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Aliases for MIR150 Gene

Subcategory (RNA class) for MIR150 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR150 Gene

  • MicroRNA 150 2 3 5
  • Hsa-Mir-150 3
  • MiRNA150 3
  • Mir-150 3
  • MIRN150 3

External Ids for MIR150 Gene

Previous HGNC Symbols for MIR150 Gene

  • MIRN150

Previous GeneCards Identifiers for MIR150 Gene

  • GC19M054698
  • GC19M050004

Summaries for MIR150 Gene

Entrez Gene Summary for MIR150 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR150 Gene

MIR150 (MicroRNA 150) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Hematopoietic Stem Cell Differentiation and EV release from cardiac cells and their functional effects.

fRNAdb sequence ontologies for MIR150 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR150 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR150 Gene

Genomics for MIR150 Gene

GeneHancer (GH) Regulatory Elements for MIR150 Gene

Promoters and enhancers for MIR150 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I049494 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.8 1824 9.7 CLOCK FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D RPS11 SNORD35B GC19P049558 MIR150 GC19M049503 PRR12 ALDH16A1 SNORD35A IRF3 NUP62
GH19I049558 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 12.2 -59.9 -59857 4.3 HDAC1 BCOR TFAP4 ZMYM3 ZNF664 ZFHX2 FOXK2 EGR1 ADNP VEZF1 NOSIP PIR42034 PRR12 RCN3 FCGRT MIR150 RPS11 SNORD35B SNORD35A SNORD34
GH19I049567 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.4 -68.7 -68698 4.6 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF121 PRR12 NOSIP SNORD35B PRRG2 POLD1 NUP62 PTOV1-AS2 SNORD35A FCGRT MIR150
GH19I049552 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.1 -54.5 -54482 5.7 PKNOX1 FOXA2 ARID4B ZNF143 MIXL1 EGR2 ZNF362 ZNF623 NR2F2 ZNF24 NOSIP PRR12 FCGRT RCN3 PRRG2 MIR150 RPS11 SNORD35B SNORD33 SNORD34
GH19I049564 Enhancer 0.6 ENCODE dbSUPER 12.4 -64.6 -64635 2.2 NFIC NFIB ENSG00000207073 GC19P049568 PRR12 NOSIP FCGRT MIR150 RPS11 SNORD35B RCN3 SLC17A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR150 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR150 Gene

Genomic Locations for MIR150 Gene
chr19:49,500,785-49,500,868
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr19:50,004,042-50,004,125
(GRCh37/hg19)

Genomic View for MIR150 Gene

Genes around MIR150 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR150 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR150 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR150 Gene

ORGUL Member Location for MIR150 Gene

ORGUL Member Location for MIR150 gene

Proteins for MIR150 Gene

Post-translational modifications for MIR150 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR150 Gene

Domains & Families for MIR150 Gene

Gene Families for MIR150 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR150: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR150 Gene

Function for MIR150 Gene

Phenotypes From GWAS Catalog for MIR150 Gene

Gene Ontology (GO) - Molecular Function for MIR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23765923
genes like me logo Genes that share ontologies with MIR150: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR150 Gene

Localization for MIR150 Gene

Gene Ontology (GO) - Cellular Components for MIR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR150: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR150 Gene

Pathways & Interactions for MIR150 Gene

genes like me logo Genes that share pathways with MIR150: view

Pathways by source for MIR150 Gene

Interacting Proteins for MIR150 Gene

Gene Ontology (GO) - Biological Process for MIR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23765923
GO:0045603 positive regulation of endothelial cell differentiation IDA 23765923
GO:1905562 NOT regulation of vascular endothelial cell proliferation IDA 23765923
GO:1905772 positive regulation of mesodermal cell differentiation IDA 23765923
genes like me logo Genes that share ontologies with MIR150: view

No data available for SIGNOR curated interactions for MIR150 Gene

Drugs & Compounds for MIR150 Gene

No Compound Related Data Available

Transcripts for MIR150 Gene

mRNA/cDNA for MIR150 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR150 Gene

No ASD Table

Relevant External Links for MIR150 Gene

GeneLoc Exon Structure for
MIR150
ECgene alternative splicing isoforms for
MIR150

Expression for MIR150 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR150 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR150 Gene:

MIR150
genes like me logo Genes that share expression patterns with MIR150: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR150 Gene

Orthologs for MIR150 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR150 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-150 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir150 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-150 34
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-150 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-150 34
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-150 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-150 34
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-150 34
  • 66 (a)
OneToOne
Species where no ortholog for MIR150 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR150 Gene

ENSEMBL:
Gene Tree for MIR150 (if available)
TreeFam:
Gene Tree for MIR150 (if available)

Paralogs for MIR150 Gene

No data available for Paralogs for MIR150 Gene

Variants for MIR150 Gene

Sequence variations from dbSNP and Humsavar for MIR150 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000196537 -- 49,501,994(-) T/G upstream_transcript_variant
rs1000963591 -- 49,501,078(-) T/G upstream_transcript_variant
rs1001416581 -- 49,500,981(-) C/T upstream_transcript_variant
rs1001701454 -- 49,502,051(-) C/T upstream_transcript_variant
rs1002208133 -- 49,500,420(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR150 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for MIR150 Gene

Gene Damage Index Score: 10.58; 91.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIR150 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR150

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR150 Gene

Disorders for MIR150 Gene

Additional Disease Information for MIR150

No disorders were found for MIR150 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR150 Gene

Publications for MIR150 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 58
  2. Quantitative miR analysis in chronic lymphocytic leukaemia/small lymphocytic lymphoma - proliferation centres are characterized by high miR-92a and miR-155 and low miR-150 expression. (PMID: 28407516) Szurián K … Reiniger L (Leukemia research 2017) 3 58
  3. MiR-150 regulates human keratinocyte proliferation in hypoxic conditions through targeting HIF-1α and VEGFA: Implications for psoriasis treatment. (PMID: 28399173) Li Y … Zhang G (PloS one 2017) 3 58
  4. MicroRNA-150 Modulates Ischemia-Induced Neovascularization in Atherosclerotic Conditions. (PMID: 28254813) Desjarlais M … Rivard A (Arteriosclerosis, thrombosis, and vascular biology 2017) 3 58
  5. MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells. (PMID: 28110404) Qin B … Lu Z (Molecular and cellular biochemistry 2017) 3 58

Products for MIR150 Gene

Sources for MIR150 Gene

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