microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR16-2 Gene

Subcategory (RNA class) for MIR16-2 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR16-2 Gene

  • MicroRNA 16-2 2 3 5
  • Hsa-MiR-16-2-3p 166 177
  • Hsa-MiR-16-5p 166 177
  • Hsa-Mir-16-2 3
  • MIMAT0004518 51
  • MIMAT0000069 51
  • MI0000115 51
  • Mir-16-2 3
  • Mir-16-3 3
  • MIRN16-2 3
  • MIR16-2 2
  • RF00254 172

External Ids for MIR16-2 Gene

Previous HGNC Symbols for MIR16-2 Gene

  • MIRN16-2

Previous GeneCards Identifiers for MIR16-2 Gene

  • GC03P161613
  • GC03P160123
  • GC03P160124
  • GC03P160130
  • GC03P160136
  • GC03P160405
  • GC03P160407
  • GC03P160417
  • GC03P160418
  • GC03P160416
  • GC03P160408
  • GC03P160409
  • GC03P160410
  • GC03P160411
  • GC03P160412
  • GC03P160413

Summaries for MIR16-2 Gene

Entrez Gene Summary for MIR16-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR16-2 Gene

MIR16-2 (MicroRNA 16-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR16-2 include Esophageal Cancer and Leukemia, Chronic Lymphocytic. Among its related pathways are Cell Differentiation - Index and Parkinsons Disease Pathway.

Rfam classification for MIR16-2 Gene

  • mir-16 microRNA precursor family

Additional gene information for MIR16-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR16-2 Gene

Genomics for MIR16-2 Gene

GeneHancer (GH) Regulatory Elements for MIR16-2 Gene

Promoters and enhancers for MIR16-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J160398 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.6 -2568 8 FOXK2 ZNF217 SIN3A NRF1 TCF12 POLR2G NCOR1 GTF2E2 PHF8 TEAD4 IFT80 SMC4 B3GAT3P1 MIR15B MIR16-2 RF00254 ENSG00000248710 TRIM59-IFT80-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR16-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR16-2 Gene

Genomic Locations for MIR16-2 Gene
chr3:160,404,745-160,404,825
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr3:160,122,533-160,122,613
(GRCh37/hg19)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR16-2 Gene

Genes around MIR16-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR16-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR16-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR16-2 Gene

Proteins for MIR16-2 Gene

Post-translational modifications for MIR16-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR16-2 Gene

Domains & Families for MIR16-2 Gene

Gene Families for MIR16-2 Gene

genes like me logo Genes that share domains with MIR16-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR16-2 Gene

Function for MIR16-2 Gene

Phenotypes From GWAS Catalog for MIR16-2 Gene

Gene Ontology (GO) - Molecular Function for MIR16-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR16-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR16-2 Gene

Localization for MIR16-2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR16-2 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for MIR16-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
GO:0005623 cell IEA --
GO:0070062 extracellular exosome IDA 23233752
genes like me logo Genes that share ontologies with MIR16-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR16-2 Gene

Pathways & Interactions for MIR16-2 Gene

genes like me logo Genes that share pathways with MIR16-2: view

Pathways by source for MIR16-2 Gene

2 BioSystems pathways for MIR16-2 Gene
1 KEGG pathway for MIR16-2 Gene
;

Gene Ontology (GO) - Biological Process for MIR16-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 21885851
GO:0008285 negative regulation of cell proliferation IGI 22139073
GO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS --
GO:0016525 negative regulation of angiogenesis IDA 21885851
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 30365148
genes like me logo Genes that share ontologies with MIR16-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR16-2 Gene

Drugs & Compounds for MIR16-2 Gene

No Compound Related Data Available

Transcripts for MIR16-2 Gene

mRNA/cDNA for MIR16-2 Gene

4 RNACentral transcripts :
2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
11 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR16-2 Gene

No ASD Table

Relevant External Links for MIR16-2 Gene

GeneLoc Exon Structure for
MIR16-2

Expression for MIR16-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR16-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR16-2

genes like me logo Genes that share expression patterns with MIR16-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR16-2 Gene

Orthologs for MIR16-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR16-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-16-2 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-16-2 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir16-2 31
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-16-2 31
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-16b 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-16b 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-16-2 31
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-16a 31
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-16a 31
  • 63 (a)
ManyToMany
dre-mir-457b 31
  • 59 (a)
ManyToMany
Species where no ortholog for MIR16-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR16-2 Gene

ENSEMBL:
Gene Tree for MIR16-2 (if available)
TreeFam:
Gene Tree for MIR16-2 (if available)

Paralogs for MIR16-2 Gene

No data available for Paralogs for MIR16-2 Gene

Variants for MIR16-2 Gene

Additional dbSNP identifiers (rs#s) for MIR16-2 Gene

Additional Variant Information for MIR16-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR16-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR16-2 Gene

Disorders for MIR16-2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR16-2 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR16-2

genes like me logo Genes that share disorders with MIR16-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR16-2 Gene

Publications for MIR16-2 Gene

  1. The mechanism of miR-16-5p protection on LPS-induced A549 cell injury by targeting CXCR3. (PMID: 30957556) Liu GP … Shang AQ (Artificial cells, nanomedicine, and biotechnology 2019) 3 54
  2. MiR-15/16 mediate crosstalk between the MAPK and Wnt/β-catenin pathways during hepatocyte differentiation from amniotic epithelial cells. (PMID: 30753902) Bai C … Gao Y (Biochimica et biophysica acta. Gene regulatory mechanisms 2019) 3 54
  3. Plasma let-7i, miR-16, and miR-221 levels as candidate biomarkers for the assessment of ankylosing spondylitis in Mexican patients naïve to anti-TNF therapy. (PMID: 30911942) Reyes-Loyola P … Amezcua-Guerra LM (Clinical rheumatology 2019) 3 54
  4. Serum miR-16 as a potential biomarker for human cancer diagnosis: results from a large-scale population. (PMID: 30706130) Huang Z … Hua D (Journal of cancer research and clinical oncology 2019) 3 54
  5. miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells. (PMID: 30664182) Han T … Zou J (International journal of molecular medicine 2019) 3 54

Products for MIR16-2 Gene

Sources for MIR16-2 Gene