315n54 CNV gain+loss 21841781
dgv3316n54 CNV gain 21841781
dgv3317n54 CNV loss 21841781
esv28603 CNV loss 19812545
nsv562696 CNV loss 21841781
nsv562697 CNV loss 21841781
nsv832679 CNV gain 17160897

Additional Variant Information for MIR17HG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR17HG Gene

Disorders for MIR17HG Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR17HG Gene - From: LncRNADisease, HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
feingold syndrome 2
  • fglds2
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
  • glioblastoma multiforme
feingold syndrome 1
  • fglds1
mantle cell lymphoma
  • lymphoma, mantle cell
- elite association - COSMIC cancer census association via MalaCards


  • Feingold syndrome 2 (FGLDS2) [MIM:614326]: A syndrome characterized by microcephaly, short stature, and digital abnormalities including brachydactyly, brachymesophalangy of the second and fifth fingers, hypoplastic thumbs of variable severity, and cutaneous syndactyly of the toes. {ECO:0000269 PubMed:21892160}. Note=The disease is caused by mutations affecting the gene represented in this entry. Microdeletions encompassing the MIR17HG locus can be responsible of FGLDS2.

Additional Disease Information for MIR17HG

genes like me logo Genes that share disorders with MIR17HG: view

No data available for Genatlas for MIR17HG Gene

Publications for MIR17HG Gene

  1. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. (PMID: 16266980) Hayashita Y … Takahashi T (Cancer research 2005) 2 3 4 22 58
  2. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. (PMID: 15126345) Ota A … Seto M (Cancer research 2004) 2 3 4 58
  3. Role of microRNA in the pathogenesis of malignant lymphoma. (PMID: 23551855) Tagawa H … Sawada K (Cancer science 2013) 2 3 58
  4. Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans. (PMID: 21892160) de Pontual L … Amiel J (Nature genetics 2011) 3 4 58
  5. Role for amplification and expression of glypican-5 in rhabdomyosarcoma. (PMID: 17210683) Williamson D … Shipley J (Cancer research 2007) 2 3 58

Products for MIR17HG Gene

Sources for MIR17HG Gene

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