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Aliases for MIR153-1 Gene

Subcategory (RNA class) for MIR153-1 Gene

miRNA

Quality Score for this RNA gene is

13.2

Aliases for MIR153-1 Gene

  • MicroRNA 153-1 2 3 5
  • Hsa-Mir-153-1 3
  • Mir-153-1 3
  • MIRN153-1 3

External Ids for MIR153-1 Gene

Previous HGNC Symbols for MIR153-1 Gene

  • MIRN153-1

Previous GeneCards Identifiers for MIR153-1 Gene

  • GC02M219868
  • GC02M220158

Summaries for MIR153-1 Gene

Entrez Gene Summary for MIR153-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR153-1 Gene

MIR153-1 (MicroRNA 153-1) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR153-1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

Additional gene information for MIR153-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR153-1 Gene

Genomics for MIR153-1 Gene

GeneHancer (GH) Regulatory Elements for MIR153-1 Gene

Promoters and enhancers for MIR153-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J219294 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 650.7 -0.6 -647 1.6 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 MIR153-1 PTPRN CNOT9 NHEJ1 STK11IP RNF25 ZNF142 CNPPD1 USP37 SLC23A3
GH02J219244 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.5 +44.1 44082 11.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 GLB1L TUBA4A STK16 ZFAND2B LINC00608 LINC01803 ATG9A ANKZF1 DNAJB2 MIR153-1
GH02J219121 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 +169.1 169131 7.2 CLOCK ATF1 FOXA2 ARID4B YBX1 TCF12 FOS ATF7 RUNX3 NFKBIZ SLC23A3 NHEJ1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 CNPPD1 RETREG2
GH02J219080 Enhancer 1 ENCODE dbSUPER 10.6 +212.2 212241 2.4 FOXA2 DNMT3B ZSCAN9 RARA CREM IKZF2 THAP11 HMG20B SP5 KAT8 IHH NHEJ1 SLC23A3 LOC100129175 MIR375 MIR153-1 PTPRN RESP18 ENSG00000272644 RN7SL764P
GH02J219362 Enhancer 0.7 ENCODE 10.6 -68.5 -68458 1 PAX8 EBF1 BATF ZIC2 IRF4 ZFHX2 GLIS2 ZNF366 POLR2A EED PTPRN RESP18 MIR153-1 TUBA4A DNAJB2 TUBA4B SPEG ENSG00000232789 LOC105373883
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR153-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR153-1 Gene

Genomic Locations for MIR153-1 Gene
chr2:219,294,111-219,294,200
(GRCh38/hg38)
Size:
90 bases
Orientation:
Minus strand
chr2:220,158,833-220,158,922
(GRCh37/hg19)

Genomic View for MIR153-1 Gene

Genes around MIR153-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR153-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR153-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR153-1 Gene

ORGUL Member Location for MIR153-1 Gene

ORGUL Member Location for MIR153-1 gene

Proteins for MIR153-1 Gene

Post-translational modifications for MIR153-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR153-1 Gene

Domains & Families for MIR153-1 Gene

Gene Families for MIR153-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR153-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR153-1 Gene

Function for MIR153-1 Gene

Phenotypes From GWAS Catalog for MIR153-1 Gene

Gene Ontology (GO) - Molecular Function for MIR153-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR153-1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR153-1 Gene

Localization for MIR153-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR153-1 Gene

Pathways & Interactions for MIR153-1 Gene

SuperPathways for MIR153-1 Gene

No Data Available

Interacting Proteins for MIR153-1 Gene

Gene Ontology (GO) - Biological Process for MIR153-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20829195
GO:0060087 relaxation of vascular smooth muscle ISS --
GO:1903817 negative regulation of voltage-gated potassium channel activity ISS --
GO:1905651 regulation of artery morphogenesis ISS --
genes like me logo Genes that share ontologies with MIR153-1: view

No data available for Pathways by source and SIGNOR curated interactions for MIR153-1 Gene

Drugs & Compounds for MIR153-1 Gene

No Compound Related Data Available

Transcripts for MIR153-1 Gene

mRNA/cDNA for MIR153-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(2) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR153-1 Gene

No ASD Table

Relevant External Links for MIR153-1 Gene

GeneLoc Exon Structure for
MIR153-1
ECgene alternative splicing isoforms for
MIR153-1

Expression for MIR153-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR153-1 Gene

genes like me logo Genes that share expression patterns with MIR153-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR153-1 Gene

Orthologs for MIR153-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR153-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-153-1 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-153-1 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-153-1 34
  • 59 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-153-2 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-153c 34
  • 51 (a)
OneToMany
dre-mir-153b 34
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-153 34
  • 50 (a)
OneToMany
Species where no ortholog for MIR153-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR153-1 Gene

ENSEMBL:
Gene Tree for MIR153-1 (if available)
TreeFam:
Gene Tree for MIR153-1 (if available)

Paralogs for MIR153-1 Gene

No data available for Paralogs for MIR153-1 Gene

Variants for MIR153-1 Gene

Sequence variations from dbSNP and Humsavar for MIR153-1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001043528 -- 219,295,620(-) C/T upstream_transcript_variant
rs1001931698 -- 219,294,717(-) C/T upstream_transcript_variant
rs1002385811 -- 219,294,878(-) C/G upstream_transcript_variant
rs1003483728 -- 219,293,792(-) G/A downstream_transcript_variant
rs1004024354 -- 219,295,884(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR153-1 Gene

Variant ID Type Subtype PubMed ID
nsv508885 CNV insertion 20534489
nsv527936 CNV loss 19592680
nsv584501 CNV loss 21841781
nsv834543 CNV loss 17160897

Additional Variant Information for MIR153-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR153-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR153-1 Gene

Disorders for MIR153-1 Gene

Additional Disease Information for MIR153-1

No disorders were found for MIR153-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR153-1 Gene

Publications for MIR153-1 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 58
  2. MicroRNA-153-3p suppress cell proliferation and invasion by targeting SNAI1 in melanoma. (PMID: 28400282) Zeng HF … Wu SF (Biochemical and biophysical research communications 2017) 3 58
  3. miR-153 enhances the therapeutic effect of gemcitabine by targeting Snail in pancreatic cancer. (PMID: 28459992) Liu F … Ma Z (Acta biochimica et biophysica Sinica 2017) 3 58
  4. MiR-153 as a Tumor Suppressor in Glioblastoma Multiforme is Downregulated by DNA Methylation. (PMID: 27215075) Ghasemi A … Ansari M (Clinical laboratory 2016) 3 58
  5. MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis. (PMID: 27012032) Wang B … Liu Q (Clinical laboratory 2016) 3 58

Products for MIR153-1 Gene

Sources for MIR153-1 Gene

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