microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR155 Gene

Subcategory (RNA class) for MIR155 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR155 Gene

  • MicroRNA 155 2 3 5
  • Hsa-Mir-155 2 3 178
  • Hsa-MiR-155-5p 163 173
  • MIR155 2 5
  • Hsa-MiR-155-3p 173
  • MIMAT0004658 50
  • MIMAT0000646 50
  • MI0000681 50
  • MiRNA155 3
  • MIRN155 3
  • Mir-155 3
  • RF00731 168

External Ids for MIR155 Gene

Previous HGNC Symbols for MIR155 Gene

  • MIRN155

Previous GeneCards Identifiers for MIR155 Gene

  • GC21P025871
  • GC21P026946

Summaries for MIR155 Gene

Entrez Gene Summary for MIR155 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR155 Gene

MIR155 (MicroRNA 155) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR155 include Diffuse Large B-Cell Lymphoma and Pancreatic Ductal Adenocarcinoma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR155 Gene

Additional gene information for MIR155 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR155 Gene

Genomics for MIR155 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR155 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J025570 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 600.7 -0.8 -751 4.8 POLR2A JUND RELA SMAD5 TRIM22 HDAC1 SOX6 PKNOX1 EED RAD21 MIR155 lnc-MRPL39-2 MRPL39 lnc-JAM2-1 EU375836 MIR155HG JAM2
GH21J025420 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 11.6 -150.6 -150617 4.9 CTCF POLR2A STAT3 ZNF143 RELA SMAD5 RAD21 IKZF2 TRIM22 YY1 LINC00158 MIR155HG MIR155 MRPL39 lnc-MRPL39-18 lnc-MRPL39-19 JAM2
GH21J025456 Enhancer 1.1 FANTOM5 ENCODE 11.1 -116.4 -116418 2.6 SP1 BACH1 STAT3 JUND RELA TCF12 IKZF2 POLR2A RCOR1 TRIM22 LINC00158 MIR155HG MIR155 MRPL39 piR-39858-409 lnc-MRPL39-4 JAM2
GH21J025461 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.7 -111.7 -111699 1.7 POLR2A SMAD5 RELA TRIM22 YY1 PKNOX1 EED ARID3A RELB RUNX3 MIR155HG LINC00158 MIR155 MRPL39 lnc-MRPL39-4 piR-39858-409 JAM2
GH21J025463 Enhancer 0.9 FANTOM5 ENCODE 9.7 -109.6 -109593 1 POLR2A STAT3 RELA SMAD5 TRIM22 PKNOX1 ARID3A ZSCAN29 RELB RUNX3 MIR155HG LINC00158 MIR155 MRPL39 lnc-MRPL39-4 piR-39858-409 JAM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR155 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR155 Gene

Genomic Locations for MIR155 Gene
chr21:25,573,980-25,574,044
(GRCh38/hg38)
Size:
65 bases
Orientation:
Plus strand
chr21:26,934,221-26,947,480
(GRCh37/hg19)
Size:
13,260 bases
Orientation:
Plus strand

Genomic View for MIR155 Gene

Genes around MIR155 on UCSC Golden Path with GeneCards custom track
MIR155 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR155 Gene

Proteins for MIR155 Gene

Post-translational modifications for MIR155 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR155 Gene

Domains & Families for MIR155 Gene

Gene Families for MIR155 Gene

HGNC:
genes like me logo Genes that share domains with MIR155: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR155 Gene

Function for MIR155 Gene

Phenotypes From GWAS Catalog for MIR155 Gene

Gene Ontology (GO) - Molecular Function for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22815348
genes like me logo Genes that share ontologies with MIR155: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR155 Gene

Localization for MIR155 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR155 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
GO:0005623 cell IEA --
GO:0048471 perinuclear region of cytoplasm ISS --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with MIR155: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR155 Gene

Pathways & Interactions for MIR155 Gene

PathCards logo

SuperPathways for MIR155 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR155: view

