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Aliases for MIR155 Gene

Subcategory (RNA class) for MIR155 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR155 Gene

  • MicroRNA 155 2 3 5
  • Hsa-Mir-155 3
  • MiRNA155 3
  • Mir-155 3
  • MIRN155 3

External Ids for MIR155 Gene

ORGUL Members for MIR155 Gene

Previous HGNC Symbols for MIR155 Gene

  • MIRN155

Previous GeneCards Identifiers for MIR155 Gene

  • GC21P025871
  • GC21P026946

Summaries for MIR155 Gene

Entrez Gene Summary for MIR155 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR155 Gene

MIR155 (MicroRNA 155) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR155 include Diffuse Large B-Cell Lymphoma and Pancreatic Ductal Adenocarcinoma. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR155 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR155 Gene

Genomics for MIR155 Gene

GeneHancer (GH) Regulatory Elements for MIR155 Gene

Promoters and enhancers for MIR155 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J025570 Enhancer 1.2 Ensembl ENCODE dbSUPER 650.7 -0.8 -751 4.8 HDGF HDAC1 PKNOX1 ATF1 RB1 STAT5A BATF IRF4 EGR1 ATF7 GC21P025574 MIR155 MRPL39 MIR155HG
GH21J025420 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.6 -150.6 -150637 4.8 HDGF PKNOX1 SMAD1 BMI1 BATF IRF4 RAD21 ZNF143 ATF7 BCLAF1 MIR155HG MIR155 MRPL39 GC21M025430 LINC00158 GC21M025409
GH21J025456 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.1 -116.4 -116418 2.6 SMAD1 STAT5A BMI1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 IKZF2 LINC00158 MIR155HG MIR155 MRPL39 GC21M025492
GH21J025463 Enhancer 1 FANTOM5 ENCODE 9.7 -109.6 -109593 1 PKNOX1 STAT5A EBF1 BMI1 BATF IRF4 RELA NFATC1 ZNF207 ATF7 MIR155HG LINC00158 MIR155 MRPL39 GC21M025492
GH21J025461 Enhancer 0.9 FANTOM5 ENCODE 10.7 -111.7 -111699 1.7 PKNOX1 SMAD1 RELA POLR2A EED NFATC1 ATF7 CREM RUNX3 ZNF687 MIR155HG LINC00158 MIR155 MRPL39 GC21M025492
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR155 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR155 Gene

Genomic Locations for MIR155 Gene
chr21:25,573,980-25,574,044
(GRCh38/hg38)
Size:
65 bases
Orientation:
Plus strand
chr21:26,934,221-26,947,480
(GRCh37/hg19)
Size:
13,260 bases
Orientation:
Plus strand

Genomic View for MIR155 Gene

Genes around MIR155 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR155 Gene

Proteins for MIR155 Gene

Post-translational modifications for MIR155 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR155 Gene

Domains & Families for MIR155 Gene

Gene Families for MIR155 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR155: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR155 Gene

Function for MIR155 Gene

Phenotypes From GWAS Catalog for MIR155 Gene

Gene Ontology (GO) - Molecular Function for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20550618
genes like me logo Genes that share ontologies with MIR155: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR155 Gene

Localization for MIR155 Gene

Gene Ontology (GO) - Cellular Components for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA,IDA 26646931
GO:0048471 perinuclear region of cytoplasm ISS --
GO:0070062 extracellular exosome IDA 28408180
genes like me logo Genes that share ontologies with MIR155: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR155 Gene

Pathways & Interactions for MIR155 Gene

SuperPathways for MIR155 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR155: view

Pathways by source for MIR155 Gene

1 KEGG pathway for MIR155 Gene

Interacting Proteins for MIR155 Gene

Gene Ontology (GO) - Biological Process for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002696 positive regulation of leukocyte activation ISS --
GO:0002739 regulation of cytokine secretion involved in immune response ISS --
GO:0010613 positive regulation of cardiac muscle hypertrophy ISS --
GO:0010628 positive regulation of gene expression ISS --
GO:0010629 negative regulation of gene expression ISS --
genes like me logo Genes that share ontologies with MIR155: view

No data available for SIGNOR curated interactions for MIR155 Gene

Drugs & Compounds for MIR155 Gene

No Compound Related Data Available

Transcripts for MIR155 Gene

mRNA/cDNA for MIR155 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR155 Gene

No ASD Table

Relevant External Links for MIR155 Gene

GeneLoc Exon Structure for
MIR155
ECgene alternative splicing isoforms for
MIR155

Expression for MIR155 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR155 Gene:

MIR155
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR155 Gene

Orthologs for MIR155 Gene

Evolution for MIR155 Gene

ENSEMBL:
Gene Tree for MIR155 (if available)
TreeFam:
Gene Tree for MIR155 (if available)

No data available for Orthologs for MIR155 Gene

Paralogs for MIR155 Gene

No data available for Paralogs for MIR155 Gene

Variants for MIR155 Gene

Sequence variations from dbSNP and Humsavar for MIR155 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000971287 -- 25,574,213(+) G/T downstream_transcript_variant
rs1001572008 -- 25,572,220(+) T/C upstream_transcript_variant
rs1002022760 -- 25,572,573(+) C/T upstream_transcript_variant
rs1002858050 -- 25,572,874(+) A/T upstream_transcript_variant
rs1003543875 -- 25,571,999(+) G/T upstream_transcript_variant

Additional Variant Information for MIR155 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR155

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR155 Gene

Disorders for MIR155 Gene

MalaCards: The human disease database

(30) MalaCards diseases for MIR155 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
dermatitis, atopic
  • atod
rheumatoid arthritis
  • ra
bone marrow cancer
  • bone marrow neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR155

genes like me logo Genes that share disorders with MIR155: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR155 Gene

Publications for MIR155 Gene

  1. MiR-155-5p promotes fibroblast cell proliferation and inhibits FOXO signaling pathway in vulvar lichen sclerosis by targeting FOXO3 and CDKN1B. (PMID: 29339071) Ren L … Wu X (Gene 2018) 3 58
  2. Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. (PMID: 29550489) Zheng R … Zhang R (Biochemical and biophysical research communications 2018) 3 58
  3. Targeted delivery of anti-miR-155 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy. (PMID: 29535520) Li Y … Yu X (International journal of nanomedicine 2018) 3 58
  4. MicroRNA-155 promotes gastric cancer growth and invasion by negatively regulating transforming growth factor-β receptor 2. (PMID: 29247570) Qu Y … Ba Y (Cancer science 2018) 3 58
  5. MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis. (PMID: 28031239) Fernández C … Salar A (Cancer genomics & proteomics 2017) 3 58

Products for MIR155 Gene

Sources for MIR155 Gene

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