microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR16-1 Gene

Subcategory (RNA class) for MIR16-1 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR16-1 Gene

  • MicroRNA 16-1 2 3 5
  • Hsa-MiR-16-1-3p 168 179
  • Hsa-MiR-16-5p 168 179
  • Hsa-Mir-16-1 3
  • MIMAT0000069 53
  • MIMAT0004489 53
  • MiRNA16-1 3
  • MI0000070 53
  • Mir-16-1 3
  • MIRN16-1 3
  • MIR16-1 2
  • RF00254 174

External Ids for MIR16-1 Gene

Previous HGNC Symbols for MIR16-1 Gene

  • MIRN16-1

Previous GeneCards Identifiers for MIR16-1 Gene

  • GC13M049527
  • GC13M050623

Summaries for MIR16-1 Gene

Entrez Gene Summary for MIR16-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR16-1 Gene

MIR16-1 (MicroRNA 16-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR16-1 include Pituitary Adenoma and Leukemia, Chronic Lymphocytic. Among its related pathways are DNA Damage Response and MicroRNAs in cancer.

Rfam classification for MIR16-1 Gene

  • mir-16 microRNA precursor family

Additional gene information for MIR16-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR16-1 Gene

Genomics for MIR16-1 Gene

GeneHancer (GH) Regulatory Elements for MIR16-1 Gene

Promoters and enhancers for MIR16-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J050015 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 11.6 +32.7 32661 4.4 TEAD4 CBFA2T2 PRDM1 DPF2 PKNOX1 GATAD2B EP300 SOX6 TCF12 OSR2 KCNRG MIR16-1 TRIM13 DLEU1 EBPL RCBTB1 piR-56497-041 DLEU2
GH13J050026 Enhancer 0.9 Ensembl ENCODE 12 +21.9 21864 0.8 ETV6 RELA MAFK MLLT1 ZNF687 CREM IKZF1 BACH1 TRIM22 IKZF2 MIR16-1 CAB39L lnc-KCNRG-1 ENSG00000277913 DLEU2
GH13J050023 Enhancer 0.3 FANTOM5 12 +25.6 25554 0.3 lnc-KCNRG-1 MIR16-1 TRIM13 RCBTB1 piR-56497-041 DLEU2
GH13J050025 Enhancer 0.2 Ensembl 12 +23.6 23560 0.6 lnc-KCNRG-1 MIR16-1 ENSG00000277913 DLEU2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR16-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR16-1 Gene

Genomic Locations for MIR16-1 Gene
chr13:50,048,973-50,049,061
(GRCh38/hg38)
Size:
89 bases
Orientation:
Minus strand
chr13:50,623,109-50,623,197
(GRCh37/hg19)
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR16-1 Gene

Genes around MIR16-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR16-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR16-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR16-1 Gene

Proteins for MIR16-1 Gene

Post-translational modifications for MIR16-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR16-1 Gene

Domains & Families for MIR16-1 Gene

Gene Families for MIR16-1 Gene

genes like me logo Genes that share domains with MIR16-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR16-1 Gene

Function for MIR16-1 Gene

Gene Ontology (GO) - Molecular Function for MIR16-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR16-1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR16-1 Gene

Localization for MIR16-1 Gene

Gene Ontology (GO) - Cellular Components for MIR16-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
GO:0005623 cell IEA --
GO:0016442 RISC complex IEA --
GO:0070062 extracellular exosome IDA 23233752
genes like me logo Genes that share ontologies with MIR16-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR16-1 Gene

Pathways & Interactions for MIR16-1 Gene

genes like me logo Genes that share pathways with MIR16-1: view

Gene Ontology (GO) - Biological Process for MIR16-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 21885851
GO:0008285 negative regulation of cell proliferation IGI 22139073
GO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS --
GO:0016525 negative regulation of angiogenesis IDA 21885851
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 30365148
genes like me logo Genes that share ontologies with MIR16-1: view

No data available for SIGNOR curated interactions for MIR16-1 Gene

Drugs & Compounds for MIR16-1 Gene

No Compound Related Data Available

Transcripts for MIR16-1 Gene

mRNA/cDNA for MIR16-1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) RNACentral transcripts :
(2) TarBase transcripts :
(11) ENA transcripts :
(1) Rfam transcripts :
(3) miRBase transcripts :
(2) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR16-1 Gene

No ASD Table

Relevant External Links for MIR16-1 Gene

GeneLoc Exon Structure for
MIR16-1
ECgene alternative splicing isoforms for
MIR16-1

Expression for MIR16-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR16-1 Gene

genes like me logo Genes that share expression patterns with MIR16-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR16-1 Gene

Orthologs for MIR16-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR16-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-16-1 33
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-16-1 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-16a 33
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-16-1 33
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir16-1 33
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-16a 33
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-16-1 33
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-16b 33
  • 43 (a)
OneToMany
dre-mir-16c 33
  • 39 (a)
OneToMany
Species where no ortholog for MIR16-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR16-1 Gene

ENSEMBL:
Gene Tree for MIR16-1 (if available)
TreeFam:
Gene Tree for MIR16-1 (if available)

Paralogs for MIR16-1 Gene

No data available for Paralogs for MIR16-1 Gene

Variants for MIR16-1 Gene

Sequence variations from dbSNP and Humsavar for MIR16-1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1001996172 -- 50,049,917(-) G/A upstream_transcript_variant
rs1003576601 -- 50,050,378(-) A/G upstream_transcript_variant
rs1003739787 -- 50,048,595(-) T/C downstream_transcript_variant
rs1005123286 -- 50,048,629(-) A/G/T downstream_transcript_variant
rs1005480841 -- 50,049,132(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR16-1 Gene

Variant ID Type Subtype PubMed ID
esv3580637 CNV loss 25503493
nsv1035151 CNV loss 25217958
nsv1054415 CNV loss 25217958
nsv561618 CNV loss 21841781

Additional Variant Information for MIR16-1 Gene

Human Gene Mutation Database (HGMD)
MIR16-1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR16-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR16-1 Gene

Disorders for MIR16-1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR16-1 Gene - From: HGMD, miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
leukemia, chronic lymphocytic
  • cll
mantle cell lymphoma
  • mcl
acute promyelocytic leukemia
  • apl
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR16-1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR16-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR16-1 Gene

Publications for MIR16-1 Gene

  1. Investigation of the miR16-1 (C > T) + 7 Substitution in Seven Different Types of Cancer from Three Ethnic Groups. (PMID: 19865490) Yazici H … Santella RM (Journal of oncology 2009) 3 43 56
  2. The mechanism of miR-16-5p protection on LPS-induced A549 cell injury by targeting CXCR3. (PMID: 30957556) Liu GP … Shang AQ (Artificial cells, nanomedicine, and biotechnology 2019) 3 56
  3. The expression levels of miRNA-15a and miRNA-16-1 in circulating tumor cells of patients with diffuse large B-cell lymphoma. (PMID: 30552617) Tuncer SB … Yazici H (Molecular biology reports 2019) 3 56
  4. Upregulation of microRNA‑16 alters the response to inhaled β‑agonists in patients with asthma though modulating expression of ADRB2. (PMID: 30942450) Yu B … Xing T (Molecular medicine reports 2019) 3 56
  5. Serum miR-16 as a potential biomarker for human cancer diagnosis: results from a large-scale population. (PMID: 30706130) Huang Z … Hua D (Journal of cancer research and clinical oncology 2019) 3 56

Products for MIR16-1 Gene

Sources for MIR16-1 Gene