microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR148B Gene

RNA type for MIR148B Gene

miRNA

Aliases for MIR148B Gene

External Ids for MIR148B Gene

Previous HGNC Symbols for MIR148B Gene

  • MIRN148B

Previous GeneCards Identifiers for MIR148B Gene

  • GC12P053019
  • GC12P054731

Summaries for MIR148B Gene

Entrez Gene Summary for MIR148B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR148B Gene

MIR148B (MicroRNA 148b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR148B include Asthma and Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 1. Among its related pathways are Metastatic brain tumor and miRNA targets in ECM and membrane receptors.

Rfam classification for MIR148B Gene

  • mir-148/mir-152 microRNA precursor family

Additional gene information for MIR148B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR148B Gene

Genomics for MIR148B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR148B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J054336 Enhancer 1.1 ENCODE dbSUPER 250.7 +1.0 1021 2.6 ZNF654 IKZF1 NCOR1 ZNF580 CEBPA REST TBP MNT ARNT TAF9B MIR148B GPR84 RNU6-950P COPZ1 CBX5 lnc-HNRNPA1-5 ENSG00000258344
GH12J054337 Enhancer 0.7 ENCODE 250.7 -0.6 -574 0.2 IKZF1 ZNF600 ZNF580 CTCF REST TBP ARNT NFATC3 NBN SMC3 MIR148B RF00026-233 RNU6-950P GPR84 COPZ1 ENSG00000258344
GH12J054338 Promoter 0.3 Ensembl 250.7 -1.1 -1115 0.2 MIR148B FLJ12825 RF00026-233 RNU6-950P GPR84 COPZ1 ENSG00000258344
GH12J054291 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 -40.1 -40104 11.8 ZNF654 NCOR1 IKZF1 MYC ZNF600 SSRP1 ZNF580 POLR2A ZIC2 MXD4 NFE2 HNRNPA1 RNU6-950P MIR148B GPR84 ZNF385A FLJ12825 GTSF1 AAAS COPZ1
GH12J054278 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.3 -53.0 -53043 13.9 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 SSRP1 ZNF580 ZNF592 HNRNPA1 CBX5 NONHSAG011287.2 lnc-COPZ1-3 SP1 PCBP2 ENSG00000258344 ATF7 AAAS MAP3K12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR148B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR148B Gene

Latest Assembly
chr12:54,337,216-54,337,314
(GRCh38/hg38)
Size:
99 bases
Orientation:
Plus strand

Previous Assembly
chr12:54,731,000-54,731,098
(GRCh37/hg19 by Entrez Gene)
Size:
99 bases
Orientation:
Plus strand

chr12:54,731,000-54,731,098
(GRCh37/hg19 by Ensembl)
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR148B Gene

Genes around MIR148B on UCSC Golden Path with GeneCards custom track
MIR148B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR148B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR148B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR148B Gene

Proteins for MIR148B Gene

Post-translational modifications for MIR148B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR148B Gene

Domains & Families for MIR148B Gene

Gene Families for MIR148B Gene

genes like me logo Genes that share domains with MIR148B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR148B Gene

Function for MIR148B Gene

Phenotypes From GWAS Catalog for MIR148B Gene

Gene Ontology (GO) - Molecular Function for MIR148B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR148B: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR148B Gene

Localization for MIR148B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR148B gene
Compartment Confidence
plasma membrane 2
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR148B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR148B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR148B Gene

Pathways & Interactions for MIR148B Gene

genes like me logo Genes that share pathways with MIR148B: view

Pathways by source for MIR148B Gene

Gene Ontology (GO) - Biological Process for MIR148B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR148B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR148B Gene

Drugs & Compounds for MIR148B Gene

No Compound Related Data Available

Transcripts for MIR148B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR148B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000521626_9606 miRNA 22 6

RefSeq: NR_029894,

LncBase: hsa-miR-148b-3p,

miRBase: MIMAT0000759,

MirGeneDB: Hsa-Mir-148-P3_3p,

TarBase: hsa-miR-148b-3p,

ENA: LM379264.1:1..22:ncRNA, LM608729.1:63..84:ncRNA,

URS00005A7A84_9606 miRNA 22 5

RefSeq: NR_029894,

LncBase: hsa-miR-148b-5p,

miRBase: MIMAT0004699,

TarBase: hsa-miR-148b-5p,

ENA: LM380359.1:1..22:ncRNA, LM608729.1:25..46:ncRNA,

URS000075C16C_9606 pre_miRNA 99 4

RefSeq: NR_029894,

Ensembl: ENST00000362252 (view in UCSC) ,

miRBase: MI0000811,

ENA: LM608729.1:1..99:precursor_RNA,

URS00000C61A6_9606 pre_miRNA 87 1

Rfam: RF00248,

URS0001BC6A0C_9606 pre_miRNA 87 1

Rfam: RF00248,

MIR148B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR148B Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR148B Gene

No ASD Table

Relevant External Links for MIR148B Gene

GeneLoc Exon Structure for
MIR148B

Expression for MIR148B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR148B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR148B

genes like me logo Genes that share expression patterns with MIR148B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR148B Gene

Orthologs for MIR148B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR148B Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-148b 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-148b 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-148b 30
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir148b 30
  • 94 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-148b 30
  • 89 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-148 30
  • 72 (a)
ManyToMany
Species where no ortholog for MIR148B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR148B Gene

ENSEMBL:
Gene Tree for MIR148B (if available)
TreeFam:
Gene Tree for MIR148B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR148B

Paralogs for MIR148B Gene

No data available for Paralogs for MIR148B Gene

Variants for MIR148B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR148B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR148B Gene

Variant ID Type Subtype PubMed ID
nsv1049160 CNV gain 25217958

Additional Variant Information for MIR148B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR148B
Leiden Open Variation Database (LOVD)
MIR148B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR148B Gene

Disorders for MIR148B Gene

MalaCards: The human disease database

(20) MalaCards diseases for MIR148B Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
muscular dystrophy, limb-girdle, autosomal recessive 1
  • lgmdr1
dermatomyositis
  • amyopathic dermatomyositis
nemaline myopathy
  • nemaline body disease
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR148B

genes like me logo Genes that share disorders with MIR148B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR148B Gene

Publications for MIR148B Gene

  1. HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma. (PMID: 33527791) Seo SI … Lee SK (Yonsei medical journal 2021) 3
  2. Long non-coding RNA H19 confers resistance to gefitinib via miR-148b-3p/DDAH1 axis in lung adenocarcinoma. (PMID: 31503013) Huang Z … Yang Y (Anti-cancer drugs 2020) 3
  3. LncRNA TUG1 regulates proliferation and apoptosis by regulating miR-148b/IGF2 axis in ox-LDL-stimulated VSMC and HUVEC. (PMID: 31926240) Wu X … Ma C (Life sciences 2020) 3
  4. Long non-coding RNA MIAT/miR-148b/PAPPA axis modifies cell proliferation and migration in ox-LDL-induced human aorta vascular smooth muscle cells. (PMID: 32470448) Zhou Y … Sun H (Life sciences 2020) 3
  5. MiR-148b suppressed non-small cell lung cancer progression via inhibiting ALCAM through the NF-κB signaling pathway. (PMID: 31883226) Jiang Z … Sun Y (Thoracic cancer 2020) 3

Products for MIR148B Gene

Sources for MIR148B Gene