microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR17 Gene

Subcategory (RNA class) for MIR17 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR17 Gene

  • MicroRNA 17 2 3 5
  • Hsa-MiR-17-5p 163 173
  • Hsa-MiR-17-3p 163 173
  • Hsa-Mir-17 2 3
  • MIR17 2 5
  • Hsa-Mir-17-P1a 178
  • MIMAT0000070 50
  • MIMAT0000071 50
  • MI0000071 50
  • MIR17-5p 3
  • MiR17-3p 3
  • MiRNA17 3
  • MiRNA91 3
  • RF00051 168
  • MIRN17 3
  • MIRN91 3
  • MiR-17 3
  • MIR91 3

External Ids for MIR17 Gene

Previous HGNC Symbols for MIR17 Gene

  • MIRN17

Previous GeneCards Identifiers for MIR17 Gene

  • GC13P090870
  • GC13P090878
  • GC13P092002

Summaries for MIR17 Gene

Entrez Gene Summary for MIR17 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR17 Gene

MIR17 (MicroRNA 17) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR17 include B-Cell Lymphoma and Polycystic Kidney Disease. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

Rfam classification for MIR17 Gene

  • mir-17 microRNA precursor family

Additional gene information for MIR17 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR17 Gene

Genomics for MIR17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J091346 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.6 -1604 5.2 GATAD2A CTCF TFE3 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 ZNF143 MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 AB372624 MIR19B1 MIR20A MIR92A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR17 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR17 Gene

Genomic Locations for MIR17 Gene
chr13:91,350,605-91,350,688
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR17 Gene

Genes around MIR17 on UCSC Golden Path with GeneCards custom track
MIR17 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR17 Gene

Proteins for MIR17 Gene

Post-translational modifications for MIR17 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR17 Gene

Domains & Families for MIR17 Gene

Gene Families for MIR17 Gene

genes like me logo Genes that share domains with MIR17: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR17 Gene

Function for MIR17 Gene

Gene Ontology (GO) - Molecular Function for MIR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 19390056
genes like me logo Genes that share ontologies with MIR17: view

Animal Model Products

CRISPR Products

miRNA for MIR17 Gene

miRTarBase miRNAs that target MIR17

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR17 Gene

Localization for MIR17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR17 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005739 mitochondrion IEA --
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR17 Gene

Pathways & Interactions for MIR17 Gene

genes like me logo Genes that share pathways with MIR17: view

Pathways by source for MIR17 Gene

1 KEGG pathway for MIR17 Gene

Gene Ontology (GO) - Biological Process for MIR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003085 negative regulation of systemic arterial blood pressure ISS --
GO:0003151 outflow tract morphogenesis ISS --
GO:0010629 negative regulation of gene expression IDA 22161164
GO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS --
GO:0010989 negative regulation of low-density lipoprotein particle clearance IDA 23285084
genes like me logo Genes that share ontologies with MIR17: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR17 Gene

Drugs & Compounds for MIR17 Gene

No Compound Related Data Available

Transcripts for MIR17 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR17 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00002075FA_9606 miRNA 23 6

RefSeq: NR_029487,

LncBase: hsa-miR-17-5p,

miRBase: MIMAT0000070,

MirGeneDB: Hsa-Mir-17-P1a_5p,

TarBase: hsa-miR-17-5p,

ENA: LM378757.1:1..23:ncRNA, LM608160.1:14..36:ncRNA,

URS000032AA22_9606 precursor_RNA 84 5

HGNC: 31547,

RefSeq: NR_029487,

Ensembl: ENST00000385012 (view in UCSC) ,

miRBase: MI0000071,

ENA: LM608160.1:1..84:precursor_RNA,

URS00004636A3_9606 miRNA 22 5

RefSeq: NR_029487,

LncBase: hsa-miR-17-3p,

miRBase: MIMAT0000071,

TarBase: hsa-miR-17-3p,

ENA: EU293794.1:38..59:ncRNA, LM378758.1:1..22:ncRNA, LM608160.1:51..72:ncRNA,

URS00003E2EF2_9606 precursor_RNA 82 2

Rfam: RF00051,

ENA: AB176708.1:1049..1130:ncRNA, AF480562.1:1..82:misc_RNA,

URS0000EFD067_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-17-P1a,

MIR17 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR17 Gene

4 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR17 Gene

No ASD Table

Relevant External Links for MIR17 Gene

GeneLoc Exon Structure for
MIR17

Expression for MIR17 Gene

Evidence on tissue expression from TISSUES for MIR17 Gene

  • Blood(2.7)
  • Heart(2.4)
  • Intestine(2.4)
  • Liver(2.4)
  • Nervous system(2.4)
  • Muscle(2.3)
  • Skin(2.3)
  • Lymph node(2.3)
  • Kidney(2.3)
  • Bone marrow(2.1)
  • Lung(2.1)
  • Pancreas(2.1)
  • Saliva(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR17 Gene

Orthologs for MIR17 Gene

Evolution for MIR17 Gene

ENSEMBL:
Gene Tree for MIR17 (if available)
TreeFam:
Gene Tree for MIR17 (if available)

No data available for Orthologs for MIR17 Gene

Paralogs for MIR17 Gene

No data available for Paralogs for MIR17 Gene

Variants for MIR17 Gene

Additional dbSNP identifiers (rs#s) for MIR17 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR17 Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR17 Gene

Human Gene Mutation Database (HGMD)
MIR17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR17 Gene

Disorders for MIR17 Gene

MalaCards: The human disease database

(162) MalaCards diseases for MIR17 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphoma
  • b-cell lymphocytic neoplasm
polycystic kidney disease
  • pkd
pulmonary hypertension
  • primary pulmonary hypertension
sezary's disease
  • sezary disease
thyroid gland anaplastic carcinoma
  • anaplastic thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MIR17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR17 Gene

Publications for MIR17 Gene

  1. Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients. (PMID: 20810544) Pastrello C … Maestro R (Carcinogenesis 2010) 3 41
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
  3. Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions. (PMID: 32159700) Silva-Sousa AC … Küchler EC (Brazilian dental journal 2020) 3
  4. Circulatory miRNA biomarkers of metabolic syndrome. (PMID: 31435783) Ramzan F … Cameron-Smith D (Acta diabetologica 2020) 3
  5. LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy. (PMID: 30387831) Huang FX … Miao LJ (International journal of oncology 2019) 3

Products for MIR17 Gene

Sources for MIR17 Gene