microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR15B Gene

Subcategory (RNA class) for MIR15B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR15B Gene

  • MicroRNA 15b 2 3 5
  • Hsa-MiR-15b-5p 163 173
  • Hsa-MiR-15b-3p 163 173
  • Hsa-Mir-15b 2 3
  • MIR15B 2 5
  • Hsa-Mir-15-P1b 178
  • MIMAT0004586 50
  • MIMAT0000417 50
  • MI0000438 50
  • MIRN15B 3
  • MiR-15b 3
  • RF00455 168

External Ids for MIR15B Gene

Previous HGNC Symbols for MIR15B Gene

  • MIRN15B

Previous GeneCards Identifiers for MIR15B Gene

  • GC03P161612
  • GC03P160122

Summaries for MIR15B Gene

Entrez Gene Summary for MIR15B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15B Gene

MIR15B (MicroRNA 15b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR15B include Glioma and Gastric Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Ectoderm Differentiation.

Rfam classification for MIR15B Gene

  • mir-15 microRNA precursor family

Additional gene information for MIR15B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR15B Gene

Genomics for MIR15B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR15B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J160398 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.4 -2411 8 BRCA1 ARHGAP35 CREB1 TEAD4 PRDM10 ZNF629 RFX1 LEF1 IKZF1 ZNF692 IFT80 SMC4 B3GAT3P1 MIR15B MIR16-2 RF00254 ENSG00000248710 TRIM59-IFT80
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR15B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR15B Gene

Genomic Locations for MIR15B Gene
chr3:160,404,588-160,404,685
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand
chr3:160,122,376-160,122,473
(GRCh37/hg19)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR15B Gene

Genes around MIR15B on UCSC Golden Path with GeneCards custom track
MIR15B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15B Gene

Proteins for MIR15B Gene

Post-translational modifications for MIR15B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15B Gene

Domains & Families for MIR15B Gene

Gene Families for MIR15B Gene

genes like me logo Genes that share domains with MIR15B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR15B Gene

Function for MIR15B Gene

Phenotypes From GWAS Catalog for MIR15B Gene

Gene Ontology (GO) - Molecular Function for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 23688497
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18449891
genes like me logo Genes that share ontologies with MIR15B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15B Gene

Localization for MIR15B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR15B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 28254819
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR15B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR15B Gene

Pathways & Interactions for MIR15B Gene

genes like me logo Genes that share pathways with MIR15B: view

Pathways by source for MIR15B Gene

Gene Ontology (GO) - Biological Process for MIR15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 branching involved in blood vessel morphogenesis IMP 23688497
GO:0003300 cardiac muscle hypertrophy ISS --
GO:0008285 negative regulation of cell proliferation IGI 22139073
GO:0016525 negative regulation of angiogenesis ISS --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with MIR15B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR15B Gene

Drugs & Compounds for MIR15B Gene

No Compound Related Data Available

Transcripts for MIR15B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR15B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000045A9D7_9606 miRNA 22 6

RefSeq: NR_029663,

LncBase: hsa-miR-15b-3p,

miRBase: MIMAT0004586,

MirGeneDB: Hsa-Mir-15-P1b_3p,

TarBase: hsa-miR-15b-3p,

ENA: LM380264.1:1..22:ncRNA, LM608478.1:58..79:ncRNA,

URS00004AD914_9606 miRNA 22 6

RefSeq: NR_029663,

LncBase: hsa-miR-15b-5p,

miRBase: MIMAT0000417,

MirGeneDB: Hsa-Mir-15-P1b_5p,

TarBase: hsa-miR-15b-5p,

ENA: HB859644.1:1..22:misc_RNA, LM379035.1:1..22:ncRNA, LM608478.1:20..41:ncRNA,

URS000041CB9C_9606 precursor_RNA 98 5

HGNC: 31544,

RefSeq: NR_029663,

Ensembl: ENST00000385045 (view in UCSC) ,

miRBase: MI0000438,

ENA: LM608478.1:1..98:precursor_RNA,

URS0000685300_9606 precursor_RNA 86 1

Rfam: RF00455,

URS0000EFE533_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-15-P1b,

MIR15B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR15B Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15B Gene

No ASD Table

Relevant External Links for MIR15B Gene

GeneLoc Exon Structure for
MIR15B

Expression for MIR15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR15B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR15B

Evidence on tissue expression from TISSUES for MIR15B Gene

  • Blood(2.4)
  • Heart(2.1)
  • Nervous system(2.1)
  • Liver(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with MIR15B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15B Gene

Orthologs for MIR15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR15B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-15b 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-15b 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-15b 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir15b 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-15a 31
  • 65 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-15b 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-15b 31
  • 93 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-15a 31
  • 82 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-15c 31
  • 72 (a)
OneToOne
Species where no ortholog for MIR15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR15B Gene

ENSEMBL:
Gene Tree for MIR15B (if available)
TreeFam:
Gene Tree for MIR15B (if available)

Paralogs for MIR15B Gene

No data available for Paralogs for MIR15B Gene

Variants for MIR15B Gene

Additional dbSNP identifiers (rs#s) for MIR15B Gene

Additional Variant Information for MIR15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR15B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR15B Gene

Disorders for MIR15B Gene

MalaCards: The human disease database

(57) MalaCards diseases for MIR15B Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR15B

genes like me logo Genes that share disorders with MIR15B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR15B Gene

Publications for MIR15B Gene

  1. Long non-coding RNA AGAP2-AS1 promotes the proliferation of glioma cells by sponging miR-15a/b-5p to upregulate the expression of HDGF and activating Wnt/β-catenin signaling pathway. (PMID: 30684575) Zheng Y … Zheng J (International journal of biological macromolecules 2019) 3
  2. SSTR5‑AS1 functions as a ceRNA to regulate CA2 by sponging miR‑15b‑5p for the development and prognosis of HBV‑related hepatocellular carcinoma. (PMID: 31638225) Xu J … Wang Y (Molecular medicine reports 2019) 3
  3. LncRNA-H19 activates CDC42/PAK1 pathway to promote cell proliferation, migration and invasion by targeting miR-15b in hepatocellular carcinoma. (PMID: 30543848) Zhou Y … Zha WZ (Genomics 2019) 3
  4. Upregulated microRNA-15b alleviates ovarian cancer through inhitbition of the PI3K/Akt pathway by targeting LPAR3. (PMID: 31140597) Li GC … Gong JL (Journal of cellular physiology 2019) 3
  5. MiR-15/16 mediate crosstalk between the MAPK and Wnt/β-catenin pathways during hepatocyte differentiation from amniotic epithelial cells. (PMID: 30753902) Bai C … Gao Y (Biochimica et biophysica acta. Gene regulatory mechanisms 2019) 3

Products for MIR15B Gene

Sources for MIR15B Gene