Pathways by source for MIR155 Gene

1 KEGG pathway for MIR155 Gene

Gene Ontology (GO) - Biological Process for MIR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IDA --
GO:0002696 positive regulation of leukocyte activation ISS --
GO:0002739 regulation of cytokine secretion involved in immune response ISS --
GO:0010613 positive regulation of cardiac muscle hypertrophy ISS --
GO:0010628 positive regulation of gene expression IMP --
genes like me logo Genes that share ontologies with MIR155: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR155 Gene

Drugs & Compounds for MIR155 Gene

No Compound Related Data Available

Transcripts for MIR155 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR155 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000062749E_9606 precursor_RNA 65 6

HGNC: 31542,

RefSeq: NR_030784,

Ensembl: ENST00000385060 (view in UCSC) ,

miRBase: MI0000681,

Rfam: RF00731,

ENA: LM608611.1:1..65:precursor_RNA,

URS000034309A_9606 miRNA 22 5

RefSeq: NR_030784,

miRBase: MIMAT0004658,

MirGeneDB: Hsa-Mir-155_3p,

TarBase: hsa-miR-155-3p,

ENA: LM380322.1:1..22:ncRNA, LM608611.1:43..64:ncRNA,

URS0000D54CAD_9606 miRNA 24 3

RefSeq: NR_030784,

miRBase: MIMAT0000646,

MirGeneDB: Hsa-Mir-155_5p,

URS0000338542_9606 miRNA 23 3

LncBase: hsa-miR-155-5p,

TarBase: hsa-miR-155-5p,

ENA: LM379168.1:1..23:ncRNA, LM608611.1:4..26:ncRNA,

URS0000EFBD7B_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-155,

MIR155 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR155 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR155 Gene

No ASD Table

Relevant External Links for MIR155 Gene

GeneLoc Exon Structure for
MIR155

Expression for MIR155 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR155

Evidence on tissue expression from TISSUES for MIR155 Gene

  • Blood(3.1)
  • Lymph node(2.8)
  • Heart(2.6)
  • Liver(2.6)
  • Spleen(2.6)
  • Nervous system(2.6)
  • Bone marrow(2.5)
  • Intestine(2.5)
  • Muscle(2.5)
  • Kidney(2.5)
  • Skin(2.4)
  • Lung(2.3)
  • Urine(2.3)
  • Pancreas(2.2)
  • Saliva(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR155 Gene

Orthologs for MIR155 Gene

Evolution for MIR155 Gene

ENSEMBL:
Gene Tree for MIR155 (if available)
TreeFam:
Gene Tree for MIR155 (if available)

No data available for Orthologs for MIR155 Gene

Paralogs for MIR155 Gene

No data available for Paralogs for MIR155 Gene

Variants for MIR155 Gene

Additional dbSNP identifiers (rs#s) for MIR155 Gene

Additional Variant Information for MIR155 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR155

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR155 Gene

Disorders for MIR155 Gene

MalaCards: The human disease database

(119) MalaCards diseases for MIR155 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
rheumatoid arthritis
  • ra
dermatitis, atopic
  • atod
myeloproliferative neoplasm
  • campomelic dysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR155

genes like me logo Genes that share disorders with MIR155: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR155 Gene

Publications for MIR155 Gene

  1. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. (PMID: 18055230) Vigorito E … Turner M (Immunity 2007) 2 3
  2. Association of miR-155 and Angiotensin Receptor Type 1 Polymorphisms with the Risk of Ischemic Stroke in a Chinese Population. (PMID: 31721599) Li Y … Ma G (DNA and cell biology 2020) 3
  3. MiR-155 targeting FoxO3a regulates oral cancer cell proliferation, apoptosis, and DDP resistance through targeting FoxO3a. (PMID: 31771044) Li X … Jiang Z (Cancer biomarkers : section A of Disease markers 2020) 3
  4. miR-155 is high-expressed in polycystic ovarian syndrome and promotes cell proliferation and migration through targeting PDCD4 in KGN cells. (PMID: 31851829) Xia H … Zhao Y (Artificial cells, nanomedicine, and biotechnology 2020) 3
  5. One DNA circle capture probe with multiple target recognition domains for simultaneous electrochemical detection of miRNA-21 and miRNA-155. (PMID: 31726271) Xu S … Chai Y (Biosensors & bioelectronics 2020) 3

Products for MIR155 Gene

Sources for MIR155 Gene