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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR149 (MicroRNA 149) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR149 include Follicular Lymphoma and Glioblastoma Multiforme.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23595570 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010719 | negative regulation of epithelial to mesenchymal transition | IDA | 25916550 |
GO:0030336 | negative regulation of cell migration | IDA | 26498692 |
GO:0032715 | negative regulation of interleukin-6 production | IGI | 24299952 |
GO:0032916 | positive regulation of transforming growth factor beta3 production | ISS | -- |
GO:0032967 | positive regulation of collagen biosynthetic process | ISS | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000071F654_9606 | precursor_RNA | 89 | 6 |
HGNC: 31536, RefSeq: NR_029702, Ensembl: ENST00000384879 (view in UCSC) , miRBase: MI0000478, Rfam: RF00829, |
URS00001C770D_9606 | miRNA | 23 | 6 |
RefSeq: NR_029702, LncBase: hsa-miR-149-5p, miRBase: MIMAT0000450, MirGeneDB: Hsa-Mir-149_5p, TarBase: hsa-miR-149-5p, |
URS000042C6A6_9606 | miRNA | 21 | 5 |
RefSeq: NR_029702, LncBase: hsa-miR-149-3p, miRBase: MIMAT0004609, TarBase: hsa-miR-149-3p, |
URS0000EFDAD6_9606 | precursor_RNA | 63 | 1 |
MirGeneDB: Hsa-Mir-149, |
URS000075A34E_9606 | miRNA | 22 | 1 |
MirGeneDB: Hsa-Mir-149_3p, |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-149 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-149 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir149 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-149 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv7359n54 | CNV | loss | 21841781 |
esv2759119 | CNV | gain | 17122850 |
esv3594798 | CNV | gain | 21293372 |
nsv460157 | CNV | loss | 19166990 |
nsv460158 | CNV | loss | 19166990 |
nsv508899 | CNV | insertion | 20534489 |
nsv516179 | CNV | loss | 19592680 |
nsv584809 | CNV | gain | 21841781 |
nsv584810 | CNV | loss | 21841781 |
nsv819854 | CNV | gain | 19587683 |
nsv834585 | CNV | loss | 17160897 |
nsv955288 | CNV | deletion | 24416366 |
nsv997288 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
follicular lymphoma |
|
|
glioblastoma multiforme |
|
|
pituitary adenoma |
|
|
diffuse large b-cell lymphoma |
|
|
melanoma |
|