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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR149 Gene
Subcategory (RNA class) for MIR149 Gene
miRNA
Aliases for MIR149 Gene
- MIMAT0000450 (miRBase)
- MI0000478 (miRBase)
- MIRN149 (NCBI Entrez Gene)
- Mir-149 (NCBI Entrez Gene)
- RF00829 (Rfam)
- MIR149 (Ensembl)
External Ids for MIR149 Gene
- HGNC: 31536
- NCBI Entrez Gene: 406941
- Ensembl: ENSG00000207611
- OMIM®: 615209
- miRBase: hsa-mir-149
Previous HGNC Symbols for MIR149 Gene
- MIRN149
Previous GeneCards Identifiers for MIR149 Gene
- GC02P241044
- GC02P241395
Summaries for MIR149 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR149 Gene
MIR149 (MicroRNA 149) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR149 include Follicular Lymphoma and Pituitary Adenoma.
Rfam classification for MIR149 Gene
-
microRNA mir-149
Additional gene information for MIR149 Gene
- HGNC (31536)
- NCBI Entrez Gene (406941)
- Ensembl (ENSG00000207611)
- OMIM® (615209)
- Open Targets Platform(ENSG00000207611)
- Search for MIR149 at DataMed
- Search for MIR149 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR149 Gene
Genomics for MIR149 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR149 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J240452 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE CraniofacialAtlas | 250.7 | -0.1 | -117 | 7.6 | ZNF217 ZIC2 SIN3A ZNF341 GABPB1 CTBP1 RARA TEAD3 SP2 THRB | LOC100130449 MIR149 HDLBP GPC1 DUSP28 | |
| GH02J240521 | Promoter | 0.4 | Ensembl | 11.4 | +64.0 | 64000 | 0.4 | EZH2 | LOC100130449 MIR149 GPC1 ANKMY1 piR-50695 lnc-AQP12B-6 DUSP28 | |
| GH02J240519 | Enhancer | 0.3 | Ensembl CraniofacialAtlas | 11.4 | +63.6 | 63591 | 0.4 | LOC100130449 MIR149 GPC1 piR-50695 lnc-AQP12B-6 DUSP28 ANKMY1 | ||
| GH02J240412 | Enhancer | 0.3 | Ensembl | 11.5 | -43.5 | -43500 | 0.2 | PKNOX1 | GPC1 LOC100130449 MIR149 HSALNG0023567 HSALNG0023568 OTOS | |
| GH02J240520 | Enhancer | 0.2 | CraniofacialAtlas | 11.4 | +63.3 | 63283 | 0.2 | LOC100130449 MIR149 GPC1 piR-50695 lnc-AQP12B-6 DUSP28 ANKMY1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR149 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR149 Gene
Latest Assembly
- chr2:240,456,001-240,456,089
- (GRCh38/hg38)
- Size:
- 89 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:241,395,418-241,395,506
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 89 bases
- Orientation:
- Plus strand
- chr2:241,395,418-241,395,506
- (GRCh37/hg19 by Ensembl)
- Size:
- 89 bases
- Orientation:
- Plus strand
Genomic View for MIR149 Gene
Genes around MIR149 on UCSC Golden Path with GeneCards custom track
MIR149 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 2q37.3 by HGNC
- 2q37.3 by Entrez Gene
- 2q37.3 by Ensembl
MIR149 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR149 Gene
Proteins for MIR149 Gene
Post-translational modifications for MIR149 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR149 Gene
Domains & Families for MIR149 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR149 Gene
Function for MIR149 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IGI | 23595570 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR149 - Starting at $85 >
- * MIR149 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR149 - Starting at $45 >
- * MIR149 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR149 Gene
Localization for MIR149 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR149 Gene
Pathways & Interactions for MIR149 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010719 | negative regulation of epithelial to mesenchymal transition | IDA | 25916550 |
| GO:0030336 | negative regulation of cell migration | IDA | 26498692 |
| GO:0032715 | negative regulation of interleukin-6 production | IGI | 24299952 |
| GO:0032720 | negative regulation of tumor necrosis factor production | IGI | 23595570 |
| GO:0032916 | positive regulation of transforming growth factor beta3 production | ISS | -- |
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR149 Gene
Transcripts for MIR149 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR149 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00001C770D_9606 | miRNA | 23 | 6 |
RefSeq: NR_029702, LncBase: hsa-miR-149-5p, miRBase: MIMAT0000450, MirGeneDB: Hsa-Mir-149_5p, TarBase: hsa-miR-149-5p, |
| URS000071F654_9606 | precursor_RNA | 89 | 5 |
RefSeq: NR_029702, Ensembl: ENST00000384879 (view in UCSC) , miRBase: MI0000478, Rfam: RF00829, |
| URS000042C6A6_9606 | miRNA | 21 | 5 |
RefSeq: NR_029702, LncBase: hsa-miR-149-3p, miRBase: MIMAT0004609, TarBase: hsa-miR-149-3p, |
| URS0000EFDAD6_9606 | precursor_RNA | 63 | 1 |
MirGeneDB: Hsa-Mir-149, |
| URS000075A34E_9606 | miRNA | 22 | 1 |
MirGeneDB: Hsa-Mir-149_3p, |
MIR149 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR149 Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR149 - Starting at $85 >
- * MIR149 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR149 - Starting at $45 >
- * MIR149 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR149 Gene
- GeneLoc Exon Structure for
- MIR149
Expression for MIR149 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR149
Primer products for research
-
OriGene qPCR primer pairs for MIR149
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR149 Gene
Orthologs for MIR149 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-149 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-149 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir149 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-149 31 |
|
OneToOne |
- Species where no ortholog for MIR149 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for MIR149 Gene
No data available for Paralogs for MIR149 Gene
Variants for MIR149 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7359n54 | CNV | loss | 21841781 |
| esv2759119 | CNV | gain | 17122850 |
| esv3594798 | CNV | gain | 21293372 |
| nsv460157 | CNV | loss | 19166990 |
| nsv460158 | CNV | loss | 19166990 |
| nsv508899 | CNV | insertion | 20534489 |
| nsv516179 | CNV | loss | 19592680 |
| nsv584809 | CNV | gain | 21841781 |
| nsv584810 | CNV | loss | 21841781 |
| nsv819854 | CNV | gain | 19587683 |
| nsv834585 | CNV | loss | 17160897 |
| nsv955288 | CNV | deletion | 24416366 |
| nsv997288 | CNV | gain | 25217958 |
Additional Variant Information for MIR149 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR149 Gene
Disorders for MIR149 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| follicular lymphoma |
|
|
| pituitary adenoma |
|
|
| diffuse large b-cell lymphoma |
|
|
| melanoma |
|
|
| glioblastoma |
|
Search MIR149 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR149
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR149 Gene
Publications for MIR149 Gene
- MicroRNA-149 inhibits proliferation and invasion of glioma cells via blockade of AKT1 signaling. (PMID: 23298478) Pan SJ … Sun BM (International journal of immunopathology and pharmacology 2012) 2 3
- Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41
- Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. (PMID: 20549817) Liu Z … Wei Q (Cancer 2010) 3 41
- Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M … Ni C (Journal of human genetics 2010) 3 41
- Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J … Chen Y (Human mutation 2009) 3 41
ExternalLinks
Products for MIR149 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR149
- Origene Custom Protein Services for MIR149
- Browse OriGene Inhibitory RNA Products For MIR149
- OriGene qPCR primer pairs for MIR149
- Browse CRISPR knockouts for MIR149
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR149
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR149
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR149
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR149
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR149
Sources for MIR149 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB