microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR149 Gene

Subcategory (RNA class) for MIR149 Gene

miRNA

Aliases for MIR149 Gene

External Ids for MIR149 Gene

Previous HGNC Symbols for MIR149 Gene

  • MIRN149

Previous GeneCards Identifiers for MIR149 Gene

  • GC02P241044
  • GC02P241395

Summaries for MIR149 Gene

Entrez Gene Summary for MIR149 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR149 Gene

MIR149 (MicroRNA 149) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR149 include Follicular Lymphoma and Pituitary Adenoma.

Rfam classification for MIR149 Gene

Additional gene information for MIR149 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR149 Gene

Genomics for MIR149 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR149 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240452 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas 250.7 -0.1 -117 7.6 ZNF217 ZIC2 SIN3A ZNF341 GABPB1 CTBP1 RARA TEAD3 SP2 THRB LOC100130449 MIR149 HDLBP GPC1 DUSP28
GH02J240521 Promoter 0.4 Ensembl 11.4 +64.0 64000 0.4 EZH2 LOC100130449 MIR149 GPC1 ANKMY1 piR-50695 lnc-AQP12B-6 DUSP28
GH02J240519 Enhancer 0.3 Ensembl CraniofacialAtlas 11.4 +63.6 63591 0.4 LOC100130449 MIR149 GPC1 piR-50695 lnc-AQP12B-6 DUSP28 ANKMY1
GH02J240412 Enhancer 0.3 Ensembl 11.5 -43.5 -43500 0.2 PKNOX1 GPC1 LOC100130449 MIR149 HSALNG0023567 HSALNG0023568 OTOS
GH02J240520 Enhancer 0.2 CraniofacialAtlas 11.4 +63.3 63283 0.2 LOC100130449 MIR149 GPC1 piR-50695 lnc-AQP12B-6 DUSP28 ANKMY1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR149 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR149 Gene

Latest Assembly
chr2:240,456,001-240,456,089
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand

Previous Assembly
chr2:241,395,418-241,395,506
(GRCh37/hg19 by Entrez Gene)
Size:
89 bases
Orientation:
Plus strand

chr2:241,395,418-241,395,506
(GRCh37/hg19 by Ensembl)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR149 Gene

Genes around MIR149 on UCSC Golden Path with GeneCards custom track
MIR149 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR149 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR149 Gene

Proteins for MIR149 Gene

Post-translational modifications for MIR149 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR149 Gene

Domains & Families for MIR149 Gene

Gene Families for MIR149 Gene

HGNC:
genes like me logo Genes that share domains with MIR149: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR149 Gene

Function for MIR149 Gene

Gene Ontology (GO) - Molecular Function for MIR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 23595570
genes like me logo Genes that share ontologies with MIR149: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR149 Gene

Localization for MIR149 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR149 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR149 Gene

Pathways & Interactions for MIR149 Gene

PathCards logo

SuperPathways for MIR149 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 25916550
GO:0030336 negative regulation of cell migration IDA 26498692
GO:0032715 negative regulation of interleukin-6 production IGI 24299952
GO:0032720 negative regulation of tumor necrosis factor production IGI 23595570
GO:0032916 positive regulation of transforming growth factor beta3 production ISS --
genes like me logo Genes that share ontologies with MIR149: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR149 Gene

Drugs & Compounds for MIR149 Gene

No Compound Related Data Available

Transcripts for MIR149 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR149 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001C770D_9606 miRNA 23 6

RefSeq: NR_029702,

LncBase: hsa-miR-149-5p,

miRBase: MIMAT0000450,

MirGeneDB: Hsa-Mir-149_5p,

TarBase: hsa-miR-149-5p,

ENA: LM379068.1:1..23:ncRNA, LM608518.1:15..37:ncRNA,

URS000071F654_9606 precursor_RNA 89 5

RefSeq: NR_029702,

Ensembl: ENST00000384879 (view in UCSC) ,

miRBase: MI0000478,

Rfam: RF00829,

ENA: LM608518.1:1..89:precursor_RNA,

URS000042C6A6_9606 miRNA 21 5

RefSeq: NR_029702,

LncBase: hsa-miR-149-3p,

miRBase: MIMAT0004609,

TarBase: hsa-miR-149-3p,

ENA: LM380284.1:1..21:ncRNA, LM608518.1:56..76:ncRNA,

URS0000EFDAD6_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-149,

URS000075A34E_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-149_3p,

MIR149 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR149 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR149 Gene

No ASD Table

Relevant External Links for MIR149 Gene

GeneLoc Exon Structure for
MIR149

Expression for MIR149 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR149 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR149

genes like me logo Genes that share expression patterns with MIR149: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR149 Gene

Orthologs for MIR149 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR149 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-149 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-149 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir149 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-149 31
  • 90 (a)
OneToOne
Species where no ortholog for MIR149 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR149 Gene

ENSEMBL:
Gene Tree for MIR149 (if available)
TreeFam:
Gene Tree for MIR149 (if available)

Paralogs for MIR149 Gene

No data available for Paralogs for MIR149 Gene

Variants for MIR149 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR149 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR149 Gene

Variant ID Type Subtype PubMed ID
dgv7359n54 CNV loss 21841781
esv2759119 CNV gain 17122850
esv3594798 CNV gain 21293372
nsv460157 CNV loss 19166990
nsv460158 CNV loss 19166990
nsv508899 CNV insertion 20534489
nsv516179 CNV loss 19592680
nsv584809 CNV gain 21841781
nsv584810 CNV loss 21841781
nsv819854 CNV gain 19587683
nsv834585 CNV loss 17160897
nsv955288 CNV deletion 24416366
nsv997288 CNV gain 25217958

Additional Variant Information for MIR149 Gene

Human Gene Mutation Database (HGMD)
MIR149
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR149

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR149 Gene

Disorders for MIR149 Gene

MalaCards: The human disease database

(75) MalaCards diseases for MIR149 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
follicular lymphoma
  • lymphoma, follicular
pituitary adenoma
  • adenoma of the pituitary gland
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
melanoma
  • malignant melanoma
glioblastoma
  • adult glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR149

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MIR149: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR149 Gene

Publications for MIR149 Gene

  1. MicroRNA-149 inhibits proliferation and invasion of glioma cells via blockade of AKT1 signaling. (PMID: 23298478) Pan SJ … Sun BM (International journal of immunopathology and pharmacology 2012) 2 3
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41
  3. Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. (PMID: 20549817) Liu Z … Wei Q (Cancer 2010) 3 41
  4. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M … Ni C (Journal of human genetics 2010) 3 41
  5. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J … Chen Y (Human mutation 2009) 3 41

Products for MIR149 Gene

Sources for MIR149 Gene