microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR155 Gene

Subcategory (RNA class) for MIR155 Gene

miRNA

Aliases for MIR155 Gene

External Ids for MIR155 Gene

Previous HGNC Symbols for MIR155 Gene

  • MIRN155

Previous GeneCards Identifiers for MIR155 Gene

  • GC21P025871
  • GC21P026946

Summaries for MIR155 Gene

Entrez Gene Summary for MIR155 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR155 Gene

MIR155 (MicroRNA 155) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR155 include Diffuse Large B-Cell Lymphoma and Pancreatic Ductal Adenocarcinoma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR155 Gene

Additional gene information for MIR155 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR155 Gene

Genomics for MIR155 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR155 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J025570 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 250.7 -0.8 -751 4.8 BCL11A POLR2A ZNF639 TRIM22 IRF4 EBF1 MAX JUND FOSL1 CBFB MIR155 lnc-MRPL39-2 MRPL39 lnc-JAM2-1 MIR155HG EU375836 JAM2
GH21J025420 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 11.6 -150.6 -150617 4.9 POLR2A CTCF SIN3A IRF4 TRIM22 EBF1 SMC3 MAX RAD21 TAF1 LINC00158 MIR155HG MIR155 MRPL39 lnc-MRPL39-18 lnc-MRPL39-19 JAM2
GH21J025456 Enhancer 1.1 FANTOM5 ENCODE 11.1 -116.4 -116418 2.6 SP1 BCL11A NR2C1 IRF4 TRIM22 EBF1 CBFB SPI1 BHLHE40 RFX5 LINC00158 MIR155HG MIR155 MRPL39 piR-39858-409 lnc-MRPL39-4 JAM2
GH21J025461 Enhancer 0.9 FANTOM5 ENCODE 10.7 -111.7 -111699 1.7 POLR2A TRIM22 TAF1 BHLHE40 ASH2L NFATC1 MTA3 NR2F1 ATF2 ZNF217 MIR155HG LINC00158 MIR155 MRPL39 lnc-MRPL39-4 piR-39858-409 JAM2
GH21J025463 Enhancer 0.9 FANTOM5 ENCODE 9.7 -109.6 -109593 1 BCL11A NR2C1 POLR2A TRIM22 IRF4 EBF1 TAF1 BATF STAT5A NFATC1 MIR155HG LINC00158 MIR155 MRPL39 lnc-MRPL39-4 piR-39858-409 JAM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR155 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR155 Gene

Latest Assembly
chr21:25,573,980-25,574,044
(GRCh38/hg38)
Size:
65 bases
Orientation:
Plus strand

Previous Assembly
chr21:26,946,292-26,946,356
(GRCh37/hg19 by Entrez Gene)
Size:
65 bases
Orientation:
Plus strand

Genomic View for MIR155 Gene

Genes around MIR155 on UCSC Golden Path with GeneCards custom track
MIR155 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR155 Gene

Proteins for MIR155 Gene

Post-translational modifications for MIR155 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR155 Gene

Domains & Families for MIR155 Gene

Gene Families for MIR155 Gene

HGNC:
genes like me logo Genes that share domains with MIR155: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR155 Gene

Function for MIR155 Gene

Phenotypes From GWAS Catalog for MIR155 Gene

Gene Ontology (GO) - Molecular Function for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22815348
genes like me logo Genes that share ontologies with MIR155: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR155 Gene

Localization for MIR155 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR155 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
GO:0048471 perinuclear region of cytoplasm ISS --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with MIR155: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR155 Gene

Pathways & Interactions for MIR155 Gene

PathCards logo

SuperPathways for MIR155 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR155: view

Pathways by source for MIR155 Gene

1 KEGG pathway for MIR155 Gene

Gene Ontology (GO) - Biological Process for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IDA 22815348
GO:0002696 positive regulation of leukocyte activation ISS --
GO:0002718 regulation of cytokine production involved in immune response ISS --
GO:0010613 positive regulation of cardiac muscle hypertrophy ISS --
GO:0010628 positive regulation of gene expression IMP --
genes like me logo Genes that share ontologies with MIR155: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR155 Gene

Drugs & Compounds for MIR155 Gene

No Compound Related Data Available

Transcripts for MIR155 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR155 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000062749E_9606 precursor_RNA 65 5

RefSeq: NR_030784,

Ensembl: ENST00000385060 (view in UCSC) ,

miRBase: MI0000681,

Rfam: RF00731,

ENA: LM608611.1:1..65:precursor_RNA,

URS000034309A_9606 miRNA 22 5

RefSeq: NR_030784,

miRBase: MIMAT0004658,

MirGeneDB: Hsa-Mir-155_3p,

TarBase: hsa-miR-155-3p,

ENA: LM380322.1:1..22:ncRNA, LM608611.1:43..64:ncRNA,

URS0000D54CAD_9606 miRNA 24 3

RefSeq: NR_030784,

miRBase: MIMAT0000646,

MirGeneDB: Hsa-Mir-155_5p,

URS0000338542_9606 miRNA 23 3

LncBase: hsa-miR-155-5p,

TarBase: hsa-miR-155-5p,

ENA: LM379168.1:1..23:ncRNA, LM608611.1:4..26:ncRNA,

URS0001BC7FF5_9606 pre_miRNA 65 1

Rfam: RF00731,

MIR155 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR155 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR155 Gene

No ASD Table

Relevant External Links for MIR155 Gene

GeneLoc Exon Structure for
MIR155

Expression for MIR155 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR155

Evidence on tissue expression from TISSUES for MIR155 Gene

  • Blood(2.8)
  • Lymph node(2.4)
  • Heart(2.3)
  • Liver(2.3)
  • Spleen(2.3)
  • Nervous system(2.3)
  • Bone marrow(2.2)
  • Intestine(2.2)
  • Muscle(2.2)
  • Kidney(2.2)
  • Skin(2.2)
  • Lung(2.1)
  • Urine(2)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR155 Gene

Orthologs for MIR155 Gene

Evolution for MIR155 Gene

ENSEMBL:
Gene Tree for MIR155 (if available)
TreeFam:
Gene Tree for MIR155 (if available)

No data available for Orthologs for MIR155 Gene

Paralogs for MIR155 Gene

No data available for Paralogs for MIR155 Gene

Variants for MIR155 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR155 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR155 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR155

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR155 Gene

Disorders for MIR155 Gene

MalaCards: The human disease database

(126) MalaCards diseases for MIR155 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
dermatitis, atopic
  • atod
myeloproliferative neoplasm
  • chronic myeloproliferative disease
rheumatoid arthritis
  • ra
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR155

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MIR155: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR155 Gene

Publications for MIR155 Gene

  1. MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. (PMID: 20673989) Sonkoly E … Pivarcsi A (The Journal of allergy and clinical immunology 2010) 3 74
  2. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. (PMID: 18759964) Pauley KM … Chan EK (Arthritis research & therapy 2008) 3 74
  3. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. (PMID: 17668390) Sethupathy P … Antonarakis SE (American journal of human genetics 2007) 3 74
  4. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. (PMID: 18055230) Vigorito E … Turner M (Immunity 2007) 2 3
  5. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. (PMID: 15738415) Eis PS … Dahlberg JE (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 74

Products for MIR155 Gene

Sources for MIR155 Gene