microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR150 Gene

RNA type for MIR150 Gene

miRNA

Aliases for MIR150 Gene

External Ids for MIR150 Gene

Previous HGNC Symbols for MIR150 Gene

  • MIRN150

Previous GeneCards Identifiers for MIR150 Gene

  • GC19M054698
  • GC19M050004

Summaries for MIR150 Gene

Entrez Gene Summary for MIR150 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR150 Gene

MIR150 (MicroRNA 150) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR150 include Rheumatoid Arthritis and Gastric Cancer. Among its related pathways are Hematopoietic Stem Cell Differentiation and EV release from cardiac cells and their functional effects.

Rfam classification for MIR150 Gene

Additional gene information for MIR150 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR150 Gene

Genomics for MIR150 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR150 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049494 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.8 1824 9.7 BCLAF1 SP1 ZNF207 ZNF654 NCOR1 MYC ZNF600 IKZF1 SIX5 SSRP1 RPS11 SNORD35B MIR150 PRR12 RPL13A SNRNP70 PIH1D1 ALDH16A1 CPT1C CD37
GH19J049558 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 12.2 -59.8 -59779 4.5 MNT NFE2 FOXK2 EGR1 NRF1 ZNF664 TFAP4 ZMYM3 CREM ATF1 NOSIP lnc-RRAS-1-002 piR-49035 PRR12 RCN3 FCGRT MIR150 RPS11 SNORD35B SNORD34
GH19J049567 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 12.4 -68.7 -68698 4.6 BCLAF1 ZNF654 ZNF600 ZNF223 ZNF10 REST CTCF TRIM22 FEZF1 MNT PRR12 NOSIP SNORD35B PRRG2 POLD1 NUP62 PTOV1-AS2 SNORD35A FCGRT MIR150
GH19J049552 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 -54.5 -54482 5.7 POLR2A ZNF623 SAP130 ZNF146 ZNF205 CBX1 SUPT5H HNF4A SCRT1 TAF1 NOSIP PRR12 FCGRT RCN3 PRRG2 MIR150 RPS11 SNORD35B SNORD33 SNORD34
GH19J049564 Enhancer 0.5 ENCODE dbSUPER 12.4 -64.6 -64635 2.2 NFIC NFIB ENSG00000207073 PRR12 NOSIP FCGRT MIR150 RPS11 SNORD35B RCN3 SLC17A7 lnc-RRAS-1-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR150 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR150 Gene

Latest Assembly
chr19:49,500,785-49,500,868
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand

Previous Assembly
chr19:50,004,042-50,004,125
(GRCh37/hg19 by Entrez Gene)
Size:
84 bases
Orientation:
Minus strand

chr19:50,004,042-50,004,125
(GRCh37/hg19 by Ensembl)
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR150 Gene

Genes around MIR150 on UCSC Golden Path with GeneCards custom track
MIR150 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR150 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR150 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR150 Gene

Proteins for MIR150 Gene

Post-translational modifications for MIR150 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR150 Gene

Domains & Families for MIR150 Gene

Gene Families for MIR150 Gene

HGNC:
genes like me logo Genes that share domains with MIR150: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR150 Gene

Function for MIR150 Gene

Phenotypes From GWAS Catalog for MIR150 Gene

Gene Ontology (GO) - Molecular Function for MIR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18667440
genes like me logo Genes that share ontologies with MIR150: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR150 Gene

Localization for MIR150 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR150 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR150: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR150 Gene

Pathways & Interactions for MIR150 Gene

genes like me logo Genes that share pathways with MIR150: view

Pathways by source for MIR150 Gene

Gene Ontology (GO) - Biological Process for MIR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045603 positive regulation of endothelial cell differentiation IDA 23765923
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISS --
GO:1905562 NOT regulation of vascular endothelial cell proliferation IDA 23765923
GO:1905772 positive regulation of mesodermal cell differentiation IDA 23765923
genes like me logo Genes that share ontologies with MIR150: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR150 Gene

Drugs & Compounds for MIR150 Gene

No Compound Related Data Available

Transcripts for MIR150 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR150 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000016FD1A_9606 miRNA 22 6

RefSeq: NR_029703,

LncBase: hsa-miR-150-5p,

miRBase: MIMAT0000451,

MirGeneDB: Hsa-Mir-150_5p,

TarBase: hsa-miR-150-5p,

ENA: LM379069.1:1..22:ncRNA, LM608519.1:16..37:ncRNA,

URS00006B7D0F_9606 pre_miRNA 84 5

RefSeq: NR_029703,

Ensembl: ENST00000385048 (view in UCSC) ,

miRBase: MI0000479,

Rfam: RF00767,

ENA: LM608519.1:1..84:precursor_RNA,

URS00005EAAAD_9606 miRNA 22 5

RefSeq: NR_029703,

LncBase: hsa-miR-150-3p,

miRBase: MIMAT0004610,

TarBase: hsa-miR-150-3p,

ENA: LM380285.1:1..22:ncRNA, LM608519.1:51..72:ncRNA,

URS0001BBFE7D_9606 pre_miRNA 84 1

Rfam: RF00767,

URS0000EFDC4C_9606 pre_miRNA 57 1

MirGeneDB: Hsa-Mir-150,

MIR150 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR150 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR150 Gene

No ASD Table

Relevant External Links for MIR150 Gene

GeneLoc Exon Structure for
MIR150

Expression for MIR150 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR150 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR150

Evidence on tissue expression from TISSUES for MIR150 Gene

  • Blood(2.5)
  • Heart(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with MIR150: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR150 Gene

Orthologs for MIR150 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR150 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-150 30
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir150 30
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-150 30
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-150 30
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-150 30
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-150 30
  • 43 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-150 30
  • 72 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-150 30
  • 66 (a)
OneToOne
Species where no ortholog for MIR150 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR150 Gene

ENSEMBL:
Gene Tree for MIR150 (if available)
TreeFam:
Gene Tree for MIR150 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR150

Paralogs for MIR150 Gene

No data available for Paralogs for MIR150 Gene

Variants for MIR150 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR150 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR150 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for MIR150 Gene

Gene Damage Index Score: 10.58; 91.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIR150 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR150
Leiden Open Variation Database (LOVD)
MIR150

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR150 Gene

Disorders for MIR150 Gene

MalaCards: The human disease database

(77) MalaCards diseases for MIR150 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • ra
gastric cancer
  • gastric cancer, somatic
primary biliary cholangitis
  • biliary liver cirrhosis
polycythemia vera
  • pv
endometriosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR150

genes like me logo Genes that share disorders with MIR150: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR150 Gene

Publications for MIR150 Gene

  1. miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3. (PMID: 23159943) Honda N … Ihn H (The American journal of pathology 2013) 2 3
  2. MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2. (PMID: 20067763) Wu Q … Fan D (Biochemical and biophysical research communications 2010) 3 72
  3. MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice. (PMID: 33181172) Liu L … Sui Z (Life sciences 2021) 3
  4. The involvement of miR-150/β-catenin axis in colorectal cancer progression. (PMID: 31731194) He Z … Zhang Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  5. LncRNA PART1 regulates colorectal cancer via targeting miR-150-5p/miR-520h/CTNNB1 and activating Wnt/β-catenin pathway. (PMID: 31669140) Zhou T … Chen S (The international journal of biochemistry & cell biology 2020) 3

Products for MIR150 Gene

Sources for MIR150 Gene