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Aliases for MIR154 Gene

Subcategory (RNA class) for MIR154 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR154 Gene

  • MicroRNA 154 2 3 5
  • Hsa-Mir-154 3
  • Mir-154 3
  • MIRN154 3

External Ids for MIR154 Gene

Previous HGNC Symbols for MIR154 Gene

  • MIRN154

Previous GeneCards Identifiers for MIR154 Gene

  • GC14P100836
  • GC14P100926
  • GC14P101527
  • GC14P101556
  • GC14P101590
  • GC14P101629
  • GC14P101657
  • GC14P101691
  • GC14P101729
  • GC14P101769
  • GC14P101827
  • GC14P101967
  • GC14P102164
  • GC14P101269
  • GC14P101885
  • GC14P102201
  • GC14P102369
  • GC14P102540
  • GC14P102718
  • GC14P102891
  • GC14P103064

Summaries for MIR154 Gene

Entrez Gene Summary for MIR154 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR154 Gene

MIR154 (MicroRNA 154) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR154 include Muscular Dystrophy, Limb-Girdle, Type 2A and Facioscapulohumeral Muscular Dystrophy 1.

Additional gene information for MIR154 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR154 Gene

Genomics for MIR154 Gene

GeneHancer (GH) Regulatory Elements for MIR154 Gene

Promoters and enhancers for MIR154 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101096 Enhancer 0.7 FANTOM5 ENCODE 11 +38.6 38593 3.2 ATF4 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101004 Enhancer 0.7 Ensembl ENCODE 11 -54.7 -54670 1.9 GATA3 MNT MYC TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14J101176 Enhancer 0.5 ENCODE 10.7 +117.6 117611 2 ZNF680 ZFP3 RCOR1 CHD2 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-2 SNORD113-3 ENSG00000222185
GH14J101008 Enhancer 0.2 ENCODE 11 -51.1 -51056 0.2 MIR487A MIR134 MIR323B MIR485 MIR154 MIR377 MIR496 MIR1185-1 MIR300 MIR376C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR154 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR154 Gene

Genomic Locations for MIR154 Gene
chr14:101,059,755-101,059,838
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr14:101,526,092-101,526,175
(GRCh37/hg19)
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR154 Gene

Genes around MIR154 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR154 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR154 Gene

Proteins for MIR154 Gene

Post-translational modifications for MIR154 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR154 Gene

Domains & Families for MIR154 Gene

Gene Families for MIR154 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR154: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR154 Gene

Function for MIR154 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR154 Gene

Localization for MIR154 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR154 Gene

Pathways & Interactions for MIR154 Gene

SuperPathways for MIR154 Gene

No Data Available

Interacting Proteins for MIR154 Gene

Gene Ontology (GO) - Biological Process for MIR154 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR154 Gene

Drugs & Compounds for MIR154 Gene

No Compound Related Data Available

Transcripts for MIR154 Gene

mRNA/cDNA for MIR154 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR154 Gene

No ASD Table

Relevant External Links for MIR154 Gene

GeneLoc Exon Structure for
MIR154
ECgene alternative splicing isoforms for
MIR154

Expression for MIR154 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR154 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR154 Gene:

MIR154
genes like me logo Genes that share expression patterns with MIR154: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR154 Gene

Orthologs for MIR154 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR154 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-154 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir154 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-154a 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 52 (a)
ManyToMany
Species where no ortholog for MIR154 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR154 Gene

ENSEMBL:
Gene Tree for MIR154 (if available)
TreeFam:
Gene Tree for MIR154 (if available)

Paralogs for MIR154 Gene

No data available for Paralogs for MIR154 Gene

Variants for MIR154 Gene

Sequence variations from dbSNP and Humsavar for MIR154 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000002293 -- 101,057,939(+) A/G upstream_transcript_variant
rs1001204786 -- 101,059,431(+) T/C upstream_transcript_variant
rs1001278131 -- 101,059,011(+) G/A upstream_transcript_variant
rs1001675581 -- 101,059,634(+) T/C upstream_transcript_variant
rs1003403054 -- 101,060,227(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR154 Gene

Variant ID Type Subtype PubMed ID
nsv565860 CNV gain 21841781
nsv565859 CNV gain 21841781
nsv509551 CNV insertion 20534489
nsv1040993 CNV gain 25217958
esv3635521 CNV gain 21293372

Additional Variant Information for MIR154 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR154

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR154 Gene

Disorders for MIR154 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR154 Gene - From: miR2Disease

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR154

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR154: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR154 Gene

Publications for MIR154 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. miRNA-154-5p Inhibits Proliferation, Migration and Invasion by Targeting E2F5 in Prostate Cancer Cell Lines. (PMID: 27074041) Zheng Y … Hua L (Urologia internationalis 2017) 3 58
  3. Down-expression of miR-154 suppresses tumourigenesis in CD133(+) glioblastoma stem cells. (PMID: 27338789) Yang L … Li C (Cell biochemistry and function 2016) 3 58
  4. Downregulation of miR-154 in human glioma and its clinicopathological and prognostic significance. (PMID: 27417886) Wang L … Wu J (The Journal of international medical research 2016) 3 58
  5. MiR-154 directly suppresses DKK2 to activate Wnt signaling pathway and enhance activation of cardiac fibroblasts. (PMID: 27542661) Sun LY … Yang J (Cell biology international 2016) 3 58

Products for MIR154 Gene

Sources for MIR154 Gene

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