microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR15A Gene

Subcategory (RNA class) for MIR15A Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR15A Gene

  • MicroRNA 15a 2 3 5
  • Hsa-MiR-15a-5p 166 177
  • Hsa-MiR-15a-3p 166 177
  • MIMAT0004488 51
  • MIMAT0000068 51
  • Hsa-Mir-15a 3
  • MI0000069 51
  • MiRNA15A 3
  • Mir-15a 3
  • MIRN15A 3
  • RF00455 172
  • MIR15A 2

External Ids for MIR15A Gene

Previous HGNC Symbols for MIR15A Gene

  • MIRN15A

Previous GeneCards Identifiers for MIR15A Gene

  • GC13M049528
  • GC13M050624
  • GC13M050625
  • GC13M050601
  • GC13M049983

Summaries for MIR15A Gene

Entrez Gene Summary for MIR15A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR15A Gene

MIR15A (MicroRNA 15a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR15A include Pituitary Adenoma and Polycystic Kidney Disease. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR15A Gene

  • mir-15 microRNA precursor family

Additional gene information for MIR15A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR15A Gene

Genomics for MIR15A Gene

Genomic Locations for MIR15A Gene

Genomic Locations for MIR15A Gene
chr13:50,049,118-50,049,202
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand
chr13:50,601,269-50,699,856
(GRCh37/hg19)
Size:
98,588 bases
Orientation:
Minus strand

Genomic View for MIR15A Gene

Genes around MIR15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR15A Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR15A Gene

Proteins for MIR15A Gene

Post-translational modifications for MIR15A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR15A Gene

Domains & Families for MIR15A Gene

Gene Families for MIR15A Gene

genes like me logo Genes that share domains with MIR15A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR15A Gene

Function for MIR15A Gene

Gene Ontology (GO) - Molecular Function for MIR15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR15A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR15A Gene

Localization for MIR15A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR15A gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005623 cell IEA --
GO:0070062 extracellular exosome IDA 23233752
genes like me logo Genes that share ontologies with MIR15A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR15A Gene

Pathways & Interactions for MIR15A Gene

PathCards logo

SuperPathways for MIR15A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR15A: view

Pathways by source for MIR15A Gene

1 KEGG pathway for MIR15A Gene
;

Gene Ontology (GO) - Biological Process for MIR15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 23353574
GO:0008285 negative regulation of cell proliferation IGI 22139073
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IDA 27343180
GO:0016525 negative regulation of angiogenesis IMP 23867820
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 30365148
genes like me logo Genes that share ontologies with MIR15A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR15A Gene

Drugs & Compounds for MIR15A Gene

No Compound Related Data Available

Transcripts for MIR15A Gene

mRNA/cDNA for MIR15A Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR15A Gene

No ASD Table

Relevant External Links for MIR15A Gene

GeneLoc Exon Structure for
MIR15A

Expression for MIR15A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR15A

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR15A Gene

Orthologs for MIR15A Gene

Evolution for MIR15A Gene

ENSEMBL:
Gene Tree for MIR15A (if available)
TreeFam:
Gene Tree for MIR15A (if available)

No data available for Orthologs for MIR15A Gene

Paralogs for MIR15A Gene

No data available for Paralogs for MIR15A Gene

Variants for MIR15A Gene

Additional dbSNP identifiers (rs#s) for MIR15A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR15A Gene

Variant ID Type Subtype PubMed ID
esv3580637 CNV loss 25503493
nsv1035151 CNV loss 25217958
nsv1054415 CNV loss 25217958
nsv561618 CNV loss 21841781

Additional Variant Information for MIR15A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR15A Gene

Disorders for MIR15A Gene

MalaCards: The human disease database

(67) MalaCards diseases for MIR15A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
polycystic kidney disease
  • pkd
leukemia, chronic lymphocytic
  • cll
polycystic liver disease
  • congenital cystic liver disease
acute promyelocytic leukemia
  • apl
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR15A

genes like me logo Genes that share disorders with MIR15A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR15A Gene

Publications for MIR15A Gene

  1. miR-15 and miR-16 induce apoptosis by targeting BCL2. (PMID: 16166262) Cimmino A … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 23 54
  2. ADRB2 suppresses IL-13-induced allergic rhinitis inflammatory cytokine regulated by miR-15a-5p. (PMID: 31104300) Wang L … Zhang J (Human cell 2019) 3 54
  3. Long non-coding RNA AGAP2-AS1 promotes the proliferation of glioma cells by sponging miR-15a/b-5p to upregulate the expression of HDGF and activating Wnt/β-catenin signaling pathway. (PMID: 30684575) Zheng Y … Zheng J (International journal of biological macromolecules 2019) 3 54
  4. miR‑15a‑3p affects the proliferation, migration and apoptosis of lens epithelial cells. (PMID: 30569090) Liu SJ … Li YB (Molecular medicine reports 2019) 3 54
  5. Long non-coding RNA HULC promotes proliferation, migration and invasion of pancreatic cancer cells by down-regulating microRNA-15a. (PMID: 30593805) Feng H … Zhang Y (International journal of biological macromolecules 2019) 3 54

Products for MIR15A Gene

Sources for MIR15A Gene