microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR152 Gene

RNA type for MIR152 Gene

miRNA

Aliases for MIR152 Gene

External Ids for MIR152 Gene

Previous HGNC Symbols for MIR152 Gene

  • MIRN152

Previous GeneCards Identifiers for MIR152 Gene

  • GC17U901085
  • GC17M043473
  • GC17M046114

Summaries for MIR152 Gene

Entrez Gene Summary for MIR152 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR152 Gene

MIR152 (MicroRNA 152) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR152 include Cholangiocarcinoma and Leukemia, Acute Lymphoblastic. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR152 Gene

  • mir-148/mir-152 microRNA precursor family

Additional gene information for MIR152 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR152 Gene

Genomics for MIR152 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR152 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR152 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR152 Gene

Latest Assembly
chr17:48,037,161-48,037,247
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand

Previous Assembly
chr17:46,114,527-46,114,613
(GRCh37/hg19 by Entrez Gene)
Size:
87 bases
Orientation:
Minus strand

chr17:46,114,527-46,114,613
(GRCh37/hg19 by Ensembl)
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR152 Gene

Genes around MIR152 on UCSC Golden Path with GeneCards custom track
MIR152 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR152 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR152 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR152 Gene

Proteins for MIR152 Gene

Post-translational modifications for MIR152 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR152 Gene

Domains & Families for MIR152 Gene

Gene Families for MIR152 Gene

genes like me logo Genes that share domains with MIR152: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR152 Gene

Function for MIR152 Gene

Phenotypes From GWAS Catalog for MIR152 Gene

Gene Ontology (GO) - Molecular Function for MIR152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 28258379
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24813629
genes like me logo Genes that share ontologies with MIR152: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR152 Gene

Localization for MIR152 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR152 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR152: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR152 Gene

Pathways & Interactions for MIR152 Gene

PathCards logo

SuperPathways for MIR152 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR152: view

Pathways by source for MIR152 Gene

1 KEGG pathway for MIR152 Gene

Gene Ontology (GO) - Biological Process for MIR152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 29693139
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA 24813629
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043065 positive regulation of apoptotic process IDA 29693139
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 24813629
genes like me logo Genes that share ontologies with MIR152: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR152 Gene

Drugs & Compounds for MIR152 Gene

No Compound Related Data Available

Transcripts for MIR152 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR152 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00003AFD9B_9606 miRNA 21 6

RefSeq: NR_029687,

LncBase: hsa-miR-152-3p,

miRBase: MIMAT0000438,

MirGeneDB: Hsa-Mir-148-P2_3p,

TarBase: hsa-miR-152-3p,

ENA: LM379056.1:1..21:ncRNA, LM608502.1:54..74:ncRNA,

URS00006A0932_9606 pre_miRNA 87 5

RefSeq: NR_029687,

Ensembl: ENST00000385212 (view in UCSC) ,

miRBase: MI0000462,

Rfam: RF00248,

ENA: LM608502.1:1..87:precursor_RNA,

URS000000C73C_9606 miRNA 23 4

RefSeq: NR_029687,

miRBase: MIMAT0026479,

MirGeneDB: Hsa-Mir-148-P2_5p,

ENA: LM608502.1:16..38:ncRNA,

URS0001BC4EB3_9606 pre_miRNA 87 1

Rfam: RF00248,

URS0000EFCA8E_9606 pre_miRNA 60 1

MirGeneDB: Hsa-Mir-148-P2,

MIR152 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR152 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR152 Gene

No ASD Table

Relevant External Links for MIR152 Gene

GeneLoc Exon Structure for
MIR152

Expression for MIR152 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR152 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR152

genes like me logo Genes that share expression patterns with MIR152: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR152 Gene

Orthologs for MIR152 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR152 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-152 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-152 30
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir152 30
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-152 30
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-152 30
  • 90 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-152 30
  • 79 (a)
OneToOne
Species where no ortholog for MIR152 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR152 Gene

ENSEMBL:
Gene Tree for MIR152 (if available)
TreeFam:
Gene Tree for MIR152 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR152

Paralogs for MIR152 Gene

No data available for Paralogs for MIR152 Gene

Variants for MIR152 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR152 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR152 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV loss 16826518

Additional Variant Information for MIR152 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR152
Leiden Open Variation Database (LOVD)
MIR152

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR152 Gene

Disorders for MIR152 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIR152 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cholangiocarcinoma, susceptibility to
leukemia, acute lymphoblastic
  • all
asthma
  • asthma, susceptibility to
neuroblastoma
  • nb
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR152

genes like me logo Genes that share disorders with MIR152: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR152 Gene

Publications for MIR152 Gene

  1. BRAFi induced demethylation of miR-152-5p regulates phenotype switching by targeting TXNIP in cutaneous melanoma. (PMID: 32056038) Li K … Jin S (Apoptosis : an international journal on programmed cell death 2020) 3
  2. Silencing of miR-152 contributes to DNMT1-mediated CpG methylation of the PTEN promoter in bladder cancer. (PMID: 32861793) Liu P … Li Y (Life sciences 2020) 3
  3. Long non-coding RNA colon cancer-associated transcript-1 regulates tumor cell proliferation and invasion of non-small-cell lung cancer through suppressing miR-152. (PMID: 32227563) Li N … Du Y (Geriatrics & gerontology international 2020) 3
  4. Long Noncoding RNA H19 Promotes Tumorigenesis of Multiple Myeloma by Activating BRD4 Signaling by Targeting MicroRNA 152-3p. (PMID: 31712391) Zheng JF … Cheng J (Molecular and cellular biology 2020) 3
  5. From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia. (PMID: 32337535) Frazier S … Graham D (Clinical science (London, England : 1979) 2020) 3

Products for MIR152 Gene

Sources for MIR152 Gene