microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR153-1 Gene

Data sources for MIR153-1 Gene:

RNA type for MIR153-1 Gene

miRNA

Aliases for MIR153-1 Gene

External Ids for MIR153-1 Gene

Previous HGNC Symbols for MIR153-1 Gene

  • MIRN153-1

Previous GeneCards Identifiers for MIR153-1 Gene

  • GC02M219868
  • GC02M220158

Summaries for MIR153-1 Gene

Entrez Gene Summary for MIR153-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR153-1 Gene

MIR153-1 (MicroRNA 153-1) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR153-1 Gene

Additional gene information for MIR153-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR153-1 Gene

Genomics for MIR153-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR153-1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR153-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR153-1 Gene

Latest Assembly
chr2:219,294,111-219,294,200
(GRCh38/hg38)
Size:
90 bases
Orientation:
Minus strand

Previous Assembly
chr2:220,158,833-220,158,922
(GRCh37/hg19 by Entrez Gene)
Size:
90 bases
Orientation:
Minus strand

chr2:220,158,833-220,158,922
(GRCh37/hg19 by Ensembl)
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR153-1 Gene

Genes around MIR153-1 on UCSC Golden Path with GeneCards custom track
MIR153-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR153-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR153-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR153-1 Gene

Proteins for MIR153-1 Gene

Post-translational modifications for MIR153-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR153-1 Gene

Domains & Families for MIR153-1 Gene

Gene Families for MIR153-1 Gene

genes like me logo Genes that share domains with MIR153-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR153-1 Gene

Function for MIR153-1 Gene

Phenotypes From GWAS Catalog for MIR153-1 Gene

Gene Ontology (GO) - Molecular Function for MIR153-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 21982160
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR153-1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR153-1 Gene

Localization for MIR153-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR153-1 Gene

Pathways & Interactions for MIR153-1 Gene

PathCards logo

SuperPathways for MIR153-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR153-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process IDA 21982160
GO:0060087 relaxation of vascular smooth muscle ISS --
GO:1902430 negative regulation of amyloid-beta formation IDA 22733824
GO:1903817 negative regulation of voltage-gated potassium channel activity ISS --
genes like me logo Genes that share ontologies with MIR153-1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR153-1 Gene

Drugs & Compounds for MIR153-1 Gene

No Compound Related Data Available

Transcripts for MIR153-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR153-1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000068B85_9606 miRNA 22 5

RefSeq: NR_029688, NR_029689,

miRBase: MIMAT0000439,

MirGeneDB: Hsa-Mir-153-P1_3p, Hsa-Mir-153-P2_3p,

TarBase: hsa-miR-153-3p,

ENA: LM379057.1:1..22:ncRNA, LM608503.1:54..75:ncRNA, LM608504.1:53..74:ncRNA,

URS0000111CD2_9606 pre_miRNA 90 4

RefSeq: NR_029688,

Ensembl: ENST00000384914 (view in UCSC) ,

miRBase: MI0000463,

ENA: LM608503.1:1..90:precursor_RNA,

URS000064E02B_9606 pre_miRNA 86 1

Rfam: RF00650,

URS0000EFECDC_9606 pre_miRNA 61 1

MirGeneDB: Hsa-Mir-153-P1,

URS000075ACEA_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-153-P1_5p,

MIR153-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR153-1 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR153-1 Gene

No ASD Table

Relevant External Links for MIR153-1 Gene

GeneLoc Exon Structure for
MIR153-1

Expression for MIR153-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR153-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR153-1

genes like me logo Genes that share expression patterns with MIR153-1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR153-1 Gene

Orthologs for MIR153-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR153-1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-153-1 30
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-153-1 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-153-1 30
  • 59 (a)
OneToMany
-- 30
  • 59 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-153-2 30
  • 59 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-153c 30
  • 51 (a)
OneToMany
dre-mir-153b 30
  • 49 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-153 30
  • 50 (a)
OneToMany
Species where no ortholog for MIR153-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR153-1 Gene

ENSEMBL:
Gene Tree for MIR153-1 (if available)
TreeFam:
Gene Tree for MIR153-1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR153-1

Paralogs for MIR153-1 Gene

No data available for Paralogs for MIR153-1 Gene

Variants for MIR153-1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR153-1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR153-1 Gene

Variant ID Type Subtype PubMed ID
nsv508885 CNV insertion 20534489
nsv527936 CNV loss 19592680
nsv584501 CNV loss 21841781
nsv834543 CNV loss 17160897

Additional Variant Information for MIR153-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR153-1
Leiden Open Variation Database (LOVD)
MIR153-1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR153-1 Gene

Disorders for MIR153-1 Gene

Additional Disease Information for MIR153-1

No disorders were found for MIR153-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR153-1 Gene

Publications for MIR153-1 Gene

  1. MiR-153-5p promotes sensibility of colorectal cancer cells to oxaliplatin via targeting Bcl-2-mediated autophagy pathway. (PMID: 32380907) He Y … Yin XZ (Bioscience, biotechnology, and biochemistry 2020) 3
  2. LncRNA FGD5-AS1 promotes tumor growth by regulating MCL1 via sponging miR-153-3p in oral cancer. (PMID: 32675387) Ge C … Wei J (Aging 2020) 3
  3. Downregulation of NEAT1 Suppresses Cell Proliferation, Migration, and Invasion in NSCLC Via Sponging miR-153-3p. (PMID: 32380843) Zhao L … Shi M (Cancer biotherapy & radiopharmaceuticals 2020) 3
  4. OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis. (PMID: 32196594) Zhi XH … Zhou LQ (European review for medical and pharmacological sciences 2020) 3
  5. MicroRNA-153-3p regulates cell proliferation and cisplatin resistance via Nrf-2 in esophageal squamous cell carcinoma. (PMID: 32012470) Zuo J … Shen H (Thoracic cancer 2020) 3

Products for MIR153-1 Gene

Sources for MIR153-1 Gene