Aliases for MIR150 Gene
Subcategory (RNA class) for MIR150 Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR150 Gene
- HGNC: 31537
- Entrez Gene: 406942
- Ensembl: ENSG00000207782
- OMIM: 611114
- miRBase: hsa-mir-150
ORGUL Members for MIR150 Gene
Previous HGNC Symbols for MIR150 Gene
- MIRN150
Previous GeneCards Identifiers for MIR150 Gene
- GC19M054698
- GC19M050004
Summaries for MIR150 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR150 Gene
MIR150 (MicroRNA 150) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Hematopoietic Stem Cell Differentiation and EV release from cardiac cells and their functional effects.
fRNAdb sequence ontologies for MIR150 Gene
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
Additional gene information for MIR150 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR150 Gene
Genomics for MIR150 Gene
GeneHancer (GH) Regulatory Elements for MIR150 Gene
Promoters and enhancers for MIR150 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR150 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR150 Gene
Genomic Locations for MIR150 Gene
- chr19:49,500,785-49,500,868
- (GRCh38/hg38)
- Size:
- 84 bases
- Orientation:
- Minus strand
- chr19:50,004,042-50,004,125
- (GRCh37/hg19)
Genomic View for MIR150 Gene
Genes around MIR150 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Ensembl
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC
MIR150 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR150 Gene
ORGUL Member Location for MIR150 Gene
Proteins for MIR150 Gene
Post-translational modifications for MIR150 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR150
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR150
- Origene Custom Protein Services for MIR150
- Search GeneTex for Proteins for MIR150
No data available for DME Specific Peptides for MIR150 Gene
Domains & Families for MIR150 Gene
Gene Families for MIR150 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR150 Gene
Function for MIR150 Gene
Phenotypes From GWAS Catalog for MIR150 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23765923 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR150
-
- Search ViGene Biosciences for MIR150
CRISPR Products
- Browse CRISPR knockouts for MIR150
- Applied Biological Materials CRISPR for MIR150
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR150
Clone Products
- GenScript: Custom all cDNA clones Services for MIR150
- VectorBuilder custom plasmid, inducible vectors for MIR150
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR150
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR150
- Applied Biological Materials Clones for MIR150
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR150 Gene
Localization for MIR150 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR150 Gene
Pathways & Interactions for MIR150 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Cell Differentiation - Index | ||
| 3 | EV release from cardiac cells and their functional effects | ||
| 4 | Hematopoietic Stem Cell Differentiation | ||
Pathways by source for MIR150 Gene
3 BioSystems pathways for MIR150 Gene
1 KEGG pathway for MIR150 Gene
Interacting Proteins for MIR150 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA | 23765923 |
| GO:0045603 | positive regulation of endothelial cell differentiation | IDA | 23765923 |
| GO:1905562 | NOT regulation of vascular endothelial cell proliferation | IDA | 23765923 |
| GO:1905772 | positive regulation of mesodermal cell differentiation | IDA | 23765923 |
No data available for SIGNOR curated interactions for MIR150 Gene
Transcripts for MIR150 Gene
mRNA/cDNA for MIR150 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR150
- Applied Biological Materials CRISPR for MIR150
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR150
Clone Products
- GenScript: Custom all cDNA clones Services for MIR150
- VectorBuilder custom plasmid, inducible vectors for MIR150
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR150
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR150
- Applied Biological Materials Clones for MIR150
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR150 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR150 Gene:
MIR150Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR150 Gene
Orthologs for MIR150 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-150 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mir150 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | cfa-mir-150 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-mir-150 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-150 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-150 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | aca-mir-150 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dre-mir-150 34 |
|
OneToOne |
- Species where no ortholog for MIR150 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR150 Gene
No data available for Paralogs for MIR150 Gene
Variants for MIR150 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000196537 | -- | 49,501,994(-) | T/G | upstream_transcript_variant | |
| rs1000963591 | -- | 49,501,078(-) | T/G | upstream_transcript_variant | |
| rs1001416581 | -- | 49,500,981(-) | C/T | upstream_transcript_variant | |
| rs1001701454 | -- | 49,502,051(-) | C/T | upstream_transcript_variant | |
| rs1002208133 | -- | 49,500,420(-) | A/G | downstream_transcript_variant |
Gene Damage Index Score:
10.58;
91.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MIR150 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR150
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR150 Gene
Disorders for MIR150 Gene
Additional Disease Information for MIR150
No disorders were found for MIR150 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR150 Gene
Publications for MIR150 Gene
- Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 58
- Quantitative miR analysis in chronic lymphocytic leukaemia/small lymphocytic lymphoma - proliferation centres are characterized by high miR-92a and miR-155 and low miR-150 expression. (PMID: 28407516) Szurián K … Reiniger L (Leukemia research 2017) 3 58
- MiR-150 regulates human keratinocyte proliferation in hypoxic conditions through targeting HIF-1α and VEGFA: Implications for psoriasis treatment. (PMID: 28399173) Li Y … Zhang G (PloS one 2017) 3 58
- MicroRNA-150 Modulates Ischemia-Induced Neovascularization in Atherosclerotic Conditions. (PMID: 28254813) Desjarlais M … Rivard A (Arteriosclerosis, thrombosis, and vascular biology 2017) 3 58
- MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells. (PMID: 28110404) Qin B … Lu Z (Molecular and cellular biochemistry 2017) 3 58
Products for MIR150 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
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- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR150
- Origene Custom Protein Services for MIR150
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- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR150
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR150
- GenScript: Custom all cDNA clones Services for MIR150
- GenScript Custom Purified and Recombinant Proteins Services for MIR150
- GenScript Custom Assay Services for MIR150
- GenScript Custom overexpressing Cell Line Services for MIR150
- Browse GenScript CRISPR for MIR150
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR150
- VectorBuilder custom plasmid, inducible vectors for MIR150
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR150
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR150
- Search GeneTex for Antibodies for MIR150
- Search GeneTex for Proteins for MIR150
- Search ViGene Biosciences for MIR150
Sources for MIR150 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems