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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR150 (MicroRNA 150) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR150 include Rheumatoid Arthritis and Gastric Cancer. Among its related pathways are Hematopoietic Stem Cell Differentiation and EV release from cardiac cells and their functional effects.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 18667440 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Cell Differentiation - Index | ||
3 | EV release from cardiac cells and their functional effects | ||
4 | Hematopoietic Stem Cell Differentiation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0045603 | positive regulation of endothelial cell differentiation | IDA | 23765923 |
GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | ISS | -- |
GO:1905562 | NOT regulation of vascular endothelial cell proliferation | IDA | 23765923 |
GO:1905772 | positive regulation of mesodermal cell differentiation | IDA | 23765923 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00006B7D0F_9606 | precursor_RNA | 84 | 6 |
HGNC: 31537, RefSeq: NR_029703, Ensembl: ENST00000385048 (view in UCSC) , miRBase: MI0000479, Rfam: RF00767, |
URS000016FD1A_9606 | miRNA | 22 | 6 |
RefSeq: NR_029703, LncBase: hsa-miR-150-5p, miRBase: MIMAT0000451, MirGeneDB: Hsa-Mir-150_5p, TarBase: hsa-miR-150-5p, |
URS00005EAAAD_9606 | miRNA | 22 | 5 |
RefSeq: NR_029703, LncBase: hsa-miR-150-3p, miRBase: MIMAT0004610, TarBase: hsa-miR-150-3p, |
URS0000EFDC4C_9606 | precursor_RNA | 57 | 1 |
MirGeneDB: Hsa-Mir-150, |
URS00007E46EF_9606 | miRNA | 21 | 1 |
MirGeneDB: Hsa-Mir-150_3p, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-150 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir150 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-150 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-150 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-150 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-150 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-150 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-150 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
rheumatoid arthritis |
|
|
gastric cancer |
|
|
primary biliary cirrhosis |
|
|
polycythemia vera |
|
|
leiomyoma, uterine |
|