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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR155 Gene
Subcategory (RNA class) for MIR155 Gene
miRNA
Aliases for MIR155 Gene
- MI0000681 (miRBase)
- MiRNA155 (NCBI Entrez Gene)
- MIRN155 (NCBI Entrez Gene)
- Mir-155 (NCBI Entrez Gene)
- RF00731 (Rfam)
- MIR155 (Ensembl)
External Ids for MIR155 Gene
- HGNC: 31542
- NCBI Entrez Gene: 406947
- Ensembl: ENSG00000283904
- OMIM®: 609337
- miRBase: hsa-mir-155
Previous HGNC Symbols for MIR155 Gene
- MIRN155
Previous GeneCards Identifiers for MIR155 Gene
- GC21P025871
- GC21P026946
Summaries for MIR155 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR155 Gene
MIR155 (MicroRNA 155) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR155 include Diffuse Large B-Cell Lymphoma and Pancreatic Ductal Adenocarcinoma. Among its related pathways are MicroRNAs in cancer.
Rfam classification for MIR155 Gene
-
microRNA mir-155
Additional gene information for MIR155 Gene
- HGNC (31542)
- NCBI Entrez Gene (406947)
- Ensembl (ENSG00000283904)
- OMIM® (609337)
- Open Targets Platform(ENSG00000283904)
- Search for MIR155 at DataMed
- Search for MIR155 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR155 Gene
Genomics for MIR155 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR155 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR155 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR155 Gene
Latest Assembly
- chr21:25,573,980-25,574,044
- (GRCh38/hg38)
- Size:
- 65 bases
- Orientation:
- Plus strand
Previous Assembly
- chr21:26,946,292-26,946,356
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 65 bases
- Orientation:
- Plus strand
Genomic View for MIR155 Gene
Genes around MIR155 on UCSC Golden Path with GeneCards custom track
MIR155 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 21q21.3 by HGNC
- 21q21.3 by Entrez Gene
- 21q21.3 by Ensembl
MIR155 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR155 Gene
Proteins for MIR155 Gene
Post-translational modifications for MIR155 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR155 Gene
Domains & Families for MIR155 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR155 Gene
Function for MIR155 Gene
Phenotypes From GWAS Catalog for MIR155 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 22815348 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR155 - Starting at $85 >
- * MIR155 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR155 - Starting at $45 >
- * MIR155 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for MIR155
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR155 Gene
Localization for MIR155 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | -- |
| GO:0048471 | perinuclear region of cytoplasm | ISS | -- |
| GO:0070062 | extracellular exosome | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR155 Gene
Pathways & Interactions for MIR155 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR155 Gene
1 KEGG pathway for MIR155 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001818 | negative regulation of cytokine production | IDA | 22815348 |
| GO:0002696 | positive regulation of leukocyte activation | ISS | -- |
| GO:0002718 | regulation of cytokine production involved in immune response | ISS | -- |
| GO:0010613 | positive regulation of cardiac muscle hypertrophy | ISS | -- |
| GO:0010628 | positive regulation of gene expression | IMP | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR155 Gene
Transcripts for MIR155 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR155 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000062749E_9606 | precursor_RNA | 65 | 5 |
RefSeq: NR_030784, Ensembl: ENST00000385060 (view in UCSC) , miRBase: MI0000681, Rfam: RF00731, |
| URS000034309A_9606 | miRNA | 22 | 5 |
RefSeq: NR_030784, miRBase: MIMAT0004658, MirGeneDB: Hsa-Mir-155_3p, TarBase: hsa-miR-155-3p, |
| URS0000D54CAD_9606 | miRNA | 24 | 3 |
RefSeq: NR_030784, miRBase: MIMAT0000646, MirGeneDB: Hsa-Mir-155_5p, |
| URS0000338542_9606 | miRNA | 23 | 3 |
LncBase: hsa-miR-155-5p, TarBase: hsa-miR-155-5p, |
| URS0001BC7FF5_9606 | pre_miRNA | 65 | 1 |
Rfam: RF00731, |
MIR155 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR155 Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR155 - Starting at $85 >
- * MIR155 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR155 - Starting at $45 >
- * MIR155 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for MIR155
Relevant External Links for MIR155 Gene
- GeneLoc Exon Structure for
- MIR155
Expression for MIR155 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR155
Evidence on tissue expression from TISSUES for MIR155 Gene
- Blood(2.8)
- Lymph node(2.4)
- Heart(2.3)
- Liver(2.3)
- Spleen(2.3)
- Nervous system(2.3)
- Bone marrow(2.2)
- Intestine(2.2)
- Muscle(2.2)
- Kidney(2.2)
- Skin(2.2)
- Lung(2.1)
- Urine(2)
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for MIR155
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR155 Gene
Orthologs for MIR155 Gene
No data available for Orthologs for MIR155 Gene
Paralogs for MIR155 Gene
No data available for Paralogs for MIR155 Gene
Variants for MIR155 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR155 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR155
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR155 Gene
Disorders for MIR155 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diffuse large b-cell lymphoma |
|
|
| pancreatic ductal adenocarcinoma |
|
|
| dermatitis, atopic |
|
|
| myeloproliferative neoplasm |
|
|
| rheumatoid arthritis |
|
Search MIR155 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR155
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR155 Gene
Publications for MIR155 Gene
- MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. (PMID: 20673989) Sonkoly E … Pivarcsi A (The Journal of allergy and clinical immunology 2010) 3 74
- Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. (PMID: 18759964) Pauley KM … Chan EK (Arthritis research & therapy 2008) 3 74
- Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. (PMID: 17668390) Sethupathy P … Antonarakis SE (American journal of human genetics 2007) 3 74
- microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. (PMID: 18055230) Vigorito E … Turner M (Immunity 2007) 2 3
- Accumulation of miR-155 and BIC RNA in human B cell lymphomas. (PMID: 15738415) Eis PS … Dahlberg JE (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 74
ExternalLinks
Products for MIR155 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR155
- Origene Custom Protein Services for MIR155
- Browse OriGene Inhibitory RNA Products For MIR155
- OriGene qPCR primer pairs for MIR155
- Browse CRISPR knockouts for MIR155
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR155
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIR155
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR155
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR155
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR155
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR155
Sources for MIR155 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB