microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR149 Gene

Subcategory (RNA class) for MIR149 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR149 Gene

  • MicroRNA 149 2 3 5
  • Hsa-MiR-149-5p 168 179
  • Hsa-MiR-149-3p 168 179
  • MIMAT0000450 53
  • MIMAT0004609 53
  • Hsa-Mir-149 3
  • MI0000478 53
  • Mir-149 3
  • MIRN149 3
  • RF00829 174
  • MIR149 2

External Ids for MIR149 Gene

Previous HGNC Symbols for MIR149 Gene

  • MIRN149

Previous GeneCards Identifiers for MIR149 Gene

  • GC02P241044
  • GC02P241395

Summaries for MIR149 Gene

Entrez Gene Summary for MIR149 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR149 Gene

MIR149 (MicroRNA 149) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR149 include Glioblastoma Multiforme and Follicular Lymphoma.

Rfam classification for MIR149 Gene

Additional gene information for MIR149 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR149 Gene

Genomics for MIR149 Gene

GeneHancer (GH) Regulatory Elements for MIR149 Gene

Promoters and enhancers for MIR149 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240452 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas 750.6 -0.1 -117 7.6 NR2F6 POLR2A NCOA3 GLIS2 CREB1 ZIC2 RXRB CTBP1 PATZ1 SP2 LOC100130449 MIR149 HDLBP GPC1
GH02J240519 Promoter/Enhancer 0.5 Ensembl CraniofacialAtlas 11.4 +63.9 63892 0.6 LOC100130449 MIR149 GPC1 ANKMY1 piR-50695 lnc-AQP12B-6
GH02J240412 Enhancer 0.3 Ensembl 11.5 -43.5 -43500 0.2 PKNOX1 GPC1 LOC100130449 MIR149 HSALNG0023567
GH02J240520 Enhancer 0.2 CraniofacialAtlas 11.4 +63.3 63283 0.2 LOC100130449 MIR149 GPC1 piR-50695 lnc-AQP12B-6 ANKMY1
GH02J240432 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -19.9 -19887 6.3 CTCF POLR2A NFYC L3MBTL2 MAX RAD21 ZNF148 SP1 MAFK SP5 GPC1 LOC100130449 MIR149
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR149 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR149 Gene

Genomic Locations for MIR149 Gene
chr2:240,456,001-240,456,089
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr2:241,395,418-241,395,506
(GRCh37/hg19)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR149 Gene

Genes around MIR149 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR149 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR149 Gene

Proteins for MIR149 Gene

Post-translational modifications for MIR149 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR149 Gene

Domains & Families for MIR149 Gene

Gene Families for MIR149 Gene

HGNC:
genes like me logo Genes that share domains with MIR149: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR149 Gene

Function for MIR149 Gene

Gene Ontology (GO) - Molecular Function for MIR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23595570
genes like me logo Genes that share ontologies with MIR149: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR149 Gene

Localization for MIR149 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR149 gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for MIR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR149: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR149 Gene

Pathways & Interactions for MIR149 Gene

PathCards logo

SuperPathways for MIR149 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 25916550
GO:0030336 negative regulation of cell migration IDA 26498692
GO:0032715 negative regulation of interleukin-6 production IGI 24299952
GO:0032916 positive regulation of transforming growth factor beta3 production ISS --
GO:0032967 positive regulation of collagen biosynthetic process ISS --
genes like me logo Genes that share ontologies with MIR149: view

No data available for Pathways by source and SIGNOR curated interactions for MIR149 Gene

Drugs & Compounds for MIR149 Gene

No Compound Related Data Available

Transcripts for MIR149 Gene

mRNA/cDNA for MIR149 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(2) LncBase transcripts :
(2) TarBase transcripts :
(5) ENA transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR149 Gene

No ASD Table

Relevant External Links for MIR149 Gene

GeneLoc Exon Structure for
MIR149
ECgene alternative splicing isoforms for
MIR149

Expression for MIR149 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR149 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR149 Gene:

MIR149
genes like me logo Genes that share expression patterns with MIR149: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR149 Gene

Orthologs for MIR149 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR149 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-149 33
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-149 33
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir149 33
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-149 33
  • 90 (a)
OneToOne
Species where no ortholog for MIR149 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR149 Gene

ENSEMBL:
Gene Tree for MIR149 (if available)
TreeFam:
Gene Tree for MIR149 (if available)

Paralogs for MIR149 Gene

No data available for Paralogs for MIR149 Gene

Variants for MIR149 Gene

Sequence variations from dbSNP and Humsavar for MIR149 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000205312 -- 240,455,237(+) C/T upstream_transcript_variant
rs1000555968 -- 240,455,110(+) A/G upstream_transcript_variant
rs1000941104 -- 240,454,536(+) G/A upstream_transcript_variant
rs1001151167 -- 240,454,136(+) G/A upstream_transcript_variant
rs1001520288 -- 240,454,277(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR149 Gene

Variant ID Type Subtype PubMed ID
dgv7359n54 CNV loss 21841781
esv2759119 CNV gain 17122850
esv3594798 CNV gain 21293372
nsv460157 CNV loss 19166990
nsv460158 CNV loss 19166990
nsv508899 CNV insertion 20534489
nsv516179 CNV loss 19592680
nsv584809 CNV gain 21841781
nsv584810 CNV loss 21841781
nsv819854 CNV gain 19587683
nsv834585 CNV loss 17160897
nsv955288 CNV deletion 24416366
nsv997288 CNV gain 25217958

Additional Variant Information for MIR149 Gene

Human Gene Mutation Database (HGMD)
MIR149
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR149

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR149 Gene

Disorders for MIR149 Gene

MalaCards: The human disease database

(13) MalaCards diseases for MIR149 Gene - From: miR2Disease, HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glioblastoma multiforme
  • adult glioblastoma multiforme
follicular lymphoma
  • lymphoma, follicular
pituitary adenoma
  • adenoma of the pituitary gland
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR149

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR149: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR149 Gene

Publications for MIR149 Gene

  1. MicroRNA-149 inhibits proliferation and invasion of glioma cells via blockade of AKT1 signaling. (PMID: 23298478) Pan SJ … Sun BM (International journal of immunopathology and pharmacology 2012) 2 3 56
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 43 56
  3. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M … Ni C (Journal of human genetics 2010) 3 43 56
  4. Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. (PMID: 20549817) Liu Z … Wei Q (Cancer 2010) 3 43 56
  5. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J … Chen Y (Human mutation 2009) 3 43 56

Products for MIR149 Gene

Sources for MIR149 Gene