microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR15B Gene

RNA type for MIR15B Gene

miRNA

Aliases for MIR15B Gene

External Ids for MIR15B Gene

Previous HGNC Symbols for MIR15B Gene

  • MIRN15B

Previous GeneCards Identifiers for MIR15B Gene

  • GC03P161612
  • GC03P160122

Summaries for MIR15B Gene

Entrez Gene Summary for MIR15B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15B Gene

MIR15B (MicroRNA 15b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR15B include Glioma and Gastric Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

Rfam classification for MIR15B Gene

  • mir-15 microRNA precursor family

Additional gene information for MIR15B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR15B Gene

Genomics for MIR15B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR15B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J160398 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.3 -2311 8.2 BCLAF1 MYC NCOR1 IKZF1 ATF2 POLR2A ZNF10 BRCA1 YY1 MXD4 IFT80 SMC4 HSALNG0030223 HSALNG0030224-001 B3GAT3P1 MIR15B MIR16-2 RF00254 ENSG00000248710 TRIM59-IFT80
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR15B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR15B Gene

Latest Assembly
chr3:160,404,588-160,404,685
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand

Previous Assembly
chr3:160,122,376-160,122,473
(GRCh37/hg19 by Entrez Gene)
Size:
98 bases
Orientation:
Plus strand

chr3:160,122,376-160,122,473
(GRCh37/hg19 by Ensembl)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR15B Gene

Genes around MIR15B on UCSC Golden Path with GeneCards custom track
MIR15B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15B Gene

Proteins for MIR15B Gene

Post-translational modifications for MIR15B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15B Gene

Domains & Families for MIR15B Gene

Gene Families for MIR15B Gene

genes like me logo Genes that share domains with MIR15B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR15B Gene

Function for MIR15B Gene

Phenotypes From GWAS Catalog for MIR15B Gene

Gene Ontology (GO) - Molecular Function for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 23688497
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18449891
genes like me logo Genes that share ontologies with MIR15B: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15B Gene

Localization for MIR15B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR15B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 28254819
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR15B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR15B Gene

Pathways & Interactions for MIR15B Gene

genes like me logo Genes that share pathways with MIR15B: view

Pathways by source for MIR15B Gene

Gene Ontology (GO) - Biological Process for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 branching involved in blood vessel morphogenesis IMP 23688497
GO:0003300 cardiac muscle hypertrophy ISS --
GO:0008285 negative regulation of cell proliferation IGI 22139073
GO:0016525 negative regulation of angiogenesis ISS --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with MIR15B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR15B Gene

Drugs & Compounds for MIR15B Gene

No Compound Related Data Available

Transcripts for MIR15B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR15B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000045A9D7_9606 miRNA 22 6

RefSeq: NR_029663,

LncBase: hsa-miR-15b-3p,

miRBase: MIMAT0004586,

MirGeneDB: Hsa-Mir-15-P1b_3p,

TarBase: hsa-miR-15b-3p,

ENA: LM380264.1:1..22:ncRNA, LM608478.1:58..79:ncRNA,

URS00004AD914_9606 miRNA 22 6

RefSeq: NR_029663,

LncBase: hsa-miR-15b-5p,

miRBase: MIMAT0000417,

MirGeneDB: Hsa-Mir-15-P1b_5p,

TarBase: hsa-miR-15b-5p,

ENA: HB859644.1:1..22:misc_RNA, LM379035.1:1..22:ncRNA, LM608478.1:20..41:ncRNA,

URS000041CB9C_9606 pre_miRNA 98 4

RefSeq: NR_029663,

Ensembl: ENST00000385045 (view in UCSC) ,

miRBase: MI0000438,

ENA: LM608478.1:1..98:precursor_RNA,

URS0000685300_9606 pre_miRNA 86 1

Rfam: RF00455,

URS0000EFE533_9606 pre_miRNA 61 1

MirGeneDB: Hsa-Mir-15-P1b,

MIR15B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR15B Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15B Gene

No ASD Table

Relevant External Links for MIR15B Gene

GeneLoc Exon Structure for
MIR15B

Expression for MIR15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR15B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR15B

Evidence on tissue expression from TISSUES for MIR15B Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR15B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15B Gene

Orthologs for MIR15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR15B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-15b 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-15b 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-15b 30
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir15b 30
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-15a 30
  • 65 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-15b 30
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-15b 30
  • 93 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-15a 30
  • 82 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-15c 30
  • 72 (a)
OneToOne
Species where no ortholog for MIR15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR15B Gene

ENSEMBL:
Gene Tree for MIR15B (if available)
TreeFam:
Gene Tree for MIR15B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR15B

Paralogs for MIR15B Gene

No data available for Paralogs for MIR15B Gene

Variants for MIR15B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR15B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR15B
Leiden Open Variation Database (LOVD)
MIR15B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR15B Gene

Disorders for MIR15B Gene

MalaCards: The human disease database

(60) MalaCards diseases for MIR15B Gene - From: MID, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR15B

genes like me logo Genes that share disorders with MIR15B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR15B Gene

Publications for MIR15B Gene

  1. MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. (PMID: 19135980) Xia H … Lin MC (Biochemical and biophysical research communications 2009) 3 72
  2. miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. (PMID: 18449891) Xia L … Fan D (International journal of cancer 2008) 3 72
  3. Circulating miR-15b, miR-34a and miR-218 as promising novel early low-invasive biomarkers of cervical carcinogenesis. (PMID: 33112434) Ocadiz-Delgado R … Gariglio P (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2021) 3
  4. MiR-15b and miR-16 suppress TGF-β1-induced proliferation and fibrogenesis by regulating LOXL1 in hepatic stellate cells. (PMID: 33545201) Ma L … Kang Y (Life sciences 2021) 3
  5. MicroRNA-15a, microRNA-15b and microRNA-16 inhibit the human dopamine D1 receptor expression in four cell lines by targeting 3'UTR -12 bp to + 154 bp. (PMID: 31858826) Wu X … Yao J (Artificial cells, nanomedicine, and biotechnology 2020) 3

Products for MIR15B Gene

Sources for MIR15B Gene