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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR155 Gene
Subcategory (RNA class) for MIR155 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR155 Gene
External Ids for MIR155 Gene
- HGNC: 31542
- Entrez Gene: 406947
- Ensembl: ENSG00000283904
- OMIM: 609337
- miRBase: hsa-mir-155
Previous HGNC Symbols for MIR155 Gene
- MIRN155
Previous GeneCards Identifiers for MIR155 Gene
- GC21P025871
- GC21P026946
Summaries for MIR155 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR155 Gene
MIR155 (MicroRNA 155) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR155 include Diffuse Large B-Cell Lymphoma and Pancreatic Ductal Adenocarcinoma. Among its related pathways are MicroRNAs in cancer.
Rfam classification for MIR155 Gene
-
microRNA mir-155
Additional gene information for MIR155 Gene
- HGNC(31542)
- Entrez Gene(406947)
- Ensembl(ENSG00000283904)
- OMIM(609337)
- Open Targets Platform(ENSG00000283904)
- Search for MIR155 at DataMed
- Search for MIR155 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR155 Gene
Genomics for MIR155 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR155 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR155 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR155 Gene
Genomic Locations for MIR155 Gene
- chr21:25,573,980-25,574,044
- (GRCh38/hg38)
- Size:
- 65 bases
- Orientation:
- Plus strand
- chr21:26,934,221-26,947,480
- (GRCh37/hg19)
- Size:
- 13,260 bases
- Orientation:
- Plus strand
Genomic View for MIR155 Gene
Genes around MIR155 on UCSC Golden Path with GeneCards custom track
MIR155 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 21q21.3 by HGNC
- 21q21.3 by Entrez Gene
- 21q21.3 by Ensembl
MIR155 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR155 Gene
Proteins for MIR155 Gene
Post-translational modifications for MIR155 Gene
No Post-translational modifications
Antibody Products
- Creative Biolabs Recombinant Anti-Human MIR155 Antibody Fab Fragment
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR155
- Origene Custom Protein Services for MIR155
No data available for DME Specific Peptides for MIR155 Gene
Domains & Families for MIR155 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR155 Gene
Function for MIR155 Gene
Phenotypes From GWAS Catalog for MIR155 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 22815348 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR155 - Select products 50% OFF >
- * MIR155 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR155
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR155 - Select products 50% OFF >
- * MIR155 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR155
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR155 Gene
Localization for MIR155 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | ISS | -- |
| GO:0070062 | extracellular exosome | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR155 Gene
Pathways & Interactions for MIR155 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR155 Gene
1 KEGG pathway for MIR155 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001818 | negative regulation of cytokine production | IDA | -- |
| GO:0002696 | positive regulation of leukocyte activation | ISS | -- |
| GO:0002739 | regulation of cytokine secretion involved in immune response | ISS | -- |
| GO:0010613 | positive regulation of cardiac muscle hypertrophy | ISS | -- |
| GO:0010628 | positive regulation of gene expression | IMP | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR155 Gene
Transcripts for MIR155 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR155 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000062749E_9606 | precursor_RNA | 65 | 6 |
HGNC: 31542, RefSeq: NR_030784, Ensembl: ENST00000385060 (view in UCSC) , miRBase: MI0000681, Rfam: RF00731, |
| URS000034309A_9606 | miRNA | 22 | 5 |
RefSeq: NR_030784, miRBase: MIMAT0004658, MirGeneDB: Hsa-Mir-155_3p, TarBase: hsa-miR-155-3p, |
| URS0000D54CAD_9606 | miRNA | 24 | 3 |
RefSeq: NR_030784, miRBase: MIMAT0000646, MirGeneDB: Hsa-Mir-155_5p, |
| URS0000338542_9606 | miRNA | 23 | 3 |
LncBase: hsa-miR-155-5p, TarBase: hsa-miR-155-5p, |
| URS0000EFBD7B_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-155, |
MIR155 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR155 Gene
- 1 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR155 - Select products 50% OFF >
- * MIR155 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR155
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR155 - Select products 50% OFF >
- * MIR155 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR155
Relevant External Links for MIR155 Gene
- GeneLoc Exon Structure for
- MIR155
Expression for MIR155 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR155
Evidence on tissue expression from TISSUES for MIR155 Gene
- Blood(3.1)
- Lymph node(2.8)
- Heart(2.6)
- Liver(2.6)
- Spleen(2.6)
- Nervous system(2.6)
- Bone marrow(2.5)
- Intestine(2.5)
- Muscle(2.5)
- Kidney(2.5)
- Skin(2.4)
- Lung(2.3)
- Urine(2.3)
- Pancreas(2.2)
- Saliva(2.2)
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for MIR155
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR155 Gene
Orthologs for MIR155 Gene
No data available for Orthologs for MIR155 Gene
Paralogs for MIR155 Gene
No data available for Paralogs for MIR155 Gene
Variants for MIR155 Gene
Additional Variant Information for MIR155 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR155
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR155 Gene
Disorders for MIR155 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diffuse large b-cell lymphoma |
|
|
| pancreatic ductal adenocarcinoma |
|
|
| rheumatoid arthritis |
|
|
| dermatitis, atopic |
|
|
| myeloproliferative neoplasm |
|
Search MIR155 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR155
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR155 Gene
Publications for MIR155 Gene
- microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. (PMID: 18055230) Vigorito E … Turner M (Immunity 2007) 2 3
- Association of miR-155 and Angiotensin Receptor Type 1 Polymorphisms with the Risk of Ischemic Stroke in a Chinese Population. (PMID: 31721599) Li Y … Ma G (DNA and cell biology 2020) 3
- MiR-155 targeting FoxO3a regulates oral cancer cell proliferation, apoptosis, and DDP resistance through targeting FoxO3a. (PMID: 31771044) Li X … Jiang Z (Cancer biomarkers : section A of Disease markers 2020) 3
- miR-155 is high-expressed in polycystic ovarian syndrome and promotes cell proliferation and migration through targeting PDCD4 in KGN cells. (PMID: 31851829) Xia H … Zhao Y (Artificial cells, nanomedicine, and biotechnology 2020) 3
- One DNA circle capture probe with multiple target recognition domains for simultaneous electrochemical detection of miRNA-21 and miRNA-155. (PMID: 31726271) Xu S … Chai Y (Biosensors & bioelectronics 2020) 3
ExternalLinks
Products for MIR155 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR155
- Origene Custom Protein Services for MIR155
- Browse OriGene Inhibitory RNA Products For MIR155
- OriGene qPCR primer pairs for MIR155
- Browse CRISPR knockouts for MIR155
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR155
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIR155
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR155
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR155
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR155
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR155
Sources for MIR155 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB